Povidone Iodine Ointment Research Articles

Povidone-iodine ointment demonstrates in vitro efficacy against biofilm formation.

Anti‐infectives used to treat chronic exuding wounds are diluted by wound exudates, absorbed into dressings, metabolised by proteases and destroyed by pH. In order to mimic such effects of exudates, the efficacy of six topical wound agents was assessed undiluted and at 10% concentrations, including povidone‐iodine ointment and a silver‐impregnated wound dressing, to remove biofilms of Pseudomonas aeruginosa, multi‐species biofilms of Candida albicans and methicillin‐resistant Staphylococcus aureus (MRSA) in vitro in a Centers for Disease Control and Prevention (CDC) reactor. Povidone‐iodine was also diluted to 3·3% and 33·3% of the commercial concentrations. Viable microorganisms in each preparation were quantified by colony count. No viable P. aeruginosa biofilm material was recovered after 4 and 24 hours of treatment with povidone‐iodine ointment at the 100% and 10% concentrations. No C. albicans/MRSA biofilm material was recovered after 4 and 24 hours of treatment with povidone‐iodine ointment at the 100% concentration. In general, following dilution, povidone‐iodine ointment appeared to exhibit greater biofilm removal than the other agents tested. Further research involving different microorganisms in vitro and in vivo over a longer period of time will help elucidate the full potential of povidone‐iodine ointment and liposomal hydrogel.

Pharmacological Investigation of the Wound Healing Activity of Cestrum nocturnum (L.) Ointment in Wistar Albino Rats.

Objectives. The present study was aimed at investigating the wound healing effect of ethanolic extract of Cestrum nocturnum (L.) leaves (EECN) using excision and incision wound model. Methods. Wistar albino rats were divided into five groups each consisting of six animals; group I (left untreated) considered as control, group II (ointment base treated) considered as negative control, group III treated with 5% (w/w) povidone iodine ointment (Intadine USP), which served as standard, group IV treated with EECN 2% (w/w) ointment, and group V treated with EECN 5% (w/w) ointment were considered as test groups. All the treatments were given once daily. The wound healing effect was assessed by percentage wound contraction, epithelialization period, and histoarchitecture studies in excision wound model while breaking strength and hydroxyproline content in the incision wound model. Result. Different concentration of EECN (2% and 5% w/w) ointment promoted the wound healing activity significantly in both the models studied. The high rate of wound contraction (P < 0.001), decrease in the period for epithelialization (P < 0.01), high skin breaking strength (P < 0.001), and elevated hydroxyproline content were observed in animal treated with EECN ointments when compared to the control and negative control group of animals. Histopathological studies of the EECN ointments treated groups also revealed the effectiveness in improved wound healing. Conclusions. Ethanolic extract of Cestrum nocturnum (EECN) leaves possesses a concentration dependent wound healing effect.

Measurements in wound healing with observations on the effects of topical agents on full thickness dermal incised wounds

IntroductionA multitude of topical wound treatments are used today. Although it is well established that the micro-environment of healing wounds can be altered to improve healing, it is difficult to measure the subtle differences in outcome where therapies are compared. MethodWe compared wound healing properties between four different topical agents in surgically incised wounds in a pig model. The four topical agents, 5% Povidone-Iodine cream, 1% Silver-Sulphadiazine, 2% Mupirocin, and 1% Silver-Sulphadiazine plus 1mg/100g recombinant-human epithelial growth factor (EGF) were randomly assigned to four test animals each. Test agents were compared to each other and to untreated controls. We investigated existing and new methodologies of measurement of wound healing: clinical and histological visual scoring systems, immuno-histochemistry, and computerized image analysis of the wounds on days 3, 7, and 28. ResultsAll agents were found to have improved healing rates with better cellular architecture. Healing was faster, histological appearance resembled normal architecture sooner, clinical appearance improved, mitotic activity was stimulated and more collagen was deposited in comparison to the wounds with no agents. EGF-treated wounds showed an increased rate of epithelisation, but the rate of healing did not correlate well with evaluation of cosmetic outcome. ConclusionTopical agents improve all aspects of wound healing. The addition of a human recombinant EGF to Silver-Sulphadiazine increases epithelial growth and amounts of collagen in the regenerating wounds at day 7.

