Statistical Data Processing Research Articles

STUDY OF THE EFFECT OF THE SCUTELLARIA BAICALENSIS GEORGI EXTRACT ON THE CONTENT OF MINERALS IN THE BLOOD SERUM OF RATS UNDER "SOCIAL" STRESS

Background. The study of the influence of "social" stress on biogenic elements involved in mineral metabolism and playing an important role in the life of the human body, the search for agents that have a leveling effect on their content, is an urgent problem of modern pharmacological science. Purpose. To study changes in the content of biogenic elements in the course of mineral metabolism in the blood serum of rats under conditions of "social" stress and under the influence of Scutellaria baicalensis Georgi extract. Materials and methods. Experimental studies were carried out on 96 mature male non-linear rats weighing 295±12.17 g at the age of 7-9 months. The first stage of the experiment involved the study of mineral metabolism in the norm. Individuals of the first group of animals were injected with water; the second was an extract of Scutellaria baicalensis Georgi (100 mg/kg/day); the third – medicinal product (MP) "Mebicar®" (25 mg/kg/day) and the fourth - MP "Phezam®" (45 mg/kg/day). At the second stage of the experiment, “social” stress was reproduced on animals, in groups of which aggressors and victims were identified after the formation of inter-male confrontations for 21 days. These individuals received the solutions used earlier (stage I) for two weeks. The content of sodium and potassium ions in plasma was determined by flame photometry; the level of total calcium - by the photometric method; the concentration of phosphorus and magnesium - by biochemical analysis; the amount of chloride ions - by mercurimetric titration. Statistical data processing was performed using the Statistica 10 package. Results. It was found that the introduction of the extract of Scutellaria baicalensis Georgi, MP "Mebikar®" and "Phezam®" normally does not affect the content of minerals in plasma. It has been shown that modeling of "social" stress in control animals with both dominant and submissive types of character contributes to a significant decrease in the concentration of calcium, phosphorus and magnesium ions compared with individuals of the intact group. A statistically significant difference in the content of chloride ions was proved only in the case of a group of victims. Comparable values of mineral metabolism parameters of the group that received the extract under stress conditions were obtained with the first stage of the experiment in the norm of both intact and experimental animals, as a result of which the leveling effect of the extract of Scutellaria baicalensis Georgi was substantiated. Statistically significant differences in the concentration of magnesium ions in the group of victims exposed to "social" stress under the influence of the type of behavior were determined. Conclusion. The analysis of the data obtained forms an idea of the mineral composition of blood plasma in normal conditions and under conditions of "social" stress. The results of the study characterize the extract of Scutellaria baicalensis Georgi as a remedy that has a leveling effect in conditions of anxiety-depressive state caused by inter-male confrontations.

INTEGRATED ANALYSIS OF IMMUNOLOGICAL BLOOD PARAMETERS IN PRESCHOOL CHILDREN WITH RECURRENT RESPIRATORY INFECTIONS

Background. Recurrent respiratory infections are a very pressing problem in everyday pediatric practice. They are most commonly diagnosed in preschool children. According to different researchers, their incidence varies considerably (6-30%). The temporary immaturity of immune system is thought to be one of the causes of frequent episodes of acute respiratory infections (ARI). Aim: To determine the state of interdependence between the particular indicators of complex immunological blood test and the frequency of ARI episodes in preschool children. Materials and methods. A total of 26 children (11 boys and 15 girls) aged 1-4 years, undergoing inpatient treatment on ARI, were involved in the clinical study. The number of ARI episodes during the previous year of their life was taken into account. Additionally, two integral indices of ARI recurrence, specifically the infection index and resistance index, were calculated. The children underwent a clinical blood test. Also, the particular indicators of humoral and cellular immunity, functional activity of immune cells (neutrophil phagocytic activity (PhA), lymphocyte blast transformation reaction), complement system (C3c, C4) and the several classes of circulating immune complexes (CIC) were analyzed. The statistical processing of the digital data was performed using IBM SPSS Statistics 28 licensed software with the calculation of the confidence interval (CI) for the main indicators. Results. The prevalent majority of the examined children (80.8%) had an increased serum CIC(small) level. There was a moderate positive correlation between the resistance index values and the CIC(small) level [ρ = 0.392; p = 0.048; CI: 0.072–0.644]. The tightest interdependence was found in the following pairs of studied indicators: 1) CIC(medium)*CIC(small) [ρ=0.732; p<0.001; CI: 0.471–0.875]; 2) C3c*C4 [ρ=0.658; p<0.001; CI: 0.352–0.837]; 3) CIC(large)*Ig(A+M+G) [ρ=0.643; p<0.001; CI: 0.330–0.829]; 4) PhA(spontaneous)*PhA(induced) [ρ=0.601; p=0.001; CI: 0.267–0.806]. A linear regression analysis showed that the predicted resistance index was dependent on only one of the immunological blood parameters considered, specifically total leukocyte antigen. Among other possible predictors, the impact of this antigen on the dependent variable was 18.4%. Conclusions. The particular indicators of a complex immunological blood test are highly interrelated. The results obtained should be taken into account when developing an integrated model for predicting the likelihood of recurrent ARI episodes in preschool children.

