Public Datasets Research Articles

Research on Student’s T-Distribution Point Cloud Registration Algorithm Based on Local Features

LiDAR offers a wide range of uses in autonomous driving, remote sensing, urban planning, and other areas. The laser 3D point cloud acquired by LiDAR typically encounters issues during registration, including laser speckle noise, Gaussian noise, data loss, and data disorder. This work suggests a novel Student’s t-distribution point cloud registration algorithm based on the local features of point clouds to address these issues. The approach uses Student’s t-distribution mixture model (SMM) to generate the probability distribution of point cloud registration, which can accurately describe the data distribution, in order to tackle the problem of the missing laser 3D point cloud data and data disorder. Owing to the disparity in the point cloud registration task, a full-rank covariance matrix is built based on the local features of the point cloud during the objective function design process. The combined penalty of point-to-point and point-to-plane distance is then added to the objective function adaptively. Simultaneously, by analyzing the imaging characteristics of LiDAR, according to the influence of the laser waveform and detector on the LiDAR imaging, the composite weight coefficient is added to improve the pertinence of the algorithm. Based on the public dataset and the laser 3D point cloud dataset acquired in the laboratory, the experimental findings demonstrate that the proposed algorithm has high practicability and dependability and outperforms the five comparison algorithms in terms of accuracy and robustness.

Heterogeneous Meta-Path Graph Learning for Higher-Order Social Recommendation

Recommendation systems have become an indispensable part of daily life. Social recommendation systems, which utilize social relationships and past behaviors to infer users’ preferences, have gained popularity in recent years. Exploring the inherent characteristics implied by higher-order relationships offers a new approach to social recommendation. However, it is challenging due to sparse social networks, influence heterogeneity, and noisy feedback. In this article, we propose a Heterogeneous Meta-path Graph Learning model for Higher-order Social Recommendation (HEAL). Within HEAL, we introduce a heterogeneous graph in social recommendation and utilize a meta-path-guided random walk to generate higher-order relationships. By encoding higher-order structures and semantics along different meta-graphs, HEAL can mitigate the limitation of data sparsity. Moreover, HEAL exploits aspect-aware and semantic-aware attentions to adaptively propagate and aggregate useful features from different meta-neighbors and higher-order relations. These attention-based aggregation layers allow HEAL to suppress the heterogeneity of social influences. Furthermore, HEAL adopts contrastive learning as a supplemental task to the recommendation task by maximizing the consistency between the self-discriminating objectives. This auxiliary task enables the model to learn more differentiated representations, further reducing its sensitivity to noisy feedback. We evaluate the performance of HEAL through extensive experiments on public datasets. The results demonstrate that leveraging higher-order relations can enhance the quality of social recommendations by better capturing the complexity and diversity of users’ preferences and interactions.

NetraDeep: An Integrated Deep Learning and Image Processing System for Precise Detection of Hard Exudates

Hard Exudate (HE) is a common manifestation of various eye diseases, such as diabetic retinopathy (DR), and a prominent cause of vision loss and blindness. Researchers aim to visualize and quantify these exudates using deep learning (DL) and image processing (IP) models from retinal images. However, the requirement for a large number of labelled image datasets for DL models to work on diverse and poor-quality images makes this task challenging. To address this challenge, we introduce NetraDeep, a system that integrates data-driven DL and rule-based IP techniques for exudate segmentation. Our system uses IP models to detect and extract some features and assists DL models in detecting more advanced features and vice versa. The IP models are rule-based and use predefined rules to process images, while the DL models are data-driven and learn from the input data. NetraDeep provides visual and quantitative assessments while mitigating noise and other confounding factors such as artifacts and noise. The training of DL models of this system requires only a limited number of labelled fundus images from publicly available datasets. It provides accurate pixel-wise segmentation results on the public and private image datasets collected from local eye hospitals. Through extensive evaluation, our system achieved remarkable performance, with a dice coefficient of \(0.84\) for the public dataset and a rating of \(9.78\) and \(9.43\) out of 10, as corroborated by two medical experts with experience of more than 20 and 5 years, respectively, for the private image dataset.

