PIAL CIRCULATION AND SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEX

Abstract

ArticlesPIAL CIRCULATION AND SPREADING DEPRESSION OF ACTIVITY IN THE CEREBRAL CORTEXAristides A. P. LeoAristides A. P. LeoPublished Online:01 Nov 1944https://doi.org/10.1152/jn.1944.7.6.391MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation CollectionsJNP CollectionsClassic ArticlesHistorical Articles Cited ByMaternal voluntary physical exercise in the adult rat: evidence of exercise-associated differences in maternal food intake, and in brain effects on the progeny12 January 2023 | Nutritional NeuroscienceVascular responses of penetrating vessels during cortical spreading depolarization with ultrasound dynamic ultrafast Doppler imaging16 November 2022 | Frontiers in Neuroscience, Vol. 16Development of Mechanistic Neural Mass (mNM) Models that Link Physiology to Mean-Field Dynamics28 September 2022 | Frontiers in Network Physiology, Vol. 2Cortical Anoxic Spreading Depolarization During Cardiac Arrest is Associated with Remote Effects on Peripheral Blood Pressure and Postresuscitation Neurological Outcome21 June 2022 | Neurocritical Care, Vol. 37, No. S1Migraine Aura, Transient Ischemic Attacks, Stroke, and Dying of the Brain Share the Same Key Pathophysiological Process in Neurons Driven by Gibbs–Donnan Forces, Namely Spreading Depolarization10 February 2022 | Frontiers in Cellular Neuroscience, Vol. 16Increase of Lactate Concentration During Spreading Depression15 April 2022Cortical Spreading Depolarizations in Aneurysmal Subarachnoid Hemorrhage: An Overview of Current Knowledge and Future Perspectives18 August 2022Introduction and Historical Background20 October 2022Discussion and Conclusions20 October 2022Basic Principles and Technology of NADH and Multiparametric Monitoring Used in Studying Cortical Spreading Depression (CSD)20 October 2022Sequence of Physiological Responses Recorded During Induced CSD Event20 October 2022The Effects of Brain Metabolic and Other Perturbations on the Responses to Induced CSD20 October 2022Effects of Pharmacological Agents on CSD20 October 2022Clinical Monitoring of Cortical Spreading Depression (CSD) in the Human Brain20 October 2022CSD and the LifenLight Score (LLS)20 October 2022Is Spreading Depolarization a Risk Factor for Late Epilepsy? A Prospective Study in Patients with Traumatic Brain Injury and Malignant Ischemic Stroke Undergoing Decompressive Craniectomy30 September 2020 | Neurocritical Care, Vol. 34, No. 3Migraine Visual Aura and Cortical Spreading Depression—Linking Mathematical Models to Empirical Evidence10 June 2021 | Vision, Vol. 5, No. 2An underrepresented majority: A systematic review utilizing allodynic criteria to examine the present scarcity of discrete animal models for episodic migraine1 November 2020 | Cephalalgia, Vol. 41, No. 3Advances in migraine therapeutics: The role of calcitonin gene-related peptideCortical Spreading Depression Phenomena Are Frequent in Ischemic and Traumatic Penumbra: A Prospective Study in Patients With Traumatic Brain Injury and Large Hemispheric Ischemic Stroke4 November 2019 | Journal of Clinical Neurophysiology, Vol. 38, No. 1A non‐convulsant delta‐opioid receptor agonist, KNT‐127, reduces cortical spreading depression and nitroglycerin‐induced allodynia16 December 2020 | Headache: The Journal of Head and Face Pain, Vol. 61, No. 1Headache, Visual Loss and Papilledema7 October 2020Low Back Pain, Abdominal Pain and Headache2 December 2020The role of Toll-like receptor signaling pathways in cerebrovascular disorders: the impact of spreading depolarization7 April 2020 | Journal of Neuroinflammation, Vol. 17, No. 1Serum Homocysteine, Pyridoxine, Folate, and Vitamin B12 Levels in Migraine: Systematic Review and Meta‐Analysis2 July 2020 | Headache: The Journal of Head and Face Pain, Vol. 60, No. 8Cortical Spreading Depression in the Setting of Traumatic Brain InjuryWorld Neurosurgery, Vol. 134Migraine a Disorder Involving