DETERMINING THE DENSITY AND MOLAR MASS OF AIR IN A HOME EXPERIMENT

Formulation of the problem. Experimental research is an integral part of physics education. During distance learning, students can carry out hands-on experiments only at home. Modern smartphones, equipped with various sensors, offer significant capabilities for this purpose. The literature offers quite extensive descriptions of experiments aimed at determining mechanical, acoustic, and optical quantities using smartphones. At the same time, insufficient attention has been paid to determining gas parameters that can be measured using the pressure sensor embedded in smartphones. Therefore, the relevant task is to develop a methodology for experimenting to determine the density of air and its molar mass at home using a pressure sensor. Materials and methods. To achieve the objective of the study, we used the analysis of the curriculum of the course "General Physics for Bachelor of Engineering", a review of the methodological instructions for performing laboratory work in the section "Molecular Physics and Thermodynamics" of the physics course of technical universities, a review of the literature on the topic of the study, and an analysis of the results of student research on the dependence of air pressure on altitude. We also surveyed students about the possibility of conducting the research at home and their interest in conducting other experiments using a smartphone. Results. The methodology for determining the density and molar mass of air was developed based on the results of a study of the pressure-height dependence. It is shown that it is necessary to perform statistical processing of experimental data to estimate the sought quantities. The experimental results allowed us to obtain values of density and molar mass of air that show a good correlation with the tabulated values. Conclusions. Studying the pressure-altitude relationship using a smartphone and the PhyPhox application allows for fairly accurate calculations of air density and molar mass. According to the survey results, students responded positively to conducting home experiments using smartphones.

SOME BIOLOGICAL AND ECOLOGICAL FEATURES OF HYPODERMA LATREILLE, 1818 IN TAVUSH REGION OF ARMENIA

Background. Cattle hypodermosis is a chronic parasitic disease (entomosis) that occurs as a result of parasitizing the larvae of warble flies in the body of animals. Disease is common in more than 55 countries of the world, causing great economic damage. It is considered as a parasitic disease with a certain zoonotic potential. Purpose. To conduct research on biological and ecological features of the warble flies that determines certain epidemiological traits of the caused pathology in Tavush Region of Armenia. Materials and methods. The observations were carried out in Tavush Region, and the experiments were carried out at the Research Center for Veterinary Medicine and Veterinary Sanitary Expertise at the Armenian National Agrarian University. The warble flies marked with stain, were released at a distance of 0.5 to 1.5 km from livestock farms with subsequent search and trapping of insects, located on pastures and on the skin of animals. Generally, 275 warble flies were released. Warble fly activity was evaluated visually counting the comparative number of flying insects at the fixed point per minute at different times of the day, as well as animal anxiety state caused by warble flies was identified. Statistical processing of experimental data was performed by means of “Vassart.net” online calculator. Results. Female warble flies Hypoderma bovis flew up to 12.1 km, while female warble flies H. lineatum did it up to 8.6 km. Females of H. bovis and H. lineatum demonstrated various spatial and circadian flying activity that depends on season, and altitude above the sea level. Spring generation of warble flies is more resistant to low air temperatures compared to the summer generation. Mild and humid summers, as well as an increase in the number of animals, contribute to an increase in the population of warble flies, while high temperature and high soil moisture contribute to the mass death of warble fly pupae developing in the ground. Conclusion. The research data cited in the article, detect the presence of a wide range of biocenotic factors that determine the epidemiology of cattle hypodermosis in the Tavush region of the Republic of Armenia. Cattle hypodermosis control plan was designed based on the results of the research, as well as natural and climatic conditions of Tavush region. Pasture prevention activities and periodic treatment of the cattle with insecticides were emphasized.

Экологический аспект устойчивого развития высокогорных регионов в условиях формирования инновационной экономики

