Objective To explore the influence of comprehensive intervention and regular follow-up on hypertension awareness,treatment rate,control rate and its complications incidence rate of the patients who were diagnosed as primary hypertension in physical examination.Methods Selected 1 183 cases that were diagnosed as primary hypertension in our health examination center from January 2007 to January 2009,which were divided into the intervention group (n =587) and the control group (n =596) randomly.The control group was given a health education at the first,then the patients managed themselves,their treatment and behavior were not required,and we followed them annual.The intervention group was given regular follow-up and comprehensive treatment intervention (including drug and non-drug),we followed the four basic steps that assessment→plan→implementation→ evaluation in circulation,and regular followed-up for 3 years.Results After 3 years,hypertension treatment rate and control rate in the intervention group (89.8%,69.5%) was higher than that in the control group (36.4%,22.1%),and the difference was statistically significant (x2 =360.92,267.34,respectively; P < 0.01).The ratio of diet control,participate in sports activities,wine limited and smoking cessation in the intervention group (68.5%,71.9%,88.9%,87.4%) were higher than those in the control group (37.2%,58.2%,49.3%,66.9%),and the differences between the two groups were statistically significant (x2 =117.94,30.62,220.62,71.18,respectively; P < 0.01).The values of cholesterol,triglycerides,blood glucose,serum creatinine,and BMI in the intervention group [(4.3 ±0.7) mmol/L,(1.52 ±0.5)mmol/L,(5.3 ±0.8)mmol/L,(93.2 ± 12.5)mol/L,(23.7 ±4.4)kg/m2] were lower than those in the control group [(4.9 ± 0.4) mmol/L,(1.76 ± 0.6) mmol/L,(5.7 ± 0.7) mmol/L,(99.5 ± 15.8) mol/L,(26.6 ± 4.8) kg/m2],and the differences were statistically significant (t =18.134,7.468,9.156,7.598,10.828,respectively; P < 0.05).Conclusions The implementation of personalized drug and non-drug intervention can reduce a variety of risk factors,improve the awareness of health care knowledge in hypertension patient,correct bad behavior and habits,reduce the psychological stress and tension,improve patient medication compliance,so as to improve the rates of hypertension awareness,treatment and control,and control and delay the complications effectively. Key words: Hypertension; Comprehensive intervention; Regular follow-up; Disease control