Technological Process Of Production Research Articles

ОБОСНОВАНИЕ ПРИМЕНЕНИЯ НОВОЙ ТЕХНОЛОГИИ ПРОИЗВОДСТВА ШПИНТОНОВ

This study objective is to analyze the effectiveness of using the technology of tail suspension of cars as a way to increase the reliability and comfort of movement in railway transport. To achieve this goal, the following task was defined: identification and analysis of internal defects that are the causes of product rejection, and the subsequent development of recommendations for their elimination. The main research method is the analysis of current operating procedure of manufacturing parts, the study of materials and methods of their processing used to strengthen tails. The priority is to identify the key factors contributing to increasing the durability of the tail assembly through the use of reinforcing technology. Both theoretical analysis of existing scientific papers on this topic and practical experiments on stress tests are used as research methods. The novelty of the work is in offering a more environmentally friendly product processing technology, as well as confirming the possibility of replacing the tail material with a more cost-effective one. It is worth noting that the issue of ensuring the quality of truck tails of subway cars, the ecological purity of the heat treatment process, and cost reduction is being solved through a new heat treatment technology – quenching with a fast-moving stream of water and replacing 40X alloy steel with 35 carbon steel without reducing operational properties. As a result, the proposed measures contribute to improving the manufacturing quality of tail assemblies and reducing the percentage of their rejection at the production testing stage.

Comparative analysis of the efficiency of catalytic methane pyrolysis technology for hydrogen production based on DEA method

This paper presents a comprehensive analysis of the efficiency of methane pyrolysis technologies and various catalysts using the DEA method. The study is based on an extensive set of experimental data obtained under laboratory conditions. Application of DEA method allowed to identify key factors affecting the pyrolysis process performance, including costs, process parameters and catalyst properties. Particular attention is paid to the role of catalysts in the methane pyrolysis process. Highly efficient catalysts show significant increases in reaction rate and decreases in energy costs. The DEA method allowed the identification of key factors affecting process efficiency, including the choice of catalyst carrier, temperature conditions and composition of active components. The analysis revealed that catalyst stability and its ability to maintain high activity over the reaction time were particularly important for industrial applications. The results of the analysis allowed us to evaluate the relative efficiency of each catalyst and identify the most optimal combinations of reaction conditions. It was found that catalysts with high nickel content (more than 80%) on Al₂O₃ carrier show the highest efficiency at about 750 ℃, achieving high values of methane conversion and hydrogen yield. SiO₂ based catalysts show high initial activity, but tend to deactivate or carbonize with time, which in turn markedly reduces their efficiency in long-term processes. The results highlight the importance of optimal catalyst composition and reaction conditions to improve the efficiency and economic viability of the methane pyrolysis process. The study demonstrates the potential of DEA method as a tool for comprehensive assessment and optimization of technological processes of hydrogen production and emphasizes the prospects for further development and implementation of methane pyrolysis technology in industrial hydrogen production as a component of the transition to low-carbon energy production.

Systematic review on sustainable management of natural resources with smart technologies for food production

Introduction: The environmental problems related to global warming, climate change, and alterations in natural resources deepen the food supply worldwide, so the applicability of cutting-edge digital technology raises viable alternatives for the transformation of the agricultural sector with generative, resilient, sustainable and adaptive practices to meet the challenges of food insecurity and malnutrition. Based on the applicability of intelligent technologies in production processes, processing, conservation, monitoring, simulation, modeling, and management of natural resources to ensure the goal of sustainable development and zero hunger. Therefore, the object of analysis of the bibliometric review on the sustainable management of natural resources with smart technologies for food production was raised, for which the main databases Scopus, IEEE Eplore, MDPI, and Springer were explored, during a period of six years, with the use of the methodology (PRISMA, 2020). To conclude, it is concluded that the incorporation of smart technologies such as industry 4.0, 5.0, IoT, AI, robotics, smart irrigation, satellite imagery, simulation, autonomous learning Big Data, blockchain that allow ensuring healthy, nutritious and sustainable food

Identifying Transformations in Labor and Production Activities of Industrial Park Workers in the Context of the Fourth Industrial Revolution: A Case Study of Dong Nai Industrial Parks