Trigeminal Pathways Modulated by the Brainstem and DiencephalonMitochondrial function and brain Metabolic Score (BMS) in ischemic Stroke: Evaluation of “neuroprotectants” safety and efficacyMitochondrion, Vol. 50Segregation of seizures and spreading depolarization across cortical layers21 November 2019 | Epilepsia, Vol. 60, No. 12Pathophysiology of MigraineNeurologic Clinics, Vol. 37, No. 4Endogenous Na+, K+-ATPase inhibitors and CSF [Na+] contribute to migraine formation7 June 2019 | PLOS ONE, Vol. 14, No. 6Brain Aging and Electrophysiological Signaling: Revisiting the Spreading Depression Model7 June 2019 | Frontiers in Aging Neuroscience, Vol. 11Cortical Spreading Depression Denotes Concussion InjuryJournal of Neurotrauma, Vol. 36, No. 7Neurovascular mechanisms of migraine and cluster headache26 September 2017 | Journal of Cerebral Blood Flow & Metabolism, Vol. 39, No. 4Neonatal treatment with ovarian hormones and suckling among distinct litter sizes: Differential effects on recognition memory and spreading depression at adulthood10 September 2017 | Nutritional Neuroscience, Vol. 22, No. 3Occurrence of Spontaneous Cortical Spreading Depression Is Increased by Blood Constituents and Impairs Neurological Recovery after Subdural Hematoma in RatsJournal of Neurotrauma, Vol. 36, No. 2Ethanol and Cortical Spreading Depression: The Protective Role of α-TocopherolCellular Automata and Artificial Brain Dynamics16 November 2018 | Mathematical and Computational Applications, Vol. 23, No. 4Emerging drugs for migraine treatment: an update30 November 2018 | Expert Opinion on Emerging Drugs, Vol. 23, No. 4The Migraine PostdromeCONTINUUM: Lifelong Learning in Neurology, Vol. 24, No. 4Active role of capillary pericytes during stimulation-induced activity and spreading depolarization27 June 2018 | Brain, Vol. 141, No. 7Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during strokeNeuropharmacology, Vol. 134Arguments against the role of cortical spreading depression in migraine19 January 2018 | Neurological Research, Vol. 40, No. 3Recent Advances in Pharmacotherapy for Migraine Prevention: From Pathophysiology to New Drugs2 February 2018 | Drugs, Vol. 78, No. 4Direct Current Coupled Recordings of Cortical Spreading Depression Using Silicone Probes21 December 2017 | Frontiers in Cellular Neuroscience, Vol. 11An update on migraine: current understanding and future directions20 March 2017 | Journal of Neurology, Vol. 264, No. 9A computational multiscale model of cortical spreading depression propagationComputers & Mathematics with Applications, Vol. 74, No. 5Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brainProgress in Neurobiology, Vol. 156From Cortical Spreading Depression to Trigeminovascular Activation in Migraine19 June 2017Animal Models of Migraine Aura19 June 2017The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy21 July 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 37, No. 5‘Spreading depression of Leão’ and its emerging relevance to acute brain injury in humans21 July 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 37, No. 5Heterogeneous incidence and propagation of spreading depolarizations1 October 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 37, No. 5Pathophysiology of Migraine: A Disorder of Sensory ProcessingPeter J. Goadsby, Philip R. Holland, Margarida Martins-Oliveira, Jan Hoffmann, Christoph Schankin, and Simon Akerman8 February 2017 | Physiological Reviews, Vol. 97, No. 2Temporal Excitation Patterns on the Cerebral Cortex as a Result of Migraine Modeling8 March 2017Intrinsic Optical Signal Imaging of Seizures and Cortical Spreading Depression☆Leão, Aristides ☆Front blocking and propagation in cylinders with varying cross section16 April 2016 | Calculus of Variations and Partial Differential Equations, Vol. 55, No. 3High-Performance Bioinstrumentation for Real-Time Neuroelectrochemical Traumatic Brain Injury Monitoring19 May 2016 | Frontiers in Human Neuroscience, Vol. 