Prospects For Development Research Articles

Research Progress on Synthesis of Superoxide Dismutase Mimics

Research on the synthesis of superoxide dismutase mimics by chemical and biological synthetic methods were reviewed. The advantages and limitations were analyzed. A prospect for the future development of superoxide dismutase mimics is proposed.

Young cardiologists: innovative approaches and development prospects. Activities of the working group "Young Cardiologists" of the Russian Society of Cardiology

Рабочая группа Российского кардиологического общества (РКО) "Молодые кардиологи" по праву занимает первое место среди всех структур общества по активности и включенности членов группы в совместную работу.

Antibody-Drug Conjugates in the Treatment of Genitourinary Cancers: An Updated Review of Data.

The treatment landscape of genitourinary cancers has significantly evolved over the past few years. Renal cell carcinoma, bladder cancer, and prostate cancer are the most common genitourinary malignancies. Recent advancements have produced new targeted therapies, particularly antibody-drug conjugates (ADCs), due to a better understanding of the underlying oncogenic factors and molecular mechanisms involved. ADCs function as a 'drug delivery into the tumor' system. They are composed of an antigen-directed antibody linked to a cytotoxic drug that releases cytotoxic components after binding to the tumor cell's surface antigen. ADCs have been proven to be extremely promising in the treatment of several cancer types. For GU cancers, this novel treatment has only benefited patients with metastatic urothelial cancer (mUC). The rest of the GU cancer paradigm does not have any FDA-approved ADC treatment options available yet. In this study, we have thoroughly completed a narrative review of the current literature and summarized preclinical studies and clinical trials that evaluated the utility, activity, and toxicity of ADCs in GU cancers, the prospects of ADC development, and the ongoing clinical trials. Prospective clinical trials, retrospective studies, case reports, and scoping reviews were included.

Relevance of Lev Karsavin’s Ideas on State Cultural Policy

The article substantiates the expediency of using domestic philosophical heritage in the development of concepts and other normative documents of Russia’s cultural policy in the current situation. At present, Russian society has gained an understanding of the need to abandon the strategy of catch-up modernization and to implement socio-cultural development on the ways of deepening the country’s traditional spiritual values and its own historical vision of the multipolarity of the world. The ideas of the Russian religious philosopher L.P. Karsavin concerning such fundamental aspects of cultural policy as the peculiarities of the development of state ideology, the design of culture and state cultural programmes, the vocabulary and language of cultural studies are considered. Special attention is paid to Karsavin’s understanding of Russian culture as having Orthodox origins and developing on the basis of Orthodoxy. Attention is drawn to the importance of ensuring the unifying and living, creative character of Russian culture, the conditions of equality of different cultures and, at the same time, the presence of a hierarchy of interpenetrating cultural spheres. The development of some of L.P. Karsavin’s ideas by his followers is outlined, including the need to clarify the Christian meaning of atheism and to overcome the “irreconcilable” antagonism between religious and atheistic worldviews. The study outlines a line of enrichment of cultural theory with little-known works by L.P. Karsavin and A.A. Vaneev, which, according to the authors of the article, opens prospects for further development of new approaches to understanding the essence of cultural policy.

Protonated g-C3N4/oxygen-doped g-C3N4 S-scheme homojunction fabricated by electrostatic self-assembly for photocatalytic hydrogen evolution and tetracycline hydrochloride degradation

S-scheme photocatalytic systems with high redox ability and separation efficiency of photoexcited charge carriers supply considerable prospects for environmental optimization and sustainable energy development. However, coupling well-suited reduction and oxidation components for target reactions remains a challenge worth exploring. Herein, an efficient S-scheme system for H2 generation and tetracycline hydrochloride (TCH) photodegradation based on protonated g-C3N4 (PCN) coupling with oxygen-doped g-C3N4 (OCN) is fabricated via a facile electrostatic self-assembly strategy. Intimate interfacial interactions originating from the ultrathin nanostructure and staggered energy band arrangement for the S-scheme charge transfer pathway provide compelling advantages for the highly efficient separation of photoinduced electron-hole pairs in the as-designed PCN/OCN homojunction. The in-situ irradiated X-ray photoelectron spectroscopy (ISI-XPS) techniques and electron paramagnetic resonance (EPR) measurements are applied to confirm the successful construction and the validity of the S-scheme charge transfer pathway. The obtained PCN/OCN composites with optimal ratio achieve a decent H2 generation rate of 6184.7 μmol g−1 h−1 outpacing the single PCN by approximately 4.8-fold, and 90.5 % TCH photodegradation efficiency is also realized within 90 min. This work provides a delicate fresh round of elevation for the exploration of an effective photocatalytic system.