The Fourth Industrial Revolution has been a pivotal force driving transformations in labor and production activities, including innovations in production methods and improvements in working environments. These developments profoundly impact workers across all sectors. In industrial parks, technological advancements significantly influence how workers perform their jobs, necessitating rapid adaptation and continuous skill enhancement in an increasingly professional and competitive working environment. The adoption of technology in production processes enhances efficiency, increases productivity, reduces costs, and improves product quality. However, it also poses challenges such as technological unemployment for workers. Dong Nai, one of the provinces with the largest number of industrial parks in Vietnam, has attracted investors from 43 countries and territories, maintaining its position as an industrial hub in recent years. In Dong Nai’s industrial parks, the intensification of technology transfer and development presents both challenges and opportunities. These dynamics enable workers to enhance their skills, boost competitiveness, and integrate more deeply into global value chains. This paper analyzes key transformations in the labor and production activities of workers in Dong Nai’s industrial parks amidst the context of this new industrial revolution. It also proposes solutions to enhance the capabilities and skills of industrial park workers to meet current demands.

GENERAL PRINCIPLES OF FORMALIZATION OF TECHNOLOGICAL PROCESS CONTROL OF MINING PRODUCTION IN A DYNAMIC DISTRIBUTED SYSTEM

Context. The problem of synthesis, modeling, and analysis of automated control of complex technological processes of mining production as a dynamic structure with distributed parameters. Objective. On the example of the technological line of ore beneficiation, the general principles of formalization of control of mining production processes as a dynamic system with distributed parameters are considered. Method. The modeling of interactions between individual components of the control system is carried out using the methods of coordinated distributed control. In accordance with this approach, the technological line is decomposed into a set of separate subsystems (technological units, enrichment cycles). Under these circumstances, the solution to the global optimization problem is also decomposed into a corresponding set of individual subproblems of optimizing the control of subsystems. To solve the global problem, this formulation uses a two-level structure with coordinating variables that are fed to the input of local control systems for technological units and cycles. At the lower level of control, sets of subtasks have independent solutions, coordinated by the coordinating variables formed at the upper level. Results. The paper proposes a method for forming control of a distributed system of technological units of an ore dressing line based on the decomposition of the dynamics of the distributed system into time and space components. In the spatial domain, the control synthesis problem is solved as a sequence of approximation problems of a set of spatial components of the dynamics of the controlled system. In the time domain, the solution of the control synthesis problem is based on the methods of synthesizing control systems with concentrated parameters. Conclusions. The use of the proposed approach to the formation of technological process management at mining enterprises of the Kryvyi Rih iron ore basin will improve the quality of iron ore concentrate supplied to metallurgical processing, increase the productivity of technological units and reduce energy consumption.

MATHEMATICAL MODEL OF THE MOVEMENT OF TABLE BEET ROOT CROP ALONG THE SPIRALS OF A VIBRATING CLEANER

A pressing issue in the technological process of table beet production is the cleaning of root crops from adhered soil, loose impurities, and plant residues after harvesting. The efficiency of this process significantly determines the quality of the final product, its suitability for long-term storage, and subsequent processing. Modern root crop cleaning technologies widely use mechanical methods, among which vibrational and spiral cleaning systems hold a special place. However, many existing designs have several shortcomings, such as insufficient impurity removal efficiency or an increased risk of root crop damage. This study presents a new design of a vibrational spiral cleaner developed to enhance the efficiency of table beet root cleaning. A mathematical model of the root crop's movement along the working channel of the cleaner was constructed to analyze and optimize the operation of this design. It is during this movement that adhered soil, loose impurities, and plant residues are removed. Based on the developed equivalent scheme, a system of differential equations describing the dynamics of the root crop's movement along the surface of the working channel was formulated. Numerical solutions of this system on a personal computer made it possible to study the influence of structural parameters (spiral geometry, pitch, and material) and kinematic parameters (vibration frequency and amplitude) on the speed of root crop movement and the cleaning quality. The analysis of the obtained results showed that optimizing the cleaner's parameters ensures uniform cleaning, reduces the likelihood of root crop damage, and increases the overall process efficiency. The results of this research have practical significance for the further improvement of cleaner designs and their implementation in industrial technologies. The application of the proposed technical solutions will contribute to improving the cleaning quality of table beet root crops, enhancing production efficiency, and reducing equipment maintenance costs.