10Geometry Shapes Propagation: Assessing the Presence and Absence of Cortical Symmetries through a Computational Model of Cortical Spreading Depression2 February 2016 | Frontiers in Computational Neuroscience, Vol. 10Arteriovenous malformations and headacheJournal of Clinical Neuroscience, Vol. 23Magnetic Resonance Imaging of Pediatric Neurologic EmergenciesTopics in Magnetic Resonance Imaging, Vol. 24, No. 6Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading2 September 2015 | The Journal of Neuroscience, Vol. 35, No. 35Variation of repetitive cortical spreading depression waves is related with relative refractory period: a computational study7 November 2015 | Quantitative Biology, Vol. 3, No. 3Cortical spreading depression in migraine-time to reconsider?Arquivos de Neuro-Psiquiatria, Vol. 73, No. 8Spreading Depression, Spreading Depolarizations, and the Cerebral VasculatureCenk Ayata and Martin Lauritzen1 July 2015 | Physiological Reviews, Vol. 95, No. 3Aristides Leão: a birth centennial homage with comments on his spreading depressionArquivos de Neuro-Psiquiatria, Vol. 73, No. 6Headache, Cerebral Aneurysms, and the Use of Triptans and Ergot Derivatives22 April 2015 | Headache: The Journal of Head and Face Pain, Vol. 55, No. 5Characterization of the Relationship Between Intracranial Pressure and Electroencephalographic Monitoring in Burst-Suppressed Patients21 August 2014 | Neurocritical Care, Vol. 22, No. 2Responses of NADH to Physiological and Pathophysiological ConditionsFenómenos de despolarización cortical propagada en los pacientes con lesiones cerebrales traumáticas e isquémicas. Resultados de un estudio pilotoMedicina Intensiva, Vol. 38, No. 7Detecting Tissue Deterioration after Brain Injury: Regional Blood Flow Level versus Capacity to Raise Blood Flow2 April 2014 | Journal of Cerebral Blood Flow & Metabolism, Vol. 34, No. 7Complexity measures and self-similarity on spreading depression wavesPhysica A: Statistical Mechanics and its Applications, Vol. 401Leão, AristidesOxidative Stress and Neuronal Zinc Signaling26 August 2014Cortical spreading depression as a target for anti-migraine agents23 July 2013 | The Journal of Headache and Pain, Vol. 14, No. 1Cortical spreading depression and migraine17 September 2013 | Nature Reviews Neurology, Vol. 9, No. 11Alterations of regional spontaneous neuronal activity and corresponding brain circuit changes during resting state in migraine without aura24 January 2013 | NMR in Biomedicine, Vol. 26, No. 9Insights into the pharmacological targeting of the trigeminocervical complex in the context of treatments of migraine9 January 2014 | Expert Review of Neurotherapeutics, Vol. 13, No. 9Cortical spreading depression and central pain networks in trigeminal nuclei modulation: time for an integrated migraine pathogenesis perspective22 May 2013 | Neurological Sciences, Vol. 34, No. S1Casein Kinase Iδ Mutations in Familial Migraine and Advanced Sleep PhaseScience Translational Medicine, Vol. 5, No. 183Is Spreading Depolarization Characterized by an Abrupt, Massive Release of Gibbs Free Energy from the Human Brain Cortex?24 July 2012 | The Neuroscientist, Vol. 19, No. 1Emerging genomic biomarkers in migraineFuture Neurology, Vol. 8, No. 1Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasmBritish Journal of Anaesthesia, Vol. 109, No. 3Ovariectomy in the developing rat decelerates cortical spreading depression in adult brain15 February 2012 | International Journal of Developmental Neuroscience, Vol. 30, No. 5Imaging mass spectrometry to visualize biomolecule distributions in mouse brain tissue following hemispheric cortical spreading depressionJournal of Proteomics, Vol. 75, No. 16The use of cortical spreading depression for studying the brain actions of antioxidants19 July 2013 | Nutritional Neuroscience, Vol. 15, No. 3Correcting the detrimental effects of nonuniform intensity distribution on fiber-transmitting laser speckle imaging of blood flow21 December 