Objective: to carry out the comparative assessment of the intensity and duration of the antibacterial effect of monofilament polypropylene and polyfilament threads made of polyglycolic acid modified with antibiotic-containing coating. Material and methods. The antibacterial activity of thread samples containing an antibacterial preparation from the group of fluoroquinolones against E. coli and P. aeruginosa and its dynamics after soaking the threads in isotonic sodium chloride solution for 18 days with a daily change of the solution were studied.The comparative analysis of other antibacterial threads was carried out. Results. The new biologically active surgical suture material based on polypropylene and polyglycolic acid modified with fluoroquinolone-containing coating has a pronounced and prolonged antibacterial activity against E. coli, P. aeruginosa . Conclusion. The new biologically active surgical suture has proved to be more effective than some known antibacterial threads