Thermal Degradation Study of Hydrogel Nanocomposites Based on Polyacrylamide and Nanosilica Used for Conformance Control and Water Shutoff.

The application of nanocomposites based on polyacrylamide hydrogels as well as silica nanoparticles in various tasks related to the petroleum industry has been rapidly developing in the last 10-15 years. Analysis of the literature has shown that the introduction of nanoparticles into hydrogels significantly increases their structural and mechanical characteristics and improves their thermal stability. Nanocomposites based on hydrogels are used in different technological processes of oil production: for conformance control, water shutoff in production wells, and well killing with loss circulation control. In all these processes, hydrogels crosslinked with different crosslinkers are used, with the addition of different amounts of nanoparticles. The highest nanoparticle content, from 5 to 9 wt%, was observed in hydrogels for well killing. This is explained by the fact that the volumes of injection of block packs are counted only in tens of cubic meters, and for the sake of trouble-free workover, it is very important to preserve the structural and mechanical properties of block packs during the entire repair of the well. For water shutoff, the volumes of nanocomposite injection, depending on the well design, are from 50 to 150 m3. For conformance control, it is required to inject from one to several thousand cubic meters of hydrogel with nanoparticles. Naturally, for such operations, service companies try to select compositions with the minimum required nanoparticle content, which would ensure injection efficiency but at the same time would not lose economic attractiveness. The aim of the present work is to develop formulations of nanocomposites with increased structural and mechanical characteristics based on hydrogels made of partially hydrolyzed polyacrylamide crosslinked with resorcinol and paraform, with the addition of commercially available nanosilica, as well as to study their thermal degradation, which is necessary to predict the lifetime of gel shields in reservoir conditions. Hydrogels with additives of pyrogenic (HCSIL200, HCSIL300, RX380) and hydrated (white carbon black grades: 'BS-50', 'BS-120 NU', 'BS-120 U') nanosilica have been studied. The best samples in terms of their structural and mechanical properties have been established: nanocomposites with HCSIL200, HCSIL300, and BS-120 NU. The addition of hydrophilic nanosilica HCSIL200 in the amount of 0.4 wt% to a hydrogel consisting of partially hydrolyzed polyacrylamide (1%), resorcinol (0.04%), and paraform (0.09%) increased its elastic modulus by almost two times and its USS by almost three times. The thermal degradation of hydrogels was studied at 140 °C, and the experimental time was converted to the exposure time at 80 °C using Van't Hoff's rule. It was found that the nanocomposite with HCSIL200 retains its properties at a satisfactory level for 19 months. Filtration studies on water-saturated fractured reservoir models showed that the residual resistance factor and selectivity of the effect of nanocomposites with HCSIL200 on fractures are very high (226.4 and 91.6 for fracture with an opening of 0.05 cm and 11.0 for porous medium with a permeability of 332.3 mD). The selectivity of the isolating action on fractured intervals of the porous formation was noted.

Exterior and Interior Quality of Peking Duck Eggs Reared by the Monggelemong Duck Farmer Group Dasan Cermen Sandubaya Mataram

One of the factors that influences the quality of duck eggs is the rearing system. This study aimed to determine the exterior and interior quality of Peking duck eggs produced by the Monggelemong Duck Farmer Group, Dasan Cermen Sandubaya, Mataram. The eggs were obtained from members of a group of farmers who are members of the Monggelemong Duck Farmer Group. Egg collection is carried out in turns every day for each member of the farmer group by randomly taking 10% of the total egg production so that 170 eggs are collected. The quality of the eggs was then measured at the Laboratory of Animal Products Processing Technology, Faculty of Animal Science, University of Mataram. The research results concluded that the internal quality of Peking duck eggs produced by the Monggelemong Duck Farming Group was categorized as excellent grade (AA grade), but with low external quality.

