Background: In India around 56 % of women is undergoing for episiotomy in all vaginal deliveries and in Maharashtra the episiotomy rate is too high, as it ranges from 80% to 90% and in Pune the rate is about 80%. Objective: To assess the effectiveness of Povidone Iodine Ointment versus Framycetin Sulphate Cream over episiotomy wound healing among postnatal mothers. Methodology: Pre- experimental; one-shot case study design was used in this study and the total sample size was 40 (20 in experimental group -1and 20in experimental group -II) . The Experimental group1 was given the application of Povidone Iodine and the experimental group II was given group was given the Framycetin Sulphate Cream. Healing of episiotomy wound was assessed by using modified REEDA scale and the episiotomy Pain was assessed by Visual Analogue Scale amongst both the groups. Results: In Povidone application group, the average change in REEDA score was 1.1 on day 2, 1.6 on day 3, 2.7 on day 4 and 3.2 on day 5. In Framycetin application group, average change in REEDA score was 0.6 on day 2, 1.7on day 3, 2.5 on day 4 and 3.1 on day 5. t-values for these groups were 1.9, 0.1, 0.5 and 0.2 with 38 degrees of freedom. Corresponding to p-values were 0.034, 0.444, 0.305 and 0.405, which indicates that p-value is small (less than 0.05), the Povidone is significantly more effective as compared to Framycetin group. On day3, day 4 and day5, p-values are large (greater than 0.05), the difference between the effect of Povidine and Framycetin application is not significant. Conclusion: Hence it can be concluded that the Povidone Iodine Ointment and the Framycetin Sulphate Cream are effective in healing of episiotomy wound. But Povidone iodine has hot more effective than Framycetin in the process of healing of episiotomy wound.