The advancements and future prospects of pedestrian action recognition based on machine learning algorithms

This paper highlights the shift from classical machine learning to deep learning models and describes the fundamental methodology and developments in pedestrian activity recognition. The four main steps of the workflow are the gathering of datasets, pre-processing, designing and training the model, and evaluating the outcome. To extract pedestrian feature vectors, data must first be collected, cleaned, and processed from public or proprietary datasets. These vectors are used to train deep learning or machine learning models, which are subsequently assessed and fine-tuned for use in practical applications such as behaviour analysis and surveillance. For action recognition, conventional machine learning techniques like Random Forests (RF) and Support Vector Machines (SVM) have been used. SVMs, despite their potential for computing complexity, identify the best hyperplanes for classification. The categorization rates for a variety of human behaviours have been enhanced by a combination strategy utilizing SVMs and decision trees. As shown in a study that uses smartphone accelerometers to accurately identify everyday activities, RFs can manage enormous datasets. Deep learning models that automatically learn complicated feature representations, such as VA-fusion, AGC-LSTM, and LC-POSEGAIT, provide improved performance. These models capture minute differences in pedestrian behaviour using CNNs, RNNs, and LSTM architectures. Interpretability, generalization to new datasets, and computing demands are some of the difficulties they encounter. Future developments could include using transfer learning to improve performance in many circumstances, combining deep learning and expert systems for improved interpretability, and utilizing distributed computing for processing in an effective manner.

Integrative mRNA and miRNA Expression Profiles from Developing Zebrafish Head Highlight Brain-Preference Genes and Regulatory Networks.

Zebrafish is an emerging animal model for studying molecular mechanism underlying neurodevelopmental disorder due to its advantage characters. miRNAs are small non-coding RNAs that play a key role in brain development. Understanding of dynamic transcriptional and post-transcriptional molecules and their regulation during the head development is important for the study of neurodevelopmental disorder. In this study, we performed the high-throughput sequencing of mRNAs and miRNAs in developing zebrafish head from pharyngula to early larval stages and carried out bioinformatic analysis including differential expression and functional enrichment as well as joint analysis of miRNAs and mRNAs, and also compared with other related public sequencing datasets to aid our interpretation. A large number of differential expression genes with a large fold change were detected during the head development. Further clustering and functional enrichment analyses indicated that genes in late stage were most related with synaptic signaling. Overlap test analysis showed a significant enrichment of brain-preference and synapse-associated gene set in the head transcriptome compared with the whole embryo transcriptome. We also constructed miRNA-mRNA network for those brain-preference genes and focused on those densely connected network components. CRISPR-Cas9-mediated snap25b mutants led to embryonic development defects and decreases locomotor activity. Altogether, the present study provides developmental profiles of head-enriched mRNAs and miRNAs at three critical windows for nervous system development, which may contribute to the study of neurodevelopmental disorder.

A Practical Approach to Intrusion Detection in IoV Networks Using LCCDE Ensemble Framework

Abstract: With the rapid development of the Internet of Things (IoT) and the Internet of Vehicles (IoV) technologies, modern vehicles are increasingly adopting network-controlled functionalities, exposing them to a variety of cyber threats. To address these security challenges, this paper implements and evaluates a novel ensemble Intrusion Detection System (IDS) framework, named Leader Class and Confidence Decision Ensemble (LCCDE). The LCCDE framework integrates three advanced Machine Learning (ML) algorithms—XGBoost, LightGBM, and CatBoost—to detect various types of cyber-attacks on both intra-vehicle and external vehicular networks.This study demonstrates the effectiveness of the LCCDE framework using two public IoV security datasets: the Car-Hacking dataset and the CICIDS2017 dataset. By identifying the best-performing ML model for each class of attacks and leveraging prediction confidence values, LCCDE achieves high detection accuracy and robustness against diverse attack types. The experimental results show that the proposed framework outperforms traditional IDS approaches in terms of detection accuracy, computational efficiency, and adaptability to different types of cyber-attacks. This paper provides practical insights into the implementation and deployment of IDS in IoV systems, highlighting the potential of ensemble learning methods to enhance vehicular network security.

NCNet: deformable medical image registration network based on neighborhood cross-attention combined with multi-resolution constraints.


Existing registration networks based on cross-attention design usually divide the image pairs to be registered into patches for input. The division and merging operations of a series of patches are difficult to maintain the topology of the deformation field and reduce the interpretability of the network. Therefore, our goal is to develop a new network architecture based on a cross-attention mechanism combined with a multi-resolution strategy to improve the accuracy and interpretability of medical image registration.
Approach: We propose a new deformable image registration network NCNet based on neighborhood cross-attention combined with multi-resolution strategy. The network structure mainly consists of a multi-resolution feature encoder, a multi-head neighborhood cross-attention module and a registration decoder. The hierarchical feature extraction capability of our encoder is improved by introducing large kernel parallel convolution blocks; the cross-attention module based on neighborhood calculation is used to reduce the impact on the topology of the deformation field and double normalization is used to reduce its computational complexity.
Main result: We performed atlas-based registration and inter-subject registration tasks on the public 3D brain magnetic resonance imaging datasets LPBA40 and IXI respectively. Compared with the popular VoxelMorph method, our method improves the average DSC value by 7.9% and 3.6% on LPBA40 and IXI. Compared with the popular TransMorph method, our method improves the average DSC value by 4.9% and 1.3% on LPBA40 and IXI.
Significance: We proved the advantages of the neighborhood attention calculation method compared to the window attention calculation method based on partitioning patches, and analyzed the impact of the pyramid feature encoder and double normalization on network performance. This has made a valuable contribution to promoting the further development of medical image registration methods.&#xD.

Modeling QTL-by-environment interactions for multi-parent populations

Multi-parent populations (MPPs) are attractive for genetic and breeding studies because they combine genetic diversity with an easy-to-control population structure. Most methods for mapping QTLs in MPPs focus on the detection of QTLs in single environments. Little attention has been given to mapping QTLs in multienvironment trials (METs) and to detecting and modeling QTL-by-environment interactions (QEIs). We present mixed model approaches for the detection and modeling of consistent versus environment-dependent QTLs, i.e., QTL-by-environment interaction (QEI). QTL effects are assumed to be normally distributed with variances expressing consistency or dependence on environments and families. The entries of the corresponding design matrices are functions of identity-by-descent (IBD) probabilities between parents and offspring and follow from the parental origin of offspring DNA. A polygenic effect is added to the models to account for background genetic variation. We illustrate the wide applicability of our method by analyzing several public MPP datasets with observations from METs. The examples include diallel, nested association mapping (NAM), and multi-parent advanced inter-cross (MAGIC) populations. The results of our approach compare favorably with those of previous studies that used tailored methods.

Mixed T-domain and TF-domain Magnitude and Phase representations for GAN-based speech enhancement

Deep learning has made significant advancements in speech enhancement, which plays a crucial role in improving the quality of speech signals in noisy conditions. In this paper, we propose a new approach called M-DGAN, which introduces a time (T)-domain encoder-decoder structure with rich channel representations into the time-frequency (TF)-domain generator framework, resulting in a new generator structure with mixed magnitude and phase representations in the T and TF-domains. The proposed mixed T-domain and TF-domain generator, incorporating the cascaded reworked conformer (CRC) structure, exhibits improved modeling capability and adaptability. Test results on the Voice Bank + DEMAND public dataset show that our method achieves the highest score with PSEQ=3.52\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$PSEQ=3.52$$\\end{document} and performs well on all the remaining metrics when compared to the current state-of-the-art methods. In addition, tests on the NISQA_TEST_LIVETALK real dataset of the NISQA Corpus show the breadth and robustness of our model on speech enhancement tasks.

