Organizations that may want to have a healthy work environment and success can be able to realize that through having proper human resources management. The objective of the study was thus to investigate the management approaches that can be adopted by healthy and successful organizations in terms of human resources management strategies. The methodology of the study involved the use of secondary data to analyze the human resources management approaches and success of organizations in the long run. The specific areas that were analyzed involved the management of employees, the leadership approach, and organization structure. The findings showed that Walmart adequately managed its employees through its recruiting, training, and development of employees. The findings also revealed that a visionary and transformative leadership and a hierarchical functional organizational structure can result in a healthy and successful organization. The healthcare industry was also investigated to determine the critical factors that could result in a successful organization. From the analysis, it was also revealed that management of employees through training and a leadership that emphasized on emotional intelligence and transformational leadership was critical to realize a successful organization.