Pulse Wave Velocity In Patients Research Articles

Clinical usefulness of ankle brachial index and brachial-ankle pulse wave velocity in patients with ischemic stroke.

Ankle brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) are widely used noninvasive modalities to evaluate atherosclerosis. Recently, evidence has increased supporting the use of ABI and baPWV as markers of cerebrovascular disease. This study sought to examine the relationship between ABI and baPWV with ischemic stroke. This study also aimed to determine which pathogenic mechanism, large artery disease (LAD) or small vessel disease (SVD), is related to ABI or baPWV. Retrospectively, 121 patients with ischemic stroke and 38 subjects with no obvious ischemic stroke history were recruited. First, ABI and baPWV were compared between the groups. Then, within the stroke group, the relevance of ABI and baPWV with regard to SVD and LAD, which were classified by brain magnetic resonance image (MRI) and magnetic resonance angiography (MRA) or computed tomography angiography (CTA) findings, was assessed. The baPWV was higher in the stroke group than non-stroke group (1,944.18±416.6 cm/s vs. 1,749.76±669.6 cm/s, P<0.01). Regarding LAD, we found that mean ABI value was lower in the group with extracranial large artery stenosis (P<0.01), and there was an inverse linear correlation between ABI and the grade of extracranial large artery stenosis (P<0.01). For SVD, there was a significant correlation between SVD and baPWV (2,057.6±456.57 cm/s in the SVD (+) group vs. 1,491±271.62 cm/s in the SVD (-) group; P<0.01). However, the grade of abnormalities detected in SVD did not correlate linearly with baPWV. These findings show that baPWV is a reliable surrogate marker of ischemic stroke. Furthermore, baPWV and ABI can be used to indicate the presence of small vessel disease and large arterial disease, respectively.

Impact of Disease Duration on Vascular Surrogates of Early Atherosclerosis in Childhood-Onset Systemic Lupus Erythematosus.

To determine whether longer disease duration negatively impacts carotid intima-media thickness (CIMT), flow-mediated dilation (FMD), and pulse wave velocity (PWV) in a cohort of patients with childhood-onset systemic lupus erythematosus (SLE), and to compare CIMT, FMD, and PWV in patients with childhood-onset SLE with those in healthy children and explore determinants of vascular test results in childhood-onset SLE. Cross-sectional analysis was performed in a prospective longitudinal cohort of patients with childhood-onset SLE at the latest followup visit. Clinical and laboratory data were collected for patients with childhood-onset SLE. CIMT, FMD, and PWV were measured using standardized protocols in patients with childhood-onset SLE and healthy children. Correlations between disease duration and results of the 3 vascular tests were performed. Vascular data in patients with childhood-onset SLE were compared with those in healthy children. Multivariable linear regression was used to identify determinants of CIMT, FMD, and PWV in childhood-onset SLE. Patients with childhood-onset SLE (n = 149) and healthy controls (n = 178) were enrolled. The median age of the patients was 17.2 years (interquartile range [IQR] 15.7-17.9 years), and their median disease duration was 3.2 years (IQR 1.8-4.9 years). The median age of the healthy children was 14.7 years (IQR 13.1-15.9 years). Longer disease duration correlated with worse FMD (r = -0.2, P = 0.031) in patients with childhood-onset SLE. Patients with childhood-onset SLE had smaller (better) CIMT, higher (better) FMD, and similar PWV compared with healthy controls. Linear regression analysis explained <24% of the variation in vascular test results in patients with childhood-onset SLE, suggesting that other variables should be explored as important determinants of CIMT, FMD, and PWV. In this cohort of 149 patients with childhood-onset SLE, patients did not have worse CIMT, FMD, or PWV than did healthy controls. Longer disease duration was associated with worse FMD, suggesting progressive endothelial dysfunction over time.