Sustainable development of high-mountain regions is one of the key tasks of the modern world in the context of growing environmental problems and the need to transition to an innovative economy. High-mountain regions, such as the territories of the North Caucasus Federal District (NCFD), are characterized by unique natural conditions, but at the same time they face many environmental challenges associated with active economic activity, climate change and anthropogenic impact. These territories are particularly vulnerable to environmental risks, which requires the development of integrated approaches for their sustainable development. The formation of an innovative economy provides new opportunities for achieving environmental sustainability in high-mountain regions. Innovative technologies and environmentally friendly approaches to production can help reduce the negative impact on the environment, improve the quality of life of the local population and increase the competitiveness of the region. However, the transition to such a development model requires a comprehensive assessment of environmental aspects, which will take into account the specifics of natural conditions, socio-economic factors and the characteristics of the economic activity of these territories. The objective of the study is to analyze current environmental problems of mountainous territories and improve initiatives taken to ensure environmental safety in the context of transition to an economy of advanced scientific and technological development. Research methods. The study was conducted on the basis of dialectical cognition, system and comparative approaches, forecasting, classification, induction and deduction, the method of processing statistical and empirical data. Research results: 1) the state of the territories of the North Caucasus Federal District was analyzed from the point of view of environmental safety; 2) world experience was studied using the example of innovation-oriented countries regarding issues of environmental conservation in the process of increasing production capacities; 3) an analysis of the tools used by government bodies was carried out in order to maintain consensus between the ongoing environmental and innovation policies; 4) innovative ways to solve the problem of ensuring environmental safety in the studied mountainous regions of the country are presented. Conclusion. The study provided a comprehensive analysis of the environmental aspects of sustainable development of the highland regions of the North Caucasus Federal District (NCFD) in the context of the formation of an innovative economy. It was revealed that the environmental situation in most regions of the North Caucasus Federal District remains unfavorable, despite significant investments in improving infrastructure and modernizing production. The main problems are air and water pollution, degradation of agricultural land, accumulation of waste and deterioration of forests. High emissions of pollutants from mobile and stationary sources, discharge of contaminated wastewater and growth in the volume of municipal solid waste have a negative impact on the environmental situation. As a result, the quality of life of the population deteriorates, health risks increase, and the productivity of agricultural land decreases, which has a negative impact on the economy of the region. To solve these problems, it is necessary to implement a comprehensive approach, including the introduction of innovative technologies in industry and agriculture, improving the waste management system, developing environmental monitoring and modernizing production. An important role should be played by government support measures aimed at stimulating environmentally oriented investments and reducing the man-made burden on the environment. China, which is actively developing “green” investments and reducing the negative impact of industrial enterprises, can serve as an example of a successful environmental policy. China’s experience can be useful for Russia in developing long-term environmental safety strategies. Thus, to ensure sustainable development of high-mountain regions in the context of an innovative economy, it is necessary to form a comprehensive system of measures aimed at protecting the environment, improving public health and increasing the competitiveness of the region.

STUDY OF THE VALUE SPHERE OF OVERWEIGHT WOMEN

Background. According to statistics, the number of obese people is growing rapidly. Attitude to one's own weight, as well as a negative assessment of appearance by others, can negatively affect self-esteem, lead to psychological and emotional problems. Values are a fundamental component of personality. They will include concepts and beliefs that transcend specific situations and guide the choice or assessment of behavior or events (Schwartz S. H.). Taboos and stigma associated with excess weight can greatly affect the quality of life of women, limiting their social contacts, career opportunities and individual self-expression (Zenkov A. S.; Polskaya N.A., Yakubovskaya D.K.; Sayamov Yu.N.; Brewis A.; Dressler W. W.). The analysis of the value sphere will help to identify social, cultural beliefs and attitudes related to overweight in women. The purpose of our study was to determine the characteristics of the value sphere of overweight women. The sample consisted of two groups of 15 people. The first group included overweight women who turned to a psychologist or nutritionist with this problem. The second group includes women with a standard weight. Three diagnostic methods were used to study the features of the value sphere «The level of value and accessibility in various spheres of life» (E. B. Fantalova); «Portrait value questionnaire» (Sh. Schwartz); «Morphological test of life values» (V.F. Sopov L.V. Karpushina. The results of the study (without taking into account statistical processing data) showed that the value sphere of overweight women is characterized by a lower value-accessibility discrepancy index; higher values of stimulation, interpersonal conformity and universalism (in relation to other people and the environment); the importance of the value of spiritual satisfaction and the life sphere of hobbies is more developed.

Application of remote sensing methods to assess the environmental situation in the upper Lena River basin

This article addresses the problem of pollution in the Lena River caused by gold mining enterprises operating in its upper regions. It highlights the ongoing industrial exploitation of ore and placer gold deposits in five regions within the Siberian and Far Eastern federal districts. The most large-scale development is carried out in the Irkutsk region, Buryatia, and Yakutia. Further intensification of gold mining activities will result in significant negative impacts on the ecosystems of the upper reaches of the Lena River basin. In this context, the potential applications of Sentinel-2 satellite data for assessing the ecological conditions of river systems in Yakutia are being explored. The most common water indices, NDTI, AMWI, and Harma, were used in this study. The indices were applied to analyze the area of the Vitim River mouth, which contains the highest concentration of active gold mining license areas in the basin. Test sites were allocated on the Vitim and Lena rivers, as well as on Lake Okhninskoye for control purposes. Water indices were analyzed using the ArcGIS software package, and statistical data processing was conducted in the MS Excel program. It is revealed that the best results for estimating surface water turbidity in the area of the Vitim River mouth are obtained using the AMWI index. Spatial regularities are demonstrated, and the seasonal dynamics of turbidity in the studied water bodies are analyzed. The proposed methodology using the AMWI index can be applied for operational assessment of the state of water bodies in Yakutia under conditions of active anthropogenic pollution. This can facilitate timely implementation of preventive environmental protection measures.

