Abstract

ArticlesFURTHER OBSERVATIONS ON THE SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEXAristides A. P. LeoAristides A. P. LeoPublished Online:01 Nov 1947https://doi.org/10.1152/jn.1947.10.6.409MoreSectionsPDF (953 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation CollectionsJNP CollectionsClassic ArticlesHistorical Articles Cited BySpreading depolarization and neuronal damage or survival in mouse neocortical brain slices immediately and 12 hours following middle cerebral artery occlusionDylan Petrin, Peter J. Gagolewicz, Rasha H. Mehder, Brian M. Bennett, Albert Y. Jin, and R. David Andrew23 April 2019 | Journal of Neurophysiology, Vol. 121, No. 5Cortical spreading depression as a site of origin for migraine: Role of CGRP25 April 2018 | Cephalalgia, Vol. 39, No. 3Pilocarpine/ascorbic acid interaction in the immature brain: Electrophysiological and oxidative effects in well-nourished and malnourished ratsBrain Research Bulletin, Vol. 142The Migraine PostdromeCONTINUUM: Lifelong Learning in Neurology, Vol. 24, No. 4Ictal–Interictal ContinuumJournal of Clinical Neurophysiology, Vol. 35, No. 4Monitoring anoxic depolarization at the bedside: A step closer to the 24th century2 July 2018 | Journal of Cerebral Blood Flow & Metabolism, Vol. 38, No. 7The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex16 April 2018 | Brain, Vol. 141, No. 6Near-infrared diffuse reflectance signals for monitoring spreading depolarizations and progression of the lesion in a male rat focal cerebral ischemia model18 November 2017 | Journal of Neuroscience Research, Vol. 96, No. 5Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during strokeNeuropharmacology, Vol. 134Neurotransmitters in the mediation of cerebral ischemic injuryNeuropharmacology, Vol. 134Arguments against the role of cortical spreading depression in migraine19 January 2018 | Neurological Research, Vol. 40, No. 3Terminal spreading depolarization and electrical silence in death of human cerebral cortex15 February 2018 | Annals of Neurology, Vol. 83, No. 2Detecting Cortical Spreading Depolarization with Full Band Scalp Electroencephalography: An Illusion?25 January 2018 | Frontiers in Neurology, Vol. 9Management to Optimal Parameters: Euboxia?13 September 2018Magnesium and Human Health: Perspectives and Research DirectionsInternational Journal of Endocrinology, Vol. 2018Protein kinase C epsilon delays latency until anoxic depolarization through arc expression and GluR2 internalization6 June 2017 | Journal of Cerebral Blood Flow & Metabolism, Vol. 37, No. 12Evidence of an inverse correlation between serotonergic activity and spreading depression propagation in the rat cortexBrain Research, Vol. 1672A computational multiscale model of cortical spreading depression propagationComputers & Mathematics with Applications, Vol. 74, No. 5Enhancing Continuous Online Microdialysis Using Dexamethasone: Measurement of Dynamic Neurometabolic Changes during Spreading Depolarization18 May 2017 | ACS Chemical Neuroscience, Vol. 8, No. 8Pathophysiology of Migraine: A Disorder of Sensory ProcessingPeter J. Goadsby, Philip R. Holland, Margarida Martins-Oliveira, Jan Hoffmann, Christoph Schankin, and Simon Akerman8 February 2017 | Physiological Reviews, Vol. 97, No. 2Cortical spreading depression preconditioning mediates neuroprotection against ischemic stroke by inducing AMP-activated protein kinase-dependent autophagy in a rat cerebral ischemic/reperfusion injury model12 January 2017 | Journal of Neurochemistry, Vol. 140, No. 5Simulation of spreading depolarization trajectories in cerebral cortex: Correlation of velocity and susceptibility in patients with aneurysmal subarachnoid hemorrhageNeuroImage: Clinical, Vol. 16Arteriovenous malformations and headacheJournal of Clinical Neuroscience, Vol. 23Spreading Depression, Spreading Depolarizations, and the Cerebral VasculatureCenk Ayata and Martin Lauritzen1 July 2015 | Physiological Reviews, Vol. 95, No. 3Cortical spreading depression as a target for anti-migraine agents23 July 2013 | The Journal of Headache and