Evaluation of Arteriosclerosis Using the Brachial-Ankle Pulse Wave Velocity in Patients with Visceral Lesion-Free Systemic Lupus Erythematosus Characterized by Skin Lesions

Recently, the cardio-/cerebrovascular lesion-related mortality rate has been high in patients with systemic lupus erythematosus (SLE). In these patients, the risk of cardio-/cerebrovascular lesions is also higher than in the general population. Cardio-/cerebrovascular lesions may occur during long-term follow-up. In this study, we evaluated arteriosclerosis using the brachial-ankle pulse wave velocity (baPWV) in visceral lesion-free SLE patients with skin lesions. In these patients, baPWV was higher than in healthy adults even at a young age. This suggests that baPWV is a possible tool to evaluate the patient’s vascular function, which was difficult to evaluate using a conventional sera arteriosclerosis index. Even when conditions are characterized by skin lesions, it may be important to consider the influence on the cardio-/cerebrovascular systems, as indicated for patients with systemic symptoms.

Periodontitis and arterial stiffness: a systematic review and meta-analysis.

Patients with periodontitis have a higher risk of cardiovascular diseases, although a causal relationship between these conditions remains unclear. Arterial stiffness is considered a marker of arteriosclerosis and a risk factor for cardiovascular diseases. A systematic review of the literature on clinical studies using pulse wave velocity (PWV) to assess arterial stiffness in patients with periodontitis was carried out to answer the following questions: (i) Do patients with periodontitis have impaired arterial stiffness compared to non-periodontal diseased subjects? (ii) Is periodontal treatment effective as a means to improve arterial stiffness in patients with periodontitis? Literature search was done on different databases up to September 2014. All clinical studies (excluding case reports) using PWV in patients with periodontitis were retrieved for a full-text evaluation. A total of 10 studies were included. Patients with periodontitis have increased arterial stiffness compared to controls (PWV mean difference 0.85m/s; 95% confidence interval: 0.53-1.16; p<0.00001). The only two interventional studies showed contradictory results on the effects of periodontal treatment on PWV. Patients with periodontitis appear to have higher values of PWV compared to controls. The effect of periodontal treatment on arterial stiffness remains unclear.

Estimation of pulse wave velocity in patients with peripheral artery disease: a word of caution.

Estimation of pulse wave velocity in patients with peripheral artery disease: a word of caution

Association between environmental particulate matter and arterial stiffness in patients undergoing hemodialysis.

BackgroundAortic pulse wave velocity (PWV) has been shown to be an independent predictor of cardiovascular mortality in patients with end-stage renal disease and the general population. Atmospheric particulate- matter (PM) concentrations and their effects on cardiovascular system by affecting arterial stiffness and central hemodynamic parameters had been noted. The purpose of this study was to access the correlation of air pollution variables and PWV in patients undergoing hemodialysis (HD).MethodsThis study analyzed 127 HD patients treated at the outpatient HD center. Brachial-ankle pulse wave velocity (baPWV) was measured by using a Vascular Profiler 1000 (VP-1000). Air pollution levels were recorded by a network of 27 monitoring stations near or in the patients’ living areas throughout Taiwan. The 12-month average concentrations of PM with an aerodynamic diameter of <10 and <2.5 mm (PM10 and PM2.5, respectively), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide(CO), and ozone (O3) were included.Results and DiscussionMultivariate linear regression analyses indicated that systolic blood pressure (SBP) (β = 0.589, P < 0.025), age (β = 0.316, P < 0.001), serum aluminum level (Al) (β = 0.149, P = 0.020), and PM10 (β = 0.133, P = 0.036) were positively correlated with baPWV.ConclusionThis cross-sectional study shows that in HD patients, the environmental PM10 level is associated with the baPWV.

