Propagation Of Spreading Depression Research Articles

Absence of conduction of spreading depression through cortical region damaged by asphyxiation

An area of cerebral cortex was asphyxiated for 30–35 min by application of a weight exerting a pressure on the tissue greater than the blood pressure. Three days later the asphyxiated region showed in most experiments a marked loss of nerve cells. The glia seemed to be better preserved. Spreading depression could not be made to pass through the area when asphyxiation had caused substantial neuronal destruction. These observations do not support a possible involvement of the glia in the propagation of spreading depression.

Spreading cortical depression of Leao.

Spreading cortical depression of Leao.

Cortical discontinuity and propagation of spreading depression.

The transmissibility of spreading depression across a cut severing all layers of the cortex was investigated in preparations in which 3 weeks to 3 months was allowed for healing of such an injury. No unequivocal signs of transmission of the spreading depression across the scar were observed, although in some instances the scar was less than 0.1 mm wide. In some experiments a small slow potential change was led off from the cortex on the nonstimulated side by an electrode placed in the immediate vicinity of the scar. This potential was considered as evidence for the physical spread across the scar of the potential field produced by the slow potential change which accompanies the spreading depression on the stimulated side. The failure of transmission of spreading depression across a scar does not support the concept that the slow potential change is the agent involved in the propagation of this phenomenon.

Effect of pentobarbital and ether on the spreading cortical depression.

ArticleEffect of Pentobarbital and Ether on the Spreading Cortical DepressionA. van Harreveld, and J. S. StammA. van HarreveldFrom the Kerckhoff Laboratories of the Biological Sciences, California Institute of Technology, Pasadena, California, and J. S. StammFrom the Kerckhoff Laboratories of the Biological Sciences, California Institute of Technology, Pasadena, CaliforniaPublished Online:31 Mar 1953https://doi.org/10.1152/ajplegacy.1953.173.1.164MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByInterneuronal dynamics facilitate the initiation of spike block in cortical microcircuits19 April 2022 | Journal of Computational Neuroscience, Vol. 50, No. 3Discussion and Conclusions20 October 2022The Effects of Brain Metabolic and Other Perturbations on the Responses to Induced CSD20 October 2022Differential neuromodulatory role of endocannabinoids in the rodent trigeminal sensory ganglion and cerebral cortex relevant to pain processingNeuropharmacology, Vol. 131Stress hormone corticosterone enhances susceptibility to cortical spreading depression in familial hemiplegic migraine type 1 mutant miceExperimental Neurology, Vol. 263Extendable, miniaturized multi-modal optical imaging system: cortical hemodynamic observation in freely moving animals17 January 2013 | Optics Express, Vol. 21, No. 2Enhanced Subcortical Spreading Depression in Familial Hemiplegic Migraine Type 1 Mutant Mice13 April 2011 | The Journal of Neuroscience, Vol. 31, No. 15Spreading Depression: From Serendipity to Targeted Therapy in Migraine Prophylaxis1 October 2009 | Cephalalgia, Vol. 29, No. 10The impact of anesthetics and hyperoxia on cortical spreading depressionExperimental Neurology, Vol. 212, No. 1Effects of anesthesia on the responses to cortical spreading depression in the rat brain in vivo19 July 2013 | Neurological Research, Vol. 28, No. 2Heptanol But Not Fluoroacetate Prevents the Propagation of Spreading Depression in Rat Hippocampal SlicesCarlota Largo, Geoffrey C. Tombaugh, Peter G. Aitken, Oscar Herreras, and George G. Somjen1 January 1997 | Journal of Neurophysiology, Vol. 77, No. 1Inhalational Anesthetics Inhibit Spreading Depression: Relevance to Migraine7 November 2016 | Cephalalgia, Vol. 16, No. 2Halothane, but not α-chloralose, blocks potassium-evoked cortical spreading depression in catsBrain Research, Vol. 699, No. 1The glial spike theory. I. On an active role of neuroglia in spreading depression and migraine1 January 1997 | Proceedings of the Royal Society of London. Series B: Biological Sciences, Vol. 250, No. 1329Susceptibility to Spreading Depression and Anoxia: Regional Differences and Drug ControlMorphological and electrophysiological properties of a novel in vitro preparation: the electrosensory lateral line lobe brain sliceJournal of Comparative Physiology A, Vol. 163, No. 4Ketamine blockade of cortical spreading depression in ratsElectroencephalography and Clinical Neurophysiology, Vol. 66, No. 4Factors affecting the oxygen balance in the awake cerebral cortex exposed to spreading depressionBrain Research, Vol. 236, No. 1The interrelation between brain PO2 and NADH oxidation-reduction state in the gerbilJournal of Neuroscience Research, Vol. 5, No. 3Blockage of Cortical Spreading Depression by Picrotoxin Foci of Paroxysmal ActivityEpilepsia, Vol. 16, No. 1Potassium activity in rabbit cortexBrain Research, Vol. 75, No. 1ReferencesMembrane potential of cerebral cortical cells during spreading depression and asphyxiaExperimental Neurology, Vol. 15, No. 4The Nature of Spreading Depression in Neural NetworksThe Cortical Control of Movement A Contribution to the Surgical Physiology of SeizuresEpilepsia, Vol. 1, No. 1-5The ontogenetic development of steady potential differences in the cerebral cortex in animalsElectroencephalography and Clinical Neurophysiology, Vol. 9, No. 1SOME METABOLIC ASPECTS OF LEÃO'S SPREADING DEPRESSION12 December 2006 | Journal of Neurochemistry, Vol. 1, No. 2 More from this issue > Volume 173Issue 1March 1953Pages 164-170 Copyright & PermissionsCopyright © 1953 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1953.173.1.164PubMed13050781History Received 12 October 1952 Published online 31 March 1953 Published in print 31 March 1953 Metrics

FURTHER OBSERVATIONS ON THE SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

FURTHER OBSERVATIONS ON THE SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

PIAL CIRCULATION AND SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

PIAL CIRCULATION AND SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX