Position Of Organs Research Articles

Design of Government Organs to Achieve Regulatory Reform in Indonesia: Learning from Malaysia and Vietnam

In an attempt to reform regulation in Indonesia, this study looks at best practice designs that have been adopted in Malaysia and Vietnam in order to determine the optimum government organ in the field of law. Indonesia ought to take a cue from the successful regulatory reform initiatives in Malaysia and Vietnam and establish dedicated agencies that have enhanced the calibre of legislation and regulations. This essay uses a normative legal approach that is descriptive as well as prescriptive. The talk explains how government bodies that deal with a variety of laws are designed to meet the specific demands of the several nations that make up the group. Vietnam adopts the institution's design, which is the assembly in the field of laws and regulations, which holds the position of the highest representative organ, while Malaysia adopts the design of a particular institution with the primary function of guaranteeing the entire process of forming laws and regulations that apply centrally. As per Law Number 15 of 2019 regarding Amendments to Law Number 12 of 2011 regarding the Establishment of Legislation, Indonesia is recommended to establish ministries or institutions whose specific design and existence must be determined as close to the center of government as possible.

The interaction between heterochrony and mechanical forces as main driver of floral evolution.

Heterochrony acts as a fundamental process affecting the early development of organisms in creating a subtle shift in the timing of initiation or the duration of a developmental process. In flowers this process is linked with mechanical forces that cause changes in the interaction of neighbouring floral organs by altering the timing and rate of initiation of organs. Heterochrony leads to a delay or acceleration of the development of neighbouring primordia, inducing a change in the morphospace of the flowers. As changes in the timing of development may affect organs differently at different stages of development, these shifts eventually lead to major morphological changes such as altered organ positions, fusions, or organ reductions with profound consequences for floral evolution and the diversification of flowers. By concentrating on early developmental stages in flowers it is possible to understand how heterochrony is responsible for shifts in organ position and the establishment of a novel floral Bauplan. However, it remains difficult to separate heterochrony as a process from pattern, as both are intimately linked. Therefore it is essential to connect different patterns in flowers through the process of developmental change.Examples illustrating the importance of heterochronic shifts affecting different organs of the flower are presented and discussed. These cover the transition from inflorescence to flower through the interaction of bracts and bracteoles, the pressure exercised by the perianth on the androecium and gynoecium, the inversed influence of stamens on petals, and the centrifugal influence of carpels on the androecium. Different processes are explored, including the occurrence of obdiplostemony, the onset of common primordia, variable carpel positions, and organ reduction and loss.

First case of a reversed Parabothus taiwanensis Amaoka & Shen, 1993 from Taiwan (Pleuronectiformes: Bothidae), with first evidence of situs inversus viscerum in bothid.

Reversed condition is rarely found in most flatfishes in natural environment, except for some certain species. The mechanism controlling the reversals in flatfishes has been studied in some cultivated species, whereas some have only few cases for the entire family and remain unclear. Here, we report the first record of a dextral (reversed) specimen of Parabothus taiwanensis Amaoka & Shen, 1993 collected off southwestern Taiwan recently. It represents the second reversed case ever recorded in Bothidae. We aim to provide a detailed description of this dextral specimen and compared to the sinistral (normal) specimens collected from the vicinity. Specimens were fixed in 4% formaldehyde and transferred to 70% ethanol for preservation. Meristic and morphometric characters were examined for both dextral and sinistral specimens. Dissections were made on specimens to confirm the position of internal organs. Lastly, X-radiographs were taken to elucidate the osteological features. As a result, no differences of both meristic and morphometric characters were observed between the dextral and sinistral specimens. Nevertheless, situs inversus viscerum is discovered in the dextral specimen for the first time in Bothidae and the sixth record within flatfishes.

Roles and mechanisms of biomechanical-biochemical coupling in pelvic organ prolapse.