Evaluation of carotid artery elasticity and its related factors in patients with acute ischemic stroke using shear wave elastography

Objective To measure the longitudinal elastic modulus in patients with acute ischemic stroke by shear wave elasotography(SWE), and to study its feasibility and related factors. Methods There were 179 cases with acute ischemic stroke (AIS) including 103 cases with large artery atherosclerosis and 76 cases with lacunar infarction classified according to the TOAST classification. There were 168 age and sex-matched cases as control group. Pulse wave velocity (PWV) of bilateral carotid was measured by radiofrequency ultrasound. The 20 areas of superficial walls of bilateral carotid artery were analyzed by SWE, and the average values of longitudinal average elastic modulus (MEmean), the maximum elastic modulus (MEmax) and minimum elastic modulus (MEmin) were calculated. The independent factors of MEmean were analyzed using multiple linear regression analysis. Results ①Compared with control group, PWV in patients with AIS was increased (P<0.05). ②The MEmax and MEmean of carotid artery in patients with AIS were more than those in the control group (P<0.05). ③Age, systolic blood pressure, PWV and low-density lipoprotein cholesterol(LDL-C) were positively related to MEmean (r=0.221, 0.174, 0.776 and 0.173, respectively, P<0.05), and were independent factors for MEmean. Conclusions SWE can evaluated the arterial stiffness using longitudinal elastic modulus of carotid. Age, systolic blood pressure, PWV and LDL were independent factors for longitudinal elastic modulus. Key words: Elasticity imaging techniques; Stroke; Carotid arteries; Arterial stiffness; Pulse wave velocity

Left ventricular remodeling and arterial remodeling in patients with chronic kidney disease stage 1–3

Introduction: Chronic kidney disease (CKD) is an independent factor for cardiovascular system complications, such as arterial hypertension, left ventricular hypertrophy (LVH), heart failure or accelerated atherosclerosis progression. The aim of the paper was to analyze left ventricular and arterial remodeling in patients with CKD stages 1–3 to identify the subclinical marker of cardiovascular system damage which changes first in the course of CKD. Methods: The examined group consisted of 90 patients with CKD stage 1–3 and 30 subjects constituting the control group. Left ventricular mass index (LVMI), left ventricular relative wall thickness (RWT) and ejection fraction (EF) were determined by echocardiographic examination. Pulse wave velocity (PWV) between the carotid and femoral arteries as well as common carotid artery intima–media thickness (IMT) was measured. 24-h ambulatory blood pressure monitoring was performed in all subjects. Results: No differences were found between blood pressure values in the examined groups of patients with CKD1, CKD2 and CKD3. Concentric remodeling was found in 20.0%, concentric hypertrophy in 22.2% and eccentric hypertrophy in 18.9% of patients. LVMI values in patients with CKD2 and 3 were higher than in the control group. IMT values in patients with CKD3 were higher than in patients with CKD2. PWV in patients with stage 3 CKD was significantly higher than in the control group (p < 0.05). Conclusions: In the course of CKD, the left ventricle undergoes remodeling earlier than large arterial vessels. Echocardiographic assessment of LVH in early stages of CKD may identify patients at increased cardiovascular risk.

Coronary artery calcification, intima-media thickness, aortic pulse wave velocity in patients over 65 years old on peritoneal dialysis (PD)

Coronary artery calcification, intima-media thickness, aortic pulse wave velocity in patients over 65 years old on peritoneal dialysis (PD)

PP.20.08

Objective: Ageing is characterized by deposition of complexes of carbohydrates and proteins that form irreversible links with collagen in the vessel wall, called advanced glycation end-products (AGEs). The receptors for AGEs(RAGE) are also present in the circulating form and once activated by AGEs, they trigger inflammation, formation of reactive oxygen species and a pro-thromobotic state, resulting in stiff arteries and increased risk of cardiovascular events. We wanted to study the relationship between RAGE polymorphisms 429T > C and -374T > A and arterial stiffness in a never treated hypertensive population. Design and method: Three hundred and ten untreated hypertensive patients were recruited.and tested for genotypes of –374T > A and –429T > C. Haemodynamic measurements included brachial and aortic blood pressure, pulse wave velocity(PWV) and augmentation index(AIx).Results were analysed with JMP(SAS for Windows, p < 0.05 considered significant. Results: Both polymorphisms were in Hardy-Weinberg equilibrium. 429C allele carriers had lower PWV compared to 429TT individuals, indicating T to be the risk allele. -429CC individuals had lower PWV compared to wild type homozygotes (-429TT) plus heterozygotes (-429CT) -374T allele carriers had higher PWV compared to 374AA individuals, indicating T to be the risk allele.-374AA individuals had lower PWV compared to wild type homozygotes (-374TT) plus heterozygotes (-374AT). Similar relationship was seen after adjusting for confounders including age, mean arterial pressure, heart rate, BMI for both polymorphism. Haplotype analysis further confirmed the protective effect on PWV by these two alleles. No such relationship was observed for AIx. Conclusions: The present study shows a dose-response relationship between polymorphisms in the RAGE gene (–374 T > A and –429T > C promoter region and PWV in never-treated hypertensive patients. Furthermore, both polymorphisms were independent predictors of arterial stiffness in these patients. The T allele carriers in both the–374 T > A and –429T > C polymorphism have significantly higher arterial stiffness which is independent of other confounding factors. Finally, there is a dose-response relationship between the haplotypes of the two polymorphisms and PWV in this patient population. No significant relationship was observed between the polymorphisms and AIx.