New Solutions in Pipe Billet Production

This paper proposes a method for determining the speed of hollow steel billet casting to produce seamless oil and gas pipes. At the same time, the use of hollow billet excludes, in the technological process of pipe production, the piercing of the billet. The results of industrial production modeling were recalculated into natural quantities according to the Fourier number similarity criterion. The calculations determined that the optimal drawing speed and casting speed of a billet with a diameter of 210 mm are 2.01 m/min and 0.273 t/min, respectively. At the same time, productivity increased by 16%, compared to the one when casting a solid billet. To ensure the homogeneity of structure and mechanical properties over the entire cross-section of the hollow billet, the optimum ratio of coolant flow rates into the inner cavity and outside the billet in the secondary cooling zone was determined, considering the area of the cooled surface, which is equal to 1.46.

Exploring the Training of Film and Video Talents in Higher Vocational Colleges under the Background of AIGC

With the rapid development of Artificial Intelligence Generated Content (AIGC) technology, the film and video industry's production process and creation mode are profoundly transforming. This technological advancement has put forward new requirements for film and video talent cultivation in higher vocational colleges, prompting the education system to make targeted optimisation in key areas such as curriculum, practical teaching, teacher construction and school-enterprise cooperation. Based on the talent demand of the film and video industry in the context of AIGC, this study analyses the main challenges facing film and Video education in higher vocational colleges, including the disconnection between the curriculum content and the development of the industry, the insufficiency of practical teaching resources, and the weakness of the faculty. Because of these problems, the study proposes the strategies of building an interdisciplinary curriculum system, strengthening practical teaching, deepening university-enterprise cooperation and improving the ‘dual-teacher’ teaching team to provide effective references for the cultivation of high-quality film and video talents with innovative ability and practical skills in higher vocational colleges.

Intelligent control system for technological complexes of aluminum industry enterprises

Relevance. Aluminum production is one of the most important industries all over the world. It has a high environmental load, resource and energy intensity. To reduce the negative impact of aluminum production, efforts are underway to improve its technological processes, aimed at increasing aluminum recovery rates, reducing waste volumes, and lowering energy consumption. The reduction of energy consumption can be achieved, among others, through implementing control systems that provide energy management. Due to the complexity and multiplicity of technological processes in aluminum production, the use of traditional linear approaches for such control systems is ineffective, and adequate mathematical models are required. At the same time, for the production level, the use of mathematical models based on a phenomenological description of the ongoing physical processes overly complicates the control task. As a result, the use of intelligent and adaptive approaches to both the mathematical description of technological processes and the optimal energy consumption management is relevant. Objects. Technological complexes of aluminum production, which have the properties of inertia, nonlinearity, and closedness; and the control system based on artificial intelligence methods. Alumina production is chosen as an illustration. Aim. To develop mathematical models capable of adequately describing the interrelated processes in the technological complexes under consideration, as well as the control system that allows optimal energy consumption management. Methods. For the mathematical model based on balance equations under uncertainty, the fuzzy-set theory was used along with the gradient descent method to identify the model parameters; for the optimization task, the genetic algorithm method was used. Results. The mass balance model and the process conditions changing model have been developed to determine the energy consumption for the technological complexes of aluminum production with continuous inertial nonlinear closed production. Based on these models, the dynamic characteristics of energy consumption and the parameters of technological processes were determined depending on the main controlled parameters, allowing us to predict emergencies. Considering technological parameters and cost factors, the optimization task for energy consumption management was solved.

Barriers in Proliferating Digital Technologies at Russian Companies: Causes and Effects

The article analyzes work of enterprises dealing with digital technology introduction and use of such technologies in production and managerial processes, at the same time it studies reasons for this technology rejection. Topicality of the research is envisaged by high interest of Russian companies in using digital technologies in management and production processes. The rising popularity of digital technologies, in particular AI is based on searching for alternative methods of business-process optimization, raising efficiency and competitiveness of enterprises. It should be pointed out that in creation and introduction of digital technologies enterprises face various difficulties, including fragmentation and non-coordination of ideas about the essence of these technologies, opportunities of their application and control. The authors provide recommendations for enterprises on overcoming barriers in introduction of digital technologies, available at the time of the research, based on comprehensive analysis of strategies of their use with regard to concrete needs and characteristics of the organization. Theoretical and methodological foundation of the research was formed by achievements of the managerial approach to innovation introduction. Methods of expert and comparative analysis were used in the research. The information base of the project was built by works dealing with current trends and practices of management in view of digital transformation. As a result a systematized picture of enterprise functioning was developed in the context of overcoming barriers in introducing digital technologies and identification of situational and contextual variables influencing the effect of their introduction. These results can be used for further investigation of different aspects of enterprises’ work and management in conditions of digital economy.