Pain, Vol. 14, No. 1Vascular, electrophysiological, and metabolic consequences of cortical spreading depression in a mouse model of simulated neurosurgical conditions12 November 2013 | Neurological Research, Vol. 34, No. 3One case of sporadic hemiplegic migraine with multiple pulmonary arteriovenous malformation19 January 2011 | The Journal of Headache and Pain, Vol. 12, No. 3Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma7 April 2011 | Brain, Vol. 134, No. 5Recovery of Slow Potentials in AC-Coupled Electrocorticography: Application to Spreading Depolarizations in Rat and Human Cerebral CortexJed A. Hartings*, Tomas Watanabe*, Jens P. Dreier, Sebastian Major, Leif Vendelbo, and Martin Fabricius1 October 2009 | Journal of Neurophysiology, Vol. 102, No. 4Cortical Spreading Depression—New Insights and Persistent Questions1 October 2009 | Cephalalgia, Vol. 29, No. 10Persisting Depletion of Brain Glucose following Cortical Spreading Depression, despite Apparent Hyperaemia: Evidence for Risk of an Adverse Effect of Leão's Spreading Depression24 September 2008 | Journal of Cerebral Blood Flow & Metabolism, Vol. 29, No. 1The Structure of the Emotions and the Limbic System30 May 2008Spreading Depression in the Brainstem of the Adult Rat: Electrophysiological Parameters and Influences on Regional Brainstem Blood Flow5 December 2007 | Journal of Cerebral Blood Flow & Metabolism, Vol. 28, No. 5Endogenous Activation of Adenosine A1 Receptors Accelerates Ischemic Suppression of Spontaneous Electrocortical ActivityAndrei Ilie, Dragos Ciocan, Ana-Maria Zagrean, Dragos Alexandru Nita, Leon Zagrean, and Mihai Moldovan1 November 2006 | Journal of Neurophysiology, Vol. 96, No. 5Is Spreading Depression Bad for You? Focus on “Repetitive Normoxic Spreading Depression-Like Events Result in Cell Damage in Juvenile Hippocampal Slice Cultures”George G. Somjen1 January 2006 | Journal of Neurophysiology, Vol. 95, No. 1Aristides Leão’s discovery of cortical spreading depressionG. G. Somjen1 July 2005 | Journal of Neurophysiology, Vol. 94, No. 1Dr. Bernice Grafstein’s paper on the mechanism of spreading depressionAnthony J. Strong1 July 2005 | Journal of Neurophysiology, Vol. 94, No. 1Blocking the Anoxic Depolarization Protects Without Functional Compromise Following Simulated Stroke in Cortical Brain SlicesTrent R. Anderson, Cathryn R. Jarvis, Alyson J. Biedermann, Christine Molnar, and R. David Andrew1 February 2005 | Journal of Neurophysiology, Vol. 93, No. 2Auras and other hallucinations: windows on the visual brainArachidonic Acid Metabolites Contribute to the Irreversible Depolarization Induced by In Vitro IschemiaE. Tanaka, S. Niiyama, S. Sato, A. Yamada, and H. Higashi1 November 2003 | Journal of Neurophysiology, Vol. 90, No. 5Spreading Depression Can Be Elicited in Brain Stem of Immature But Not Adult RatsFrank Richter, Sven Rupprecht, Alfred Lehmenkühler, and Hans-Georg Schaible1 October 2003 | Journal of Neurophysiology, Vol. 90, No. 4Measurement of diffusion parameters using a sinusoidal iontophoretic source in rat cortexJournal of Neuroscience Methods, Vol. 122, No. 1Cortical spreading depression in the feline brain following sustained and transient stimuli studied using diffusion‐weighted imaging1 October 2002 | The Journal of Physiology, Vol. 544, No. 1Imaging and preventing spreading depression independent of cerebral blood flowInternational Congress Series, Vol. 1235Ischemia caused by inverse coupling between neuronal activation and cerebral blood flow in ratsInternational Congress Series, Vol. 1235Ischemia-Induced Brain Damage Depends on Specific Gap-Junctional Coupling31 August 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 22, No. 4Neuronal mechanisms of the anoxia-induced network oscillations in the rat hippocampus in vitro5 August 2004 | The Journal of Physiology, Vol. 536, No. 2Mechanisms of Spreading Depression and Hypoxic Spreading Depression-Like DepolarizationGeorge G. Somjen1 July 2001 | Physiological Reviews, Vol. 81, No. 3Imaging Anoxic Depolarization During Ischemia-Like Conditions in the Mouse