Predominant Approach Research Articles

Development and Evaluation of Venlafaxine Hydrochloride Tablets for Oral Drug Delivery Technology

Oral pills are the predominant, simple, and straightforward approach for administering drugs. The project’s primary goal is to create a pharmaceutical product that is equal in terms of its medicinal properties. A controlled-release version of the antidepressant venlafaxine hydrochloride was created and compared to the formulation currently available on the market. The launch of the branded product was assessed through an innovator and prototype evaluation. In order to develop stable and bioavailable dosage forms, it is necessary to gather pertinent data through preformulation testing. In order to create stable and bioavailable dosage forms, preformulation testing must be performed to gather relevant information among the several mixes, high-performance polymer copolymer K100M, ethyl cellulose, and cross-linked polyvinyl pyrrolidone 0.45%. The precise release mechanism could be determined by conducting in-vitro solubility tests on the created formulations and analyzing the results with a number of exponential equations. We used fourier-transform infrared (FTIR) and differential scanning calorimetry (DSC) studies to check if the polymers were compatible with the medicine.

Відбування покарань неповнолітніми в країнах західної та східної Європи порівняно з Україною

The system of dealing with children in trouble with the law has existed for more than a century, starting with the creation of separate institutions for juvenile delinquents and "at-risk" children, which was soon followed by a series of regulations. Although different models have been in place from the very beginning, the predominant approach has been one focused on ensuring the well-being of the child, i.e. ensuring the best interests of the child. This approach is based on the concept of intervention in the best interests of children, which focuses on their needs, not their actions, and which is based on the involvement of social workers to assist the court in matters within their professional competence. Often around such juvenile justice systems there are socio-therapeutic and educational institutions for the rehabilitation and reintegration of juvenile offenders or those at risk of becoming one. Other juvenile justice systems that may be considered distinctive are based on a justice system that more closely resembles the criminal justice system for adults, or administrative commissions or other informal justice processes. In some countries, there are no (or very few) special provisions for juvenile offenders. As a result, there are huge differences in the forms and types of courts, services and institutions that make up the juvenile justice system. With regard to children in conflict with the law, the main aspect is that in criminal proceedings the latter, due to their age and immaturity, are assigned a separate regime, different from that applied to adult offenders. The prerequisite for this is the special vulnerability and limited capabilities of children whose development process has not yet been completed. Not only should any actions be evaluated in accordance with the standards of ensuring the best interests of the child, but the system itself should be responsive to the child's developmental needs in care, in order to ensure the reintegration of children into society as law-abiding citizens. Therefore, the juvenile justice system should focus its attention not only on the nature of the offense committed, but also on the root causes of its commission, as well as on the specific circumstances of each child.

Abstract 678: Experimental therapy of triple negative breast cancer with next-generation of MDM2 inhibitors

Abstract Patients with triple-negative breast cancer (TNBC) typically experience minimal benefits from the existing hormonal or trastuzumab-based therapies, necessitating reliance on chemotherapy as the predominant treatment approach, which, unfortunately, is limited by insufficient efficacy, significant side effects, and the development of drug resistance. These issues highlight an urgent demand for the discovery and development of more effective and safer therapeutics for TNBC. Overexpression and amplification of the MDM2 oncogene frequently occur in TNBC, which is associated with invasive and high-grade/late-stage tumors, metastasis, and recurrence, and is an independent negative prognostic factor for TNBC patients. Extensive studies have indicated that MDM2 represents a novel molecular target for TNBC. Thus far, multiple strategies aiming at MDM2 inhibition have not succeeded in Phase II-III clinical trials, largely due to factors like inadequate efficacy, significant drug toxicity, and emergence of resistance. In addition, TNBC tumors commonly harbor mutant p53, and the existing MDM2 inhibitors that block p53-MDM2 binding and depend on wild-type p53 expression in the tumor to exert anticancer effects would have little or no clinical responses or even induce resistant clones by increasing MDM2 expression and its oncogenic activity. Therefore, there is a need for developing new-generation MDM2 inhibitors that are p53-independent. We recently discovered a novel class of MDM2 degraders, representing a paradigm shift in the strategy of targeting MDM2. One of these analogs, WW68, was identified as a potent and selective MDM2 inhibitor. Its in vitro and in vivo anti-breast cancer activities and underlying mechanisms of action were evaluated in breast cancer cell lines with various p53 backgrounds. Our results demonstrate that WW68 effectively induces MDM2 protein degradation. It selectively inhibits breast cancer cell growth, decreases cell proliferation, and induces G2/M phase arrest and apoptosis in breast cancer cells, regardless of p53 status. Notably, in clinically relevant TNBC PDX models, WW68 inhibited MDM2 and suppressed tumor growth without causing host toxicity. In conclusion, WW68 represents a new class of MDM2 inhibitor that exerts its anticancer activity through directly down-regulating MDM2, and may be developed as a novel anti-TNBC therapeutic agent. (Supported by NIH R01CA214019 and R01CA240447; and DoD W81XWH2010011) Citation Format: Wei Wang, Hao Chen, Yang Xie, Sayantap Datta, Wei Li, Ruiwen Zhang. Experimental therapy of triple negative breast cancer with next-generation of MDM2 inhibitors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 678.

