Psycho-emotional Changes Research Articles

Медико-психологічні предиктори емоційно-поведінкового періоду материнства

Being in a war area or during regular rockets or artillery attacks, the inability to leave the location of a pregnant woman or a woman in postpartum period can affected the psycho-emotional condition of a woman. Therefore, in today's context, attention should be focused on creating predictors and identifying factors that can negatively affect a pregnant woman, the duration of pregnancy and labor, and the postpartum period. During pregnancy, one of the physiological changes in a woman's body is a change in the functioning of the nervous system. This is because during the implantation of the blastocyst, several types of receptors send impulses to the central nervous system, where information is received, scanned and analyzed in the cerebral cortex and produces the phenomenon of increased excitability. As a result of physiological transformations of this increased excitability, due to physiological mechanisms, it is transformed and reduces the excitability of the nervous system for the formation of the embryo and its complementary structures. As a result, pregnant women may experience psycho-emotional changes, sometimes with an unstable duration, mood changes, fatigue or drowsiness, sometimes obsession with pregnancy and worries about the correct growth of the fetus in the womb or various effects or nutritional factors (consumption or exclusion of certain foods or drinks) that may negatively affect it. The factors affecting the psycho-emotional condition during pregnancy (prenatal period) are identified and analyzed: external, social, economic, physiological, psychological, emotional and willed. The factors affecting the psycho-emotional well-being of women in the postnatal period are analyzed: medical, emotional and psychological, and communicative.

THE INFLUENCE OF THE PSYCHO-EMOTIONAL STATE ON THE REPRODUCTIVE HEALTH OF WOMEN AFTER THE EXPERIENCED DISEASE OF COVID-19

Introduction. The coronavirus disease (COVID-19) recognized as a pandemic caused by the rapid spread of the SARS-CoV-2 coronavirus has become a serious challenge for the health care system around the world. Consequences of psychological health during recovery from COVID-19 can contribute to social alienation, social isolation, and economic losses. In particular, it remains to be investigated how the reproductive system can be directly or indirectly affected by SARS-CoV-2, in the long-term, precisely against the background of psycho-emotional changes. Aim. To study the psycho-emotional state of women and the impact on the reproductive system due to the impact of SARS-CoV-2. Materials and methods. In order to determine the impact of changes in the psycho-emotional state after suffering from the COVID-19 disease on the reproductive function of women with infertility, we included 80 patients who applied to the Carpathian Center for Human Reproduction in Ivano-Frankivsk in the period 2020–2022 for infertility treatment in a comprehensive examination, aged 18–40. Results. Vegetative dysfunction syndrome (VD), which was previously called vegetovascular dystonia (VDD), is attracting the attention of researchers again, in particular in association with "long-Covid-19", an increase in stressogenic loads. Currently, in world medicine, the term somatoform autonomic dysfunction is used, which most often refers to symptoms that are a consequence of another disease. Personal psycho-emotional characteristics of patients play a certain role in the occurrence and course of diseases, especially psychosomatic ones, which include the long-COVID-19 syndrome. A strong correlation of the severity of SVD with three main scales of the FPI personality test was established: with neuroticism (the strongest direct relationship, ρ = 0.72), depression (strong direct relationship, ρ = 0.64) and equanimity (strong inverse relationship, ρ = -0.61). Thus, the vast majority of women with long-Covid-19 were in an anxious state (91.2% vs. 30.0% of women in the control group, p<0.05), 22.5% had an anxiety level of 11 or higher and corresponded to clinically expressed, only 5.5% patients with clinically expressed anxiety were found in the group without COVID-19 (p<0.05). Clinically expressed depression in the main group was diagnosed 5 times more often than in the control group (13.8% vs. 2.5%, respectively, p<0.05). Conclusions. Disturbance of the psycho-emotional state in women with impaired fertility of reproductive age after suffering from Covid-19 has an impact on the effectiveness of infertility treatment. Understanding the mechanisms of the impact of the SARS-CoV-2 virus on the psycho-emotional state of women with infertility will contribute to the search for ways to prevent reproductive losses and pregnancy complications in women who have experienced COVID-19.