Search for molecular markers of joint hypermobility

Background: Joint hypermobility (JH) is a condition that can be either benign or accompanied by pain and early development of osteoarthritis. For early verification of the risk of complications, it is necessary to study the molecular pathogenesis of various JH variants. The aim of the study: The aim of this study was to search for candidate genes involved in connective tissue metabolism and causing joint hypermobility in a form isolated or combined with connective tissue dysplasia (CTD). Materials and methods: The study involved young (21,86±0,22 y.o.) people (n=181). A clinical study was conducted for the presence of signs of JH (Beighton scale) and CTD (tables Kadurina T.I.). Further, a molecular genetic study was carried out and the search for associations of polymorphic variants of genes (vitamin D receptor (VDR), lumican (LUM), tenascin (TNXB), growth/differentiation factor 5 (GDF5), magnesium ion channel TRPM6), bone morphogenetic protein type 5 (BMP5)) and JH, CTD in isolated and combined forms. Statistical data processing was carried out by comparing qualitative features using the χ2 test, Fisher's exact test, and the χ2 test with Yates' correction for contingency tables 2x2. The strength of associations was assessed in terms of the odds ratio (Odds Ratio, OR, at p<0.05), the correction for multiple comparisons was carried out using the FDR method (Benjamin- Hochberg). Quantitative data were evaluated in pairs using the Student's t-test, the normality of distribution according to the Kolmogorov-Smirnov test. Results: Associations of the G allele and the GG genotype of the rs3734444 locus of the BMP5 gene with the presence of JH (OR=3.70 and OR=5.10), the A allele of the rs1470527 locus of the BMP5 gene and the presence of JH+CTD- (OR=8.00), the T allele and the TT genotype of the rs11144134 locus of the TRPM6 gene with JH in isolated (OR=3.00 and OR =10.19) and in the forms combined with CTD (OR=3.17 and OR=11.28), the TT genotype was also associated with the isolated form of CTD (OR=3.74). The GT genotype of the rs73611720 locus of the GDF5 gene was associated with isolated CTD (OR=4.15). No statistically significant associations were found for polymorphic variants rs11540149 (VDR), rs2268578 and rs3759222 (LUM), rs3130342 (TNXB). Conclusion: The G allele of locus rs3734444 of the BMP5 gene is a potential risk marker for JH in general, the A allele of locus rs1470527 is an isolated JH, the GT genotype of locus rs73611720 of the GDF5 gene is a marker for isolated CTD, the T allele of locus rs11144134 of the TRPM6 gene is a marker for JH combined with CTD.

Порівняльний аналіз клінічної ефективності і безпечності сучасних методів артифіційного переривання вагітності в ранніх термінах. Результати когортного дослідження

WHO experts have determined that medical abortion and vacuum aspiration are currently safe methods of terminating an unintended pregnancy in the first trimester. Aim - to conduct a comparative analysis of the clinical effectiveness and safety of modern methods of early artificial abortions. Materials and methods. An analysis of early and late complications of early abortion was carried out in 54 women with medical abortion using mifepristone and misoprostol (group I) and 65 respondents after abortion by vacuum aspiration (group II). Statistical data processing was carried out using the SPSS 21 program. Results. The frequency of fetal egg retention, pregnancy progression, abnormal uterine bleeding, and endometrial polyps was significantly higher after medical abortion, and endometritis - after vacuum aspiration. Women who underwent medical abortion compared to termination of pregnancy by vacuum aspiration have a 2.3 and 3.6 times lower risk of placental complications and the threat of termination of future pregnancy (odds ratio (OR): 0.28; 95% confidence interval (95% CI): 0.12-0.64 and OR: 0.24; 95% CI: 0.06-0.88), as well as cesarean delivery (OR: 0.34; 95% CI: 0.14-0.84). Conclusions. The effectiveness of the medical method of early termination of pregnancy was 90.7%, vacuum aspiration - 98.5%, which is a relatively safe alternative to surgical abortion. This study did not involve any experiments on animals or humans. No conflict of interests was declared by the authors.