Methodological Approach to an Integrated Assessment of Systems for Remote Renewable Energy Supply

The use of renewable energy sources to reduce greenhouse gas emissions has become a global trend. According to forecasts of various international energy research organizations, this trend will persist in the future. As resources located near consumption centers are developed, the long-distance renewable energy transportation from areas where renewable sources operate with greater efficiency becomes a more pressing issue. Thus, the objective to establish an energy system using remote renewable sources arises. The study aims to elaborate a methodological approach for an integrated assessment of systems for energy supply from remote renewable energy sources. A distinctive feature of the proposed approach is a separate analysis of the main technological processes of production, conversion, storage, and use of energy carriers, with specific attention given to the generation of electricity from renewable energy sources. The Technique for order of preference by similarity to ideal solution (TOPSIS) is used for multi-criteria analysis of various solutions. This study aims to compare different energy systems for a project designed to export renewable energy from Russia (Sakhalin Island) to Japan (Yamagata Prefecture).

Commercialization of Posco Lithium Prodcution Technology

The increasing demands for lithium, a vital component in secondary batteries, driven by the rapid growth of the IT and electric vehicle markets, have necessitated innovative approaches to lithium production. Over the past 13 years, Posco has been developing advanced lithium production technology from both ore and brine sources. Recent advancements include the operation of a successful Demo Plant for lithium hydroxide monohydrate (LHM) production for three years, with commercial production plants now operational. This presentation explains the application of Bipolar-electrodialysis (BPED) technology in commercial lithium production processes in South Korea and in Argentina, extracting lithium sulfate solution from ore and brine sources, respectively. Through the BPED process, lithium sulfate solution is converted into lithium hydroxide solution and sulfuric acid. The resulting Lithium Hydroxide monohydrate, the final product, is obtained through the crystallizer, while the sulfuric acid is recycled within the production process. The utilization of BPED technology has significantly reduced chemical usage and waste generation, promoting environmental sustainability and efficiency in lithium production. Posco's dedication to enhancing the economic efficiency of BPED technology has led to the establishment of a robust supply chain for high-performance and cost-effective BPED membranes. These domestically developed membranes, a result of collaborative research efforts, play a crucial role in achieving sustainable and efficient lithium production processes for the evolving energy storage industry.