Association of estimated central blood pressure measured non-invasively with pulse wave velocity in patients with coronary artery disease

Please cite this article as: Sueta Daisuke, Yamamoto Eiichiro, Tanaka Tomoko, Hirata Yoshihiro, Sakamoto Kenji, Tsujita Kenichi, Kojima Sunao, Nishiyama Koichi, Kaikita Koichi, Hokimoto Seiji, Jinnouchi Hideaki, Ogawa Hisao, Association of Estimated Central Blood Pressure Measured Non-invasively with Pulse Wave Velocity in Patients with Coronary Artery Disease, International Journal of Cardiology (2015), doi: 10.1016/j.ijcha.2015.05.004

Thoracic but not abdominal phase contrast magnetic resonance-derived aortic pulse wave velocity is elevated in patients with abdominal aortic aneurysm.

Increased stiffening of the aortic wall could contribute to the development of abdominal aortic aneurysm (AAA). We investigated regional aortic wall pulse wave velocity (PWV) in patients with AAA. Forty-six men diagnosed with a small AAA and 42 control men were recruited from the AAA surveillance and screening programmes at Guy's and St Thomas' Hospital. Phase-contrast cardiovascular MRI was performed to determine regional PWV along the thoracic (PWVTHOR) and abdominal aorta (PWVABD). PWV over the total aorta (PWVTOTAL) was calculated from the combined regions. PWVTOTAL was significantly higher in patients with AAA compared to controls (10.0 ± 2.1 versus 8.4 ± 1.6 m/s, respectively; P < 0.0001). The difference in total aortic PWV between groups was explained by increased thoracic PWV in patients with AAA compared to controls (PWVTHOR 9.9 ± 2.8 versus 8.1 ± 2.5 m/s, respectively; P < 0.01). In contrast, there was no difference in PWV measured over the abdominal region in AAA patients compared with controls (PWVABD 10.7 ± 3.3 and 10.1 ± 3.3 m/s, in AAA and control groups, respectively; P = 0.40). In multiple regression analysis, including the whole cohort, abdominal aortic diameter remained significantly associated with PWVTOTAL and PWVTHOR (standardized regression coefficients 0.22 and 0.19, respectively; each P < 0.05 after adjustment for age and mean arterial pressure), but not with PWVABD. AAA patients have a greater PWV in the thoracic but not abdominal aorta compared to control individuals. Greater abdominal aortic diameter in patients with AAA is likely to offset effects of intrinsic stiffening of the abdominal aorta on PWV.

MP51-12 LOW SERUM TESTOSTERONE LEVEL IS ASSOCIATED WITH BRACHIAL-ANKLE PULSE WAVE VELOCITY IN PATIENTS WITH SYMPTOM OF LATEONSET HYPOGONADISM

