Abstract
Flavonoid-rich fraction and Pongamol (PONG) from Tephrosia purpurea isolated from ethyl alcohol extract by column chromatography were evaluated for wound-healing properties in diabetic rats. The ointments of PONG (0.2 and 0.5% w/w) and flavonoid-rich fraction (5% w/w) were prepared with simple ointment base B.P. An excision wound was made on each streptozotocin-induced diabetic animal, and healing was assessed by determination of protein, hydroxyproline content and antioxidants; superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) levels, and histopathological study. On the twentieth day, the TPF (ethyl acetate fraction of T. purpurea) ointment–treated group showed 100% contraction while the group treated with 0.2% w/w PONG, 0.5% w/w PONG ointment and control showed 84.28%, 96.53%, and 80.14%, respectively. The hydroxyproline, protein content, and enzyme levels (SOD, CAT, and GSH) increased in animals treated with TPF, 0.5% w/w PONG and Povidone iodine ointment USP. Presence of matured collagen fibers and fibroblasts with better angiogenesis was observed in histopathological studies.
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