A hybrid unsteady compressible computational fluid dynamics simulation (CFD) driven by pressure-sensitive paint (PSP) data is proposed, and the concept is demonstrated in two dimensions. By imposing the wall pressure acquired with PSP as the Dirichlet boundary condition, an unsteady compressible Euler equation solver is marched together with integral boundary-layer equations in time. As a result, an entire flowfield that fits the PSP measurement is created in the CFD domain. This concept is tested by taking PSP data from a past article of a wind-tunnel test using the NASA CRM65 airfoil and the steady and unsteady capabilities of this data-driven hybrid simulation are demonstrated for transonic flows in two dimensions, and the convergence characteristics are also investigated. It is found that a steady shock position, which cannot be accurately predicted by the Euler equation solver with a boundary layer, can be rectified by the hybrid simulation. Moreover, unsteady shock motion due to buffeting can also be captured well by the hybrid simulation.