Objective To explore the effective way of whole course nursing for patients with cervical cancer treated by radiotherapy, and to observe the influence of whole course nursing on psychological state and treatment effect. Methods The whole course nursing for cervical cancer patients treated with radiotherapy was introduced in our hospital after January 2014.100 cases of patients with cervical cancer treated in our hospital from January 2014 to December 2014 were divided into experimental group and control group according to the principle of complete randomization.The patients of the two groups received the same radiotherapy, the patients of the experimental group received the whole course nursing intervention, while the control group received routine nursing.The treatment efficiency of the two groups was recorded, and the incidence of complications of the two groups was analyzed.The emotional state of patients was evaluated by Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS). Results The effective rate of the treatment group was significantly higher than that of the control group (P<0.05). There was significant difference in terms of the incidence of radiation proctitis and cystitis between two groups (P<0.05). After treatment, the SAS and SDS scores of the experimental group were significantly lower than that of the control group (P<0.05). Conclusion The whole course nursing intervention for patients with cervical cancer treated with radiotherapy can effectively relieve patients with adverse emotions, increase the confidence of patients, improve the treatment rate and reduce the incidence of complications, it is worthy of clinical promotion. Key words: Nursing intervention; Cervical cancer; Radiation therapy; Psychological state