Pelvic organ prolapse (POP) is a significant contributor to hysterectomy among middle-aged and elderly women. However, there are challenges in terms of dedicated pharmaceutical solutions and targeted interventions for POP. The primary characteristics of POP include compromised mechanical properties of uterine ligaments and dysfunction within the vaginal support structure, often resulting from delivery-related injuries. Fibroblasts secrete extracellular matrix, which, along with the cytoskeleton, forms the structural foundation that ensures proper biomechanical function of the fascial system. This system is crucial for maintaining the anatomical position of each pelvic floor organ. By systematically exploring the roles and mechanisms of biomechanical-biochemical transformations in POP, we can understand the impact of forces on the injury and repair of these organs. A comprehensive analysis of the literature revealed that the extracellular matrix produced by fibroblasts, as well as their cytoskeleton, undergoes alterations in patient tissues and cellular models of POP. Additionally, various signaling pathways, including TGF-β1/Smad, Gpx1, PI3K/AKT, p38/MAPK, and Nr4a1, are implicated in the biomechanical-biochemical interplay of fibroblasts. This systematic review of the biomechanical-biochemical interplay in fibroblasts in POP not only enhances our understanding of its underlying causes but also establishes a theoretical foundation for future clinical interventions.

New deep-sea species of Aborjinia (Nematoda, Leptosomatidae) from the North-Western Pacific: an integrative taxonomy and phylogeny.

Marimermithid nematodes parasitising invertebrates are mainly found in the deep-sea environments. Several adult and juvenile specimens marimermithids of the genus Aborjinia have been found in bottom sediments and inside Polychaeta during recent cruises to the Kuril-Kamchatka trench and the Kuril Basin (the Sea of Okhotsk). New species are described based on integrative study. Aborjiniaprofundasp. nov. differs from A.eulagiscae by the location of the ventral gland cell bodies (posterior to the nerve ring vs posterior to the cardia), by the smaller body size (23-28 mm vs 103-132 mm) and shorter tail (193-263 µm vs 500-850 µm). BI and ML phylogenetic analyses based on 18S and 28S rDNA suggest that genus Aborjinia belongs to the family Leptosomatidae. Based on molecular and morphological characters the new genus Paraborjiniagen. nov. is proposed for A.corallicola. Within the family Leptosomatidae the new genus differs from all genera except Aborjinia by its endoparasitic lifestyle and hologonic ovaries. Paraborjiniagen. nov. differs from Aborjinia by the position of cephalic sensitive organs (outer labial and cephalic papillae in two separate circles vs outer labial and cephalic papillae in one circle) and by the parasitic adult (vs free-living in Aborjinia).

Anatómia a ekonómia

Anatomy is the science of the structure of the human body, its structure, position and location of internal organs. It interconnects all fields of medicine and forms the basis of most of them. Economics explains the system in which man lives his life. It interconnects scientific disciplines that are related to his daily decisions and forms the basis of sciences such as management, marketing, finance, economic policy. Anatomy is part of education from an early age. Even as small children, we learn to recognize how our body works, our parents´ guide us to be careful about falls and catching a cold. Few people are doctors, nurses, or pharmacists (these and similar professions require thorough and long-term study of anatomy), but each of us spends our whole life trying to get to know and understand our own body and make decisions that strengthen our health. The economy is similar. Early man already understood that he would not survive if he did not have water and food. On the one hand needs, on the other limited resources. The aim of the post is to point out that knowing the principles of our body's functioning is just as important as knowing the system in which we make economic decisions. We learn both anatomy and economics with our lives every day. We have enough comprehensible sources for the study of anatomy, including systematic education from preschool age, but we cannot say the same about economics.

Pelvic floor dysfunction in postpartum women: A cross-sectional study.

Pelvic floor dysfunction (PFD) is a disease of weakened pelvic floor support tissues, leading to changes in the pelvic organ position and function of pelvic organs, with long-term effects on women. This study aimed to assess pelvic floor function using electrophysiology and clinical symptoms, exploring the risk factors for PFD one month postpartum. This cross-sectional study included 845 women from postpartum outpatient clinic of Nantong Affiliated Hospital from August 2019 to October 2021. Pelvic floor muscle strength was evaluated via pelvic floor surface electromyography. Clinical symptoms (urinary incontinence (UI) and pelvic organ prolapse) were diagnosed by gynecologists. Sociodemographic, pregnancy, and obstetrical data were obtained from self-reported questionnaires and electronic records. The study identified maternal age, parity, immigrant status, and economic income as factors were related to PFD. Gestational constipation increased the risk of abnormal resting muscle strength (OR:1.553, 95%CI: 1.022-2.359). Cesarean delivery was associated with higher rates of abnormal resting muscle strength than vaginal delivery (post-resting stage: OR, 2.712; 95% CI, 1.189-6.185), but a decreased incidence of UI (OR: 0.302; 95% CI, 0.117-0.782). Increased gestational weight gain was correlated with a greater risk of developing UI (OR:1.030, 95%CI: 1.002-1.058). Women with vaginal inflammation faced a higher risk of abnormal fast-twitch muscle (OR: 2.311, 95%CI: 1.125-4.748). In addition to uncontrollable factors like mode of delivery, age, and parity, interventions targeting weight gain and constipation during pregnancy and vaginal flora could mitigate the risks of PFD. Educational programs for pregnant women should emphasize a proper diet and lifestyle. For women with vaginal inflammation, clinical treatment should be carried out as soon as possible to avoid further aggravating the damage to the pelvic floor muscles.