Minimally invasive robot-assisted and laparoscopic distal pancreatectomy in a pan-European registry a retrospective cohort study.

International guidelines recommend monitoring of the use and outcome of minimally invasive pancreatic surgery (MIPS). However, data from prospective international audits on minimally invasive distal pancreatectomy (MIDP) are lacking. This study examined the use and outcome of robot-assisted (RDP) and laparoscopic (LDP) distal pancreatectomy in the E-MIPS registry. Post-hoc analysis in a prospective audit on MIPS, including consecutive patients undergoing MIDP in 83 centers from 19 European countries (01-01-2019/31-12-2021). Primary outcomes included intraoperative events (grade 1: excessive blood loss, grade 2: conversion/change in operation, grade 3: intraoperative death), major morbidity, and in-hospital/30-day mortality. Multivariable logistic regression analyses identified high-risk groups for intraoperative events. RDP and LDP were compared in the total cohort and in high-risk groups. Overall, 1672 patients undergoing MIDP were included; 606 (36.2%) RDP and 1066 (63.8%) LDP. The annual use of RDP increased from 30.5% to 42.6% (P<0.001). RDP was associated with fewer grade 2 intraoperative events compared to LDP (9.6% vs. 16.8%, P<0.001), with longer operating time (238 vs. 201 minutes,P<0.001). No significant differences were observed between RDP and LDP regarding major morbidity (23.4% vs. 25.9%, P=0.264) and in-hospital/30-day mortality (0.3% vs. 0.8%, P=0.344). Three high-risk groups were identified; BMI>25kg/m2, previous abdominal surgery, and vascular involvement. In each group, RDP was associated with fewer conversions and longer operative times. This European registry-based study demonstrated favorable outcomes for MIDP, with mortality rates below 1%. LDP remains the predominant approach, whereas the use of RDP is increasing. RDP was associated with less conversions and longer operative time, including in high-risk subgroups. Future randomized trials should confirm these findings and assess cost differences.

Textbooks as Markers and Makers of International Law: A Brazilian Case Study

Abstract This article challenges conventional views of international law textbooks as mere instructional tools and explores them as powerful sites for shaping knowledge and the discipline. Drawing on empirical methods and critical theory, we analyse the 10 main international law textbooks used in Brazil and conduct interviews with their authors to illuminate the textbooks’ complexities and their potential for shaping the discipline and the profession. The article delves into the tension between the structure of international law as depicted in the textbooks and the agency of their authors, investigating the authors’ identities and backgrounds. Brazil serves as a compelling case study due to its numerous international law textbooks and their widespread use. Our results indicate a predominant universalist approach in Brazilian textbooks and their connection to the French international law tradition. Moreover, the study sheds light on the Brazilian ‘invisible college’ of international lawyers, revealing gender and racial disparities and institutional centralities. It also uncovers crucial omissions in the textbooks, such as the relationship of international law to colonialism, slavery, race, gender and economic inequality. Overall, this study offers a comprehensive understanding of international law as a field in Brazil and provides a valuable methodological framework for future research on textbooks’ role in shaping the discipline.

