Neurodegenerative disorders (NDD) are a group of progressive conditions that primarily affect neurons in the brain. The diseases gradually impair cognitive function, movement, and other neurological processes, leading to a decline in the individual’s quality of life. Reliable biomarkers that accurately detect and track the growth of neurological disorders are crucial for the development of effective therapeutics. People with NDDs have damage to the brainneurons, which causes strange walking patterns. To overcome this problem we proposed Chemical reaction optimization based improved generative adversarial network (CRO-IGAN) method is to improve the patient’s conditions that are affected in neurodegenerative diseases. The patient’s dataset is gathered, here we utilized min max normalization for data preprocessing is used to clean the data. Principal component analysis (PCA) is employed for feature extraction to extract the pre-processed data and remove the unwanted data. The appropriate data is selected using linear discriminant analysis (LDA) for feature selection. The parameter metrics used in this study are recall, sensitivity and specificity. The suggest techniques CRO-IGAN provides high performance of accuracy for diagnosing NDD to improve the patient health which provides a superior performance than other existing methods.