Emergence of a left-right symmetric body plan in vertebrate embryos.

External bilateral symmetry is a prevalent feature in vertebrates, which emerges during early embryonic development. To begin with, vertebrate embryos are largely radially symmetric before transitioning to bilaterally symmetry, after which, morphogenesis of various bilateral tissues (e.g somites, otic vesicle, limb bud), and structures (e.g palate, jaw) ensue. While a significant amount of work has probed the mechanisms behind symmetry breaking in the left-right axis leading to asymmetric positioning of internal organs, little is known about how bilateral tissues emerge at the same time with the same shape and size and at the same position on the two sides of the embryo. By discussing emergence of symmetry in many bilateral tissues and structures across vertebrate model systems, we highlight that understanding symmetry establishment is largely an open field, which will provide deep insights into fundamental problems in developmental biology for decades to come.

Research on the leading position of procuratorial organs in the process of applying the leniency system of guilty plea

Research on the leading position of procuratorial organs in the process of applying the leniency system of guilty plea

Advancements in artificial intelligence for pelvic floor ultrasound analysis.

Pelvic floor ultrasound provides a clear depiction of pelvic floor structures and their spatial anatomical relationships, enabling enhanced observation of pelvic organ function and position. The integration of artificial intelligence (AI) into medical imaging has revolutionized the automatic analysis of imaging data, offering efficient and accurate preprocessing and analysis. This technological advance addresses challenges associated with traditional pelvic floor ultrasound, such as reliance on operator's experience, time-intensive manual measurements, and significant potential for human error. Current AI applications in pelvic floor ultrasound encompass automatic measurement of the angle of progress (AOP), automatic segmentation of the levator hiatus (LH), and automatic identification of the levator ani muscle (LAM). AI excels in mimicking human analysis, distilling patterns from reorganized data. This paper, grounded in a comprehensive literature review, outlines the principal aspects of pelvic floor ultrasound and its augmentation through AI, highlighting the application value and progress of AI in this field.

Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function.

Heart development is a complex process that requires asymmetric positioning of the heart, cardiac growth and valve morphogenesis. The mechanisms controlling heart morphogenesis and valve formation are not fully understood. The pro-convertase FurinA functions in heart development across vertebrates. How FurinA activity is regulated during heart development is unknown. Through computational analysis of the zebrafish transcriptome, we identified an RNA motif in a variant FurinA transcript harbouring a long 3' untranslated region (3'UTR). The alternative 3'UTR furina isoform is expressed prior to organ positioning. Somatic deletions in the furina 3'UTR lead to embryonic left-right patterning defects. Reporter localisation and RNA-binding assays show that the furina 3'UTR forms complexes with the conserved RNA-binding translational repressor, Ybx1. Conditional ybx1 mutant embryos show premature and increased Furin reporter expression, abnormal cardiac morphogenesis and looping defects. Mutant ybx1 hearts have an expanded atrioventricular canal, abnormal sino-atrial valves and retrograde blood flow from the ventricle to the atrium. This is similar to observations in humans with heart valve regurgitation. Thus, the furina 3'UTR element/Ybx1 regulon is important for translational repression of FurinA and regulation of heart development.

