Prime Group Research Articles

In vitro maturation with letrozole priming: Can it be a solution for patients with cancerophobia? A pilot study.

Objective:To investigate whether letrozole priming could be used efficiently in patients undergoing in vitro maturation (IVM) as compared with follicle-stimulating hormone (FSH) priming.Materials and Methods:This is a retrospective analysis of 63 patients who underwent IVM due to the high risk of Ovarian Hyperstimulation syndrome (OHSS) (n=39), cancerophobia (n=16), and desire for IVM after failed in vitro fertilization attempts (n=8). Forty-two patients received FSH priming and 21 patients received letrozole priming.Results:The patients who had FSH or letrozole priming were statistically similar with respect to age, body mass index, duration of infertility, basal antral follicle count, serum anti-Müllerian hormone levels, and IVM indications (p>0.05 for all). When compared with the FSH priming group, the number of germinal vesicle oocytes, metaphase II and fertilized oocytes were significantly higher (p=0.003, p=0.001, and p=0.016, respectively), but the number of metaphase I oocytes was significantly lower in the letrozole priming group (p=0.002). The patients who received FSH and letrozole priming had statistically similar rates of implantation (33.3% vs 37.0%, p=0.709), clinical pregnancy (31.5% vs 33.3%, p=0.848), twinning (1.9% vs 3.7%, p=0.611), and live birth (24.1% vs 29.6%, p=0.682).Conclusion:Potential indications for IVM include patients with increased risk for OHSS and contraindication for hyperestrogenism. Aromatase inhibitors can be used to preserve the fertility of patients with estrogen-sensitive cancers. Letrozole priming appears to be an efficient approach in patients who undergo IVM, with likely less cost than FSH priming.

Priming with Horizontal Reading Influences the Deployment of Visual Attention During Word Processing1

AbstractPrevious studies on parallel processing of words have demonstrated that the orthographic properties of multiple words can be processed simultaneously. However, whether parallel lexical processing (which requires attentional allocation towards a subsequent N + 1 word) is possible has been much debated. We examined this controversy in the Japanese language with the flanker lexical decision task and investigated whether the deployment of attention changed after priming with horizontal reading. Participants allocated to the priming group read short passages written in Japanese before the flanker task. The results showed that the parallel processing of a lexical property was observed after priming, which implicates that reading facilitates the attentional allocation to the right during the processing of a current word. The results suggested that strategies to allocate attention to the right are at work during reading. Furthermore, the current study points to the possibility that word processing during reading can be assessed by combining the priming procedure and flanker lexical decision task.

Priming protects the spinal cord in an experimental aortic occlusion model

ObjectivesParaplegia is a devastating complication in aortic aneurysm surgery. Modifying the spinal cord vasculature is a promising method in spinal cord protection. The aim of this study was to assess whether the spinal cord can be primed by occluding thoracic segmental arteries before simulated aneurysm repair in a porcine model. MethodsTwelve piglets were randomly assigned to the priming group (6) and the control group (6). Eight uppermost thoracic segmental arteries were occluded at 5-minute intervals in the priming group before a 25-minute aortic crossclamp. In the control group, the aorta was crossclamped for 25 minutes. During the first 5 minutes, 8 segmental arteries were occluded. After the aortic crossclamping, piglets were observed under anesthesia for 5 hours and followed up 5 days postoperatively. Near-infrared spectroscopy, motor-evoked potentials, blood samples, neurology with the modified Tarlov score, and histopathology of the spinal cord were assessed. ResultsThe median Tarlov score during the first postoperative day was higher in the priming group than in the control group (P = .001). At the end, 50% of the control animals had paraplegia compared with 0% of paraplegia in the priming group. The mean regional histopathologic score differed between the priming group and the control group (P = .02). The priming group had higher motor-evoked potentials during the operation at separate time points. The lactate levels were lower in the priming group compared with the control group (Pg = .001, Pg×t = .18). ConclusionsAcute priming protects the spinal cord from ischemic injury in an experimental aortic crossclamp model.

