Abstract
BackgroundTo evaluate the in vitro activities of Ethiopian Thymus schimperi with other three hydro distilled essential oils against Dermatophytes (Tricophyton spp. and Microsporum spp.) and other pathogenic micro organisms.MethodsThe studies were carried out using Agar disk diffusion method for screening the most effective essential oils and Agar dilution to determine Minimum Inhibitory Concentration (MIC) of the essential oils.ResultsEssential oils of T. schimperi and Cinnamomum zeylanicum were highly active against tested organisms. The MIC were in the range of 0.08 μl/ml to 0.31 μl/ml for T. schimperi, 0.31 μl/ml to 0.16 μl/ml for C. zeylanicum, 2.5 μl/ml to1.25 μl/ml for Citrus limon and 5 μl/ml to 2.5 μl/ml for Eucalyptus camaldulensis against Tricophyton spp. and Microsporum spp. T. schimperi and C. zeylanicum oils also showed antimicrobial effect against Candida albicans, Aspegilus niger, Rhodotorula rubra, Escherichia coli, Shigella spp., Bacillus spp. and Streptococci.ConclusionsThe Ethiopian T. schimperi oil had pronounced antifungal and antibacterial activities against all the tested microbes. Therefore, it is required further investigation in order to identify the active compounds and their clinical applications for treatment of tested organisms.
Highlights
To evaluate the in vitro activities of Ethiopian Thymus schimperi with other three hydro distilled essential oils against Dermatophytes (Tricophyton spp. and Microsporum spp.) and other pathogenic micro organisms
Plant material and preparation of essential oils Four various types of herbs and spice plants were collected around Addis Ababa: T. schimperi, C. zeylanicum, C. limon, and E. camaldulensis and identified by the national herbarium of Ethiopia
The maximum antimycotic activity was shown by T. schimperi followed by C. zeylanicum
Summary
To evaluate the in vitro activities of Ethiopian Thymus schimperi with other three hydro distilled essential oils against Dermatophytes (Tricophyton spp. and Microsporum spp.) and other pathogenic micro organisms. Antimicrobial properties have been reported more frequently in a wide range of plant extracts and essential oils and natural products in an attempt to discover new chemical classes of antifungal and antibacterial drugs that could resolve strains expressing resistance to the available antifungal and antibacterial drugs [1, 2]. Natural, complex compounds characterized by a strong odor and are formed by aromatic plants as secondary metabolites. They are usually obtained by steam or hydro-distillation [3, 4]. T. pulegioides essential oil has potential as a topical antifungal agent against Dermatophytes, Aspergilus, and Candida [6]. Other species of the genus Thymus, such as T. zygis and T. vulgaris, with high amounts of phenols, show a broad spectrum of activity against a variety of pathogenic yeasts and filamentous fungi, including fungi with decreased susceptibility to fluconazole [6]
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