Protection and Renewal of China's Industrial Heritage under the Concept of Green Development Research progress and prospect

The concept of green development is the common pursuit of human development in the 21st century, and the renewal of industrial remains is the focus under the new normal of stock space. However, the research on the protection and renewal of industrial heritage based on the concept of green development is still in the exploratory stage. This paper systematically sorts out the research progress on the protection and renewal of industrial heritage in China from the aspects of the connotation of green development, the significance of green transformation and theoretical research. On the basis of analyzing the current problems in the protection and reuse research, it puts forward the direction that should be paid attention to in future research.

Application of exopolysaccharides synthesized by Xanthomonas campestris in an efficient separation system of refractory chalcopyrite and molybdenite

Bacterial polysaccharides get an abundance of attention owing to their distinctive biological activity and promising applications. Recent research found that the specificity of the molecular structure of exopolysaccharides (EPS) can be used to accomplish selective regulation of the physicochemical properties of mineral surfaces. The development and application of novel microbial EPS as a flotation reagent for chalcopyrite and molybdenite separation possesses a promising development prospect. Consequently, we attempted to create effective and sustainable molybdenite depressants in this work by optimizing the strain's fermentation settings and identifying the molecular structure of the generated EPS. Fermentation condition tests revealed patterns of influence of fermentation parameters on EPS yield, the viscosity average molecular weight, and biomass during the fermentation process, and optimized the optimal fermentation conditions. Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR), and ion chromatography (IC) analyses clarified the structure of the EPS in terms of monosaccharide composition, glycosidic bonding, and functional groups. Mixed mineral flotation tests proved that a low dosage of polysaccharide reagent (100 mg/L) at pH 10 effectively inhibited molybdenite and achieved separation targets of 21.96% Cu and 2.63% Mo in the concentrate, with separation efficiencies (SE) of 72.67% and 55.78% for Cu and Mo, respectively.

Evolution of Piano Education in China: Analysis of Socio-Cultural Impact and Prospects for Development

Evolution of Piano Education in China: Analysis of Socio-Cultural Impact and Prospects for Development

Research of Acoustic Cavitation: Results, Practical Implementation and Development Prospects

The most significant results of research performed in the Belarusian State University University of Informatics and Radioelectronics, aimed at creating methods and instruments for monitoring cavitation and controlling its activity, are presented. To achieve this goal, it was necessary to clarify the mechanisms and patterns of new and little-studied phenomena: ultrasonic capillary effect, sonoluminescence, cavitation noise and its spectral components and evaluate the possibilities of their use for hardware implementation as cavitation indicators. New cavitation phenomena have been discovered: reverse ultrasonic capillary effect, generation of constant EMF under the influence of alternating pressure of ultrasonic frequency; acoustic clearing of the cavitation area with pulsed modulation of the ultrasonic field, the effect of long-term memory of the cavitation properties of the liquid. Previously unknown patterns have been established: it is shown that the cavitation region goes through four stages of development with increasing ultrasound intensity; a theorem on the maximum cavitation activity was formulated; the spectral characteristics of cavitation noise were established, correlating with the intensity of sonoluminescence. It has been shown that pulsed modulation of the ultrasonic field makes it possible to control the dynamics of the development of the cavitation region and the activity of cavitation. Based on the data obtained, new methods and instruments have been developed to study cavitation and control its activity. In a number of parameters, the created equipment surpasses the best world samples, what is confirmed by deliveries to the Russia, EU countries, China, USA and South Korea.

Light‐Driven Multi‐Core/Shell Microdroplets as a Targeted Drug Delivery System

AbstractTargeted drug delivery system (DDS) holds exciting prospects in biomedical clinical research and drug development. However, it faces a significant challenge in achieving stable and safe targeted transportation without drug leakage while obtaining precise and controllable drug dosing with a high drug utilization rate and low side effects. Herein, an optical tweezers‐based light‐driven technique is proposed to transport and construct multi‐core/shell microdroplets enveloping drug carriers and target cells as a novel, safe, and efficient targeted DDS. Drug‐loaded microdroplets with core/shell structures are first fabricated by a new and simple injection extrusion method and then it is transported to a target cell by a dynamic optical trap with a low optical power, which ensures no drug leakage, exogenous materials, and biothermal damage are introduced during the drug delivery process. Next, precise drug dosing is realized by pushing the target cell into the drug‐loaded microdroplet under the actions of optical forces, which constructs a multi‐core/shell microdroplet structure with a pure drug environment to improve the drug action efficiency. Moreover, quantitative drug dosing with a high drug utilization rate can also achieved by controlling the sizes/number of drug droplets inside the microdroplets. This light‐driven DDS is of great interest to frontier medical research and disease treatment fields.

