The rational design of the turbine support structure ensures the safe operation of the system, achieves significant economic benefits and improves the efficiency of the turbine. This paper presents a novel turbine support structure capable of vertical movement along the guide column. In addition, the GA-FA-BP method has been developed for the optimization design of the support structure, which combines genetic algorithm (GA), firefly algorithm (FA) and back-propagation neural network (BP). The use of quadratic response surface (RS) method along with NSGA-II for the result validation of the GA-FA-BP model ensures the robustness and reliability of the optimization results. A finite element model is set up to analyse the mechanical behaviour of the support structure under 10 different combined load conditions. The most critical load conditions in the static mechanical models are used to generate training data, and the mass, deformation and equivalent stress of the optimized and unoptimized support structures are analyzed and compared. The results show that the optimized support structure can maintain deformation and equivalent stress within a weight reduction of 21.83% compared to the original design. Compared to a single optimization model, the proposed GA-FA-BP model shows higher accuracy with a correlation coefficient up to 0.9989.