In the 21st century, with globalization and the “Belt and Road” economic activities. As an important financial means, supply chain financing plays a key role in trade transactions between enterprises. Supply chain financing refers to providing financial support and services to different participants in the entire supply chain through financial instruments to meet the financial needs of their production and trade activities. To address the issue of “blockchain+supply chain” financing, specifically in the traditional supply chain, the downstream of the SMEs financing difficulties has been one of the factors plaguing its development. Still, also one of the constraints on the overall supply chain operational efficiency, we use the principles of game theory to establish a game theory model between financial institutions and SMEs and use Matlab software to solve the simulation data. We use the principle of game theory to establish a game theory model between financial institutions and MSMEs, use Matlab software to solve the simulation data and analyze the financial institutions to adopt the “blockchain+supply chain” financing strategy, and MSMEs to adopt the trustworthy strategy so that the two sides can maximize the benefits, and also maximize the benefits for the whole supply side. In addition, the research process and results can provide references for relevant state departments and various social enterprises and organizations.