Opinion, uptake and current practice of robot-assisted upper gastrointestinal and oesophagogastric surgery in the UK: AUGIS national survey results.

The uptake of upper gastrointestinal (GI) robotic surgery in the United Kingdom (UK), and Europe more widely, is expanding rapidly. This study aims to present a current snapshot of the practice and opinions of the upper GI community with reference to robotic surgery, with an emphasis on tertiary cancer (oesophagogastric) resection centres. An electronic survey was circulated to the UK upper GI surgical community via national mailing lists, social media and at an open-invitation conference on robotic upper GI surgery in January 2023. The survey included questions on surgeons' current practice or planned adoption (if any) of robotics at individual and unit level, and their opinions on robotic upper GI surgery in general. Priority ranking and Likert-scale response options were used. In total, 81 respondents from 43 hospitals were included. Thirty-four resectional centres responded, including 30 of 31 (97%) recognised upper GI cancer centres in England. Respondents reported performing robotic surgery in 21 of 34 (61.8%) resectional centres, with a median of 65 procedures per centre performed at the time of the survey (range 0-500, interquartile range 93.75). Every centre without a robotic programme expressed a desire or had active plans to implement one. Respondents ranked surgeon ergonomics as the most important reason for pursuing robotics, followed by improvements in patient outcomes and oncological efficacy. Robotic upper GI practice is nascent but rapidly growing in the UK with plans for uptake in almost all tertiary centres. There is growing opinion that this is likely to become the predominant surgical approach in future with benefits to both patients and surgeons. This snapshot offers a point of reference to all stakeholders in upper GI surgery.

ACE mRNA (Additional Chimeric Element incorporated IVT mRNA) for Enhancing Protein Expression by Modulating Immunogenicity.

The development of in vitro transcribed mRNA (IVT mRNA)-based therapeutics/vaccines depends on the management of IVT mRNA immunogenicity. IVT mRNA, which is used for intracellular protein translation, often triggers unwanted immune responses, interfering with protein expression and leading to reduced therapeutic efficacy. Currently, the predominant approach for mitigating immune responses involves the incorporation of costly chemically modified nucleotides like pseudouridine (Ψ) or N1-methylpseudouridine (m1Ψ) into IVT mRNA, raising concerns about expense and the potential misincorporation of amino acids into chemically modified codon sequences. Here, an Additional Chimeric Element incorporated mRNA (ACE mRNA), a novel approach incorporating two segments within a single IVT mRNA structure, is introduced. The first segment retains conventional IVT mRNA components prepared with unmodified nucleotides, while the second, comprised of RNA/DNA chimeric elements, aims to modulate immunogenicity. Notably, ACE mRNA demonstrates a noteworthy reduction in immunogenicity of unmodified IVT mRNA, concurrently demonstrating enhanced protein expression efficiency. The reduced immune responses are based on the ability of RNA/DNA chimeric elements to restrict retinoic acid-inducible gene I (RIG-I)and stimulator of interferon genes (STING)-mediated immune activation. The developed ACE mRNA shows great potential in modulating the immunogenicity of IVT mRNA without the need for chemically modified nucleotides, thereby advancing the safety and efficacy of mRNA-based therapeutics/vaccines.

A Systematic Review on Caries Detection, Classification, and Segmentation from X-Ray Images: Methods, Datasets, Evaluation, and Open Opportunities.

Dental caries occurs from the interaction between oral bacteria and sugars, generating acids that damage teeth over time. The importance of X-ray images for detecting oral problems is undeniable in dentistry. With technological advances, it is feasible to identify these lesions using techniques such as deep learning, machine learning, and image processing. Therefore, the survey and systematization of these methods are essential to determining the main computational approaches for identifying caries in X-ray images. In this systematic review, we investigated the primary computational methods used for classifying, detecting, and segmenting caries in X-ray images. Following the PRISMA methodology, we selected relevant studies and analyzed their methods, strengths, limitations, imaging modalities, evaluation metrics, datasets, and classification techniques. The review encompassed 42 studies retrieved from the Science Direct, IEEExplore, ACM Digital, and PubMed databases from the Computer Science and Health areas. The results indicate that 12% of the included articles utilized public datasets, with deep learning being the predominant approach, accounting for 69% of the studies. The majority of these studies (76%) focused on classifying dental caries, either in binary or multiclass classification. Panoramic imaging was the most commonly used radiographic modality, representing 29% of the cases studied. Overall, our systematic review provides a comprehensive overview of the computational methods employed in identifying caries in radiographic images and highlights trends, patterns, and challenges in this research field.

The New Orientation of Postoperative Analgesia: Remote Ischemic Preconditioning.

Postoperative analgesia is currently a significant topic in anesthesiology. Currently, the predominant approach for achieving multimodal analgesia involves the utilization of pharmacotherapy and regional anesthesia procedures. The primary objectives of this approach are to mitigate postoperative pain, enhance patient satisfaction, and diminish overall opioid usage. Nevertheless, there is a scarcity of research on the use of remote ischemia preconditioning aimed at mitigating postoperative pain. Transient stoppage of blood flow to an organ has been found to elicit remote ischemia preconditioning (RIPC), which serves as a potent intrinsic mechanism for protecting numerous organs. In addition to its established role in protecting against reperfusion injury, RIPC has recently been identified as having potential benefits in the context of postoperative analgesia. In addition to traditional perioperative analgesia, RIPC provides perioperative analgesia and organ protection.

Communication Styles of the Non-Teaching Personnel of St. Paul University Iloilo: Basis for Future Training Programs

Communication styles, as representation of individuals, exhibit the culture of a particular organization or institution. It can be viewed as a process of comprehending the set of attitudes, values, beliefs, and behaviors of each member and, at the same time, shared by everyone in the organization. This study was conducted to determine the communication styles of the non-teaching personnel of St. Paul University Iloilo. Specifically, it determined the profile of the respondents according to sex, age group, and length of service and the predominant communication style among the non-teaching personnel when taken as an entire group and when grouped according to sex, age group, and length of service. The Communication Style Measure constructed by Norton (1983), comprised of 11 styles, was utilized for this study. The results revealed that the 73 non-teaching personnel each utilized different communication styles. The Friendly communication style was regarded as the most predominant approach among the non-teaching personnel when classified as an entire group. When classified according to sex, age group, and length of service, the Friendly communication style still emerged as the most prevailing among the majority of the respondents. It is recommended that the school administrators nurture the amiable and pleasant communication atmosphere that prevails in the workplace. The friendly communication style that occurs in this working environment is an indication of a smooth interaction among its members and a collegial approach in the way the administrative staff and other employees interact with one another. Policies and activities, including the conduct of training programs that would cultivate this setting should be continuously implemented and enhanced.

Hypospadias-associated penile curvature assessment and management: A global survey of current practice

Our goal was to assess how surgical management of hypospadias-associated penile curvature (HAPC) varies across continents, focusing on factors that influence assessment and decision-making. Members of the European Society of Pediatric Urology (ESPU), Society of Pediatric Urology (SPU), and Hypospadias International Society (HIS) participated in an anonymous, 34-question online survey addressing pre-, intra-, and postoperative elements of HAPC evaluation and management. A selection of intraoperative photos were included in the survey to investigate the prevailing surgical approaches and identify management patterns. Out of the 267 participants, 38.4% of them are located in Europe. Visual estimation was the predominant approach for evaluating HAPC, although being regarded as the least dependable compared to other techniques. Surgeons who performed more than 40 cases per year were more inclined to use goniometers and had varying degrees of HAPC that were considered acceptable without requiring any correction (P<.001). Out of 58% of respondents, a significant number reported regular utilization of artificial erection tests for all categories of hypospadias. Surgeons with fewer than 10 years of expertise commonly utilized erection test as part of their regular practice. A tourniquet was employed to maintain sufficient intra-corporeal pressure, by134 (50%). 116 participants (43%) inject Saline through the corpora cavernosa through the glans, while 150 (56%) administer saline from the lateral aspect. Moreover, the decision-making process differed based on the intraoperative picture scenarios of mild to moderate penile curvature during erection testing. Contrary to temperatures ranging from 25o to 35o, decision-making in cases with less severe degrees of HAPC was uncomplicated. This survey reveals a wide range of surgical practicepatterns in the assessment and management of HAPC. To our knowledge, this global surveyof HAPC practice is the largest to date and could aid in developing new guidelines in pediatricurology. These findings may also provide a foundation for future prospective multinational studies.

Application of fuzzy-set qualitative comparative analysis (fsQCA) in hospitality and tourism research: a bibliometric study

PurposeFuzzy-set qualitative comparative analysis (fsQCA) is explored as a transformative tool rooted in complexity theory, shedding light on uncertainties shaping real-world decisions in tourism, with a focus on its application in the hospitality domain.Design/methodology/approachThis study systematically evaluates fsQCA’s application in hospitality and tourism research, employing bibliometric analysis to scrutinize the published literature since its induction in 2011. The research seeks to understand the evolving usage by qualitatively reviewing impactful studies based on total citations.FindingsThe study reveals the ascendancy of fsQCA as a predominant approach in hospitality and tourism studies, particularly in illuminating decision-making paradigms in key sectors like destination and hotel selections and entrepreneurial orientations. However, an absence of fsQCA applications in gastronomy and wine tourism is identified, signaling uncharted territories for future inquiry.Research limitations/implicationsTheoretical implications include paradigm shifts to complexity theory, configural analysis and asymmetric algorithms. Practical implications involve improved decision-making and tailored marketing, benefiting industry practitioners. Limitations include potential academic bias, while future research suggests exploring sub-sectors, sustainability and emerging technologies.Originality/valueThis study identifies gaps in the fsQCA application and pioneers its examination within the hospitality domain, offering a unique perspective on understanding intricate relationships and configurations among variables. The study emphasizes the efficacy of asymmetric methodologies in elucidating behavioral nuances in hospitality and tourism, providing a foundation for future inquiries to expand horizons and unravel the nuanced applications of fsQCA in this research domain.

Bet your Company Culture and Business Performance in Nigeria

The study examined the relationship between Bet your company culture and business performance in Nigeria. The strategic focus of any corporate venture is to maximize gains in business, which is achieved through actualizing vision and mission objectives. Bet your company as a way of life to achieve corporate success was examined in this study. A case study of NNPC was brought to focus based on some selected empirical studies in the literature. The study deployed a technique of Management by Objective (MBO) to instigate the bet company style of culture in NNPC. The review found that the concept of MBO which Udoji’s Commissions introduced as an important part of managerial process, most public enterprises in Nigeria, especially NNPC, did not afford its subordinates the opportunity to engage in goal-setting; instead, the predominant management approach involved the imposition of objectives by the leadership for associates to attain. Also, there was a report of misplaced priority by decision makers of NNPC not to train staff as and when needed, thereby stifling expected overall performances. It was recommended that NNPC and other firms adopt a bottom-up approach to decision-making. Institutions should involve the subordinates in significant decision-making and seek feedback as and when needed. Keywords: Bet your company; NNPC; Nigeria, Corporate Objectives

Staged operation in the surgical treatment of granulomatous lobular mastitis.

Granulomatous lobular mastitis (GLM) is a chronic inflammatory breast condition characterized by an unclear etiology and an undefined therapeutic approach. Surgical intervention is considered an alternative modality for managing GLM. Staged operation is the predominant and characteristic surgical approach in the treatment of GLM in our center; therefore, we evaluated the efficacy of staged operative techniques in this cohort study. We retrospectively reviewed 212 patients with GLM who underwent staged operation between August 2020 and July 2022 in the inpatient department of our institute. Their clinical history information, clinic complaints, treatment details, surgical outcomes, follow-up results, and scores on the satisfaction questionnaire were analyzed. The patients were called for follow-up and consultation with a deadline of August 2023. The median follow-up time was 27 months (range, 14-37 months). In total, 212 patients were treated with three different staged procedures according to the individual assessment and patient willingness, including 168 patients who underwent one-stage debridement operation and two-stage suture operation (DO + SO), 25 patients who underwent one-stage debridement operation without suture (DO), and 19 patients who underwent one-stage debridement and simultaneous suture operation (DSO). The median recovery time was 29 days (range, 14-60 days). A minority of patients developed postoperative complications, including effusion (1.89%), flap ischemia (0.94%), areola-nipple ischemia (0.94%) and sinus tract formation (2.36%). The scores of the satisfaction questionnaire were 43.10±3.09, and 186 patients (87.74%) gave high scores for postoperative breast appearance. Only 5 of 212 patients (2.36%) developed recurrence. Staged operation performed in our institute is an effective and safe surgical therapy in patients with GLM, yielding a short recovery time, low recurrence and good cosmetic results.

Analysis of Morphometric Variations in the Thickness of the Mandibular Symphysis in Patients at Dr. Mohammad Hoesin General Hospital Palembang, Indonesia

Introduction. Accurate knowledge of mandibular thickness is necessary for performing surgical treatments on the mandible. The Champy procedure has become the predominant approach for treating fractures of the mandible. Placing plates along these lines is believed to offer the best possible fixing and stability. The objective of this study is to analyze and compare the thickness of the mandible in patients, specifically depending on their gender. The purpose is to gain a more comprehensive understanding of the differences in mandibular architecture across various populations in South Sumatra, Indonesia.&#x0D; Methods. This study is a cross-sectional analytical-observational study. The Department of Radiology of Dr. Mohammad Hoesin Central General Hospital, located in Palembang, conducted the study. We included a total of 103 research participants in this study, all of whom met the specified inclusion criteria.&#x0D; Results. There is a notable difference in the thickness of the lower jawbone in the front part (A and B) that runs parallel to Champy's line, depending on the person's gender. Males have a greater morphometric thickness of the mandibular symphysis in comparison to females. The thickness of the mandibular symphysis closely links to gender disparities.&#x0D; Conclusion. The thickness of symphysis A in men was substantially greater than in females, while the thickness of symphysis B in males was also significantly greater than in females, with a P value less than 0.001.

The California Coast and Living Shorelines—A Critical Look

California and most other coastlines around the world are being impacted by both long-term sea-level rise and short-term extreme events. Due to California’s long and intensively developed coastline, it is an important area for evaluating responses to these challenges. The predominant historic approach to coastal erosion in California and globally has been the construction of hard coastal armoring such as seawalls and rock revetments. The concept of living shorelines—defined as using natural elements like plants, sand, or rocks to stabilize the coastline—has been widely proposed as a soft or green response to coastal erosion and flooding. However, these approaches have very limited application in high-energy environments such as California’s 1100-mile-long outer coast and are not realistic solutions for protection from wave attack at high tides or long-term sea-level rise. Each of the state’s coastal communities need to identify their most vulnerable areas, develop adaptation plans, and plan eventual relocation strategies in response to an accelerating sea-level rise.

Pd-Mn/NC Dual Single-Atomic Sites with Hollow Mesopores for the Highly Efficient Semihydrogenation of Phenylacetylene.

The direct pyrolysis of metal-zeolite imidazolate frameworks (M-ZIFs) has been widely recognized as the predominant approach for synthesizing atomically dispersed metal-nitrogen-carbon single-atom catalysts (M/NC-SACs), which have exhibited exceptional activity and selectivity in the semihydrogenation of acetylene. However, due to weak adsorption of reactants on the single site and restricted molecular diffusion, the semihydrogenation of large organic molecules (e.g., phenylacetylene) was greatly limited for M/NC-SACs. In this work, a dual single-atom catalyst (h-Pd-Mn/NC) with hollow mesopores was designed and prepared using a general host-guest strategy. Taking the semihydrogenation of phenylacetylene as an example, this catalyst exhibited ultrahigh activity and selectivity, which achieved a turnover frequency of 218 molC═CmolPd-1 min-1, 16-fold higher than that of the commercial Lindlar catalyst. The catalyst maintained high activity and selectivity even after 5 cycles of usage. The superior activity of h-Pd-Mn/NC was attributed to the 4.0 nm mesopore interface of the catalyst, which enhanced the diffusion of macromolecular reactants and products. Particularly, the introduction of atomically dispersed Mn with weak electronegativity in h-Pd-Mn/NC could drive the electron transfer from Mn to adjacent Pd sites and regulate the electronic structure of Pd sites. Meanwhile, the strong electronic coupling in Pd-Mn pairs enhanced the d-electron domination near the Fermi level and promoted the adsorption of phenylacetylene and H2 on Pd active sites, thereby reducing the energy barrier for the semihydrogenation of phenylacetylene.