Effect of Albumin Addition to Cardiopulmonary Bypass Prime on Outcomes in Children Undergoing Open-Heart Surgery (EACPO Study)-A Randomized Controlled Trial.

There is a paucity of literature regarding the association of high oncotic priming solutions for pediatric cardiopulmonary bypass (CPB) and outcomes, and no consensus exists regarding the composition of optimal CPB priming solution. This study aimed to examine the impact of high oncotic pressure priming by the addition of 20% human albumin on outcomes. Double-blinded, randomized controlled study was done in the pediatric cardiac intensive care unit of a tertiary care hospital. Consecutive children with congenital heart diseases admitted for open-heart surgery were randomized into two groups, where the study group received an additional 20% albumin to conventional blood prime before CPB initiation. We enrolled 39 children in the high oncotic prime (added albumin) group and 37 children in the conventional prime group. In the first 24-hour postoperative period, children in the albumin group had significantly lower occurrence of hypotension (28.2% vs 54%, P = .02), requirement of fluid boluses (25.6% vs 54%, P = .006), and lactate clearance time (6 vs 9 hours, P < .001). Albumin group also had significantly higher platelet count (×103/µL) at 24 hours (112 vs 91, P = .02). There was no significant difference in intra-CPB hemodynamic parameters and incidence of acute kidney injury. In subgroup analysis based on risk category, significantly decreased intensive care unit stay (4 vs 5 days, P = .04) and hospital stay (5 vs 7 days, P = .002) were found in the albumin group in low-risk category. High oncotic pressure CPB prime using albumin addition might be beneficial over conventional blood prime, and our study does provide a rationale for further studies.

Effect of Retrograde Autologous Blood Priming of Cardiopulmonary Bypass on Hemodynamic Parameters and Pulmonary Mechanics in Pediatric Cardiac Surgery: A Randomized Clinical Study

The present study aimed to assess the impact of retrograde autologous priming (RAP) on hemodynamics and pulmonary mechanics in children subjected to cardiothoracic surgery. This prospective randomized study analyzed the clinical records of 124 children with risk adjustment in congenital heart surgery-1 left to right lesions subjected to cardiac surgery. They comprised 64 patients in RAP group and 60 patients in the conventional priming group. The preoperative, intraoperative and postoperative data of the studied patients were reported. The outcome measures included hematocrit (Hct) value, blood gases, lung mechanics parameters, transfusion needs, ICU stay, postoperative complications and mortality. Preoperatively, there were no significant differences between the studied groups regarding the demographic data, underlying lesions, laboratory data, blood gases and pulmonary mechanics parameters. Intraoperatively, RAP group patients had significantly lower amount of blood loss, less frequent need to packed red blood cells (RBC)s transfusion and better Hct values when compared with the control group. Postoperatively, RAP group patients had significantly higher Hct% at ICU arrival, significantly better pulmonary mechanics parameters and significantly shorter duration on mechanical ventilation. RAP in children older than 12 months subjected to cardiac surgery for risk adjustment in congenital heart surgery-1 left to right lesions is associated with less transfusion needs and better pulmonary mechanics.

Priming autobiographical memories: How recalling the past may affect everyday forms of autobiographical remembering.

This study investigated the idea that when one recalls past episodes, that the content of those memories will activate additional episodic memories with like content, and such memories will then have the potential of surfacing in subsequent acts of involuntary and voluntary recall. We tested the episodic content priming hypothesis in two experiments. In Experiment 1, priming group participants first recalled memories about specific activities or events and then they were subsequently engaged in a word-cue voluntary autobiographical memory task. The results showed that priming group participants produced more episodic memories involving the primed content on this task than control participants occupied in the same task. In Experiment 2, episodic content priming was further tested on a measure of involuntary autobiographical memory (i.e., the vigilance task). The results on this task also revealed support for the episodic content priming hypothesis, including after a delay of 24h.