GRDATFusion: A gradient residual dense and attention transformer infrared and visible image fusion network for smart city security systems in cloud and fog computing

AbstractThe infrared and visible fusion technology holds a pivotal position in smart city for cloud and fog computing, particularly in security system. By fusing infrared and visible image information, this technology enhances target identification, tracking and monitoring precision, bolstering overall system security. However, existing deep learning‐based methods rely heavily on convolutional operations, which excel at extracting local features but have limited receptive fields, hampering global information capture. To overcome this difficulty, we introduce GRDATFusion, a novel end‐to‐end network comprising three key modules: transformer, gradient residual dense and attention residual. The gradient residual dense module extracts local complementary features, leveraging a dense‐shaped network to retain potentially lost information. The attention residual module focuses on crucial input image details, while the transformer module captures global information and models long‐range dependencies. Experiments on public datasets show that GRDATFusion outperforms state‐of‐the‐art algorithms in qualitative and quantitative assessments. Ablation studies validate our approach's advantages, and efficiency comparisons demonstrate its computational efficiency. Therefore, our method makes the security systems in smart city with shorter delay and satisfies the real‐time requirement.

CLIB: Contrastive learning of ignoring background for underwater fish image classification

Aiming at the problem that the existing methods are insufficient in dealing with the background noise anti-interference of underwater fish images, a contrastive learning method of ignoring background called CLIB for underwater fish image classification is proposed to improve the accuracy and robustness of underwater fish image classification. First, CLIB effectively separates the subject from the background in the image through the extraction module and applies it to contrastive learning by composing three complementary views with the original image. To further improve the adaptive ability of CLIB in complex underwater images, we propose a multi-view-based contrastive loss function, whose core idea is to enhance the similarity between the original image and the subject and maximize the difference between the subject and the background, making CLIB focus more on learning the core features of the subject during the training process, and effectively ignoring the interference of background noise. Experiments on the Fish4Knowledge, Fish-gres, WildFish-30, and QUTFish-89 public datasets show that our method performs well, with improvements of 1.43–6.75%, 8.16–8.95%, 13.1–14.82%, and 3.92–6.19%, respectively, compared with the baseline model, further validating the effectiveness of CLIB.

A hybrid contextual framework to predict severity of infectious disease: COVID-19 case study

Infectious disease is a particular type of disorder triggered by organisms and transmitted directly or indirectly from an infected one like COVID-19. The global economy and public health are immensely affected by COVID-19, a recently emerging infectious disease. Artificial Intelligence can be helpful to predict the severity rating of COVID-19 which assists authorities to take appropriate measures to mitigate its spread in different regions, hence it results in economic reopening and reduces the degree of mortality. In this paper, a hybrid contextual framework is proposed which incorporates content embedding of Standard Operating Procedure’s (SOPs) auxiliary description along with COVID-19 temporal features of the respective region as side information. The word embedding techniques are incorporated to generate distributed representation of SOPs auxiliary description. The higher representation of auxiliary description is obtained by utilizing content embedding and then combined with temporal features to build counties profiles. These county profiles are fed into a profile learner based on an ensemble algorithm to predict the severity level of COVID-19 in different regions. The proposed contextual framework is evaluated on public datasets provided by healthdata.gov and the National Centers for Environmental Information. A comparison of the proposed contextual framework with other state-of-the-art approaches has demonstrated its ability to accurately predict the severity level of COVID-19 in different regions.

Geochemical and Radiogenic Sr‐Nd Isotope Characterization of Widespread Sandy Surface Sediments in the Great Indian Desert, Thar: Implications for Provenance Studies

