Abstract
BackgroundAortic pulse wave velocity (PWV) has been shown to be an independent predictor of cardiovascular mortality in patients with end-stage renal disease and the general population. Atmospheric particulate- matter (PM) concentrations and their effects on cardiovascular system by affecting arterial stiffness and central hemodynamic parameters had been noted. The purpose of this study was to access the correlation of air pollution variables and PWV in patients undergoing hemodialysis (HD).MethodsThis study analyzed 127 HD patients treated at the outpatient HD center. Brachial-ankle pulse wave velocity (baPWV) was measured by using a Vascular Profiler 1000 (VP-1000). Air pollution levels were recorded by a network of 27 monitoring stations near or in the patients’ living areas throughout Taiwan. The 12-month average concentrations of PM with an aerodynamic diameter of <10 and <2.5 mm (PM10 and PM2.5, respectively), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide(CO), and ozone (O3) were included.Results and DiscussionMultivariate linear regression analyses indicated that systolic blood pressure (SBP) (β = 0.589, P < 0.025), age (β = 0.316, P < 0.001), serum aluminum level (Al) (β = 0.149, P = 0.020), and PM10 (β = 0.133, P = 0.036) were positively correlated with baPWV.ConclusionThis cross-sectional study shows that in HD patients, the environmental PM10 level is associated with the baPWV.
Highlights
Aortic pulse wave velocity (PWV) has been shown to be an independent predictor of cardiovascular mortality in patients with end-stage renal disease and the general population
Intact parathyroid hormone, aluminum level (Al) and high sensitivity C-reactive protein were skewed, they were log-transformed for further analysis
The main findings of the present study were that: PM10, age, Al and systolic blood pressure (SBP) were independently correlated with Brachial-ankle pulse wave velocity (baPWV) and higher concentrations of ambient PM10 was associated with a higher magnitude of baPWV
Summary
The purpose of this study was to access the correlation of air pollution variables and PWV in patients undergoing hemodialysis (HD). Aortic pulse wave velocity (PWV) has been shown to be an independent predictor of cardiovascular mortality in patients with end-stage renal disease and the general population [2]. Adamopoulos et al [5] analyzed the atmospheric pollution variables, including atmospheric particulate- matter (PM) concentrations and their effects on cardiovascular system by affecting arterial stiffness and central hemodynamic parameters, and found that in men, PM10 air pollution levels were associated with heightened amplitude of PWV. The purpose of this study was to access the correlation of air pollution variables and baPWV in patients undergoing HD, which had never been studied before
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