RESEARCH OF THE RELIABILITY OF THE GEODETIC NETWORK IN PROVIDING GEODETIC SUPPORT OF CONSTRUCTION

The safety and reliability of buildings and structures as a complex technical system depends not only on the correct consideration of data on the structural features of the building, but also on the behavior of the soil base and on the geodetic support of the construction. Geodetic works are an integral part of the technological process of construction production and belong to the main types of work. Ensuring reliable and safe, long-term operation of buildings and structures of residential, civil, industrial and agricultural purpose, located both in ordinary and in difficult engineering-geological, earthquake-hazardous, mining-geological conditions is an urgent scientific task in our time. Buildings located on artificial territories, on subsiding soils, landslide-prone slopes or in conditions of dense urban development need to determine the development of deformation processes based on the results of periodic geomonitoring at the stage of their operation. The purpose of the work is to create a Markov discrete-continuous stochastic model of the operation of the local geodetic network (GN) to provide geodetic support for construction and perform numerical calculations of the reliability and safety of the GN depending on the features of its restoration. Analyze regulatory and legal documents on the reliability and safety of construction objects. Perform an analysis of methods for assessing the reliability and safety of technical systems. Perform a numerical calculation of reliability, safety and efficiency indicators: availability ratio, limit probability states, mean time between failures, average duration of fault-free operation of the geodetic network (GN). Methodology. Analysis of regulatory documents on the reliability and safety of construction objects. Review of methods for assessing the reliability and safety of technical systems. Application of the state space method, construction of graphs of states and transitions of a renewable geodesic network. Construction of graphs of the readiness function, the probability of operation before the first failure and the frequency of getting into an emergency situation in the Mathcad software tool. Scientific novelty. The state space method allows simulating the behavior of the designed GN in order to identify the time spent in various states of the technical system depending on the intensity of failures of geodetic points and the intensity of their recovery. On the graph of states and transitions, in contrast to the “fault tree” method, it is possible to simultaneously see all possible situations separated by masks of emergency situations. Practical value. Due to the use of stable geodetic points selected based on the results of the performed reliability assessment, there is an opportunity to improve the quality of geodetic construction support. The most expedient scheme of GN restoration has been substantiated. The results of the analysis of the functioning models of the designed GN were used and the calculated values of: availability coefficient, frequency of GN failures and the probability of operation before the first failure. Results. A graphic model of the reliability behavior of GM in the form of a graph of states and transitions has been built. Geodetic network includes 8 points. A system of Kolmogorov-Chapman linear differential equations was compiled and solved. The distribution of probabilities of being in each state of GN has been obtained. The reasonable periodicity of GN restoration depending on the intensity of failures has been substantiated. It has been proven that periodic restoration of geodetic points allows maintaining a given level of GM reliability. This increases the accuracy of geodetic monitoring of construction and ensures functional safety.

Access to finance: The role of production level technology

The integration of robots and advanced technology in firm-level production processes represents a transformative shift in modern industrial practices. However, there is a lack of cumulative knowledge about the advancement of technology in the production processes affects mitigating the gender gap. Through the lens of financial accessibility, the study investigates how technological advancements influence firms' capacity to secure external financing and get large loans. Using the 2020 WorldBank Enterprises Survey data and a probit model for the analysis, our results suggest that industry robots and a high level of technology in production have the potential to reduce the gender gap in loan approvals. The findings of this have implications for decision-makers and policymakers, seeking to navigate the evolving landscape of technology-driven production and finance to enhance productivity and inclusivity.

Si Characterization on Thinning and Singulation Processes for 2.5/3D HBM Package Integration.

As stacking technologies, such as 2.5D and 3D packages, continue to accelerate in advanced semiconductor components, the singulation and thinning of Si wafers are becoming increasingly critical. Despite their importance in producing thinner and more reliable Si chips, achieving high reliability remains a challenge, and comprehensive research on the effects of these processing techniques on Si chip integrity is lacking. In this study, the impacts of wafer thinning and singulation on the fracture strength of Si wafers were systematically compared. Three different grinding processes, namely fine grinding, poly-grinding, and polishing, were used for thinning, and the resulting surface morphology and roughness were analyzed using scanning electron microscopy and an interferometer. In addition, the residual mechanical stress on the wafer surface was measured using Raman spectroscopy. The fracture strength of Si wafers and chips was assessed through three-point bending tests. Singulation, including blade dicing, laser dicing, and stealth dicing, was evaluated for its impact on fracture strength. Among these processes, polishing for wafer thinning exhibited the lowest full-width half maximum and intensity ratio of Raman shifts (I480/I520), indicating minimal residual stress and surface defects. Consequently, Si wafers and chips processed through polishing demonstrated the highest fracture strength. Moreover, the 60 µm thick Si wafers and chips showed the highest fracture strength compared with those with thicknesses of 90 and 120 µm, possibly because of the increased flexibility, which mitigates stress. Among the singulation methods, stealth dicing yielded the highest fracture strength, outperforming blade and laser dicing. The combination of wafer thinning via polishing and singulation via stealth dicing presents an optimal solution for producing highly reliable Si chips for 2.5D and 3D packaging. These findings may be valuable in selecting optimal processing technologies for high-reliability Si chip production in industrial settings.