Hemi-Brain SliceI. Joshi, and R. D. Andrew1 January 2001 | Journal of Neurophysiology, Vol. 85, No. 1Na+ Dependence and the Role of Glutamate Receptors and Na+ Channels in Ion Fluxes During Hypoxia of Rat Hippocampal SlicesMichael Müller, and George G. Somjen1 October 2000 | Journal of Neurophysiology, Vol. 84, No. 4Mitochondrial and Intrinsic Optical Signals Imaged During Hypoxia and Spreading Depression in Rat Hippocampal SlicesS. Bahar, D. Fayuk, G. G. Somjen, P. G. Aitken, and D. A. Turner1 July 2000 | Journal of Neurophysiology, Vol. 84, No. 1Na+ and K+ Concentrations, Extra- and Intracellular Voltages, and the Effect of TTX in Hypoxic Rat Hippocampal SlicesMichael Müller, and George G. Somjen1 February 2000 | Journal of Neurophysiology, Vol. 83, No. 2The Trigeminovascular System in Humans: Pathophysiologic Implications for Primary Headache Syndromes of the Neural Influences on the Cerebral Circulation31 August 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 19, No. 2Inhibition of major cationic inward currents prevents spreading depression-like hypoxic depolarization in rat hippocampal tissue slicesBrain Research, Vol. 812, No. 1-2Similar Propagation of SD and Hypoxic SD-Like Depolarization in Rat Hippocampus Recorded Optically and ElectricallyP. G. Aitken, G. C. Tombaugh, D. A. Turner, and G. G. Somjen1 September 1998 | Journal of Neurophysiology, Vol. 80, No. 3Cortical spreading depression induces an LTP-like effect in rat neocortex in vitroBrain Research, Vol. 781, No. 1-2Effects of the Gliotoxin Fluorocitrate on Spreading Depression and Glial Membrane Potential in Rat Brain In SituCarlota Largo, José M. Ibarz, and Oscar Herreras1 July 1997 | Journal of Neurophysiology, Vol. 78, No. 1How do the Currently Used Prophylactic Agents Work in Migraine?7 November 2016 | Cephalalgia, Vol. 17, No. 2Hypertonic Environment Prevents Depolarization and Improves Functional Recovery from Hypoxia in Hippocampal Slices31 August 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 16, No. 3Hypoxic neuronal damage in the absence of hypoxic depolarization in rat hippocampal slices: the role of glutamate receptorsBrain Research, Vol. 708, No. 1-2Spreading Waves of a Reduced Diffusion Coefficient of Water in Normal and Ischemic Rat Brain28 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 15, No. 2Spreading depression of Lea˜o in rodent and human cortexBrain Research, Vol. 666, No. 1Membrane currents in CA1 pyramidal cells during spreading depression (SD) and SD-like hypoxic depolarizationBrain Research, Vol. 632, No. 1-2Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemiaBrain Research, Vol. 612, No. 1-2Role of calcium channels in spreading depression in rat hippocampal slicesBrain Research, Vol. 604, No. 1-2The Effect of Glutamate Receptor Blockade on Anoxic Depolarization and Cortical Spreading Depression29 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 12, No. 2Lasting neuron depression induced by high potassium and its prevention by low calcium and NMDA receptor blockadeBrain Research, Vol. 557, No. 1-2NMDA-, kainate- and quisqualate-stimulated release of taurine from electrophysiologically monitored rat hippocampal slicesBrain Research, Vol. 549, No. 1Calcium, magnesium, and long-term recovery from hypoxia in hippocampal tissue slicesBrain Research, Vol. 548, No. 1-2A pharmacological model of ischemia in the hippocampal sliceNeuroscience Letters, Vol. 119, No. 2Reversible effects of hypoxia on neurons in mouse dorsal root ganglia in vitroBrain Research, Vol. 520, No. 1-2Time resolved 3-dimensional recording of redox ratio during spreading depression in Gerbil brainBrain Research, Vol. 506, No. 1Spreading depression-like hypoxic depolarization in CA1 and fascia dentata of hippocampal slices: relationship to selective vulnerabilityBrain Research, Vol. 497, No. 1Prolonged exposure to high potassium concentration results in irreversible loss of synaptic transmission in hippocampal tissue slicesBrain Research, Vol. 457, No. 2Magnetic field associated with spreading depression: a model for the detection