Біологічна характеристика білого (Hypophthalmichthys molitrix Valenciennes, 1844), строкатого (Hypophthalmichthys nobilis Richardson, 1845) та гібрида товстолобиків (Hypophthalmichthys sp.) як обʼєктів випасної аквакультури в Кременчуцькому водосховищі

Purpose: Determination and analysis of parameters, which characterize the biological and fishery aspects of the formation and exploitation of the commercial stock of silver and bighead carps of the Kremenchuk Reservoir. Methodology. As primary materials, the results of field studies at the Kremenchuk Reservoir carried out in 2019-21 and 2023 have been used. Data collection and processing was carried out in accordance with generally accepted methods. Ichthyological material was collected from catches of commercial fishing nets with mesh sizes a=38-140 mm; in total, during the study period, catches of 2,254 fishing nets were examined, of which 652 individuals of silver and bighead carps as well as their hybrids were analyzed.. Predicted survival rate was assessed based on the annual natural mortality rate, which was determined based on the the Bertalanffy equation parameters. Statistical data processing was carried in MS Excel. Findings. In recent years, the basis of the commercial catches of silver, bighead carps and their hybrids in the Kremenchuk Reservoir was composed of age-7-10 fish, which was due to their predominant catch due to specialized fishing with nets with mesh sizes of a=100-140 mm, which accounted for up to 96.7% of the total catch of these species; the share of native species in the catches of these nets did not exceed 10%. The average annual absolute linear growth of these species in modal age groups was 6.0...9.6 cm, relative - 8.7...14.5%; the weight gains were 1416...3829 g and 28.1...43.5%, respectively, which indicated satisfactory grazing conditions in the Kremenchuk reservoir. The parameters of the Bertalanffy equation, which characterize the growth rate of silver, bighead carps and their hybrids in the Kremenchuk Reservoir, were: K = 1.08 (year-1), L∞ = 115.7 (cm) to = 0.17 (years). Based on the calculated natural mortality rates and 30% removal starting from age-5 fish, the fish return rate from stocking age-1+ fish into the Kremenchuk Reservoir is 10.2%. The peak culmination of ichthyomass of silver, bighead carps and their hybrids falls on age-4-6 fish; the optimal legal length of 55 cm allows ensuring the catch rates of 751 kg per 1,000 stocked age-1+ juveniles. Originality. Original data on the current state of commercial stocks of the main objects of pasture aquaculture in the Kremenchuk Reservoir were obtained from the point of view of the theoretical foundations of the formation and exploitation of their commercial stock. New methodical approaches to the assessment of fish return rate are proposed, as the main criterion for the effectiveness of measures for the artificial reproduction of ichthyofauna. Practical value. It has been established that the conditions for the formation of the commercial stock of the Kremenchuk Reservoir can be considered as satisfactory, i.e. the main limiting factor limiting the growth of their catches is the insufficient stocking volume. The obtained actual coefficients, which characterize the survival of fish seeds, can be used to forecast the volume of stocking and catch of silver, bighead carps and their hybrids. The shortcomings of the organization of modern fishery from the point of view of ensuring the maximum catch per recruitment unit have been established. The advisability of increasing the legal length for silver, bighead carps and their hybrids to 55 cm has been confirmed. Key words: Kremenchuk reservoir, pasture aquaculture, silver carp, bighead carp, organization of fishery.

CHARACTERISTICS OF FOLLICULAR FLUID MORPHOLOGY AND LEVELS OF MATRIX METALLOPROTEINASE-1 AND ITS INHIBITOR-1 IN PATIENTS WITH POLYCYSTIC OVARIES IN ASSISTED REPRODUCTIVE TECHNOLOGY

Assisted reproductive technologies in patients with polycystic ovary syndrome (PCOS) is an effective way to realize reproductive function with a global pregnancy rate of 25–30 %. The purpose of the study is to establish the correlation between the levels of matrix metalloproteinase-1 (MMP-1) and its inhibitor-1 (TIMP-1) with follicular fluid morphology in PCOS patients undergoing assisted reproductive technology. Materials and Methods. The authors examined 26 PCOS patients aged 24–40. All patients were diagnosed with primary and secondary infertility lasting from 1 to 10 years. A comparative analysis of patients was carried out depending on the presence (n=12) or absence (n=14) of concomitant pathology, a history of endometrial hyperplasia. Clinical, anamnestic, instrumental and laboratory methods were used for analysis. Concentrations of MMP-1 and TIMP-1 in follicular fluid was determined by quantitative solid-phase ELISA. Follicular fluid morphology was studied according to wedge-shaped dehydration method. Statistica 10.0 wasnused for statistical data processing. Results. TIMP-1 level in PCOS patients was 2550±57.8 ng/ml, in PCOS patients with endometrial hyperplasia – 2694.4±87.8 ng/ml (p<0.01). At the same time, the average MMP-1 level was low – 1.5±0.1 ng/ml. In PCOS patients, the 3rd (reactive) type of facies and markers indicating impaired blood supply were detected in the follicular fluid. In PCOS patients with endometrial hyperplasia, the 4th (chaotic) type of facies and markers indicating impaired elasticity, vascular sclerosis, and vasospasm was observed. It was found that the higher the TIMP-1 level, the more markers indicating destructive changes in the vessels of ovarian tissue (r=0.7) and the lower the chances of getting pregnant in assisted reproducrtive technology programs. Conclusions. In PCOS patients over 32 years of age, infertility duration of more than 4 years, having endometrial hyperplasia and surgical interventions in the past medical history (tubectomies for sactohydrosalpinx), TIMP-1 level significantly (p<0.05) increases (≥2694 ng/ml) in the follicular fluid. Moreover, markers indicating destructive changes (vascular sclerosis, vasospasm and endothelial dysfunction) are identified. Thus, the chances of getting pregnant in assisted reproducrtive technology programs become lower.

