Question: Stroke in the left hemisphere leads to deficits in language, motor cognition, and spatial attention; hereby an isolated lesion can result in deficits in multiple domains. The dual-loop model of a dorsal and ventral processing stream (Weiller, 2011) can serve as a functional-anatomic framework for task-specific but cross-domain processing. In this study, we will examine the shared variance of deficits in all three domains following a single stroke lesion to identify behavioural clusters of deficits and the associated lesion locations. Methods: In a prospective study, 165 patients (age 64.4±14.3 years) with first-ever left hemispheric stroke in the acute phase (4.79±2.08 days after symptom onset) were assessed for deficits in language (token test), motor cognition (meaningless imitation, pantomime, tool use) and spatial attention deficits (extinction, neglect). Common variance was extracted using rotated principal component analysis with oblimin rotation (PCA). Multivariate support-vector-regression lesion-symptom-mapping (SVR-LSM) based on magnetic tomography images was used to assign behavioral clusters and lesions. Results: PCA revealed two components: the first component (54.9% variance explained) included the token test, motor cognition (mainly pantomime and tool use), and neglect. It represents conceptual, semantic, and time-independent processing of information. The second component (further 10.9% variance explained) was associated with meaningless imitation, other apraxia tasks, and extinction and represents time- and space-dependent processing. In the SVR-LSM, the first component was associated with lesions in the superior/middle temporal gyrus and inferior/middle frontal lobe while the second component was related to a lesion cluster in the superior/inferior parietal lobe. Discussion: Behavioral data suggest domain-general cognitive processes (time- and-space dependent vs. conceptual, semantic, time-independent) in the left hemisphere - impairment of those leads to a specific pattern of deficits across all cognitive domains. Lesions to parietal regions of the dorsal stream led to impairment of time- and space dependent processing; impaired conceptual, semantic, and time-independent processing was related to lesions in the frontal and temporal lobe, including regions of the ventral stream. There results extend our understanding of the multidimensionality of cognitive deficits in stroke patients, which should have impact on their rehabilitative treatment. References Weiller, C., Bormann, T., Saur, D., Musso, M., & Rijntjes, M. (2011). How the ventral pathway got lost – And what its recovery might mean. Brain and Language , 118 (1–2), 29–39. https://doi.org/10.1016/j.bandl.2011.01.005 .