Femtocell technology is emerging as a key solution for mobile operators for its advantage in coverage and capacity enhancement along with its cost effectiveness. However, densely and randomly deployed femtocells while sharing the frequency spectrum of the macrocell arises a severe interference environment. In femtocells deployment, interference coming from a femtocell user affect other femtocell users and the macrocell users, where maintaining the communication of the users in both tiers is a mandatory. In this paper, a novel power control algorithm is proposed for optimizing the uplink transmission powers of femtocell users in a TDD-OFDM communication model in the presence of a channel estimation error and intra-tier interference. We consider signal to interference and noise ratio as the objective function where the proposed constraints deal with: (1) the aggregated interference coming from femtocell tier and received at the active subchannels by the macrocell tier, and (2) the maximum uplink power a femtocell user equipment is allowed to occupy per admissible subchannel. Based on Lagrangian multipliers, the proposed power control approach grants the priority in subchannel usage for macrocell user, then it allows or prohibits frequency reuse of a subchannel with the femtocell tier. A comparison is then made with a pure isolation method that does not allow femtocell user equipments to occupy the active subchannels at the macrocell tier. The numerical results of the proposed approach show a high total rate of femtocell user equipments and the average uplink power is below the maximum allowable transmission power.