IMPAIRED GAIT AND BALANCE DISORDERS AS RISK MARKERS FOR FALLS IN CHRONIC CEREBRAL ISCHEMIA

The main clinical syndromes of chronic cerebral ischemia (CCI) are impaired gait and balance disorders, which increase risks for falls. The objective of the study is to analyze correlation between impaired gait and postural instability to determine risk markers for falls in CCI patients. Materials and Methods. We examined 104 CCI patients (15 men and 89 women, median age 70 (63; 76) years). The patients did not have significant functional limitations in daily life (modified Rankin scale, 0–2 points). Thirteen patients (13 %) had a history of acute cerebrovascular accidents, thirty-seven patients (36 %) had a history of falls. Moderate cognitive impairment was detected in 53 patients (51 %). Impaired gait and balance disorders were assessed according to Tinetti test, Berg balance scale, and stabilometric platform. Statistica 13.0, SPSS 22 was used for statistical data processing. Results. According to the Tinetti test, impaired gait was detected in 101 patients (97 %), balance disorders were found in 32 patients (31 %). According to the Berg balance scale, most patients had a low risk for falls. Stabilometry showed a decrease in the limits of stability, mainly forward. Discriminant analysis revealed that significant predictors of falls in CCI patients are the “forward” limit of stability (<59 points), female gender, age (>67 y.o.), depression (>9 points, HADS), sway index (eyes closed) in the clinical test for sensory integration and balance (>0.855), balance score for the Tinetti test (<15 points), and a history of acute cerebrovascular accident. Conclusion. Stabilometry along with clinical assessment can improve the effectiveness of determining the risk group for falls in CCI patients.

Study of heart rate variability to assess the autonomic nervous system functioning in women with different degrees of obesity

In recent decades, there has been a significant increase in obese people worldwide. There is a large number of hypotheses describing the causes of the development of obesity, but few studies have addressed changes arising in the autonomic nervous system. The predominance of the sympathetic nervous system could potentially be a leading link in the pathogenesis of the development of cardiovascular complications in obesity. The aim of the study was to investigate the relationship between the ANS circuit and body weight, with age. In our work, 161 women were examined using spectral analysis of the hardware and software complex «Omega-M». Then the participants were distributed into groups according to age and body weight. Statistical grouping and data processing were carried out using Microsoft Office software package. After analyzing the group «40–49 years old», it has been revealed that the central regulation in the studied women with the 1st degree of obesity is observed in 67 % of cases, and in the women with the 2nd degree, this type of regulation prevails completely (p=0.0011). In the group «50–59 years old», the women with the 2nd degree of obesity completely lack the autonomous regulation; the central type makes up 89 % of the total number of those examined, while the intermediate type accounts for 11 % (p=0.0042). In the group «60–69 years old» in the women with normal body weight, the central regulation prevails in 83 % of cases. In the group with the 1st degree of obesity, all women have the central regulation (100 %), as in the group with the 2nd degree of obesity, where the central regulation also predominates at 92 %, while the autonomous regulation is found only in 8 % of the examined (p=0.0141). It was noted that in the women with the 2nd degree of obesity, the central regulation of heart rhythm prevails. In the group «60–69 years», this type of regulation begins to prevail regardless of body weight. Thus, with age and with increasing body weight, the predominance of the central regulation of heart rhythm is observed. The dependence of the predominant regulation circuit and age is associated with a decrease in physiological reserves in case of excessive body weight, which may cause the development of cardiovascular diseases and requires the search for effective etiopathogenetic methods of treatment.