Scalable Wildcarded Identity-Based Encryption with Full Security

Wildcarded identity-based encryption (WIBE) is an encryption system where one can encrypt messages to multiple users by specifying a pattern, which is a set of identity strings or wildcards. It is a useful primitive for practical applications where users are defined with multiple attributes (or affiliations), such as organization networks or IoT firmware updates. However, the ciphertext size in traditional WIBE schemes are linear to the number of wildcards in the pattern; since the ciphertext size determines the payload in network systems, it degrades the practicality when deployed in transmission-sensitive systems. In this paper, we represent scalable wildcarded identity-based encryption (SWIBE), which achieves a constant-size ciphertext regardless of the number of wildcards (or depth of patterns). the SWIBE scheme also allows the wildcard usage key derivation as well as encryption: a user with wildcarded pattern can delegate keys for the fixed pattern. Compared to the existing WIBE schemes, the SWIBE scheme is the first approach to yield constant-size ciphertext. Moreover, SWIBE also improves encryption time and decryption time while maintaining a key size of 2L, comparable to the key size of L in WIBE schemes (where L is a depth of the pattern). The experimental results show that the decryption time is 3 to 10 times faster than the existing WIBE schemes, and 650 times faster than the attribute-based encryption with constant-size ciphertext. For the security, we first propose the selective-CPA-secure SWIBE scheme in a prime order bilinear group and extend it to be selective-CCA-secure. Then we also propose a fully-secure SWIBE scheme which can overcome the selective security.

Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition

Type 2 cytokine responses promote parasitic immunity and initiate tissue repair but, can also result in immunopathologies when not properly restricted. Basophilia is recognized as a common feature of type 2 inflammation, however, the roles basophils play in regulating these responses remain unknown. Here, we demonstrate that helminth-induced ILC2 responses are exaggerated in the absence of basophils, resulting in increased inflammation and diminished lung function. Additionally, we show that ILC2s from basophil-depleted mice express reduced amounts of the receptor for the neuropeptide, neuromedin B (NMB). Critically, NMB stimulation inhibited ILC2 responses from control but not basophil-depleted mice, and basophils were sufficient to directly enhance NMB receptor (NMBR) expression on ILC2s. These studies suggest that basophils prime ILC2s to respond to neuron-derived signals necessary to maintain tissue integrity. Further, these data provide mechanistic insight into the functions of basophils and identify NMB as a potent inhibitor of type 2 inflammation.

On College Students' impulsive consumption psychology——the influence of trait power and money priming

Two experiments were conducted to explore the effects of trait power and money priming on College Students' impulse buying. In both experiments, Sense of Power Scale (SPS) was used to select subjects with high and low trait power to participate in the experiment; in Experiment 1, scrambled-words task was used to activate the concept of money; in Experiment 2, the method of mindset priming was used to activate the amount of money. The results show that: (1) After the concept of money is activated, individuals with low trait power have higher impulse purchase intention than those with high trait power, regardless of whether they are rich or poor; however, there is no significant difference between high and low power groups in no money concept priming group. (2) No matter whether the level of individual's trait power is high or low, compared with the condition of lack of money, individuals have higher impulse purchase intention under the condition of money abundance.

Children’s discrete proportional reasoning is related to inhibitory control and enhanced by priming continuous representations

Children can successfully compare continuous proportions as early as 4 years of age, yet they struggle to compare discrete proportions at least to 10 years of age, especially when the discrete information is misleading. This study examined whether inhibitory control contributes to individual differences in discrete proportional reasoning and whether reasoning could be enhanced by priming continuous information. A total of 49 second-graders completed two tasks. In the Hearts and Flowers (H&F) task, a measure of inhibition, children pressed on either the corresponding or opposite side, depending on the identity of the displayed figure. In the Spinners task, a measure of proportional reasoning, children chose the spinner with the proportionally larger red area across continuous and two discrete formats. In the discrete adjacent format, the continuous stimuli were segmented into sections, which could be compatible with the proportional information or misleading; the discrete mixed format interspersed the colored sections from the discrete adjacent conditions. Finally, two priming groups were formed. Children who saw the continuous format immediately before the discrete adjacent format formed the continuous priming group (n = 26). Children who saw the discrete mixed format immediately before the discrete adjacent format formed the discrete priming group (n = 23). Our results showed that children who performed better on the H&F task also had better performance on the discrete counting misleading trials. Furthermore, children in the continuous priming group outperformed children in the discrete priming group, specifically in contexts where discrete information was misleading. These results suggest that children’s proportional reasoning may be improved by fostering continuous representations of discrete stimuli and by enhancing inhibitory control skills.