2011 | Optics Express, Vol. 20, No. 1Assessment of Neurovascular Coupling6 April 2012Spontaneous Cortical Spreading Depression and Intracranial Pressure Following Acute Subdural Hematoma in a Rat13 January 2012Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex26 November 2011 | Brain, Vol. 135, No. 1Spreading depolarization, a pathophysiological mechanism of stroke and migraine auraFuture Neurology, Vol. 7, No. 1One Hundred Years of Migraine Research: Major Clinical and Scientific Observations From 1910 to 201026 April 2011 | Headache: The Journal of Head and Face Pain, Vol. 51, No. 5Differential effects of physical exercise and l -arginine on cortical spreading depression in developing rats19 July 2013 | Nutritional Neuroscience, Vol. 14, No. 3Migraine is a neuronal disease15 December 2010 | Journal of Neural Transmission, Vol. 118, No. 4Migraine-like Visual Aura Due to Focal Cerebral Lesions: Case Series and ReviewSurvey of Ophthalmology, Vol. 56, No. 2Distinct Spatiotemporal Patterns of Spreading Depolarizations during Early Infarct Evolution: Evidence from Real-Time Imaging11 August 2010 | Journal of Cerebral Blood Flow & Metabolism, Vol. 31, No. 2Fisiopatología del dolor de cabezaSubverting the hegemony of the synapse: Complicity of neurons, astrocytes, and vasculature in spreading depression and pathology of the cerebral cortexBrain Research Reviews, Vol. 66, No. 1-2Does single cortical spreading depression elicit pain behaviour in freely moving rats?31 March 2010 | Cephalalgia, Vol. 30, No. 10Effect of serotonin depletion on cortical spreading depression evoked cerebrovascular changesAsian Biomedicine, Vol. 4, No. 5Increased Vulnerability to Oxidative Stress in Pediatric Migraine PatientsPediatric Neurology, Vol. 43, No. 1Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions26 May 2010 | Brain, Vol. 133, No. 7History of migraine with aura and cortical spreading depression from 1941 and onwards1 October 2009 | Cephalalgia, Vol. 30, No. 7Essential fatty acid deficiency reduces cortical spreading depression propagation in rats: a two-generation study2 December 2013 | Nutritional Neuroscience, Vol. 13, No. 3Das Fenster zur Kopfschmerzforschung9 April 2010 | Der Schmerz, Vol. 24, No. 2Capillary Endothelial Na + , K + , ATPase Transporter Homeostasis and a New Theory for Migraine PathophysiologyHeadache: The Journal of Head and Face Pain, Vol. 50, No. 3Migraine, neuropathic pain and nociceptive pain: Towards a unifying conceptMedical Hypotheses, Vol. 74, No. 2Cortical Spreading Depression—New Insights and Persistent Questions1 October 2009 | Cephalalgia, Vol. 29, No. 10Pathophysiology of MigraineNeurologic Clinics, Vol. 27, No. 2Characterization of periinfarct flow transients with laser speckle and Doppler after middle cerebral artery occlusion in the ratJournal of Neuroscience Research, Vol. 87, No. 5L-Arginine administration during rat brain development facilitates spreading depression propagation: evidence for a dose- and nutrition-dependent effect19 July 2013 | Nutritional Neuroscience, Vol. 12, No. 2Are Cortical Spreading Depression and Headache in Migraine Causally Linked?1 February 2009 | Cephalalgia, Vol. 29, No. 2Persisting Depletion of Brain Glucose following Cortical Spreading Depression, despite Apparent Hyperaemia: Evidence for Risk of an Adverse Effect of Leão's Spreading Depression24 September 2008 | Journal of Cerebral Blood Flow & Metabolism, Vol. 29, No. 1Resting Brain Glucose Uptake in Headache-Free MigraineursHeadache: The Journal of Head and Face Pain, Vol. 49, No. 1Professor Aristides Leão. Much More Than Spreading DepressionHeadache: The Journal of Head and Face Pain, Vol. 49, No. 1Early malnutrition, but not age, modulates in the rat the l-Arginine facilitating effect on cortical spreading depressionNeuroscience Letters, Vol. 447, No. 1Mechanically-induced cortical spreading depression associated regional cerebral blood flow changes are blocked by Na+ ion channel