The One Health (OH) approach is collaborative, multisectoral, and transdisciplinary, acknowledging the interdependence among animal, human and environmental health. It has garnered attention within the scientific community, particularly in response to the rising prevalence and global spread of emerging and re-emerging infectious diseases. Common OH issues include zoonotic diseases, antimicrobial resistance (AMR), food and water safety, and the human-animal bond. Among various OH topics, AMR represents a well-described, long-term, complex issue, with a substantial global death toll and large economic costs. Whereas interdisciplinary and transdisciplinary teamwork seems appropriate to address such complex challenges, effects on knowledge production are poorly known. In this study, we investigate how the scientific community mobilizes “One Health.” A comparative bibliometric analysis of OH and AMR research enabled us to assess the level of transdisciplinary research, identify emerging themes, through a co-occurrence network analysis of keywords, and disciplines mobilized, through a co-citation network analysis of scientific journals, in research, as well as level of international collaboration through analysis of co-authorship among countries. We detected a lack of consideration for non-communicable diseases (e.g., obesity, diabetes, cardiovascular diseases) and the well-being of human and animal populations in analysis of themes. Furthermore, although many disciplines are involved in OH and AMR research, little attention was given to social sciences, environmental health, economics, and politics. There was a strong influence of major global economic powers, including the United States and China, in scientific research on OH and AMR, as well as substantial collaboration among European countries. The present results indicated that guidelines are needed to address the mentioned concerns, and specific funds are required for underrepresented countries.
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