The lower Silurian hot shale in the Ghadames Basin was investigated to provide a regional assessment of the future prospects of shale gas play as an important unconventional resource system in one of the top African superglobal petroliferous sedimentary basins. The unconventional natural gas potential of the hot shale was studied based on regional improved organofacies assessment, thermal maturity, the timing of generation and expulsion, and sweet gas spot analysis, such as gas in place (GIP), total expelled gas (TEG), and total retained gas (TRG). The integration between regional geology and organic geochemistry, together with the proper regional utilization of the multi-dimensional basin modeling to better appreciate the importance of the Silurian hot shale as a key future shale gas unconventional-rich petroleum system (URPS) in the Ghadames Basin. The relationship between the richness and thermal parameters, such as the total organic carbon indicator (%TOC), hydrogen index (HI), measured and time step (calibrated models) vitrinite and equivalent vitrinite (%VRo) reflectance were used to develop quality control models for the regional natural gas spots of the Silurian hot shale were present-day mapping presentations are utilized as well for each parameter to better appreciate the lateral variability of the dry gas volumes. Regional basin control parameters from several key wells, such as heat flow levels, formation pressure system, and basin porosity were successfully utilized for the hot shale gas play resource screening (sweet spots) study utilizing multi-dimensional modeling approaches. The established regional spatial type B marine organofacies of the hot shale with excellent geochemical properties (∼18 %TOC) and regionally sufficient thermal maturation (∼2.45 %VRo, post-mature stage) indicate a significant amount of natural gas expelled and retained that has occurred in the Silurian hot shale system. The estimated GIP of the hot shale is about 120 bcf/km2 (equivalent to 320 bcf/section). The maximum expelled gas (TEG) amount is defined with values up to 88 bcf/section and the total estimated volume of the retained gas (TRG) is up to 96 bcf/km2, with the current geological architecture, geochemical properties, volumes, and distribution of the hot shale dry gas sweet spot in the Ghadames Basin. The hot shale can be considered in the near future for extensive further studies and exploration and development plans in Libya, Algeria, or Tunisia.