blockadeBrain Research, Vol. 1229Spreading depression and brain preconditioning: A short reviewCurrent Anaesthesia & Critical Care, Vol. 19, No. 4Progress and problems in the application of focused ultrasound for blood–brain barrier disruptionUltrasonics, Vol. 48, No. 4Peripheral mechanism of action of antimigraine prophylactic drugs11 June 2008 | Neurological Sciences, Vol. 29, No. S1Chapter 42 Stroke, migraine, and headacheHeadache Treatment with Pulsing Electromagnetic Fields: A Literature Review2 November 2007 | Applied Psychophysiology and Biofeedback, Vol. 32, No. 3-4Simulating the propagation of spreading cortical depression (SCD) wavefront on human brain surfaceComputers in Biology and Medicine, Vol. 37, No. 106A-4 Focused Ultrasound Potential to Initiate Spreading Depression for Disruption of Blood Brain BarrierRelationship Between Migraine and Patent Foramen Ovale: A Study of 121 Patients with MigraineHeadache: The Journal of Head and Face Pain, Vol. 47, No. 9Differences in O2 availability resolve the apparent discrepancies in metabolic intrinsic optical signals in vivo and in vitroTrends in Neurosciences, Vol. 30, No. 8Aphasic Migraineous Aura With Left Parietal Hypoperfusion: A Case Report26 June 2016 | Cephalalgia, Vol. 27, No. 7Distinct Vascular Conduction With Cortical Spreading DepressionKevin C. Brennan, Luis Beltrán-Parrazal, Hector E. López-Valdés, Jeremy Theriot, Arthur W. Toga, and Andrew C. Charles1 June 2007 | Journal of Neurophysiology, Vol. 97, No. 6Cortical Spreading Depression—Better Understanding and More Questions. Focus on “Distinct Vascular Conduction With Cortical Spreading Depression”Peter J. Goadsby1 June 2007 | Journal of Neurophysiology, Vol. 97, No. 6Nutrition-dependent influence of peripheral electrical stimulation during brain development on cortical spreading depression in weaned rats5 September 2013 | Nutritional Neuroscience, Vol. 10, No. 3-4The Cerebellum and MigraineHeadache: The Journal of Head and Face Pain, Vol. 47, No. 6Cortical spreading depression: an adverse but treatable factor in intensive care?Current Opinion in Critical Care, Vol. 13, No. 2MigraineMigra?aMedicine - Programa de Formaci?n M?dica Continuada Acreditado, Vol. 9, No. 70Migraine Headaches: A Historical Prospective, a Glimpse into the Future, and Migraine EpidemiologyDisease-a-Month, Vol. 52, No. 10A review of diagnostic and functional imaging in headache11 August 2006 | The Journal of Headache and Pain, Vol. 7, No. 4Migraine: emerging treatment options for preventive and acute attack therapy29 August 2006 | Expert Opinion on Emerging Drugs, Vol. 11, No. 3Functional neuroimaging of primary headache disorders10 January 2014 | Expert Review of Neurotherapeutics, Vol. 6, No. 8Evaluation of Laser Speckle Flowmetry for Imaging Cortical Perfusion in Experimental Stroke Studies: Quantitation of Perfusion and Detection of Peri-Infarct Depolarisations2 November 2005 | Journal of Cerebral Blood Flow & Metabolism, Vol. 26, No. 5Time-varying spreading depression waves in rat cortex revealed by optical intrinsic signal imagingNeuroscience Letters, Vol. 396, No. 2Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex19 December 2005 | Brain, Vol. 129, No. 3Can we Develop Neurally Acting Drugs for the Treatment of Migraine?24 August 2005 | Nature Reviews Drug Discovery, Vol. 4, No. 9Aristides Leão’s discovery of cortical spreading depressionG. G. Somjen1 July 2005 | Journal of Neurophysiology, Vol. 94, No. 1Diffusion- and Perfusion-Weighted MR Imaging in Persistent Migrainous visual Disturbances26 June 2016 | Cephalalgia, Vol. 25, No. 5Functional neuroimaging of primary headache disordersCurrent Pain and Headache Reports, Vol. 9, No. 2Depolarisation Phenomena in Traumatic and Ischaemic Brain InjuryUsing Running Subtraction to Detect the Wavefront of Cortical Spreading DepressionCortical spreading depression produces long-term disruption of activity-related changes in cerebral blood volume and neurovascular couplingJournal of Biomedical Optics, Vol. 10, No. 1Cortical spreading depression: Its role in migraine pathogenesis and possible therapeutic intervention strategiesCurrent Pain and Headache Reports, Vol. 8, No. 5Cortical spreading depression activates and upregulates MMP-9Journal of Clinical Investigation, Vol. 113, No. 10Understanding the Patient With Migraine: The Evolution From Episodic Headache to Chronic Neurologic Disease. A Proposed Classification of Patients With HeadacheHeadache: The Journal of Head and Face Pain, Vol. 44, No. 5Functional neuroimaging of primary headache disordersCurrent Neurology and Neuroscience Reports, Vol. 4, No. 2Multiwavelength Optical Intrinsic Signal Imaging of Cortical Spreading DepressionAlyssa M. Ba, Michael Guiou, Nader Pouratian, Arpitha Muthialu, David E. Rex, Andrew F. Cannestra, James W. Y. Chen, and Arthur W. Toga1 November 2002 | Journal of Neurophysiology, Vol. 88, No. 5Modeling the Spreading Cortical Depression WavefrontAnnals of the New York Academy of Sciences, Vol. 972, No. 1New directions in migraine researchJournal of Clinical Neuroscience, Vol. 9, No. 4Magnetoencephalographic fields from patients with spontaneous and induced migraine aura1 January 2001 | Annals of Neurology, Vol. 50, No. 5Neuroimaging in headache1 January 2001 | Microscopy Research and Technique, Vol. 53, No. 3Cortical spreading depression and migraine: new insights from imaging?Trends in Neurosciences, Vol. 24, No. 5Responses to Cortical Spreading Depression During Normoxia and Ischemia: Multiparametric Monitoring Study in Animals and the Human BrainNew multiparametric monitoring approach for real-time evaluation of drug tissue interaction in vivo1 January 2000 | Drug Development Research, Vol. 50, No. 3-4Repetitive Cortical Spreading Depression in a Gyrencephalic Feline Brain: Inhibition by the Novel Benzoylamino-Benzopyran SB-22045317 November 2016 | Cephalalgia, Vol. 20, No. 6Perspectives on spreading depressionBrain Research Reviews, Vol. 32, No. 1Vasodilator Agents and Supracollicular Transection Fail To Inhibit Cortical Spreading Depression in the Cat25 November 2016 | Cephalalgia, Vol. 19, No. 6The Trigeminovascular System in Humans: Pathophysiologic Implications for Primary Headache Syndromes of the Neural Influences on the Cerebral Circulation31 August 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 19, No. 2Functional imaging of the brain by infrared radiation (thermoencephaloscopy)Progress in Neurobiology, Vol. 56, No. 3Magnetic Resonance Imaging Assessment of Cerebral Hemodynamics during Spreading Depression in Rats31 August 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 18, No. 9Perivascular nerves contribute to cortical spreading depression-associated hyperemia in ratsUwe Reuter, Joerg R. Weber, Lorenz Gold, Guy Arnold, Tilo Wolf, Jens Dreier, Ute Lindauer, and Ulrich Dirnagl1 June 1998 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 274, No. 6Recent advances in mechanisms of spreading depressionCurrent Opinion in Neurology, Vol. 11, No. 3Cortical spreading depression-associated hyperemia in rats: involvement of serotoninBrain Research, Vol. 783, No. 2Dietary Antioxidant Deficiency Facilitates Cortical Spreading Depression Induced by Photoactivated Riboflavin13 July 2016 | Nutritional Neuroscience, Vol. 1, No. 3Excitation waves in central grey matter: the retinal spreading depressionProgress in Retinal and Eye Research, Vol. 16, No. 4Blockade of spreading depression in chronic epileptic rats: reversion by diazepamEpilepsy Research, Vol. 27, No. 1How do the Currently Used Prophylactic Agents Work in Migraine?7 November 2016 | Cephalalgia, Vol. 17, No. 2Lamotrigine versus Placebo in the Prophylaxis of Migraine with and Without aura7 November 2016 | Cephalalgia, Vol. 17, No. 2A family with hemiplegic migraine and focal seizuresEuropean Journal of Paediatric Neurology, Vol. 1, No. 1Diffusion-Weighted Magnetic Resonance ImagingCortical spreading depression recorded from the human brain using a multiparametric monitoring systemBrain Research, Vol. 740, No. 1-2Characterization of Endothelin Receptors in the Cerebral Vasculature and Their Lack of Effect on Spreading Depression31 August 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 16, No. 4PET und Dopplersonographie bei Kopfschmerzen1 May 1996 | Der Schmerz, Vol. 10, No. 3Inhalational Anesthetics Inhibit Spreading Depression: Relevance to Migraine7 November 2016 | Cephalalgia, Vol. 16, No. 2Ischemia and lesion induced imbalances in cortical functionProgress in Neurobiology, Vol. 48, No. 2Migraine phosphenes and the retino-cortical magnification factorVision Research, Vol. 35, No. 8The Innervation of Pial Blood Vessels and their Role in Cerebrovascular RegulationMultiparametric Responses to Cortical Spreading Depression Under Nitric Oxide Synthesis InhibitionMigraine and EpilepsyNeurologic Clinics, Vol. 12, No. 1Magnetic Resonance Imaging of Propagating Waves of Spreading Depression in the Anaesthetised Rat29 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 14, No. 1Retention of cerebrovascular dilation after cortical spreading depression in anesthetized rabbits.Stroke, Vol. 24, No. 11Spreading depression induces prolonged reduction of cortical blood flow reactivity in the ratExperimental Neurology, Vol. 117, No. 3The oligemic phase of cortical spreading depression is not blocked by tirilazad mesylate (U-74006F)Brain Research, Vol. 588, No. 1Subcortical Cerebral Blood Flow and Metabolic Changes Elicited by Cortical Spreading Depression in Rat7 November 2016 | Cephalalgia, Vol. 12, No. 3Migraine visual aurasGeneral Hospital Psychiatry, Vol. 14, No. 3Pial arteriolar constriction following cortical spreading depression is mediated by prostanoidsBrain Research, Vol. 572, No. 1-2Cerebral Blood Flow and Brain Mitochondrial Redox State Responses to Various Perturbations in GerbilsCerebral Blood Flow and Oxygen Consumption in Cortical Spreading Depression29 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 11, No. 5Cortical Spreading Depression is not Seen Intra-Operatively During Temporal Lobectomy in Humans.26 September 2016 | Cephalalgia, Vol. 11, No. 11_supplEvidence against parenchymal metabolites directly promoting pial arteriolar dilation during cortical spreading depression in rabbitsBrain Research Bulletin, Vol. 26, No. 5Cerebral hemodynamics during cortical spreading depression in rabbitsBrain Research, Vol. 530, No. 2ELECTROCLINICAL STUDY OF VIDEO-GAME EPILEPSY24 August 2010 | Developmental Medicine & Child Neurology, Vol. 32, No. 6Oxygen Supply and Brain Function in Vivo: A Multiparametric Monitoring Approach in the Mongolian GerbilCortical and subcortical hyperperfusion during migraine and cluster headache measured by Xe CT-CBFNeuroradiology, Vol. 32, No. 1Migraine, Epilepsy, Post-traumatic Syndromes, and Spreading Depression12 November 2008 | Developmental Medicine & Child Neurology, Vol. 31, No. 5Metabolic Disturbances of the Blood-Brain Barrier with Special Emphasis on Glucose and Amino Acid TransportFIFTY YEARS OF MIGRAINE RESEARCH25 March 2008 | Australian and New Zealand Journal of Medicine, Vol. 18, No. 3Blood Flow and Metabolism in Cortical Spreading DepressionFinal commentsActa Neurologica Scandinavica, Vol. 76Post-epileptic headache and migraine.Journal of Neurology, Neurosurgery & Psychiatry, Vol. 50, No. 9Change of cerebrovascular reactivity after cortical spreading depression in cats and ratsBrain Research, Vol. 411, No. 1Regional cerebral blood flow during cortical spreading depression in rat brain: increased reactive hyperperfusion in low-flow statesActa Neurologica Scandinavica, Vol. 75, No. 1The Hyperexcited Brain: Glutamic Acid Release and Failure of InhibitionOn the Possible Relation of Spreading Cortical Depression to Classical Migraine4 November 2016 | Cephalalgia, Vol. 5, No. 2_supplMigraine in ChildrenNeurologic Clinics, Vol. 3, No. 1Cerebral Blood Flow Changes in