The hidden face of the pandemic that reverberates harm to the mental health of health professionals: a reflective study

Throughout the various critical phases of the Covid-19 pandemic, which has imposed an environment of panic and insecurity, the process of mental exhaustion of health professionals has been taken to the extreme, leading to the development and worsening of psychological distress. The aim of this study was to reflect on the emotions expressed by health professionals and the psychological damage caused by their active participation in the pandemic. The methodology applied was a reflective analysis study based on the reading, review, and interpretation of articles, with a time frame between 2020 and 2022. The studies analyzed reveal a major impact on the mental health of health professionals, related to the pandemic, resulting in the outbreak of anxiogenic and depressive signs, with short-term implications already identified and medium and long-term repercussions yet to be evidenced, causing mental health to present psycho-emotional changes at various levels.

The increasing of athleticness and the domination of male qualities in women's sports

Abstract. Starting from the moment of the birth of the modern sports movement, where women did not compete, and their participation was widely discussed, and until now, when women's sports are a generally accepted and everyday phenomenon, the place of women in sports has undergone tremendous transformations. In 1900, the participation of women in competitions on the world stage was officially allowed. Gradually, female athletes debunked the myths of the time, and the 2022 Beijing Winter Olympics included 45% women and became the most gender-balanced games to date.
 Of course, daily training requires high physical and emotional effort from women. Emotional and physiological changes that occur in women in the process of playing sports are an actual direction of modern research, since the psycho-emotional component is an important component of building the training process. Despite the fact that many specialists are engaged in gender research in sports (Y. Shakhlina, 2006; 2010; Maers A. M., Lips H. M., 1978, C. S. Pawlowski, C. Ergler), psycho-emotional changes still remain an understudied area, which emphasizes the relevance of this work.

Psychoemotional characteristics in psychosomatic diseases

It was prepared based on the results of the research conducted at the "Family and Women" Research Institute. This article describes psychoemotional changes in patients with psychosomatic diseases. While the emotions of anger and sadness predominate in patients with cardiological and gastrointestinal diseases, the feeling of fear is more pronounced in patients with endocrinological diseases than other emotional states. In addition, the results of the analysis of the cognitive, emotional, and conative components of the internal appearance of the disease proved that the psychological state of the patient, his attitude to his disease and the treatment process depend on the character of the disease, the possibilities of recovery, the course of the disease and the effectiveness of the treatment.