An Expressive “Test-Decrypt-Verify” Attribute-Based Encryption Scheme With Hidden Policy for Smart Medical Cloud

With the rapid development of cloud computing and the Internet of Things, many companies or individuals store their data in the cloud server, which brings new challenges to the security and privacy. Although traditional encryption schemes could solve some problems, data owners (DOs) might lose the access control over the data, which is important in some specific application scenarios, such as the smart medical cloud system. In order to address these problems, some ciphertext-policy attribute-based encryption (CP-ABE) schemes have been proposed to protect the privacy and security of data; but these schemes still have the following defects: 1) most of the existing hidden policy CP-ABE schemes only enable restricted access structure, such as “AND” gate; 2) several schemes supporting flexible access control are inefficient in decryption, because most of them are constructed in the composite order bilinear group; and 3) many of the proposed schemes fail to check the correctness of decryption message. In this article, we construct a “test-decrypt-verify” CP-ABE scheme based on prime order bilinear group to solve the above-mentioned problems. The proposed scheme supports secure outsourcing decryption, because the return value is an intermediate value unrelated to the encapsulation value of message encrypted by the DO.

Epidemiological Characteristics and Spatiotemporal Analysis of Acute Hemorrhagic Conjunctivitis from 2004 to 2018 in Chongqing, China

Chongqing is one of the five provinces in China that has the highest incidence of acute hemorrhagic conjunctivitis (AHC). Data of AHC cases from 2004 to 2018 were obtained from National Notifiable Diseases Reporting Information System (NNDRIS). Descriptive statistical methods were used to analyze the epidemiological characteristics; incidence maps were used to reflect incidence trends in each district; spatial autocorrelation was used to identify hotspot regions and spatiotemporal patterns of AHC outbreaks; spatiotemporal scan were conducted to identify AHC clusters. A total of 30,686 cases were reported with an annual incidence of 7.04 per 100,000. The incidence rates were high in 2007 and 2014, and large epidemics were observed in 2010 with the seasonal peak in September. Individuals aged 10–19 years, males, students and farmers were the prime high-risk groups. Except for 2012 and 2013, the spatial distribution of AHC did not exhibit significant global spatial autocorrelation. Local indicators of spatial association showed that the high-risk regions are Chengkou and Wuxi. The spatiotemporal scan indicated that all clusters occurred in September 2010, and the high-incidence clusters were mainly distributed in the northeast of Chongqing. The results could assist public health agencies to consider effective preventive measures based on epidemiological factors and spatiotemporal clusters in different regions.

Summary of survey report on mutual perceptions between China and the United States

In June 2019, the Institute of International and Strategic Studies (IISS) at Peking University and the US-based Prime Group, both sponsored by the China–United States Exchange Foundation (CUSEF), conducted parallel public opinion surveys on how Chinese view the United States and how Americans view China, respectively. The Chinese study divided the respondents into two groups—the Chinese public and Beijing experts, and the US polls also sent questionnaires to both the US public and Washington experts. This article highlights the findings of Chinese and US surveys, compares the perceptions of individuals in China and the US of each other and bilateral relations, and explores the background of and reasons behind those perceptions.

