The phenomenon of social entrepreneurship had grown rapidly along with poverty alleviation efforts. The Director General of Social Empowerment of the Ministry of Social Affairs seeks to develop innovative poverty reduction programs by carrying out social empowerment efforts through the Social Entrepreneurship Program (Prokus) collaboration with the Pusat Inkubator Bisnis LPPM UNSOED. This research’s aims were: 1) Identify the KPM profile of the Social Entrepreneurship Program in Brebes Regency, 2) Find out the pattern of incubation for the Social Entrepreneurship Program in Brebes Regency. Qualitative analysis was used in this study. The sampling method was carried out census on 300 KPM spread over 38 villages or sub districts in Brebes Regency. From this research, it shows that 94.3% of KPM ran a business in the Agribusiness sector, as much as 96.5% use family labor, the length of business that has been run for more than 5 years is 59.7%, the income per day below IDR 50,000 was 93%. Business incubation assistance can help increase KPM graduations. The assistance includes financial literacy, Business Model Canvas (BMC) training, Good Food Processing Practice training and packaging techniques, online marketing, product branding, business model development and networking.