INVESTIGATING INDICATORS OF ANXIETY, PSYCHOEMOTIONAL TENSION AND STRESS IN PREGNANT WOMEN DURING MARTIAL LAW

Introduction. Pregnancy is a vulnerable period marked by psychoemotional changes, ushering in a new stage with profound shifts in a woman's mental well-being. Elevated stress levels during pregnancy correlate with various adverse psychological and physiological outcomes for both the mother and child. In the current context, the ongoing war serves as an additional stressor for Ukrainian women. Pregnant women exposed to conflict face an increased risk of maternal mortality and a higher likelihood of delivering infants with health complications. Recognizing potential factors contributing to psychoemotional changes in pregnant women is a critical undertaking that should be initiated early in pregnancy.
 The purpose of this study is to assess indicators of anxiety, psychoemotional tension and stress in pregnant women during martial law
 Materials and methods. Psychometric testing of 50 pregnant women was performed by using three anxiety/stress scales: the Spielberger-Hanin Scale, the Psychological Stress Measure (PSM-25), and the Impact of Event Scale (IES-R). The participants were categorized into three groups: group 1 comprised pregnant women residing in areas directly impacted by the full-scale invasion, facing active hostilities or constant rocket fire without changing their residence (17 women, one experiencing occupation for < 1 month); group 2 included internally displaced women (13 individuals, two in settlements occupied for < 1 month); and group 3 encompassed 20 women residing in areas where active hostilities were not taking place.
 Results. According to the Spielberger-Hanin scale, the highest rate of reactive (46.2%, n=6) and personal anxiety (38.5%, n=5) was observed in the group of internally displaced women. The results of the IES-R were as follows, according to the invasion subscale: the highest level was observed in the group of women who were in settlements where there were no active hostilities (45%, n=9), avoidance was found in women who did not change their place of residence, where there was or continues to be active hostilities (58.8%, n=10), excitement – in internally displaced persons (46.2%, n=6). According to the PSM-25, no woman had a high level of stress, it was increased in women of the first group (23.5%, n=4). In the first studied group, complications were dominated by polyhydramnios (29.4%, n=5), fetal growth retardation syndrome (11.8%, n=2), umbilical cord localization pathology (5.9%, n=1), premature detachment a normally located placenta (11.8%, n=2) and one woman had surgery during pregnancy (5.9%, n=1). In the second group, there was a threat of abortion (30.8%, n=4). , preeclampsia in the first half of pregnancy (7.7%, n=1) and placenta localization pathology (7.7%, n=1). In the third group, there was a threat of premature birth (35%, n=7), preeclampsia (20% , n=4), oligohydramnios (25%, n=5), placental pathology (20%, n=4) and premature rupture of membranes (25%, n=5). Regarding the termination of pregnancies (table 4), the majority of pregnancies in all studied groups ended in term delivery, the highest percentage of premature deliveries (35%, n=7) was observed in the third group. In the group where there were women from the zone of active hostilities (group 1), one case of neonatal death was recorded, which was associated with significant fetal malformations.
 Conclusions. Stress is an adaptive process that induces changes in the body. This study revealed that each group experienced stress. It is noteworthy that stress during pregnancy is not solely attributed to war; factors such as the pregnancy itself, its parity, and the presence of somatic diseases also contribute. Consequently, there is a need to formulate measures for the psychoprophylaxis of women and to conduct further observations, assessing larger research cohorts.

Изменение способов коммуникации и использования знаковых систем при обучении в условиях цифрового общества

The article highlights an important social problem: it traces the change in the ways of communicative activity in the field of education from antiquity to the emergence of a digital society. The study of this phenomenon by specialists of various profiles proves that it has reduced motor activity – humanity has become addicted to sitting in electronic networks, the Internet, as a result of which communication has become passive. The article discusses various iconic forms of virtual communication that lead to a number of negative consequences: psycho-emotional changes, information overload, the appearance of a person’s internal closeness, unwillingness not only to perform useful purposeful actions, but also to move.

Cognitive and psychoemotional changes in menopausal transition: The possibility of medical correction

The increasing of older age group in the population determines studying of age related diseases and emergence of new investigations in this area. In Female body, entering the menopausal transition is the start of «aging» of reproductive function and linked with decreasing of sex hormons levels. A direct connection between changes of estrogen, progesterone, androgen ratios and cognitive function of women was revealed. The anatomical localization of sex hormone receptors, the mechanisms of interaction of hormones with these receptors determine the ways of implementing biological effects of steroids on the CNS. Modern theories of «healthy nerve cells» and «eu-estrogenemia» explains the role of additional criteria, such as the absence of neurological diseases history and the duration of hypoestrogenia, to the outcome of menopausal hormone therapy. Additional factors that can affect to MHT action include: the composition of hormone therapy, administration methods, regimens (cyclic, continuous), duration of treatment, history of endocrine diseases, diabetes mellitus, gynecological history (parity, menarche age, COC use), heredity. The sections present the effect of menopausal transition on the development of depression, mood changes, sleep disturbances and mental disabilities. The explanation of negative effects of menopausal hormone therapy to cognitive health is also described by modern point of view. The ambivalent opinions of researchers, the potential of new reading of the results of earlier studies, confirms the necessity of continuing study of this topic.

VESTIBULAR DYSFUNCTIONS IN CHRONIC BRAIN ISCHEMIA IN THE POST COVID PERIOD.

The aim: The aim of the study is the clinical-pathogenetic reasoning of vestibular dysfunctions (VD) development against the background of chronic brain ischemia in the presence of degenerative changes in the cervical spine (CS) in the post COVID period. Materials and methods: 82 patients, in the conditions of the clinical base of the Odessa National Medical University in 2019-2021 were examined. Group I with VD against the background of chronic brain ischemia (CBI) at the compensated phase; Group II with VD against the background of CBI at the subcom¬pensated phase (33 men; 49 women), aged from 18 to 55 years. The control group (CG) consisted of 20 patients of the corresponding gender and age. The condition of the state of the autonomic nervous system, vestibular functions, cervical spine, cerebral arteries and emotional condition were examined. Results: Vestibulo-ataxic disorders were higher compared to CG and increased along with the degree of brain damage. An important aspect of the development of VD is autonomic dysfunction against the background of pathological autonomic characteristics with predominant parasympathetic orientation of autonomic tone, especially in the case of insufficiency of autonomic recativity (AR) and pathological autonomic support of activity. Such changes significantly increased in the presence of subcompensation of CBI. The correlation between psychoemotional disorders and changes in autonomic characteristics with VD against the background of CBI with initial regularities depending on the degree of brain damage was defined. The progression of CBI is facilitated by coronavirus infection and manifested in autonomic and psychoemotional dysfunctions. A characteristic hemodynamic feature in groups with compensated and subcompensated CBI is the presence of reduced perfusion in basilar (BA) and vertebral (VA) arteries. Changes in cerebral vascular reactivity with a decrease in cerebrovascular reactivity indicators were characteristic of the subcompensated phase of CBI. Hyperactivity to rotational functional loads in both clinical groups has a high correlation with the presence of stair descent and, to a lesser extent, isolated instability in CS. Conclusions: 1. The occurrence of VD is facilitated by the presence of autonomic dysfunction and degenerative-dystrophic changes in the CS, especially in case of subcompensation of CBI. 2. Psychoemotional changes were a characteristic feature of patients with VD against the background of CBI and had certain regularities depending on the phase of CBI. 3. Suffered coronavirus infection contributes to the progression of VD and further decompensation of CBI due to direct damage to the autonomic and vascular systems of the brain. 4. Changes in cerebral hemodynamics in the form of reduced perfusion in BA and VA, a decrease in cerebrovascular reactivity, and an increase in reactivity to rotational functional load were determined in patients with VD against the background of subcompensated CBI.

Chronic back pain as a spinal osteoarthritis manifestation: rationale and practice of symptomatic slow acting drugs for osteoarthritis use

Chronic non-specific back pain (CNBP) is the most common pathology of the musculoskeletal system, affecting from 10 to 60% of the adult population in the world, causing severe suffering, disability and a significant deterioration in the quality of life. Osteoarthritis (OA) should be considered as one of the main reasons of the development of CNBP – inflammatory and degenerative changes in the facet and sacroiliac joints, as well as the spinal column itself (in particular, osteitis of the Modic 1 type). Spinal OA is accompanied by biomechanical disturbances, nociplastic (peripheral and central sensitization) and psycho-emotional changes that form a complete picture and various CNBP phenotypes.Recognizing the leading role of OA as the cause of CNBP, it is advisable to use the same therapeutic approaches in this syndrome as in OA of peripheral joints. In particular, it is necessary to consider the use of symptomatic slow acting drugs for osteoarthritis (SYSADOA) in CNBP as the main pathogenetic therapy.Alflutop is one of the most popular parenteral SYSADOA widely used in Russian practice. This drug has a good evidence base: this review presents data from 12 clinical trials of Alflutop in CNBP (n=1479), which confirmed its efficacy and safety.