Adaptively secure certificate-based broadcast encryption and its application to cloud storage service

The existing public key broadcast encryption schemes are mainly constructed in identity-based cryptosystem, which bears the inherent problems of key escrow and key distribution. The certificate-based encryption mechanism can effectively address the problems in identity-based cryptosystem. Meanwhile, it simplifies the certificate revocation issue for traditional public key cryptosystem. Inspired by the idea of certificate-based encryption, we put forward the new primitive certificate-based broadcast encryption as well as its formal definition and security model. In virtue of prime order bilinear groups, we present an instantiation scheme of certificate-based broadcast encryption. To our best knowledge, the proposed scheme is the first adaptively secure scheme for certificate-based broadcast encryption in the standard model against chosen-ciphertext attack. Compared with the previous work, our scheme has advantages in the respects of computation cost as well as security properties. Furthermore, we present an application scenario of the proposed scheme for data access control in cloud storage service.

Investigating Stereotypes Among Minority Group Members in Israel: The Role of Ingroup and Outgroup Symbols

Abstract This research examined the influence of exposure to ingroup and outgroup concepts on stereotypes of minority members toward the majority. Arab participants were primed by concepts representing group affiliation content (Jewish concepts or Arab concepts), and then their stereotypes toward Jewish people were examined. It was found that priming group concepts had differential effects on Arab minority subgroups, where the Muslim group revealed more negative stereotypes toward Jews than in the non-Muslim group. These effects were found for both ingroup and outgroup concepts: When primed with outgroup concepts Muslims perceived Jews as more unpleasant, and when primed with ingroup concepts they perceived Jews as more antagonist. The activated group content has an important role in increasing stereotypes as a function of the group affiliation among members of a minority group. Research implications and further experiments are discussed.

Human Chorionic Gonadotropin Priming Does Not Improve Pregnancy Outcomes of PCOS-IVM Cycles

Background: Influence of pre-retrieval human chorionic gonadotropin (HCG) priming on outcomes of in vitro maturation (IVM) remains controversial. This study aimed to evaluate the effect of HCG priming before oocyte retrieval on clinical outcomes of IVM cycles in patients with polycystic ovarian syndrome (PCOS).Methods: This was a retrospective cohort study analyzing data from the first IVM cycles of unstimulated PCOS patients in a reproductive center of university affiliated hospital from January 2006 to December 2017. Patients received HCG injection before oocyte retrieval were assigned to HCG priming group and those without HCG administration were categorized as none HCG priming (Non-HCG) group. Main outcomes included oocyte maturation rate, number of embryos available, clinical pregnancy rate, and live birth rate. Candidate factors of clinical pregnancy rate was explored by univariate analysis and multivariate logistic regression analysis.Results: There were 324 patients meeting the inclusion and exclusion criteria. Among them, 129 women received HCG priming and 195 other did not. Women in HCG group had significantly lower basal FSH level (5.17 ± 1.63 vs. 5.80 ± 2.38) than Non-HCG group. Both FSH levels were <10 IU/L and the absolute difference was 0.63 IU/L. Other basic characteristics were similar between groups with or without HCG priming. Oocyte maturation rate was trend to be higher in HCG group (52.68 vs. 48.56%) but no statistical significance was found (P = 0.097). No significant difference in clinical pregnancy rate was found between HCG and Non-HCG groups (31.37 vs. 35.67%). Miscarriage rates (31.25 vs. 34.43%) and live birth rates were also similar between groups. HCG priming was not correlated with clinical pregnancy rate in both univariate analysis (P = 0.468) and multivariate logistic regression analysis (P = 0.538; OR = 1.212; 95%CI: 0.657–2.237).Conclusion: HCG priming before oocyte retrieval may not improve clinical outcomes of IVM in patients with PCOS.