of migraineBrain Research, Vol. 442, No. 1Chlorpromazine protects brain tissue in hypoxia by delaying spreading depression-mediated calcium influxBrain Research, Vol. 385, No. 2Migraine in ChildrenNeurologic Clinics, Vol. 3, No. 1Positive rolandic sharp waves in neonatal EEG: Types and significanceElectroencephalography and Clinical Neurophysiology, Vol. 53, No. 3Brain extracellular ion composition and EEG activity following 10 minutes ischemia in normo- and hyperglycemic rats.Stroke, Vol. 12, No. 2Migraine with interparoxysmal sharp complexes in the EEG: Clinical features and response to anticonvulsant drugsClinical Neurology and Neurosurgery, Vol. 83, No. 2Spreading depression in elasmobranch cerebellumBrain Research, Vol. 199, No. 1Extracellular ionic variations during spreading depressionNeuroscience, Vol. 3, No. 11Simulation of cascades by video feedback19 September 2006Metabolic responses of the awake cerebral cortex to anoxia hypoxia spreading depression and epileptiform activityBrain Research, Vol. 98, No. 1An injury-induced diffuse slow potential from brainElectroencephalography and Clinical Neurophysiology, Vol. 38, No. 4Prolonged slow potential variation associated with cortical spreading depressionPhysiology & Behavior, Vol. 13, No. 3Potassium activity in rabbit cortexBrain Research, Vol. 75, No. 1A comparative study of membrane potential changes in neurons and neuroglial cells during spreading depression in the rabbitBrain Research, Vol. 65, No. 3Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in ratsBrain Research, Vol. 39, No. 1Cortical steady potential, impedance and excitability changes during and after total ischemia of cat brainExperimental Neurology, Vol. 32, No. 2Spreading depression in isolated chick retinaVision Research, Vol. 11Some aspects of the baseline transcephalic D.C. potential in psychiatric patientsJournal of Psychiatric Research, Vol. 6, No. 1Membrane potential of cerebral cortical cells during spreading depression and asphyxiaExperimental Neurology, Vol. 15, No. 4An analysis of some correlates of steady potentials in mammalian cerebral cortexElectroencephalography and Clinical Neurophysiology, Vol. 14, No. 4Seizure discharges effected by intravenously administered convulsant drugsElectroencephalography and Clinical Neurophysiology, Vol. 11, No. 1Die Wirkung des Chlorpromazins und der Glykämie auf das elektrophysiologisch kontrollierte Überleben der Hirnrinde bei verschiedenen KörpertemperaturenNaunyn-Schmiedebergs Archiv für Experimentelle Pathologie und Pharmakologie, Vol. 231, No. 6The ontogenetic development of steady potential differences in the cerebral cortex in animalsElectroencephalography and Clinical Neurophysiology, Vol. 9, No. 1Steady potential gradients in experimental cerebral vascular occlusionElectroencephalography and Clinical Neurophysiology, Vol. 6The slow voltage variation of cortical spreading depression of activityElectroencephalography and Clinical Neurophysiology, Vol. 3, No. 3On the conditions for the recording of Leao's spreading depressionElectroencephalography and Clinical Neurophysiology, Vol. 3, No. 3The slowly changing voltage of the brain and the electrocorticogramElectroencephalography and Clinical Neurophysiology, Vol. 3, No. 2Cumulative effects of minimal cortical stimulationsElectroencephalography and Clinical Neurophysiology, Vol. 2, No. 1-4The identity of spreading depression and “suppression”Electroencephalography and Clinical Neurophysiology, Vol. 2, No. 1-4The relation of dehydration of the brain to the spreading depression of LeaoElectroencephalography and Clinical Neurophysiology, Vol. 2, No. 1-4Initial survey of slow potential changes obtained under resting conditions and incident to convulsive therapyElectroencephalography and Clinical Neurophysiology, Vol. 2, No. 1-4 More from this issue > Volume 10Issue 6November 1947Pages 409-414 https://doi.org/10.1152/jn.1947.10.6.409PubMed20268874History Published online 1 November 1947 Published in print 1 November 1947 Metrics

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call