Quality of life and psychoemotional status in patients with external genital endometriosis

Introduction. Chronic pain syndrome with external genital endometriosis (EGE) causes profound psychoemotional changes, anxiety disorders, decreased physical and social activity, general well-being and mood, sexual dysfunction, and as a consequence, deteriorated quality of patients' life.Aim: to study an influence of psychoemotional disorders on the quality of life of women with painful and painless forms of EGE.Material and Methods. There were enrolled 160 patients (110 women with painful and 50 with painless forms of EGE) of reproductive age with laparoscopically and morphologically verified diagnosis, according to the Revised American Fertility Society score (R-AFS) classification. Pain syndrome and psychoemotional status were assessed using various quality of life assessment questionnaires: Visual Analog Scale (VAS), Endometriosis Health Profile-30 (EHP-30), Hospital Anxiety and Depression Scale (HADS). After surgical treatment, 8 patients refused to participate in the work (6 with painful form of EGE and 2 with painless form). Thus, 152 women passed all stages of the study. The patients were divided into 4 groups depending on the presence and/or absence of pain syndrome and tactics of the rehabilitation period ("active" or "passive"): group IA consisted of 49 (47.1 %) women with pain syndrome and "active" rehabilitation; group IБ – 55 (52.9 %) women with pain syndrome and "passive" rehabilitation tactics; group IIA – 23 (47.9 %) patients without pain syndrome and with "active" rehabilitation; group IIБ – 25 (52.1 %) patients without pain syndrome and with "passive" rehabilitation tactics.Results. It was found that painful vs. painless form of EGE differs by a more severe course of the disease and markedly decreased quality of life. In a comparative analysis of the four groups it was noted that women with "active" tactics of rehabilitation measures (IA and IIA) had a decrease in pain syndrome, improved emotional, social and sexual activity, decreased depression and anxiety scores as compared to the patients (IБ and IIБ) who underwent a set of rehabilitation measures within the National clinical guidelines.Conclusion. Timely diagnostics and correction of psychoemotional disorders will allow to develop a differentiated approach to provide specialized medical and psychological care and improve the quality of life of patients with EGE.

The influence of weight loss interventions on psycho-emotional state of young men with obesity

To assess the relationship of psychoemotional changes with obesity in young men, depending on the age of manifestation of the disease and against the background of the program of weight loss. The study included 48 young men with obesity, aged 17 to 24 years. The subjects were divided into two groups. Group A consisted of 26 men with manifestation of obesity since childhood, group B 22 patients with onset of the disease from puberty. Subsequently, the study patients were subdivided depending on the type of obesity treatment (complex and non-pharmacological). The psychological status and anthropometric parameters were assessed on screening and after 12 weeks of treatment. Depressive disorders were initially observed in 40.9% of patients in group B and in 19.2% of patients in group A. In young men who underwent complex treatment of obesity, regardless of the time of manifestation of the disease, a clinically significant decrease in symptoms of depression was revealed. All types of eating behavior were revealed in the subjects, and these manifestations are more common in patients with manifestation of the disease since childhood. In group A, the restrained eating was in 50% of young men, external eating in 42.3%, and emotional eating in 30.7%. In group B, emotional eating in 9% of patients, external eating in 40.9%, and restrained eating in 31.8% of young obese men. In the group of patients with manifestation of obesity since puberty, the frequency of depressive disorders was higher than in the group of young men with onset of obesity since childhood.

Depression and Anxiety among University Students: A Comparison between COVID-19 Pandemic Panic Period and Post-panic Period in Bangladesh