Light-Driven Radiochemistry with Fluorine-18, Carbon-11 and Zirconium-89.

This review discusses recent advances in light-driven radiochemistry for three key isotopes: fluorine-18, carbon-11, and zirconium-89, and their applications in positron emission tomography (PET). In the case of fluorine-18, the predominant approach involves the use of cyclotron-produced [18F]fluoride or reagents derived thereof. Light serves to activate either the substrate or the fluorine-18 labeled reagent. Advancements in carbon-11 photo-mediated radiochemistry have been leveraged for the radiolabeling of small molecules, achieving various transformations, including 11C-methylation, 11C-carboxylation, 11C-carbonylation, and 11C-cyanation. Contrastingly, zirconium-89 photo-mediated radiochemistry differs from fluorine-18 and carbon-11 approaches. In these cases, light facilitates a postlabeling click reaction, which has proven valuable for the labeling of large biomolecules such as monoclonal antibodies (mAbs). New technological developments, such as the incorporation of photoreactors in commercial radiosynthesizers, illustrate the commitment the field is making in embracing photochemistry. Taken together, these advances in photo-mediated radiochemistry enable radiochemists to apply new retrosynthetic strategies in accessing novel PET radiotracers.

Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

AbstractThis review discusses recent advances in light‐driven radiochemistry for three key isotopes: fluorine‐18, carbon‐11, and zirconium‐89, and their applications in positron emission tomography (PET). In the case of fluorine‐18, the predominant approach involves the use of cyclotron‐produced [18F]fluoride or reagents derived thereof. Light serves to activate either the substrate or the fluorine‐18 labeled reagent. Advancements in carbon‐11 photo‐mediated radiochemistry have been leveraged for the radiolabeling of small molecules, achieving various transformations, including 11C‐methylation, 11C‐carboxylation, 11C‐carbonylation, and 11C‐cyanation. Contrastingly, zirconium‐89 photo‐mediated radiochemistry differs from fluorine‐18 and carbon‐11 approaches. In these cases, light facilitates a postlabeling click reaction, which has proven valuable for the labeling of large biomolecules such as monoclonal antibodies (mAbs). New technological developments, such as the incorporation of photoreactors in commercial radiosynthesizers, illustrate the commitment the field is making in embracing photochemistry. Taken together, these advances in photo‐mediated radiochemistry enable radiochemists to apply new retrosynthetic strategies in accessing novel PET radiotracers.

Household willingness to pay for various attributes of residential solar panels: Evidence from a discrete choice experiment

The predominant approach in the US environmental policy so far has been to offer financial incentives for renewable energy as a more politically palatable alternative to market based policies. The policies around residential rooftop solar have generally aligned with this approach. However, recent years have witnessed a reversal in the once favorable financial terms for residential solar energy in many states largely due to concerns regarding unfair cost shifting and efficiency. Consequently, solar vendors appear to increasingly hinge their marketing strategies on the narrative of “self-reliance”. A pertinent question is whether there is enough willingness to pay for such non-market, private benefits to sustain the growth of residential solar. To address this, we designed and implemented a discrete choice experiment within a stated preference framework. Respondents were asked to make a choice among different home energy options offering varying financial terms and other attributes such as self-reliance and home battery. Notably, a random subset of the respondents was presented with the net present value (NPV) of the dollar cost of each alternative, while this information was withheld from the rest of the sample. We estimated the utility coefficients through hierarchical Bayes (HB) mixed logit and subsequently derived the marginal willingness to pay (mWTP) for each attribute, along with their individual-level confidence intervals. Our findings indicate substantial heterogeneity in preferences among decision-makers. On average, the willingness to pay for self-reliance falls short of supporting residential solar growth without financial incentives. Furthermore, respondents exposed to NPV information exhibited significantly lower mWTP values, underscoring the potential efficacy of NPV information in improving willingness to pay estimates within investment-oriented settings.