AbstractUnderstanding large desert formation/evolution contributing to regional‐to‐global dust cycles remains a challenge. This study presents the geochemical and Sr‐Nd isotope compositions of 51 surface sediment samples collected from the widespread hyper‐arid Thar Desert in northwestern India. The major objective is to determine sediment provenance for a better understanding of the formation/evolution mechanism of this Great Indian Desert as well as downwind dust contributions toward the Himalayas. The compositionally immature sandy Thar sediments (CIA ∼50 ± 4, WIP ∼49 ± 12, and EuN/Eu* ∼0.80 ± 0.13) are recycled materials derived from the Himalayan orogen and later modified by quartz addition and heavy mineral depletion/sorting processes. The 87Sr/86Sr (0.7259 ± 0.0012 and εNd (−12.5 ± 2.7) in the bulk of these Thar sediments are different from the earlier published compositions of the eolian sand deposits in northwestern India. The subcategories of Thar materials collected from different dune types exposed over different lithologies (Quaternary alluvium vs. Tertiary and Mesozoic sedimentary formations) are geochemically and isotopically indistinguishable, which indicates their cogenetic sources and/or sediment reworking. Thar sediments collected in this study have a predominant Indus origin along with significant contributions from the upwind Ghaggar‐Hakra paleochannels. The Indus sediments are most likely wind‐eroded from the shelf region exposed during the low sea stand of LGM and afterward deglaciation. Considering the new and published data sets, the Sr‐Nd isotope budget of dust deposited in the Himalayan frontal glaciers indicates that atmospheric mineral dust contribution from the upwind Indo‐Gangetic Plain proximal to the Himalayas is at par with dust parcels from distant natural deserts.

Recent advances in crack detection technologies for structures: a survey of 2022-2023 literature

IntroductionCracks, as structural defects or fractures in materials like concrete, asphalt, and metal, pose significant challenges to the stability and safety of various structures. Addressing crack detection is of paramount importance due to its implications for public safety, infrastructure integrity, maintenance costs, asset longevity, preventive maintenance, economic impact, and environmental considerations.MethodsIn this survey paper, we present a comprehensive analysis of recent advancements and developments in crack detection technologies for structures, with a specific focus on articles published between 2022 and 2023. Our methodology involves an exhaustive search of the Scopus database using keywords related to crack detection and machine learning techniques. Among the 129 papers reviewed, 85 were closely aligned with our research focus.ResultsWe explore datasets that underpin crack detection research, categorizing them as public datasets, papers with their own datasets, and those using a hybrid approach. The prevalence and usage patterns of public datasets are presented, highlighting datasets like Crack500, Crack Forest Dataset (CFD), and Deep Crack. Furthermore, papers employing proprietary datasets and those combining public and proprietary sources are examined. The survey comprehensively investigates the algorithms and methods utilized, encompassing CNN, YOLO, UNet, ResNet, and others, elucidating their contributions to crack detection. Evaluation metrics such as accuracy, precision, recall, F1-score, and IoU are discussed in the context of assessing model performance. The results of the 85 papers are summarized, demonstrating advancements in crack detection accuracy, efficiency, and applicability.DiscussionNotably, we observe a trend towards using modern and novel algorithms, such as Vision Transformers (ViT), and a shift away from traditional methods. The conclusion encapsulates the current state of crack detection research, highlighting the integration of multiple algorithms, expert models, and innovative data collection techniques. As a future direction, the adoption of emerging algorithms like ViT is suggested. This survey paper serves as a valuable resource for researchers, practitioners, and engineers working in the field of crack detection, offering insights into the latest trends, methodologies, and challenges.

Heterogeneous Views and Spatial Structure Enhancement for triple error detection

Knowledge graph error detection is to identify erroneous triples in knowledge graphs that are inconsistent with objective facts in the real world. In practice, the quality of knowledge graphs is an indispensable foundation for the widespread and accurate knowledge application services such as intelligent retrieval and human machine dialogue. Technically, the existing knowledge graph error detection methods face the following two problems: few available negative samples of triples, and an uneven data distribution. That distribution is caused by the large disparity in the number of head and tail entities belonging to the same relationship and the disparity in the number of triples with different relationships. To alleviate these problems, this paper proposes an approach based on the Heterogeneous Views and Spatial Structure Enhancement (HVSSE) in a contrastive learning framework for triple error detection task. Specifically, the heterogeneous views are constructed to include four kinds of triple views, i.e., positive and negative triple views based on head or tail entity co-occurrence. Moreover, Graph-Spatial-Transformer with an explicit spatial structure encoding is designed to fully capture the contextual information of triple nodes. Thereby, driven by the framework of contrastive learning, our HVSSE model can not only learn more discriminative embedding of triples, but also capture the local structure of triples and global contextual information of knowledge graphs. Experimental results on five public datasets indicate that our proposed approach is superior to the state-of-the-art methods, showing its the effectiveness on triple error detection.