Evaluation of Wound Healing Activity of Topical Phenytoin in an Incision Wound Model in Rats

Background: Wound healing is a significant healthcare problem in today’s medical practice. Despite extensive treatment modalities that are supposed to hasten the wound healing process, the outcomes of existing methods are far from optimal. One such agent that has been tried previously and found controversial in wound healing is phenytoin. Therefore, this study was planned to evaluate and compare wound healing effect of topical phenytoin with povidone iodine ointment in rats. Materials and Methods: Study was conducted after approval from Institutional Animal Ethics Committee (IAEC). Wound healing activity of topical phenytoin (1 gm% and 2gm%) was assessed in incision wound model in Sprague Dawley rats (n =8) which was compared with topical petroleum jelly and povidone iodine ointment. Parameters studied included measurement of wound tensile strength and estimation of hydroxyproline level in tissues obtained on the 10thpost-operative day. Results: The tensile strength was significantly more with both the preparations of phenytoin when compared to petroleum jelly and 10% povidone iodine. The hydroxyproline level was more in 1% and 2% phenytoin treated group as compared to other study groups. However, it showed significant difference only with petroleum jelly treated group and not with the povidone iodine treated group. There was no statistically significant difference between both the preparations of phenytoin. Conclusion: In this study, it was found that topical phenytoin accelerates wound healing process in an incision wound model. Keywords: Phenytoin, Povidone iodine, Incision wound

Alternative Therapy of Skin Diseases in Cattle

Fifty two cattle were clinically examined and found affected with multi-focal alopecia, pyoderma, and polypnea in some cases. Laboratory examination confirmed Staphylococcus sp, fungus, yeast and ectoparasites. Antibiotic sensitivity test showed, the organisms were resistant to most of the antibiotics. The organisms were found to be sensitive to mixture of aqueous seed extract of Sesamum indicum and Citrus limon fruit juice in agar well diffusion test. Six cattle kept as control. 10 cattle (group A) were administered Ivermectin at 0.2 mg/kg body weight subcutaneously once and Povidone Iodine ointment applied externally for 7 days. 36 cattle (group B) orally administered the mixture of palm jaggery, common salt, Sesamum indicum, buffalo ghee and Citrus limon for 7 days. No recovery noticed in control. Group A and B showed 30% and 89% recovery respectively.

Smallpox vaccine, ACAM2000: Sites and duration of viral shedding and effect of povidone iodine on scarification site shedding and immune response

The U.S. Department of Defense vaccinates personnel deployed to high-risk areas with the vaccinia virus (VACV)-based smallpox vaccine. Autoinoculations and secondary and tertiary transmissions due to VACV shedding from the vaccination site continue to occur despite education of vaccinees on the risks of such infections. The objectives of this study were to investigate, in naïve smallpox vaccinees, (a) whether the vaccination site can remain contagious after the scab separates and (b) whether the application of povidone iodine ointment (PIO) to the vaccination site inactivates VACV without affecting the immune response. These objectives were tested in 60 individuals scheduled to receive smallpox vaccine. Thirty individuals (control) did not receive PIO; 30 subjects (treatment) received PIO starting on post-vaccination day 7. Counter to current dogma, this study showed that VACV continues to shed from the vaccination site after the scab separates. Overall viral shedding levels in the PIO group were significantly lower than those in the control group (p=0.0045), and PIO significantly reduced the duration of viral shedding (median duration 14.5 days and 21 days in the PIO and control groups, respectively; p=0.0444). At least 10% of control subjects continued to shed VACV at day 28, and 3.4% continued to shed the virus at day 42. PIO reduced the proportion of subjects shedding virus from the vaccination site from day 8 until days 21–23 compared with control subjects. Groups did not differ significantly in the proportion of subjects mounting an immune response, as measured by neutralizing antibodies, IgM, IgG, and interferon-gamma enzyme-linked immunospot assay. When applied to the vaccination site starting on day 7, PIO reduced viral shedding without altering the immune response. The use of PIO in addition to a semipermeable dressing may reduce the rates of autoinoculation and contact transmission originating from the vaccination site in smallpox-vaccinated individuals.

