MP51-12 LOW SERUM TESTOSTERONE LEVEL IS ASSOCIATED WITH BRACHIAL-ANKLE PULSE WAVE VELOCITY IN PATIENTS WITH SYMPTOM OF LATEONSET HYPOGONADISM

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation II1 Apr 2015MP51-12 LOW SERUM TESTOSTERONE LEVEL IS ASSOCIATED WITH BRACHIAL-ANKLE PULSE WAVE VELOCITY IN PATIENTS WITH SYMPTOM OF LATEONSET HYPOGONADISM Akira Tsujimura, Shin-ichi Hisasue, Yoshiaki Kumamoto, Kazuhiro Kobayashi, and Shigeo Horie Akira TsujimuraAkira Tsujimura More articles by this author , Shin-ichi HisasueShin-ichi Hisasue More articles by this author , Yoshiaki KumamotoYoshiaki Kumamoto More articles by this author , Kazuhiro KobayashiKazuhiro Kobayashi More articles by this author , and Shigeo HorieShigeo Horie More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1749AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Low serum testosterone levels are associated with increased cardiovascular mortality in men. Thus, testosterone has received increased attention not only from the standpoint of lateonset hypogonadism (LOH) but also that of cardiovascular disease. We already reported a significant association between low testosterone level and carotid artery intima-media thickness even after adjustment for clinically relevant factors. In the present study, we measured brachial-ankle pulse wave velocity (baPWV), which is another widely accepted noninvasive measure of preclinical atherosclerosis, and assessed several metabolic factors, such as diabetes, hypertension and hyperlipidemia, in patients with symptom of LOH to clarify the relation between testosterone and atherosclerosis after eliminating the effects of other factors. METHODS The study comprised 222 patients with symptom of LOH. Serum total testosterone concentration was measured using radioimmunoassay (RIA) and baPWV was assessed with an automated waveform analyzer (Omron, Japan). Laboratory data included age and several endocrinological and metabolic factors. Stepwise associations between the testosterone concentration and other clinical characteristics were compared using the Jonckheere-Terpstra test for trend. To identify the contributors to baPWV, the associations between baPWV and clinical parameters, including age, triglyceride, fasting blood sugar (FBS) and serum testosterone level were assessed in multivariate linear regression models. RESULTS Mean baPWV was 1467.0 ± 292.3, 1524.3 ± 280.2, 1434.2 ± 325.7, 1345.8 ± 210.7, 1409.5 ± 287.5 cm/sec in the patients with serum testosterone levels of less than 3.7, 3.73-4.76, 4.77-5.54, 5.56-6.73, and more than 6.74 ng/ml, respectively, indicating that a lower testosterone level was associated with a higher level of baPWV (Ptrend = 0.009). Serum testosterone level was closely associated with baPWV, as well as age and FBS, by multivariate linear regression models. CONCLUSIONS We conclude that our finding showing that low testosterone level is an influencing and independent risk factor for atherosclerosis is of value in the clinical setting. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e624 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Akira Tsujimura More articles by this author Shin-ichi Hisasue More articles by this author Yoshiaki Kumamoto More articles by this author Kazuhiro Kobayashi More articles by this author Shigeo Horie More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...