Concealed hazardous object detection for terahertz images with cross-feature fusion transformer

Terahertz (THz) waves can penetrate many non-metallic materials (such as paper, plastic, and clothing), making them highly valuable in security inspection areas. However, the low contrast between target objects and the background in THz images poses problems for object detection and recognition tasks. Though many schemes have been proposed to tackle the problems, the low detection accuracy and high computational complexity remain challenges. To address these challenges, we propose a concealed hazardous object detection method called Cross-Feature Fusion Transformer YOLO (CFT-YOLO) for THz images. We design a Multi-Channel Spatial Feature Module (MCSFM) to achieve cross-channel and cross-spatial information transfer between feature maps. MCSFM also realizes the feature parameter transfer between the backbone and neck of the network. Additionally, we develop a CrossFuse-Transformer (CF-Former) module that leverages self-attention to fully exploit the correlations and structural information between different feature maps. We conduct a series of experiments on public datasets. The results show that CFT-YOLO outperforms the other advanced methods in THz hazardous object detection tasks. Moreover, the CFT-YOLO achieves a better balance between model complexity and detection accuracy compared to YOLOv8s, making it more practical for real-world applications.

An epilepsy classification based on FFT and fully convolutional neural network nested LSTM

Background and objectiveEpilepsy, which is associated with neuronal damage and functional decline, typically presents patients with numerous challenges in their daily lives. An early diagnosis plays a crucial role in managing the condition and alleviating the patients’ suffering. Electroencephalogram (EEG)-based approaches are commonly employed for diagnosing epilepsy due to their effectiveness and non-invasiveness. In this study, a classification method is proposed that use fast Fourier Transform (FFT) extraction in conjunction with convolutional neural networks (CNN) and long short-term memory (LSTM) models.MethodsMost methods use traditional frameworks to classify epilepsy, we propose a new approach to this problem by extracting features from the source data and then feeding them into a network for training and recognition. It preprocesses the source data into training and validation data and then uses CNN and LSTM to classify the style of the data.ResultsUpon analyzing a public test dataset, the top-performing features in the fully CNN nested LSTM model for epilepsy classification are FFT features among three types of features. Notably, all conducted experiments yielded high accuracy rates, with values exceeding 96% for accuracy, 93% for sensitivity, and 96% for specificity. These results are further benchmarked against current methodologies, showcasing consistent and robust performance across all trials. Our approach consistently achieves an accuracy rate surpassing 97.00%, with values ranging from 97.95 to 99.83% in individual experiments. Particularly noteworthy is the superior accuracy of our method in the AB versus (vs.) CDE comparison, registering at 99.06%.ConclusionOur method exhibits precise classification abilities distinguishing between epileptic and non-epileptic individuals, irrespective of whether the participant’s eyes are closed or open. Furthermore, our technique shows remarkable performance in effectively categorizing epilepsy type, distinguishing between epileptic ictal and interictal states versus non-epileptic conditions. An inherent advantage of our automated classification approach is its capability to disregard EEG data acquired during states of eye closure or eye-opening. Such innovation holds promise for real-world applications, potentially aiding medical professionals in diagnosing epilepsy more efficiently.

Adaptive fine-tuning based transfer learning for the identification of MGMT promoter methylation status.