Core-sheath smart polymer fiber composites with high elasticity and thermal conductivity

Thermal conductive polymer fibers have broad development prospects because of its excellent thermal and mechanical properties. However, currently reported polymer fibers cannot simultaneously possess high thermal conductivity and high resilience, which greatly limits the application of thermal conductive polymer fibers. Therefore, preparing fibers with high thermal conductivity and high resilience is extremely challenging. The thermoplastic polyurethane/boron nitride liquid metal (TPU/BN-LMs) fiber with core sheath structure is prepared by coaxial wet spinning technology, the boron nitride (BN) doped in thermoplastic polyurethane elastomer (TPU) as sheath and the liquid metal (LMs) as core. The maximum tensile strength of the fiber is 3.9 MPa, and the elongation can reach 400 %. After multiple cycles of stretching, it can return to its original state. In addition, the thermal conductivity of the fiber in the horizontal direction and the vertical direction are 10.0 W m−1 K−1 and 4.6 W m−1 K−1, respectively. This work solves the current problem of high thermal conductivity and high resilience of thermally conductive polymer fibers that are difficult to be compatible. And it provides a new research idea for the design and preparation of new high thermal conductivity and high resilience polymer fiber materials.

Study on mechanical properties of dual-channel cryogenic 3D printing scaffold for mandibular defect repair.

Mandibular defect repair has always been a clinical challenge, facing technical bottleneck. The new materials directly affect technological breakthroughs in mandibular defect repair field. Our aim is to fabricate a scaffold of advanced biomaterials for repairing of small mandibular defect. Therefore, a novel dual-channel scaffold consisting of silk fibroin/collagen type-I/hydroxyapatite (SCH) and polycaprolactone/hydroxyapatite (PCL/HA) was fabricated by cryogenic 3D printing technology with double nozzles. The mechanical properties and behaviors of the dual-channel scaffold were investigated by performing uniaxial compression, creep, stress relaxation, and ratcheting experiments respectively. The experiments indicated that the dual-channel scaffold was typical non-linear viscoelastic consistent with cancellous tissue; the Young's modulus of this scaffold was 60.1kPa. Finite element analysis (FEA) was employed performing a numerical simulation to evaluate the implantation effect in mandible. The stress distribution of the contact area between scaffold and defect was uniform, the maximum Mises stress of cortical bone and cancellous bone in defect area were 54.520MPa and 3.196MPa, and the maximum displacement of cortical bone and cancellous bone in defect area were 0.1575mm and 0.1555mm respectively, which distributed in the incisor region. The peak maximum Mises stress experienced by the implanted scaffold was 3.128 × 10-3MPa, and the maximum displacement was 6.453 × 10-2mm distributed near incisor area. The displacement distribution of the scaffold was consistent with that of cortical and cancellous bone. The scaffold recovered well when the force applied on it disappeared. Above all, the dual-channel scaffold had excellent bio-mechanical properties in implanting mandible, which provides a new idea for the reconstruction of irregular bone defects in the mandible and has good clinical development prospects.

Lacustrine shale lithofacies and depositional environment in the paleocene second member of the funing formation, subei basin, China: Insights into shale oil development prospects

Lacustrine fine-grained sedimentary rocks play a crucial role in the petroleum industry, particularly in the exploration of unconventional oil and gas resources. This study focuses on a petroliferous fine-grained succession deposited prior to the Paleocene–Eocene Thermal Maximum (PETM), specifically, the Paleocene second member of the Funing Formation. This formation represents the primary target for shale oil exploration in the Qintong Depression of the Subei Basin. Employing detailed sedimentological descriptions and utilizing multiple geochemical proxies, our investigation aimed to investigate lithofacies distribution and reconstruct the paleoenvironmental conditions prevalent in the Qintong Depression. Through the integration of lithological observation and well log data, the second member of the Funing Formation was categorized into three distinct system tracts: the early expanding system tract (EEST), the late expanding system tract (LEST), and the highstand system tract (HST). Within the established sequence stratigraphy framework, six lithofacies were identified, displaying comparable lateral and planar distributions. Results indicate that lithofacies exhibit greater thickness in the Deep Sag zone compared to the Slope and Fault Terrace. The EEST is characterized by laminated calcareous mudstone (LCM), laminated dolomitic mudstone (LDM), and massive argillaceous dolomite (MAD). Whereas the LEST predominantly comprises LCM and massive calcareous mudstone (MCM). These lithofacies were deposited under relatively arid climatic conditions, characterized by high salinity and strong terrigenous input, with a moderate abundance of organic matter consisting of type Ⅱ and type Ⅲ kerogen. In contrast, the HST is dominated by MCM with stable thickness, indicative of deposition under relatively humid climatic conditions with low salinity and terrigenous input. These conditions fostered an environment conducive to plankton and algae, resulting in a high abundance of organic matter composed of type Ⅰ kerogen. These new characterizations have significant implications for considering favorable lithofacies regarding the vertical orientation and target zones regarding the planarity of shale oil resources in the Qintong Depression of the Subei Basin.