Effect of Methanolic Extract in Ointment and Powder of Kalanchoe Pinnata (Lamk) Leaf in Ointment towards Incision Wound Healing in Mice

Wound is a very common thing that can happen to all people around the world. The purpose of this study is to investigate the effect of methanolic extract and powder of Kalanchoe pinnata (Lamk) leaf in ointment. The methodology is laboratoric experimental design. Six groups of mice (n=30) were incised for 8 mm and treated with different treatment: methanolic extract of Kalanchoe pinnata (Lamk) leaves in ointment (SEMDSB) 10%, SEMDSB 20%, Kalanchoe pinnata (Lamk) leaves powder in ointment (SSDSB) 10%, SSDSB 20%, vaseline album (ointment) as negative control, and povidone iodine ointment as positive control. Examination is carried out by measuring the width of wounds in mice every day until the wound interlocked. Data analysis used one way ANOVA continued by Tukey HSD with α=0,05. The result showed the average time for wound healing (in days) are: SEMDSB 10% (7.2), SEMDSB 20% (6.6), SSDSB 10% (8.8), SSDSB 20% (7.6), negative control (10.6), and positive control (7.8). SEMDSB 10%, SEMDSB 20%, and SSDSB 20% showed highly significant difference (p = 0,000) and SSDSB 10% showed significant difference (p=0,021) when compared to negative control. As conclusion, methanolic extract and powder of Kalanchoe pinnata (Lamk) leaves in ointment can accelerate wound healing time. Keywords: ointment, Kalanchoe pinnata (Lamk), wound healing, mice

Evaluation of wound healing activity of topical phenytoin in an excision wound model in rats

Background: Wound healing is a significant healthcare problem in today’s medical practice. Despite extensive treatment modalities that are supposed to hasten the wound healing process, the outcomes of existing methods are far from optimal. One such agent that has been tried previously and found controversial in wound healing is phenytoin. Therefore, this study was planned to evaluate and compare wound healing effect of topical phenytoin with povidone iodine ointment in rats. Methods : This study was conducted after approval from Institutional Animal Ethics Committee (IAEC). Wound healing activity of topical phenytoin (1 g% and 2 g%) was assessed in excision wound model in Sprague Dawley rats (n=8), which was compared with topical petroleum jelly and povidone iodine ointment. Parameters studied included wound area on day 0, 4, 8, 12, 16, 20, percentage wound contraction, percentage wound healing from day 0 to day 20 and period of re-epithelisation. Results: Wound surface area decreased in all treatment groups from day 0 through day 20 and the percentage wound closure was better in both the preparations (1% and 2%) of phenytoin when compared wih control and povidone iodine, but this was not statistically significant. Furthermore, the days required for complete re-epithelisation were less with phenytoin treated groups. There was no statistical difference between both the preparations of phenytoin. Conclusion: In this study, it was found that topical phenytoin accelerates wound healing process in an excision wound model.

Pharmacological Evaluation and Chemical Standardization of an Ayurvedic Formulation for Wound Healing Activity

Wound healing is a topic of substantial prominence in Ayurveda, the Indian traditional system of medicine. Test drug Kshatantak Malam (KM), otherwise named as Baharer Nani, is described in Ayurveda since a long time for wound healing activity but necessitates scientific base. The test drug was prepared in the form of natural ointment with the plants like Achyranthes aspera, Allium cepa, and Canabis sativa under the base of butter in a specialized form of preparation. Chemical standardization was made on the basis of the physical character, rancidity test, extractive value, thin-layer chromatography, and gas chromatography. An 8-mm-diameter full-thickness punch was produced in Wistar rats. The test drug was applied topically and compared with standard comparators like framycetin ointment and povidone iodine ointment. Effects were observed on the basis of physical parameters like wound contraction size (mm(2)), wound index, healing period (days), tensile strength (g) and biochemical parameters like tissue DNA (mg/g), RNA (mg/g), total protein (mg/g), hydroxyproline (mg/g), PAGE study, and histopathological observations. Significant results (P < .05) were observed with KM in the punch wound model on the basis of various physical, biochemical, and histopathological parameters. The drug was found to be safe in acute and chronic toxicity models in animals. Chemically it is enriched with fatty substances.

Vulval burn due to a recreational drug: gamma hydroxybutaric acid

Sir, Burns due to chemical agents account for 3 % of all burns, though they cause more than 30 % of burn deaths [1]. Genital burns are less frequently seen in comparison with other burns. In the study of Michielsen et al., it was 3 %, in the report of Peck et al. 5 % and Alghanem et al. 1 % [2–4]. Isolated genital burns due to chemical agents are extremely rare. Literature on burn due to gamma hydroxybutaric acid (GHB) is scarce, and we thought it is worth presenting this unusual complication. A 19-year-old girl presented with a 3-day-old burn involving the vulva, right inner thigh and buttock. She stated that she slept 2 days back with a bottle of liquid GHB in her underpants while under the influence of intravenous heroin and “ice” (methamphetamine hydrochloride). She felt severe pain around her vulval region around 1500 hours the next day. Pain had not subsided with water irrigation. She failed to give a proper history regarding the mechanism of burn as she was in an unarousable state at that night. Leakage of GHB was the most likely cause of her burns. Examination revealed patchy full-thickness burns over the right labium majus, labia minora, right inner thigh and buttock, with a total surface area of 1% (Figs. 1 and 2). There was no involvement of the urethral or vaginal orifices, and she had no difficulty in passing urine. She used to consume a cocktail of heroin, methamphetamine, benzodiazepine, ethanol and GHB. She had a past history of unsuccessful detoxification of heroin. There were no self-inflicted injuries or burn in the past. She was catheterized and the vulval burns were covered with silver sulfadiazine due to pain issue. The rest of the burn was dressed with silver-impregnated dressing. Initial management was done in the intensive care unit to treat withdrawal effects. The first theatre session took place on the fifth postburn day, and the debridement of all burn wounds was performed. Skin grafting was postponed as the depth of burn was not obvious. Thigh and buttock wounds were reexcised and mesh grafting done (postburn day 7), and the graft was secured with negative pressure wound therapy (75 mmHg). The vulval wounds were managed conservatively with regular application of povidone iodine ointment. She had an uneventful recovery and self-discharged. The first clinic review remarked complete wound healing. Unfortunately, she defaulted subsequent clinic visits to scrutinize the behaviour of scars following GHB burns. Gamma hydroxybutyric acid is a naturally occurring substance found in the human central nervous system. It is also categorized as an illegal drug in many countries and regulated in Australia, Canada, New Zealand, the USA and some European countries. It is used medically to treat conditions like narcolepsy and alcoholism. GHB is the active substance in prescribed medication sodium oxybate (Xyrem (Jazz Pharmaceuticals, Inc., Palo Alto, CA, USA), Alcover (Laboratorio

Wound healing activity of an aqueous extract of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes).

The Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes) is popular because of its health-promoting properties. The effects of G. lucidum extract on cancer, hypertension, hypercholesterolemia, and hepatitis have been reported by many researchers. This investigation was undertaken to evaluate the healing efficacy of an aqueous lyophilized extract of G. lucidum from the Indian Himalayan region on dermal excision wound in experimental rats. The extract used in the study was found to be rich in total polyphenol and flavonoid contents. The healing efficacy was comparatively assessed with a reference povidone-iodine ointment. The G. lucidum extract showed significant enhanced healing activity, evidenced by an increase in wound contraction, collagen accumulation (hydroxyproline), hexosamine, and total protein contents. Histopathological findings further supported the biochemical indices. The results suggest that aqueous lyophilized extract of G. lucidum possesses significant wound-healing activity.

Formulation of new iodophore preparation (chitosan iodine cream) and evaluation of its antimicrobial activity

A new iodophore preparation (chitosan iodine cream) was prepared. Its antimicrobial activity iast different microbial standard strains was evaluated and compared against the antimicrobial rivity produced by the commercially available povidone iodine (Betadine) ointment. The results revealed that chitosan iodine cream produced almost equal antimicrobial activity against the tested microbial standard strains to that produced by povidone iodine (Betadine) ointment. These results suggest the use of the new iodophore preparation (chitosan iodine cream) as an efficient antiseptic and as an alternative to the commercially available povidone iodine (Betadine) ointment.

Wound-Healing Effect of Flavonoid-Rich Fraction from Tephrosia purpurea Linn. on Streptozotocin-Induced Diabetic Rats

Flavonoid-rich fraction and Pongamol (PONG) from Tephrosia purpurea isolated from ethyl alcohol extract by column chromatography were evaluated for wound-healing properties in diabetic rats. The ointments of PONG (0.2 and 0.5% w/w) and flavonoid-rich fraction (5% w/w) were prepared with simple ointment base B.P. An excision wound was made on each streptozotocin-induced diabetic animal, and healing was assessed by determination of protein, hydroxyproline content and antioxidants; superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) levels, and histopathological study. On the twentieth day, the TPF (ethyl acetate fraction of T. purpurea) ointment–treated group showed 100% contraction while the group treated with 0.2% w/w PONG, 0.5% w/w PONG ointment and control showed 84.28%, 96.53%, and 80.14%, respectively. The hydroxyproline, protein content, and enzyme levels (SOD, CAT, and GSH) increased in animals treated with TPF, 0.5% w/w PONG and Povidone iodine ointment USP. Presence of matured collagen fibers and fibroblasts with better angiogenesis was observed in histopathological studies.