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation II1 Apr 2015MP51-12 LOW SERUM TESTOSTERONE LEVEL IS ASSOCIATED WITH BRACHIAL-ANKLE PULSE WAVE VELOCITY IN PATIENTS WITH SYMPTOM OF LATEONSET HYPOGONADISM Akira Tsujimura, Shin-ichi Hisasue, Yoshiaki Kumamoto, Kazuhiro Kobayashi, and Shigeo Horie Akira TsujimuraAkira Tsujimura More articles by this author , Shin-ichi HisasueShin-ichi Hisasue More articles by this author , Yoshiaki KumamotoYoshiaki Kumamoto More articles by this author , Kazuhiro KobayashiKazuhiro Kobayashi More articles by this author , and Shigeo HorieShigeo Horie More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1749AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Low serum testosterone levels are associated with increased cardiovascular mortality in men. Thus, testosterone has received increased attention not only from the standpoint of lateonset hypogonadism (LOH) but also that of cardiovascular disease. We already reported a significant association between low testosterone level and carotid artery intima-media thickness even after adjustment for clinically relevant factors. In the present study, we measured brachial-ankle pulse wave velocity (baPWV), which is another widely accepted noninvasive measure of preclinical atherosclerosis, and assessed several metabolic factors, such as diabetes, hypertension and hyperlipidemia, in patients with symptom of LOH to clarify the relation between testosterone and atherosclerosis after eliminating the effects of other factors. METHODS The study comprised 222 patients with symptom of LOH. Serum total testosterone concentration was measured using radioimmunoassay (RIA) and baPWV was assessed with an automated waveform analyzer (Omron, Japan). Laboratory data included age and several endocrinological and metabolic factors. Stepwise associations between the testosterone concentration and other clinical characteristics were compared using the Jonckheere-Terpstra test for trend. To identify the contributors to baPWV, the associations between baPWV and clinical parameters, including age, triglyceride, fasting blood sugar (FBS) and serum testosterone level were assessed in multivariate linear regression models. RESULTS Mean baPWV was 1467.0 ± 292.3, 1524.3 ± 280.2, 1434.2 ± 325.7, 1345.8 ± 210.7, 1409.5 ± 287.5 cm/sec in the patients with serum testosterone levels of less than 3.7, 3.73-4.76, 4.77-5.54, 5.56-6.73, and more than 6.74 ng/ml, respectively, indicating that a lower testosterone level was associated with a higher level of baPWV (Ptrend = 0.009). Serum testosterone level was closely associated with baPWV, as well as age and FBS, by multivariate linear regression models. CONCLUSIONS We conclude that our finding showing that low testosterone level is an influencing and independent risk factor for atherosclerosis is of value in the clinical setting. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e624 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Akira Tsujimura More articles by this author Shin-ichi Hisasue More articles by this author Yoshiaki Kumamoto More articles by this author Kazuhiro Kobayashi More articles by this author Shigeo Horie More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

Influence of obesity in central blood pressure.

Obesity is an important risk factor for cardiovascular disease and has become a major concern in healthcare due to its high prevalence worldwide. The aim of the present study was to investigate the impact of BMI on central blood pressure (BP) and pulse wave velocity (PWV) in normotensive and hypertensive patients. Normotensive and hypertensive adult patients who attended the outpatient clinic of cardiovascular risk were included. Peripheral BP was obtained in the brachial artery by using an oscillometric device (OMRON M-6). Central aortic BP waveform was reconstructed from the radial artery pressure waveforms (SphygmoCor, AtCor Medical, Sydney, Australia) and central BP was calculated. Carotid-femoral PWV was measured by an automatic device (Complior, Artech, France). We examined a total of 351 patients [50.7% women; 77 patients normal-weight (BMI < 25 kg/m)], 274 patients overweight or obese (BMI ≥25 kg/m). Central SBP showed a positive association with male sex and mean BP, but a negative association with overweight/obesity. PWV was positively associated with age, male sex, central BP, peripheral BP and BP treatment, whereas BMI of at least 25 kg/m led to a decrease in PWV in patients with the same central SBP levels. Likewise, PWV was lower in the overweight/obese group compared to the normal-weight group at the same central SBP. Overweight and obesity tend to have lower central SBP as compared to lean patients, mainly in women. Further research is required to assess the interaction between body weight and vascular dynamics and their clinical implications.

N-terminal Pro-B-type Natriuretic Peptide is Associated with Arterial Stiffness as Measured According to the Brachial-ankle Pulse Wave Velocity in Patients with Takayasu Arteritis.