Ideological Function of the Modern State: Problems of Understanding and Prospects of Development

The ideological function of the state is a significant direction of state activity at the present stage of its development in the context of revising the value guidelines of the existence of the state and the formation of a new paradigm of interstate interaction. In line with this study, the vision of the ideological function of the state in the aspect of its modern understanding, the search for certainty in the variable trends of the conceptual series is considered. Based on the consideration of problematic aspects of this topic, the concept of the ideological function of the state is proposed as the main complex direction of the state›s activity, contributing to the development of a full-fledged ideological sphere of society in line with the formation of an ideology of national importance, the revival of traditional values of society and countering destructive ideological influences. In addition to reflecting conceptual certainty, the work formulates the most important prospects for the development of the ideological function of the state. Currently, relatively independent areas of activity are being identified and will continue to develop in the future within the framework of the implementation of the analyzed function of the state – its subfunctions. The formation of the ideology of digitalization of social relations should be considered as a separate element of the content of the ideological function of the state in modern conditions. Mutual connection and mutual conditions of the ideological sphere of social relations and other spheres of modern society will also actively develop. In the process of exercising the ideological function of the state, methods of persuasion and positive coercion will receive predominant development. The detailing of modern ideology is significant. An important factor is the development of ideologies as elements of ideology and as phenomena of the language of law.

Advanced Flexible Sensing Technologies for Soft Robots

AbstractSoft robots have recently attracted increasing interest due to their advantages in durability, flexibility, and deformability, which enable them to adapt to unstructured environments and perform various complex tasks. Perception is crucial for soft robots. To better mimic biological systems, sensors need to be integrated into soft robotic systems to obtain both proprioceptive and external perception for effective usage. This review summarizes the latest advancements in flexible sensing feedback technologies for soft robotic applications. It begins with an introduction to the development of various flexible sensors for soft robots, followed by an in‐depth exploration of smart materials and advanced manufacturing methods. A detailed description of flexible sensing modalities and methodologies is also included in the review to illustrate the continuous breakthrough of the technology. In addition, the applications of soft robots based on these advanced sensing technologies are concluded as well. The challenges of flexible sensing technologies for soft robots and promising solutions are finally discussed and analyzed to provide a prospect for future development. By examining the recent advances in intelligent flexible sensing technologies, this review is dedicated to highlighting the potential of soft robotics and motivating innovation within the field.

Жизненная успешность личности сотрудников органов внутренних дел Российской Федерации: концептуальное обоснование и структурно-функциональная организация

The article is devoted to the theoretical and methodological substantiation of the content and functioning of an individual’s life successfulness as a meta-resource that performs an acceptor function, which consists in anticipating and assessing the results of subjective activity in the process of reflection by the subject of his own goals, values and meanings, taking into account integrative qualities and emotional experiences in the “goal” space. value-meaning." The work substantiates the significance of this meta-resource for the personality of employees of internal affairs bodies and indicates its predictive role in relation to indicators of professional success.
 The data from a theoretical analysis of life successfulness as a meta-resource of the individual are summarized, taking into account the philosophical and socio-philosophical contexts, as well as the leading directions of modern psychology. The main structural elements are identified and their functioning is explained from the perspective of integrating the principles of resource, regulatory and subjective approaches and the theory of functional systems. Attention is paid to the relationship between conscious self-regulation and personal resources, and their intersecting functioning is explained. The postulate of the theory of functional systems about understanding the acceptor is extrapolated to the psychological context, in particular when justifying the meaning and functions of life successfulness as a meta-resource of the individual.
 Life successfulness as a meta-resource function in the space of goals, values and meanings of the individual, through the interconnection of reflexive-technological, reflexive-axiological, reflexive-ontological mechanisms; instrumental, socio-psychological and dispositional qualities of the individual; practical, moral and existential emotional experiences.
 The prospects for further development of the meta-resource concept of life successfulness are outlined.