BACKGROUND: In Bangladesh, the rapid spread of COVID-19 virus created a panic situation among the citizen. Specially, the psycho-emotional disorder of the university students is increasing which has not been adequately investigated. AIM: Relating this, the study aimed to assess the psycho-emotional changes of the university students through investigating their level of depression and anxiety during panic and post-panic period of COVID-19 pandemic in Bangladesh. METHOD: A cross-sectional online survey was conducted among the university students in Bangladesh from April to July 2020 (panic period, n = 170) and then from August to November 2020 (post-panic period, n = 170). The Patient Health Questionnaire (PHQ)-9 and Generalized Anxiety Disorder-7 questionnaires were used to assess the depression and anxiety levels of the students, respectively. Various univariate and multivariable statistical techniques were used to analyze the data. RESULTS: The proportion of depression symptoms was 49.4% and 52.4% during the panic period and post-panic period, respectively. Anxiety symptoms were experienced by 38.2% of students during the panic period, and the percentage was nearly identical in the post-panic interval. In post-panic period, depression levels found a slight increase. Urban students reported significantly (p < 0.05) higher levels of depression and anxiety than their counterparts. Female students also exhibited significantly more anxiety symptoms (p < 0.002) than male. Depression symptoms significantly varied by family types and student’s place of residence. CONCLUSIONS: This study compared the depression and anxiety symptoms of the university students during two periods of the COVID-19 pandemic. Although the difference was small, it remains an issue for the university students in Bangladesh due to the disruption to their academic lives.

Comprehensive care of patients admitted in the Internal Medicine room of the Hospital Dr. Ernesto Torres Galdames. Chile, Tarapaca Region with a diagnosis of Covid 19 from the PNIE

Considering the importance and according to the implications of the scientific support and PNIE intermodulation, it is our purpose to share the postulates and protocols of diagnostic evaluation and treatment in 5 dimensions: Biological - Cognitive - Psycho-emotional - Socioecological and Spiritual that could guide us from a transdisciplinary vision in the Patient care with SARS-CoV2.Starting the pandemic began the psycho-emotional changes in the individuals who work in the hospital and in all the community. The fear and the uncertainty to face a new disease which no one knew was the main attention. Relocate physical spaces to isolate the infected, using protective equipment, educating workers, and establishing a diagnosis for which the medical treatment was unknown. And knowing that the outcome could be fatal. These were psycho-emotional aspects that for any individual would generate little adaptability to changes. Activating the Sympathetic Nervous System and Hypothalamus-Pituitary-Adrenal, and thus altering the PNIE Network. That’s why the need arises to look for strategies based on the PNIE, which allow us to attend to the patient according to the Postulates of the health-disease process, considering them as a psyche - soma - environment unit, taking into account the communication and intermodulation of the psychological, nervous, immune and endocrine, and attending to the Multifactorial, Multidimensionality, Temporal Convergence and Neuroplasticity of its process.

The Effect of Stress on Menstrual Dysfunction in Female Students of Higher Educational Institutions in Moscow

Background : Gynecological morbidity in women of young reproductive age remains an urgent issue in modern medicine. Along with many adverse factors affecting the health of girls and young women, who should be considered as expectant mothers, stress takes one of the leading positions. Objective : To study the level of stress in female students with menstrual dysfunction. Materials and methods : 136 female students from 18 to 23 years old (average age 19.3 ± 2.6 years). All of the participants completed a questionnaire compiled by the authors on the basis of standard questions in collecting general and gynecological anamnesis, criteria for diagnosing premenstrual syndrome, psychological stress scale PSM-25 (fully included, no changes), and Beck scale (fully included, no changes). The following features of the menstrual cycle were studied: cycle duration, menstruation duration, profusion, soreness, and regularity of menstruation as well as the presence of psycho-emotional changes during the phase changes of the cycle. A systematic review was carried out of 25 studies (review articles, qualitative studies, questionnaires, retrospective and prospective studies) published in Russian and English from 2000 to 2019 (with a predominant including (88%) data for the last 10 years) using the PubMed, ScienceDirect, ProQuest and GoogleScholar databases. Results : 82.4% (n = 112) of the examined female students had various menstrual dysfunctions; the highest frequency was premenstrual syndrome (91.1%) and primary dysmenorrhea (85.7%). Students with high levels of stress and depression expressed significantly more often (p <0.05) with irregular rhythms of menstruation in comparison to the healthy group. Conclusions : It is recommended to physicians take into account the stress influence on gynecological pathology, while the awareness of young women about their health status should also be raised.