Wound healing effect of flavonoid rich fraction and luteolin isolated from Martynia annua Linn. on streptozotocin induced diabetic rats

ObjectiveTo evaluate wound healing potential of flavonoid fractions of Martynia annua (M. annua) Linn. leaves in diabetic rats on the basis of folkloric information and preliminary study. MethodsThe flavonoid compound luteolin and apigenin were isolated from dried leaves of plant by column chromatography. The two concentrations (0.2% and 0.5% w/w) of luteolin and flavonoid fraction were selected for topically applied as ointment on diabetic wound. The Povidone Iodine Ointment USP was used as a reference. On 18th days, protein content, hydroxyproline and antioxidants (SOD, CAT and GSH) level in granuloma tissues were determined. ResultsThe results showed that, percent wound contraction were observed significantly (P<0.01) greater in MAF fraction and 0.5% w/w of luteolin treatment groups. Presence of matured collagen fibres and fibroblasts with better angiogenesis were observed in histopathological studies. ConclusionsIn conclusion, our findings suggest that flavonoid fraction (MAF) and luteolin (0.5% w/w) may have potential benefit in enhancing wound healing in diabetic condition, possibly due to free-radical scavenging activity of plant.

Wound healing potential of aqueous crude extract of Stevia rebaudiana in mice

The present study was carried out to evaluate the wound healing potential of crude aqueous extract of Stevia rebaudiana (Bertoni) Bertoni, Asteraceae, in experimental animals. All experiments were conducted following standard procedures. The crude extract was administered topically in graded doses of 150, 250 and 500mg/ kg b.w. was used for evaluating the wound healing potential in excision wound model for fourteen days and orally in the incision wound model for ten days, respectively. Povidone iodine ointment was used as standard (5.0% w/w). Dose dependent activities resulted in both the wound models when compared to the standard (povidone iodine) and the control. Topical application of crude aqueous extract of S. rebaudiana (500mg/ kg b.w) in excision wound model decreased signifi cantly the wound area by 15th day, i.e. 48.2±2.0 compared with control 94.1±1.2. Epithelization time was decreased from 17.3±0.21 to 12.0±0.10 and hydroxylproline content was increased from 32.2±0.11 to 67.6±0.10 when compared with control. In incision wound model breaking strength of wounds, wet and dry granulation of the tissue weight and hydroxyproline were increased signifi cantly from control with AESR. In conclusion, AESR leaves accelerated wound healing activity in mice and thus supports its traditional use.

Observation on curative effect of exposure therapy combined with povidone iodine cream external in treating patients with neonatal red buttock

Objective To observe the effect of exposure therapy combined with external application of povidone iodine cream in the treatment of neonatal red buttock.Methods 80 patients with eczema were divided into the experimental group and the control group with 40 cases in each group,the experiment group adopted exposure therapy plus external application of povidone iodine cream.The control group received routine cleaning buttocks to the oxygen after the coated erythromycin ointment,with buttocks not exposed.Curative effects in two groups were observed.Resulta The total effective rates of experimental group and control group were 100％ and 80％ respectively,the experimental group was better than control group (P＜0.01).Conclusion Exposure therapy combined with povidone iodine cream extemal in treatment for patients with neonatal red buttock can accelerate the subsiding of swelling,convergence wound,promote healing,with fast and good curative effect. Key words: Newborn; Red buttock; Exposure therapy; Povidone iodine ointment; Curative effect