The Properties and Development of Sulfur-Free Odorant for Town Gas

In this paper, the characteristics, advantages and disadvantages of natural gas sulfur-free odorants and traditional sulfide odorants, as well as the application examples of sulfur-free odorants at home and abroad are analyzed and compared, and the differences between the two odorants in natural gas treatment are discussed. The research shows that the natural gas sulfur-free odorant has the advantages of being more environmentally friendly, safer and more economical than the traditional sulfide odorant. Combined with the actual application cases, the future development trend and prospect of sulfur-free odorant in the natural gas industry are prospected.

Ideologists of Regionalism on the Territorial Status, Population and Development Prospects of Siberia (End of XIX - Beginning of XX centuries)

Ideologists of Regionalism on the Territorial Status, Population and Development Prospects of Siberia (End of XIX - Beginning of XX centuries)

A Micro-Mach–Zehnder Interferometer Temperature Sensing Design Based on a Single Mode–Coreless–Multimode–Coreless–Single Mode Fiber Cascaded Structure

In this paper, a temperature sensing scheme with a miniature MZI structure based on the principle of inter-mode interference is proposed. The sensing structure mainly comprises single mode–coreless–multimode–coreless–single mode fibers (SCMCSs), which have been welded together, with different core diameters. The light beam has been expanded after passing through the coreless optical fiber and is then coupled into a multimode optical fiber. Due to the light passing through the cladding and core mode of the multimode optical fiber with different optical paths, a Mach–Zehnder interferometer is formed. Moreover, due to the thermo-optic and thermal expansion effects of optical fibers, the inter-mode interference spectrum of a multimode fiber shifts when the external temperature changes. Through theoretical analysis, it is found that the change in the length of the sensing fiber during temperature detection has less of an effect on the sensitivity of the sensing structure. During the experiment, temperature changes between 20 and 100 °C are measured at sensing fiber lengths of 1.5 cm, 2.0 cm, 2.5 cm, 3.0 cm, 3.5 cm, and 4.0 cm, respectively, and the corresponding sensitivities are 65.98 pm/°C, 72.70 pm/°C, 67.75 pm/°C, 66.63 pm/°C, 74.80 pm/°C, and 72.07 pm/°C, respectively. All the corresponding correlation coefficients are above 0.9965. The experimental results indicate that in the case of a significant change in the length of the sensing fiber, the sensitivity of the sensing structure changes slightly, which is consistent with the theory that the temperature sensitivity is minimally affected by a change in the length of the sensing fiber. Therefore, the effect of the length on sensitivity in a cascade-based fiber structure is well solved. The sensing scheme has an extensive detection range, small size, good linearity, simple structure, low cost, and high sensitivity. It has a good development prospect in some detection-related application fields.

Survey Research on the Influencing Factors of Upcycled Food in China

Upcycled food is an emerging food in China. This article uses a questionnaire survey to conduct an online mode on the influencing factors, development prospects, health, waste and environmental protection of upcycled food among three groups that are students, staff, and retirees. The results showed that the tendencies of the three surveys on the acceptance, development prospects, waste and environmental protection of upcycled food were basically consistent, with employees being the highest, followed by students, and retirees being the lowest, and it is indicated that employees are the most interested in the development prospects of the upcycled food. According to the research on the impact of upcycled food on health, retired people are the highest, followed by employees, and students are the lowest. It is possible that retired people are older, frail, and have weakened body functions, so they pay more attention to the impact of food on health. In the survey of six factors that influence factors of upcycled food are nutrition, taste, price, food safety, packaging, and famous food brands, the evaluation of factors affecting upcycled food is different at different age groups. Generally speaking, the evaluations of employees and retired people in China are relatively similar. They put food safety first, followed by nutrition. Food safety still occupies a very important position in the hearts of the older people, and their evaluation of packaging is the last one, followed by the brand of food, it is shown that older people are more pragmatic about food consumption. Compared with the evaluations of employees and retired people, the difference in evaluations of students is relatively large. Students believe that price is the most important, followed by nutrition, and food safety is ranked last. In recent years, some food safety incidents have it also keeps happening, but overall the food safety situation in China is getting better. In addition to nutrition, students, employees and retirees all have the same evaluation of food brands, and they all rank second to last, which shows that people are more pragmatic in their food consumption. These survey results provide a reference for the development and promotion of upcycled food in China to a certain extent.