THE RELATIONSHIP BETWEEN CHANGES IN IMMUNE STATUS AND DISORDERS OF PSYCHO-EMOTIONAL STATE IN PREGNANT WOMEN WITH IN VITRO FERTILIZATION AND THREATENED PREMATURE BIRTH

Women who experience failures at the stage of fertilization or during pregnancy can develop psycho-emotional stress as a result of prolonged negative emotions with a high level of anxiety, neurotic conflict, often accompanied by a complicated pregnancy. The international academic literature discusses a possible link between high levels of anxiety and depression, on the one hand, and changes in the state of the immune system, on the other. The aim of the research was to identify the relationship between psycho-emotional changes in pregnant women with in vitro fertilization and threatened premature birth and changes in their immune status. The psycho-emotional state was studied in 60 women in the second trimester of pregnancy with a history of infertility, whose pregnancy resulted from IVF, and with threatened premature birth. As a control group, 20 healthy women with a physiological course of pregnancy were examined. The levels of trait (TA) and state anxiety (SA), as well as the degree of depressive disorders in these women, were assessed. In parallel, the levels of pro- and anti-inflammatory cytokines and the state of cellular-humoral immunity were determined, looking for correlations between these indicators, the levels of anxiety, and manifestations of depression in the examined patients. Pregnant women with in vitro fertilization and threatened premature birth revealed high levels of state (53.3% of women) and trait (56.8% of women) anxiety; 70% of pregnant women are dominated by euphoric, anxious, and depressive types of the psychological component of gestational dominant; 33.3% of the examined women demonstrated a state of mild and masked depression. Correlations were found between an increase in SA and TA scores and an elevated concentration of TNF-α and INF-γ, as well as between an increase in the level of TNF-α and the score of depression. A connection was found between a decrease in the number of T-helpers and an increase in the TA score in the examined patients.

PSYCHOEMOTIONAL DISORDERS IN CHILDREN ASSOCIATED WITH BRONCHIAL ASTHMA

The purpose of this review is to highlight the present state of the problem of interconnection of psycho-emotional processes with the onset, clinical course and treatment of bronchial asthma.The current researches of domestic and foreign authors is analyzed and summarized. Bronchial asthma is considered by researchers as a psychosomatic disease. The characteristic psychoneural status of children with chronic obstructive syndrome is formulated and the dependence of psycho-emotional changes on the level of bronchial asthma control is shown.The importance of further study of the psychopathogenesis of emotional disorders associated with bronchial asthma is stated in order to develop more effective methods of therapy for these conditions.

Differential immunotropic therapy of patients with acne

Acne (Acne vulgaris) is one of the most common skin diseases (registered in 80-90% of teenagers and young people of working age) with the localization of acne on exposed skin, has a chronic course that causes psycho-emotional changes in patients and reduces their quality of life.Objective. To improve the treatment of patients with acne depending onthe clinical manifestations of dermatosis and the state of their systemicimmunity through the differentiated use of immunotropic drugs.Material and methods. A comprehensive immunological examinationand treatment of 146 patients with acne aged 19 to 25 years, of which 77(52.7%) were female and 69 (47.3%) were male. The control groupconsisted of 35 healthy individuals (donors) of similar age and sex.Results. All 146 examined patients with acne were diagnosed with aninflammatory form of acne, including: in 37 (25.3%) patients - mildclinical course, in 83 (56.8%) - moderate severity and in 26 (17.9%) -severe clinical course of acne. The immunological study revealedsignificant changes in immune parameters in patients with severe andmoderate clinical course of acne, while a slight change in the immunitywas found in the patients with mild stage of acne. According to thesechanges in the immunological parameters of patients with acne, animmunotropic drug glucosaminylmuramyl dipeptide (lycopid) wasprescribed differently - 2 mg twice a day for 10 days (for the patients with moderate acne) and 10 mg once a day for 10 days (for the patients with severe clinical picture). This kind of treatment led to a positive dynamics of immunological parameters of the blood in such patients.Conclusion. Differentiated immunotropic therapy as a component ofcomplex treatment of patients with acne with the prescribtion of theimmunotropic drug glucosaminylmuramyl dipeptide (lycopid) allows usto improve the results of treatment, which is confirmed by the significantpositive dynamics of clinical and laboratory parameters.

