This Special Issue is for the 6th International Conference on Multiple Comparison Procedures (MCP 2009), which was held on 24–27 March 2009 at the Tokyo University of Science, Tokyo, Japan. At the conference approximately 250 research scientists from different subject matter areas, regulatory authorities and industrial practitioners from 20 different countries met to exchange new ideas on the theory and application of the multiple comparison procedures. The conference covered indeed a wide range of topics of multiple testing, estimation, monitoring and decision making. It was opened with keynote lectures by Yoav Benjamini and Kei Takeuchi and we are happy that both of them contributed to this Special Issue. These two keynote lectures were followed by 8 invited speakers, 75 regular oral presentations and 8 poster contributions. Benjamini gave a short review of historical trends in multiple comparisons research calling the previous decade a second golden era of this field. Various new methods for multiple comparisons have been developed in these years, motivated by the needs of applications as genome analysis, brain research as well as clinical trials. Undoubtedly, as Benjamini stated, innovative applications have been and will continue to be the driving force for the further development of multiple comparisons methodology. Takeuchi outlined fundamental ideas and concepts of multiple comparisons. As elaborated by Takeuchi, many of these ideas have been proposed already in the 1970s and had a great impact on the Japanese statistical community. Takeuchi proposed a general principle for multiple decision processes that he illustrated with a procedure to determine the sign and ordering of normal means. Takeuchi also discussed the bias arising in estimation after selection. Unfortunately, however, his work published in his seminal book (Takeuchi, 1973) did not spread beyond Japan since it was published in Japanese. We are therefore very pleased that Professor Takeuchi accepted our invitation to contribute a review of these results together with new methodology on sequential approaches. In addition to the contributions by the two keynote speakers, this Special Issue contains nine peer-reviewed papers out of 18 submissions. Seven of the accepted papers are from the field of clinical trials with four of them related to adaptive designs. Wang, Hung and O'Neil investigated the inflation of the family-wise error rate in adaptive designs with treatment selection at interim, where the final test strategy does not account for the number of candidate treatments at the first stage. In the papers by Luo, Wu and Xiong and Bebu, Luta and Dragalin new methods to address the problem of estimation after selection are proposed. Padmanabhan and Dragalin propose a combined D- and c-optimality criterion for adaptive dose ranging studies and improve the estimation of dose–response and the identification of the minimum effective dose. Hung and Wang discuss more generally the challenges in regulatory practices to multiple testing problems such as multiple doses and endpoints, non-inferiority and superiority, time of onset of a treatment effect and so on. Glimm and Läuter discuss a directional test for multiple endpoints in the two sample problem and propose two methods improving the classical approach. Imada and Yamamoto consider the same problem but in Dunnett's setting and propose the approximate likelihood ratio test approach. On the other hand Zhao, Wang and Cui discuss the basic consistency problems in multiple testing procedures (MTP). They propose a general framework consisting of several adjustment methods to construct strongly consonant and coherent MTP. Catelan, Lagazio and Biggeri applied the hierarchical Bayesian modeling to the problem of mapping the standard mortality ratio for lung cancer among males in Tuscany, Italy, and describe how to estimate the posterior classification probabilities. Through this editorial process, we were impressed by the high number and quality of submissions. Emphasis was put on the reproducible research aspect (Hothorn et al., 2009), and for many of the papers computer code is available as Supporting Information. We wish to thank all reviewers for completing the difficult task in a limited time. This Special Issue continues the tradition of the past MCP conferences (Tel Aviv, 1996; Berlin, 2000; Bethesda, 2002; Shanghai, 2005; Vienna, 2007), which resulted in special issues with selected papers from the meetings (Benjamini et al., 1999; Bauer et al., 2001; Westfall and Tamhane, 2003; Bretz et al., 2007; Posch et al., 2008). Apart from the scientific program of the MCP 2009 in Tokyo we cannot forget the Japanese traditional atmosphere around the conference venue as well as the very nice timing of flowering of the cherry blossoms. Finally, we look forward to the next MCP that will take place in Washington, DC, in September 2011.