The aim is to evaluate the peculiarities of the development of professional burnout (PB) among physicians of therapeutic and surgical specialties, as well as middle medical workers, specialised red zones, as well as its prediction and prevention in this category of workers. Material and methods. The following groups of medical workers were examined: the 1st group consisted of doctors of therapeutic specialities (GPs) working in the red zone (n=111); the 2nd group consisted of doctors of surgical specialities (MDs) working in the ‘red zone’ (n=61); the 3rd group consisted of nurses working in the red zone (n=29); the 4th group – the control group included workers of engineering, technical and economic specialities not related to work in medical organisations (n=190). Professional burnout syndrome was assessed using the Maslach Burnout questionnaire and V.V. Boyko’s technique of diagnosing the level of burnout [4, 5]. The data were processed using Statistica statistical package by StatSoft (USA). Results. It was found that the work of therapeutic and surgical doctors, as well as middle medical workers of specialised red zones, is connected with the exposure of medical workers to a number of specific risk factors related to the provision of medical care to infected patients, as well as with significant changes in the work regarding aspects related to organisation, safety, which contribute to the increase in the level of stress and the increase in the level of SP. Conclusions. The work of physicians of therapeutic and surgical specialities, as well as middle medical workers of specialised red zones, is associated with an increase in the level of professional stress and the level of SP. It is necessary to continue the research of emotional state of medical doctors and average medical workers working in conditions of extreme epidemic situations with the purpose of timely preventive treatment for preservation of health of medical workers.