Development and Evaluation of Venlafaxine Hydrochloride Tablets for Oral Drug Delivery Technology

Abstract

Oral pills are the predominant, simple, and straightforward approach for administering drugs. The project’s primary goal is to create a pharmaceutical product that is equal in terms of its medicinal properties. A controlled-release version of the antidepressant venlafaxine hydrochloride was created and compared to the formulation currently available on the market. The launch of the branded product was assessed through an innovator and prototype evaluation. In order to develop stable and bioavailable dosage forms, it is necessary to gather pertinent data through preformulation testing. In order to create stable and bioavailable dosage forms, preformulation testing must be performed to gather relevant information among the several mixes, high-performance polymer copolymer K100M, ethyl cellulose, and cross-linked polyvinyl pyrrolidone 0.45%. The precise release mechanism could be determined by conducting in-vitro solubility tests on the created formulations and analyzing the results with a number of exponential equations. We used fourier-transform infrared (FTIR) and differential scanning calorimetry (DSC) studies to check if the polymers were compatible with the medicine.