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Sylow Prime Group

Dextran- Versus Crystalloid-Based Prime in Cardiac Surgery: A Prospective Randomized Pilot Study

The optimum priming fluid for the cardiopulmonary bypass (CPB) circuit is still debated. We compared a new hyperoncotic priming solution containing dextran 40, which has an electrolyte composition that mimics extracellular fluid, with a standard crystalloid-based prime. Eighty cardiac surgery patients were included in this double-blind, randomized, single-center study. Patients were randomized to either a dextran-based prime or a crystalloid prime containing Ringer's acetate and mannitol. The primary end point was colloid oncotic pressure in serum during CPB. Secondary end points included fluid balance, bleeding and transfusion requirements, pulmonary function, hemolysis, systemic inflammation, and markers of renal, hepatic, myocardial, and brain injury. Blood samples were collected before, during, and after CPB. Colloid oncotic pressure was higher in the dextran group than in the crystalloid prime group during CPB (18.8 ± 2.9 versus 16.4 ± 2.9 mm Hg; P < .001) and 10 minutes after CPB (19.2 ± 2.7 versus 16.8 ± 2.9 mm Hg; P < .001). Patients in the dextran group required less intravenous fluid during CPB (1090 ± 499 versus 1437 ± 543 mL; P= .004) and net fluid balance was less positive 12 hours after surgery (1431 ± 741 versus 1901 ± 922 mL; P= .014). Plasma-free hemoglobin was significantly lower in the dextran group 2 hours after CPB (0.18 ± 0.11 versus 0.41 ± 0.33; P= .001). There were no significant differences in bleeding, transfusion requirements, organ function, systemic inflammation, or brain and myocardial injury markers between groups at any time point. Our results suggest that a hyperoncotic dextran-based priming solution preserves intraoperative colloid oncotic pressure compared with crystalloid prime. Larger studies with clinically valid end points are necessary to evaluate hyperoncotic prime solutions further.

Large-Universe Attribute-Based Encryption With Public Traceability for Cloud Storage

Attribute-based encryption (ABE) can be utilized to achieve both data security and fine-grained access control in a cloud computing environment. However, we need to consider the risks of key abuse and key escrow in such a setting. Specifically, the former risk category includes the illegal sharing of user’s keys (i.e., user key abuse) and illegal key distribution by an authority (i.e., authority key abuse), and the latter includes the scenario where some ciphertext is decrypted by the authority without the user’s approval. Hence, in this article, we seek to address both key abuse and key escrow concerns when deploying ABE in a cloud computing environment. In our construction, two authorities [i.e., a key generation center (KGC) and an attribute authority (AA)] participate in the generation of the user’s secret key. Both KGC and AA will not know the full decryption key or have the capability to forge one. As a result, neither KGC nor AA can illegally distribute the user’s private key to unauthorized users or decrypt user’s ciphertexts without the user’s approval. In addition, in our scheme, any private keys modified by malicious users cannot be successfully used for decryption. In the event that some user illegally shares his/her original private key, the scheme has in place a mechanism to trace the abused private key (since the user’s identity information is embedded in the private key). Hence, our scheme supports public traceability, key abuse, and key escrow. In addition, our scheme is based on prime order bilinear groups, and is shown to be selectively secure in the standard model.

Effect of Unconscious Goal Priming on Athletes’ Self-Confidence

Self-confidence is one of the most important conditions needed for athletes to succeed. The way in which the self-confidence of athletes may be improved is an eternal topic in training and competition. This study aimed to examine whether unconscious goal priming can improve athletes’ explicit and implicit self-confidence through three experiments. Experiment 1 was aimed at exploring the effect of unconscious goal priming on athletes’ self-confidence. For the purpose of this experiment, 120 athletes were randomly divided into a priming group and a control group. Experiment 2 was aimed at examining the training effect of unconscious goal priming on athletes’ self-confidence and for the purpose of this experiment 16 rhythmic gymnastics athletes were selected as subjects. Experiment 3 was aimed at checking the replication of the training effect of unconscious goal priming on athletes’ self-confidence employing 16 judo athletes as subjects. The results indicated that unconscious goal priming improved athletes’ explicit self-confidence but not implicit self-confidence, while unconscious goal priming intervention improved both athletes’ explicit and implicit self-confidence. These results provide an economical and convenient alternative for improving athletes’ self-confidence.