Background.Glioblastoma Multiforme (GBM) is an aggressive form of malignant brain tumor with a generally poor prognosis.O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been shown to be a predictive bio-marker for resistance to treatment of GBM, but it is invasive and time-consuming to determine methylation status. There has been effort to predict the MGMT methylation status through analyzing MRI scans using machine learning, which only requires pre-operative scans that are already part of standard-of-care for GBM patients.Purpose.To improve the performance of conventional transfer learning in the identification of MGMT promoter methylation status, we developed a 3D SpotTune network with adaptive fine-tuning capability. Using the pretrained weights of MedicalNet with the SpotTune network, we compared its performance with a randomly initialized network for different combinations of MR modalities.Methods.Using a ResNet50 as the base network, three categories of networks are created: (1) A 3D SpotTune network to process volumetric MR images, (2) a network with randomly initialized weights, and (3) a network pre-trained on MedicalNet. These three networks are trained and evaluated using a public GBM dataset provided by the University of Pennsylvania. The MRI scans from 240 patients are used, with 11 different modalities corresponding to a set of perfusion, diffusion, and structural scans. The performance is evaluated using 5-fold cross validation with a hold-out testing dataset.Results.The SpotTune network showed better performance than the randomly initialized network. The best performing SpotTune model achieved an area under the Receiver Operating Characteristic curve (AUC), average precision of the precision-recall curve (AP), sensitivity, and specificity values of 0.6604, 0.6179, 0.6667, and 0.6061 respectively.Conclusions.SpotTune enables transfer learning to be adaptive to individual patients, resulting in improved performance in predicting MGMT promoter methylation status in GBM using equivalent MRI modalities as compared to a randomly initialized network.

Research on a Train Safety Driving Method Based on Fusion of an Incremental Clustering Algorithm and Lightweight Shared Convolution

This paper addresses the challenge of detecting unknown or unforeseen obstacles in railway track transportation, proposing an innovative detection strategy that integrates an incremental clustering algorithm with lightweight segmentation techniques. In the detection phase, the paper innovatively employs the incremental clustering algorithm as a core method, combined with dilation and erosion theories, to expand the boundaries of point cloud clusters, merging adjacent point cloud elements into unified clusters. This method effectively identifies and connects spatially adjacent point cloud clusters while efficiently eliminating noise from target object point clouds, thereby achieving more precise recognition of unknown obstacles on the track. Furthermore, the effective integration of this algorithm with lightweight shared convolutional semantic segmentation algorithms enables accurate localization of obstacles. Experimental results using two combined public datasets demonstrate that the obstacle detection average recall rate of the proposed method reaches 90.3%, significantly enhancing system reliability. These findings indicate that the proposed detection strategy effectively improves the accuracy and real-time performance of obstacle recognition, thereby presenting important practical application value for ensuring the safe operation of railway tracks.

Analysis of the interlink between glucose-6-phosphate dehydrogenase (G6PD) and lung cancer through multi-omics databases

Glucose-6-Phosphate Dehydrogenase (G6PD) is a crucial enzyme that executes the pentose phosphate pathway. Due to its critical nodal position in the metabolic network, it is associated with different forms of cancer tumorigeneses and progression. Nonetheless, its functional role and molecular mechanism in lung cancer remain unknown. The present study provides intricate information associated with G6PD and Lung Cancer. Varieties of public datasets were retrieved by us, including UALCAN, TCGA, cBioPortal, and the UCSC Xena browser. The data obtained were used to assess the expression of G6PD, its clinical features, epigenetic regulation, relationship with tumour infiltration, tumour mutation burden, microsatellite instability, tumour microenvironment, immune checkpoint genes, genomic alteration, and patient's overall survival rate. The present study revealed that the G6PD expression was correlated with the clinical features of lung cancer including disease stage, race, sex, age, smoking habits, and lymph node metastasis. Moreover, the expression profile of G6PD also imparts epigenetic changes by modulating the DNA promoter methylation activity. Methylation of promoters changes the expression of various transcription factors, genes leading to an influence on the immune system. These events linked with G6PD-related mutational gene alterations (FAM3A, LAG3, p53, KRAS). The entire circumstance influences the patient's overall survival rate and poor prognosis. Functional investigation using STRING, GO, and KEGG found that G6PD primarily engages in hallmark functions (metabolism, immunological responses, proliferation, apoptosis, p53, HIF-1, FOXO, PI3K-AKT signaling). This work provides a wide knowledge of G6PD's function in lung cancer, as well as a theoretical foundation for possible prognostic therapeutic markers.