CONTRIBUTION TO IMPROVING OF MACHINE PARTS MECHANICAL PROPERTIES BY THERMOMECHANICAL HARDENING

Current industrial production is characterized by requirements for improving the physical and mechanical properties of the used material. This causes a workload creating a rather complex load on all types of machines and mechanisms during operation. The design of such objects is currently based on a wide range of computational and experimental methods that allow modelling their state and behaviour even in the case of complicated non-stationary loading conditions. In this paper, the authors focus on the statistical evaluation of selected manufacturing operations related to mechanical and thermomechanical processing of products [Kuric 2011]. For example, in the case of long pipe billets with a thickness coefficient of 2-4, practically the only way of their production in the metallurgical cycle is cross-roll piercing followed by reduction. This process has high productivity but at the same time certain disadvantages. These disadvantages limit the efficiency and the range of use of the pipe blanks obtained by piercing, which leads to a consequent shortening of the machine production cycle. The presented approaches allow changing the structure of technological processes of production of axisymmetric metal products, by modifying the thermomechanical processing at the beginning of the production cycle.

Validation of the technological process for the production of riamilovir-based solution for aerodispersible administration

BACKGROUND: An important step in the production of riamilovir-based solution for inhalation administration is the validation of critical stages of the technological process. First, a detailed study of all production steps, from the preparation of the initial ingredients to the final packaging, is carried out. Control tests are then conducted, including measuring key process parameters and analyzing the physical and chemical properties of the solution. One of the important aspects of process validation is also the training of production personnel. Proper understanding and adherence to all process instructions and requirements ensures that the process is followed correctly. AIM: Carry out validation activities throughout the stages of the technological process for the production of a solution for inhalation administration based on the active substance “riamilovir”. MATERIALS AND METHODS: The study was carried out using the developed Pilot Industrial Regulations for the production of the medicina. The quality assessment of pharmaceutical substances, excipients and pilot samples was carried out in accordance with the requirements of the State Pharmacopoeia of the Russian Federation and GMP rules. RESULTS: It has been established that the technological scheme for the production of a solution based on the active substance “riamilovir” contains 6 main stages. The greatest risk is observed at the following stages: Auxiliary work 3. Obtaining water — risk of bacterial contamination. Тechnological process 4. Preparation and sterilizing filtration of the solution — risks of insufficient concentration and unsterility of the solution. Тechnological process 5. Dosing the solution into vials is a risk due to underfilling, as well as violation of sterility. CONCLUSION: Validation of the technological process of production of solution for inhalation administration based on the active substance “riamilovir” has been carried out. Critical stages in the technological production process have been identified. The optimal parameters of the technological process have been determined and documented, leading to a predictable result — the release of a high-quality and safe drug.

РОЛЬ МИТНИХ ОРГАНІВ І ПРОЦЕДУР МИТНОГО ОФОРМЛЕННЯ У ФОРМУВАННІ БЕЗПЕКИ НА РИНКУ ПАРФУМЕРНО-КОСМЕТИЧНОЇ ПРОДУКЦІЇ

One of the main tasks facing the customs authorities in ensuring the economic security of the State is: replenishment of the State budget revenues in full in accordance with the State Customs Service's planned task, which is the fiscal function of the customs authorities; protection of the national producer and the domestic market from unfair foreign competition; customs control, especially in terms of movement of goods, with a view to detecting the facts of illegal import/export and smuggling. The article presents the results of the study of the role of customs authorities and the customs clearance procedures carried out by them in the course of their professional activities in the formation of security in the market of perfumery and cosmetic products. It is shown that despite the changing geopolitical, economic and trade situation on the world stage, customs and law enforcement authorities should constantly carry out effective work to detect and suppress crimes that may harm the economic security of Ukraine. The issue of safety of perfume and cosmetic products is also relevant in terms of harm to consumer health, as the safety of these products depends on the composition, quality of the initial components, technological process of production, storage and sale conditions, and consumption conditions. At each stage of the life cycle, physical and chemical processes may occur in the FCP that cause changes that are hazardous to human health. Therefore, to verify the safety of products (in particular, cosmetics), a set of various tests is carried out. Accordingly, the issue of the role and functions of customs authorities in ensuring the safety of perfumes and cosmetics is becoming more relevant in order to increase the efficiency of control over the customs value of certain goods imported into the customs territory of Ukraine and to ensure a uniform approach when deciding on their customs value. It is concluded that customs authorities are state institutions with a high potential for developing equipment in ensuring the economic security of the country, striving for constant mutual exchange of experience and for improving professional qualifications