Analysis of the Effect of Investor Sentiment, Liquidity, Solvency, and Economic Value Added (EVA) on Stock Returns with Corporate Social Responsibility (CSR) as a Moderating Variable in Health Sector Companies (Healthcare) Listed on the Indonesia Stock Exchange (IDX) Period 2018 -2022

The purpose of this study was to analyze how the influence of investor sentiment, liquidity, solvency, and economic value added can affect stock returns with moderation by corporate social responsibility disclosure in health sector companies (healthcare) listed on the Indonesia Stock Exchange (IDX) for the period 2018-2022. This research was conducted on health sector companies (healthcare) listed on the IDX, data information was obtained through the official website of the Indonesia Stock Exchange www.idx.com, the sampling technique used purposive sampling with a population of 33 health companies listed on the Indonesia Stock Exchange for the period 2018-2022 and a sample of 13 companies. Testing is done with panel data analysis regression and Moderated Regression Analysis (MRA) utilizing E-views statistical data processing software. The results of this study indicate that the variables of investor sentiment, liquidity, and economic value added have no significant effect on stock returns, while solvency variables have a significant effect on stock returns. Corporate social responsibility disclosure is also unable to moderate the relationship of investor sentiment, liquidity, solvency, and economic value added to stock returns.

Формування критеріїв розвитку інструментів управління людським капіталом

Based on the analysis of big data, methods and tools for improving the level of human potential of both individual teams of employees and the entire company have been studied. As a result of working with big data, visualization methods were used to graphically display the results of the survey, primary statistical processing of the numerical data of the online survey was carried out to evaluate the teams of employees, departments (company) for the sale of women's clothing, the trends of the studied indicators were determined, both the correlation analysis of the data and and cluster analysis, constructed dendrograms according to various criteria. A number of universal provisions regarding the use of human capital management tools are proposed, and their corresponding features in personnel management under martial law conditions are defined. Eight development criteria (five main and three auxiliary) are substantiated, which should be used to evaluate human capital management tools to increase business profitability.

Knowledge Management and Linked Data Generation in the CIS Statistics Committee

This article presents the actions implemented by the Interstate Statistical Committee of the CIS (CIS-STAT) in knowledge management information systems, preparation of linked data and «smart» (semantically rich) metadata as part of the CIS data hub that is under construction. Based on the analysis of international experience and after conducting their own long-term research, the authors set out the purpose behind the work – to increase the efficiency and potential of using statistical data by ensuring an unambiguous and meaningful data interpretation, including in consumer information systems. To reach this goal, the authors proposed new approaches and technologies for building a knowledge management system based on the semantic network, which made it possible to link machine-interpretable semantic models with human-readable knowledge representations. Addressing the objective of organizing knowledge about statistical methodology is a key to increasing the potential for using linked data and enabling collaborative processing of statistical data. The proposed methodological and technological approach is aimed at contextualizing a subject area used to develop linked data and generate «smart» metadata. It also provides new opportunities for consumers to work with statistical data and metadata – their interpretation, meaningful analysis, comparison and joint processing. Along with a description of the systems operating cycle, the article provides a meaningful analysis of the issues of harmonizing statistical terminology, identified by practical work with the «Labor Statistics» domain. Special attention is paid to the role of the expert community in developing a knowledge management system

РЕСУРСИ РЕЗИЛЬЄНТНОСТІ ОСІБ З ТРАВМАТИЧНИМ ДОСВІДОМ

Purpose. Theoretical study of resilience and the resources that determine the difference in its manifestation after critical situations, as well as empirical research on the mechanisms and resources that promote the development of resilience in people with traumatic experiences because of the war in Ukraine. Methods. Methods of theoretical analysis of scientific literature on the problem; methods of empirical research using a set of psychodiagnostic techniques; methods of mathematical statistics. Spearman's rank correlation coefficient was calculated for statistical data processing. Results. According to the results of theoretical analysis, the concept of "resilience" is considered as both a process and an outcome of successful adaptation to difficult life situations, especially through mental, emotional, and behavioral flexibility and adaptation to external and internal challenges. The empirical study revealed positive correlations of psychological resilience with resources (crisis coping strategies) "B – Belief & values" (r=0.591), “C – Cognition, thought” (r=0.540). A directly proportional correlations was also found between the overall impact of the event, the level of intrusion and avoidance with the crisis coping strategy "I – Imagination" (r=0.505; r=0.607; r=0.506), between the level of avoidance and the resource “S – Socialization” (r=0.632), between the level of intrusion and “C – Cognition, thought” (r=0.491). Conclusions. Individuals whose crisis coping strategies are based on faith (in God, in people, in miracles, or in themselves and their mission), belief systems, values and meanings, the activation of mental abilities, the ability to think logically and critically, assess situations, learn new ideas, plan, gather information, analyze problems, and solve them rationally, exhibit higher resilience indicators. Those who have higher level of impact of event and manifestations of specific PTSD symptoms more frequently use imagination, memories, and creativity to cope with crises. The level of avoidance positively correlates with the use of social ties, social support, and communication to cope with crises, and the level of intrusion positively correlates with the use of cognition and cognitive strategies.