Takayasu arteritis (TA) is associated with increased cardiovascular morbidity and mortality, and the degree of arterial stiffness is an independent predictor of cardiovascular mortality in a variety of diseases. In addition, the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), a marker of ventricular dysfunction, have been found to be higher in patients with TA than in healthy controls. In this study, we aimed to investigate the relationship between the plasma NT-proBNP levels and arterial stiffness in patients with TA. Seventy-two patients with TA were recruited in this study. The participants were analyzed with respect to the NT-proBNP levels, cardiovascular risk factors, TA-related variables and arterial stiffness assessed according to the brachial-ankle pulse wave velocity (baPWV). The patients were divided into two groups based on the mean baPWV, and the association between the NT-proBNP and baPWV values was tested using uni- and multivariate analyses. Twenty-four patients (33.3%) were classified into the high-baPWV group. The body mass index (p=0.035), systolic blood pressure (p＜0.001), diastolic blood pressure (p=0.001), mean blood pressure (p＜0.001), plasma NT-proBNP levels (p=0.036) and total cholesterol levels (p=0.030) were significantly higher in the high-baPWV group than in the low-baPWV group. A stepwise multiple linear regression analysis revealed the mean blood pressure (p＜0.001), age (p=0.002), and NT-proBNP level (p=0.002) to be independent determinants of the ba-PWV after adjusting for other confounding factors. The plasma NT-proBNP levels are independently associated with the degree of arterial stiffness measured according to the baPWV in patients with TA.

Abstract 15844: Plasma Parathyroid Hormone is Independently Related to 24-Hour Pulse Wave Velocity in Patients With Primary Hyperparathyroidism - Insights fFom The EPATH Study

Introduction: Accumulating evidence indicated that high parathyroid hormone (PTH) is associated with increased cardiovascular risk. The impact of PTH on vascular structure and function is, however, still unclear. We evaluated the relationship between pulse wave velocity (PWV) as a novel index of arterial stiffness and circulating levels of PTH in patients with PTH-excess (primary hyperparathyroidism (pHPT)). Methods and Results: We analyzed baseline data of the ongoing randomized, double-blind, placebo-controlled “Effect of Eplerenone on Parathyroid Hormone Levels in Patients with Primary Hyperparathyroidism” (EPATH) study. Inclusion criteria were age of at least 18 years and a diagnosis of pHPT according to international guidelines. Standardized blood sampling was performed after an overnight fast and 24h PWV was measured by a validated non-invasive device for ambulatory hemodynamic monitoring (Mobil O Graph, I.E.M., Stolberg, Germany). Our analysis comprised 92 pHPT patients with a mean age of 68.5 +/- 9.7 years (71 % females) and a median PTH of 102 (IQR 81 - 132) pg/ml. Mean 24h PWV was 9.8 +/- 1.8 m/s, mean daytime and mean nighttime PWV were 10.0 +/- 1.7 m/s and 9.6 +/- 1.8 m/s, respectively. In multivariate linear regression analyses adjusted for age, sex, body mass index, smoking status, mean systolic and mean diastolic 24h blood pressure, antihypertensive medication, type 2 diabetes, 25-hydroxyvitamin D, serum calcium, intake of cinacalcet and fasting serum cholesterol PTH emerged as a strong predictor of mean 24h PWV (ß=0.30, p=0.012), daytime PWV and nighttime PWV (ß=0.30, p=0.011 and ß=0.30, p=0.019, respectively). Conclusion: In a selective cohort of patients with pHPT plasma PTH was strongly related to 24h PWV. These data strengthen the notion that PTH may impact on vascular function. Interventional and mechanistic trials are needed to evaluate modulatory effects on vasculature in patients with high PTH.