Migraine: Their Possible Correspondence to the Perfusion Changes of Spreading Cortical DepressionPresumed post-myelography migraine-like phenomena8 July 2009 | Neuro-Ophthalmology, Vol. 5, No. 3Long-Lasting Reduction of Cortical Blood Flow of the Rat Brain after Spreading Depression with Preserved Autoregulation and Impaired CO 2 Response29 June 2016 | Journal of Cerebral Blood Flow & Metabolism, Vol. 4, No. 4The neurobiology of vascular head painAnnals of Neurology, Vol. 16, No. 2Transient neurological symptoms associated with mononuclear pleocytosis of the cerebrospinal fluid29 January 2009 | Acta Neurologica Scandinavica, Vol. 70, No. 2Persistent oligemia of rat cerebral cortex in the wake of spreading depression7 October 2004 | Annals of Neurology, Vol. 12, No. 5Factors affecting the oxygen balance in the awake cerebral cortex exposed to spreading depressionBrain Research, Vol. 236, No. 1Blood-Brain Glucose Transfer in Spreading DepressionJournal of Neurochemistry, Vol. 37, No. 4Spreading depression in elasmobranch cerebellumBrain Research, Vol. 199, No. 1Significance of scintillating scotoma of late onsetSurvey of Ophthalmology, Vol. 25, No. 2Relationship between local changes in cortical blood flow and extracellular K + during spreading depression*Acta Physiologica Scandinavica, Vol. 109, No. 1The interrelation between brain PO2 and NADH oxidation-reduction state in the gerbilJournal of Neuroscience Research, Vol. 5, No. 3Maintained Discharge in the Visual System and its Role for Information ProcessingIn Vivo Intrinsic Optical Signal Imaging of Neocortical EpilepsyMigraine and EpilepsyThe Lancet, Vol. 294, No. 7619Interhemispheric spread of drug-induced electrical cortical activityElectroencephalography and Clinical Neurophysiology, Vol. 26, No. 5A triple representation of the body surface in the sensorimotor cortex of the squirrel monkeyExperimental Neurology, Vol. 20, No. 3The effect of spreading depression on a simple discrimination task4 November 2013 | Psychonomic Science, Vol. 6, No. 7Cerebral Microcirculation: a Review Emphasizing the Interrelationship of Local Blood Flow and Neuronal Function2 July 2016 | Angiology, Vol. 16, No. 8AMINO ACID RELEASE FROM THE CEREBRAL CORTEX DURING SPREADING DEPRESSION AND ASPHYXIATIONJournal of Neurochemistry, Vol. 12, No. 5ReferencesJon Fluxes in the Central Nervous SystemThe Nature of Spreading Depression in Neural NetworksREFERENCESActa Physiologica Scandinavica, Vol. 52Single Unit Activity in the Rabbit Lateral Geniculate Body during Experimental EpilepsyThe Electrographic Activity of the Cooled Human Frontal Lobe and its Response to HypotensionJournal of Neurosurgery, Vol. 17, No. 5Nature of Electrocortical Potentials and Synaptic Organizations in Cerebral and Cerebellar CortexEffect of drugs on pyramidal discharges evoked by cortical stimulationElectroencephalography and Clinical Neurophysiology, Vol. 8, No. 3Some relations between resistivity and electrical activity in the cerebral cortex of the catJournal of Cellular and Comparative Physiology, Vol. 45, No. 3Untersuchungen über die fortschreitende Reduktion („spreading depression“) der corticalen Spontanaktivität1 May 1954 | Deutsche Zeitschrift für Nervenheilkunde, Vol. 171, No. 5Die Tätigkeit des NervensystemsOn the conditions for the recording of Leao's spreading depressionElectroencephalography and Clinical Neurophysiology, Vol. 3, No. 3Cumulative effects of minimal cortical stimulationsElectroencephalography and Clinical Neurophysiology, Vol. 2, No. 1-4The identity of spreading depression and “suppression”Electroencephalography and Clinical Neurophysiology, Vol. 2, No. 1-4The relation of dehydration of the brain to the spreading depression of LeaoElectroencephalography and Clinical Neurophysiology, Vol. 2, No. 1-4 More from this issue > Volume 7Issue 6November 1944Pages 391-396 https://doi.org/10.1152/jn.1944.7.6.391History Published online 1 November 1944 Published in print 1 November 1944 Metrics