ОСОБИСТІСНІ ДЕСКРИПТОРИ ЗРІЛОСТІ ГРОМАДЯНСЬКОЇ ІДЕНТИЧНОСТІ СТУДЕНТІВ

The purpose of the article is to theoretically and empirically study the personal descriptors of students' civic identity maturity. Methods. The study used psychodiagnostic methods for determining personality characteristics (the Big Five by R. McKrae and P. Costa, the locus of control test by J. Rotter, the stress level test by V. Shcherbatykh), as well as the methodology for diagnosing the level of maturity of civic identity by I. Petrovska. The methods of statistical data processing were correlation, comparative and cluster analysis. The sample of the researchers consisted of students of humanitarian specialties of 1-5 courses of universities in Lviv. Results. The correlation analysis showed that the largest number of correlations is formed by such indicators of civic identity as general maturity and resilience. Indicators of civic identity maturity are directly related to personal characteristics: conscientiousness, neuroticism, stress level (direct relationship), external locus of control, extraversion (inverse relationship). The resilience of civic identity is related to the level of stress and the localization of control. Cluster analysis showed that civic identity resilience was a parameter for dividing respondents into two subgroups. Individuals with a low level of civic identity resilience are characterized by low levels of extraversion, high levels of conscientiousness, neuroticism, and stress, as well as internalization of the locus of control. Individuals with a high level of civic identity resilience are characterized by a high level of extraversion, low levels of conscientiousness, neuroticism and stress, as well as a high level of locus of control externalization. Conclusions. The maturity of civic identity is related to such personal parameters as introversion, conscientiousness, neuroticism, high stress level, and internal locus of control. An inverse relationship between resilience and maturity of civic identity was found, which means that the characteristic feature of the latter is not rigidity but flexibility. Individuals with a high level of civic identity resilience are characterized by a high level of extraversion, low levels of conscientiousness, neuroticism and stress, as well as a high level of external locus of control.

Factors infl uencing delivery in women with multiple fetus pregnancy.

This paper aims to analyze the factors that can influence the method of childbirth in women with multiple pregnancies. Retrospective analysis of selected parameters in women with multiple pregnancies who gave birth at the 2nd Clinic of Gynecology and Obstetrics of the Faculty of Medicine (FM), Comenius University (CU) and University Hospital (UH) Bratislava in the years 2010-2022. Between 2010 and 2022, at the 2nd Clinic of Gynecology and Obstetrics of the FM CU and UH in Bratislava, 1.13% of births were multiple pregnancies. After statistical data processing, primiparity appeared statistically significant as a risk of acute caesarean section (C-section); multiparous women had a higher probability to give birth vaginally. Since 2017, the clinic has had a decreasing trend in the number of caesarean sections. Women with an acute caesarean section, in turn had on average a lower pH of both fetuses compared to vaginal delivery. However, the incidence of asphyxia in fetuses was not statistically significantly different. We found no risk factor increasing the likelihood of acute caesarean section for fetus B in twins. Multiple pregnancy has a higher morbidity not only for the woman but also for the fetuses. The incidence of multiple pregnancies is influenced by assisted reproduction. Delivery method depends on various factors such as chorionicity, fetal presentation, and history of a previous caesarean section.

The communicative and pragmatic potential of German traditional and modified phraseological units

This article examines the traditional form and modifications of the German phraseology «in Saus und Braus leben» in the modern German press on economic topics from 2018 to 2024. The purposes of using phraseological units in the economic media discourse are diverse. Journalists, in an effort to attract the attention of the readers, use vivid and expressive phraseological units often modifying them. The purpose of the article is to determine the communicative and pragmatic potential of the traditional and modified unit, to identify ways of modifying it, and to present a lexical description of the phraseology. The work describes the functioning of this phraseology both in its traditional form and as modified within media discourse. In order to conduct the research, the following methods were used: an analytical and descriptive approach, linguistic stylistic analysis, and systematization of results, continuous sampling, complex linguistic description, statistical processing, and generalization of data. The material for this study consisted of newspaper articles published in German electronic media, such as «Manager magazin», «Die Tageszeitung», «Der Spiegel», «Focus», «Taz», «Berliner Zeitung». During the study, we found that traditional and modified forms prevail in the article body, often realizing the function of attracting attention, expressive and evaluative functions. It was revealed that the frequency of implementation of the modified phraseology is almost 1.5 times higher than its implementation in the traditional form. Both traditional phrases and their modified variants are used in their original meaning without changing the meaning of the sentence. Within the framework of the studied corpus of traditional and modified phraseological units, the following modifications were identified: change of the grammatical form, expansion of phraseology through additional components, replacement of the verb, reduction of the usual form of phraseology. In the course of the study, an expanded model of the dictionary entry was proposed, considering the specifics of the modern functioning of phraseology in the texts of economic discourse. This description will reflect both the traditional form and the structural and semantic modifications of phraseological units in the media discourse on economic topics.