Comparison by Magnetic Resonance Phase Contrast Imagingof Pulse-Wave Velocity in Patients With Single Ventricle Who Have Reconstructed Aortas Versus Those Without

Pulse-wave velocity (PWV), a measure of arterial stiffness, is a known independent risk factor for cardiovascular events. Patients with single ventricle who undergo aortic to pulmonary anastomosis (recon) have noncompliant patch material inserted into the neoaorta, possibly increasing vessel stiffness and afterload. The purpose of this study is to determine if PWV in patients with single ventricle differed between those who did and those who did not undergo aortic reconstruction (nonrecon). We retrospectively reviewed cardiac magnetic resonance anatomic, cine, and phase contrast evaluations in the ascending aorta and descending aorta (DAo) at the level of the diaphragm data from 126 patients with single ventricle (8.6 ± 8.0years) from January 2012 to May 2013. Significance= p <0.05. Seventy-five patients underwent recon and 51 did not. PWV in recon was significantly higher than in nonrecon (3.9 ± 0.9m/s vs 3.2 ± 1.0m/s, p= 0.008); in recon, patients >13years old had a higher PWV than those <7years (4.5 ± 0.6 vs 3.5 ± 0.7m/s, p= 0.004). Whether <7 or >13 years old, PWV of those with recon was higher than nonrecon DAo distensibility was similar between both groups. There was no difference in age, body surface area, or cardiac index between recon and nonrecon. No correlations between various hemodynamic and ventricular function parameters with PWV were noted. In conclusion, PWV in recon is higher than in nonrecon with similar DAo distensibility implicating the aortic reconstruction as a possible cause of increased afterload; older recon patients have stiffer aortas than younger ones, possibly imposing an additional cardiovascular risk in the future. Other biomaterials may potentially moderate PWV if clinical outcome is adversely affected.

Determinants of arterial stiffness in female patients with Takayasu arteritis.

The assessment of pulse wave velocity (PWV) in Takayasu arteritis (TA) is complex because of many confounding factors. We evaluated PWV in female patients with TA and controls with comparable anthropometric and clinical variables and assessed a possible association of TA with disease variables. We evaluated 27 patients with TA consecutively. Exclusion criteria were menopause, smoking, diabetes, renal insufficiency, poorly controlled hypertension, cardiac arrhythmias, obesity, inflammatory comorbidities, pregnancy, and surgical procedures involving the aorta. Disease activity was determined by clinical and laboratory variables. As healthy controls, 27 subjects with comparable age, blood pressure, height, and weight were selected. Carotid-femoral PWV measurements were obtained using the Complior system. The mean PWV in patients with TA was higher than in healthy controls (9.77 ± 3.49 vs 7.83 ± 1.06 m/s; p = 0.009). Despite our strict selection criteria, patients with TA had an average systolic blood pressure (SBP) 8 mmHg higher than controls (p = NS), and significantly higher pulse pressure values. The multivariate linear regression model shows that 93.8% of the PWV variability is explained by the variables age, mean BP, and the disease itself (adjusted R(2) = 0.938). Stepwise logistic analysis using the PWV cutoff value established by the receiver-operator characteristic curve (> 8.34 m/s) as dependent variable, and measures with significance in univariate analysis as independent variables revealed that TA (OR 4.69; 95% CI 1.31-16.72; p = 0.017) and mean BP (OR 1.06; 95% CI 1.00-1.12; p = 0.048) were independently associated with higher PWV. Further analysis of disease variables revealed that PWV values were not correlated with erythrocyte sedimentation rate, C-reactive protein, cumulative dose of glucocorticoid, or ejection fraction (p > 0.05). In our cohort of female patients with TA, the disease itself and mean BP were the strongest determinants associated with arterial stiffness.

FRI0083 Arterial Stiffness in Patients with Rheumatoid Arthritis. Value for Cardiovascular Risk Stratification

BackgroundAnalysis of arterial stiffness is a good marker of early arterial disease, which also has a prognostic value. It can be determined in a simple, non-invasive and reproducible way through...

105 Cardiac Mri Assessment Of Pulse Wave Velocity And Aortic Distensibility Following Treatment Of Aortic Stenosis

BackgroundArterial stiffness is an independent predictor of cardiovascular mortality and can be characterised by CMR measurement of aortic distensibility (AD) and pulse wave velocity (PWV).AimTo compare AD and PWV in...