Using hypnoanalysis and guided imagery to identify and manage emotional aspects of multiple sclerosis

BackgroundTo date, no studies have used hypnosis to examine and manage the potential emotional causes of multiple sclerosis (MS) in the scientific field; therefore, we decided to compare the effectiveness of hypnoanalysis and guided imagery for determining and manage these emotional causes. MethodsFifteen participants with severe MS were included and assigned into 2 groups: hypnoanalysis and guided imagery. In the hypnoanalysis group, the participants underwent 10 hypnotic sessions to understand events related to the cause of the disease, which were restructured (the events were modified by adding the psychological resources that each involved person needed); in addition, other techniques were used to investigate the causes and solutions according to the participants’ unconscious. The guided imagery group received 10 group sessions of body relaxation and guided imagery, which were recorded for practice at home. Outcome measures, namely, disability (the Expanded Disability Status Scale, EDSS), quality of life (QoL, measured with the SF-36) and number of relapses, were evaluated 4 months previous the intervention, at baseline, post-intervention, and 3 months later. ResultsHypnoanalysis revealed that stressful events and psychoemotional maladaptive patterns acted as causal, detonating, or aggravating factors of disease, and psychoemotional changes were the most frequent and varied solutions. No changes were observed in disability between the two groups. The guided imagery group showed an improvement in 2 subscales of QoL when compared with the hypnoanalysis group (which disappeared at the follow-up); this difference is probably due to the increased number of sessions and probably due to psychoemotional maladaptive patterns being more frequently mentioned than difficult circumstances in life and/or unsolved past events. However, the techniques used in hypnoanalysis were effective in understanding the potential emotional causes of MS, which showed high intra- and inter-participant consistency. ConclusionsThe daily use of guided imagery overcame the restructuring of negative past events to improve QoL in patients with MS. Trial registrationACTRN12618002024224 (retrospectively registered)

Психоемоційні зміни у пацієнток репродуктивного віку з лейоміомою матки у динаміці лікування

The objective: was to study and evaluate changes of psychoemotion of female patient reproductive age with uterine leiomyoma in the dynamics of treatment and rehabilitation of reproductive function depending on the type of therapy. Materials and methods. SAN questionnaires, WHO mental disorder criteria, and the methods of Zung, K. Heck, and I. Hess were used to study changes in psychoemotional states. Psychoemotional changes were studied in 234 patients with conservative and surgical (organ-preserving) treatment, conservative treatment was received – 93 (39.74%) patients; the surgical group was 141 (60.26%). and was divided into two subgroups ІІа – 51 (21.8%) patients without the use of preoperative hormonal training, and ІІб – 90 (38.46%) patients using preoperative preparation. Results. In patients of reproductive age with uterine leiomyoma revealed changes in the psycho-emotional state, which depend on both internal and external factors. These changes were expressed in increased anxiety, neuroticism, mood swings, activity, wellbeing.These changes were observed in both groups, but their severity and depth depended on the duration of the disease. Conclusion. During the examination of female patient reproductive age with uterine leiomyoma was discovered same psychoemotion change. They was related both from internal and external factor and could be declared as increased anxiety neuroticism changes in health, activity, mood. The severity of these changes depends on the initial psycho-emotional state of the patient, the duration of the disease, the effectiveness of previous treatment. Therefore, in some cases an individual approach to the correction of the detected changes was used Keywords: reproductive age, uterine leiomyoma, psychoemotion change.