COMPARATIVE WOUND HEALING ACTIVITY OF PLANT ICHNOCARPUS FRUTESCENS (L.) W. T. AITON

The present work objective are to investigate indigenous plants used in wound healing in India, we hereby reported our findings related to wound healing activities of plants  Ichnocarpus frutescens (L.) W. T. Aiton in vivo model studies. The plant hydro-alcoholic (Ethanol 70:Water 30) extracts of the leaves, stems and roots of Ichnocarpus frutescens was identified and tested wound healing activity. The important secondary metabolites like Ursolic acid, Kaempferol, Trifolin, Mannitol, Flavon, Phenolic acid, Triterpene glycoside(1,4-β-D-glucopyranosyl-(1,3) α-amyrin, β –Sitosterol, alkaloid and Flavonoid identified in extracts. Ichnocarpus frutescens roots hydro-alcoholic extract showed wound healing activity significantly in the excision wound model in rats on topical application. The animals were divided into five groups with six rats in each group. Topically applied Ichnocarpus frutescens leaves, stems and roots extracts ointment. Taking povidone iodine ointment as standard. The results showed that hydro-alcoholic extract of Ichnocarpus frutescens stems on topical application was reduced the  scar area from 2.5±1.5 to 0.0±0.0 cm2, hydro-alcoholic extract of Ichnocarpus frutescens leaves on topical application was reduced the scar area from 2.5±1.5 to 0.2±0.0 cm2 , hydro-alcoholic extract of Ichnocarpus frutescens roots on topical application was reduced the scar area from 2.5±1.5 to 0.7±0.4 cm2, control on topical application was reduced the scar area from 2.5±1.5 to 1.2±1.0 cm2 and standard povidon iodine ointment on topical application was reduced the scar area from 2.5±1.5 to 0.5±0.02cm2 respectively. Significant increase in tensile strength were also observed and compared to the control and povidon iodine. The above result revealed that the hydro-alcoholic stems extract has remarkable wound healing potency and appear to justify the traditional use of Ichnocarpus frutescens in wound healing in India and offer a scientific support to the treatment of traditional healers.

“Experimental Evaluation of Indian Aloe (Aloe Vera) Leaves Pulp as Topical Medicament on Wound Healing”

Wounds are major cause of physical disabilities. Wound healing consists of orderly progression of series of events that establish the integrity of the damaged tissues. Indian Aloe (Aloe Vera) leaves pulp is used for medicinal purposes, including treatment of constipation, colitis, asthma, irritable bowel syndrome, diabetes, peptic ulcer, inflammation, heart burn, stress etc. The present study was undertaken on experimental evaluation of Indian Aloe (Aloe Vera) leaves pulp on wound healing activity through topical route on excision wound model. The activity was compared with standard drug Povidone Iodine ointment (5% w/w). Indian Aloe (Aloe Vera) leaves pulp was found to have better and faster wound healing effect than standard drug Povidone Iodine ointment on excision wound model.

Comparative research on curative effects of povidone iodine combined with MEBO and new dressing in the treatment for pressure ulcer

[Objective]To explore and find a kind of method which is cheap and effective,at the same time suitable for primary hospital clinical and community Ⅱ to Ⅳ stage pressure sore treatment,through the use of povidone iodine ointment combined with MEBO and Anpu plaster and other new types of wet dressing in the treatment of stage Ⅱ to Ⅳ pressure ulcer comparison of efficacy and cost comparison research.[Methods]30 cases of bedsore in the experimentalgroup were treated with povidone iodine combined with MEBO according to the proportion of stage Ⅱ to Ⅳ pressure ulcers and 30 cases patients with pressure sores in the control group with Algoplaque new wet dressing in treatment of different stage and dressing cost comparison of curative effect of pressure sore patients.[Results]Two groups of treatment could both promote healing of pressure ulcers.But the average healing time in the experimental group was shorter than that of the control group,and every dressing costs of pressure sores was significantly less than that of control group.The difference was statistically significant (P ＜ 0.05).[Conclusion]Compared with Anpu plaster and other new types of wet dressing,povidone iodine combined with MEBO according to the proportion of stage Ⅱ to Ⅳ stage pressure sore,the therapeutic effect is better and cheaper,worth in primary hospital clinical and community promotion application. Key words: Povidone iodine combined with MEBO; Wet dressing Pressure sore; Treatment and nursing

Enhancement of wound healing with roots of Ficus racemosa L. in albino rats

ObjectiveTo establish the wound healing activity of aqueous and ethanolic extract of roots of Ficus racemosa (F. racemosa). MethodsTwo models were performed to evaluate the wound healing activity i.e. incision and excision models. In incision model the parameter which was carried out was breaking strength of wounded skin. In excision model percentage wound contraction and period of epithelialization were established for both the extracts. Reference standard drug was povidone iodine ointment for comparison with other groups. ResultsFrom the observation in both two models, aqueous extract of F. racemosa was found to have greater wound healing activity in terms of breaking strength in incision model and percentage wound contraction, period of epithelialization in excision model than that of other groups. ConclusionsIn conclusion, our findings suggest that aqueous extract of F. racemosa possesses better wound healing ability than the ethanolic extract.