Homology of the head sensory structures between Heterotardigrada and Eutardigrada supported in a new species of water bear (Ramazzottiidae: Ramazzottius)

Phylum Tardigrada is represented by microscopic eight-legged panarthropods that inhabit terrestrial and marine environments. Although tardigrades are emerging model animals for areas of research including physiology, evolutionary biology, and astrobiology, knowledge of their external morphology remains insufficient. For instance, homologies between marine and terrestrial relatives largely remain unexplored. In the present study we provide detailed pictures of the head sensory organs in a new tardigrade, Ramazzottius groenlandensis sp. nov. Specimens were collected from a mixed moss and lichen sample on Ella Island, East Greenland. The new species differs from congeneric species in the presence of polygonal sculpturing on the dorsal cuticle, which is accentuated in the posterior region of the body, a lateral papilla on leg IV, and distinctive egg morphology. A Bayesian phylogenetic analysis (18S rRNA + 28S rRNA + COI) places the new species within the genus Ramazzottius with high confidence. Interestingly, the new species shows a full set of well-developed cephalic organs, which correspond to all sensory fields found in eutardigrades. Details on the full set of head organs were present only for heterotardigrades. The surface of these organs is covered with small pores, which presumably play a sensory role. This discovery suggests the homology of head sensory structures between heterotardigrades and eutardigrades, implying that the distinctive arrangement and positioning of sensory organs on the head is a plesiomorphic feature of tardigrades. Moreover, we find that the Ramazzottius oberhaeuseri morphotype forms a morphogroup, not a monophyletic species complex.

The internal anatomy of the scale mite Pterygosoma pseudotrapelus (Trombidiformes, Pterygosomatidae)

This study is the first description of the internal anatomy of the scale mites using the example of parasitizing Pterygosoma pseudotrapelus (Bochkov et al., 2009) – a parasite of agamid lizards. Data on histology of the integument, digestive tract, excretory organs, prosomal glands, tracheae, and body-cavity tissues of females, supplemented by the ultrastructure of major organs, are discussed in comparison with information from other groups of the Acari. The female reproductive system was examined only at the light microscopic level. The shape of mite body is adapted to the existence under the scales of the reptile, where the parasite spends its entire life. The width of the adult females is nearly twice their length, resulting in the eccentric position of certain internal organs: the large reproductive system is oriented across the body, so that the ovary with developing oocytes occupies the right side of the idiosoma, while oviduct, seminal receptacle, and vagina are displaced to the left. The structure of the tracheal system and the podocephalic complex of P. pseudotrapelus is similar to that of Tetranychoidea, a group also regarded as one of the lower taxa in the cohort Raphignathina. A number of previously unknown primitive traits identified in the study confirm a relatively basal position of the scale mites within Raphignathina. These include a panoistic ovary, the postcolon instead of an excretory organ of more advanced forms, and 2 pairs of podocephalic acinar glands against the general trend of their reduction in this cohort. An unpaired tracheal gland was found independent from the podocephalic system. The coxal glands lack a filtering sacculus and their epithelium forms mutual interdigitations with the surrounding modified ventricular wall.

A Heart Image Segmentation Method Based on Position Attention Mechanism and Inverted Pyramid

In the realm of modern medicine, medical imaging stands as an irreplaceable pillar for accurate diagnostics. The significance of precise segmentation in medical images cannot be overstated, especially considering the variability introduced by different practitioners. With the escalating volume of medical imaging data, the demand for automated and efficient segmentation methods has become imperative. This study introduces an innovative approach to heart image segmentation, embedding a multi-scale feature and attention mechanism within an inverted pyramid framework. Recognizing the intricacies of extracting contextual information from low-resolution medical images, our method adopts an inverted pyramid architecture. Through training with multi-scale images and integrating prediction outcomes, we enhance the network’s contextual understanding. Acknowledging the consistent patterns in the relative positions of organs, we introduce an attention module enriched with positional encoding information. This module empowers the network to capture essential positional cues, thereby elevating segmentation accuracy. Our research resides at the intersection of medical imaging and sensor technology, emphasizing the foundational role of sensors in medical image analysis. The integration of sensor-generated data showcases the symbiotic relationship between sensor technology and advanced machine learning techniques. Evaluation on two heart datasets substantiates the superior performance of our approach. Metrics such as the Dice coefficient, Jaccard coefficient, recall, and F-measure demonstrate the method’s efficacy compared to state-of-the-art techniques. In conclusion, our proposed heart image segmentation method addresses the challenges posed by diverse medical images, offering a promising solution for efficiently processing 2D/3D sensor data in contemporary medical imaging.

Laparoscopic Treatment of Bladder Prosthesis Exposure

Genital prolapse surgery is a functional surgery aimed at restoring the anatomical position and functions of the pelvic organs. Currently, the gold standard is laparoscopic surgery with a polypropylene prosthesis. This is functional surgery involving the interposition of strips and their fixation to the spine. This technique avoids the need for a vaginal opening and is therefore less prone to infectious complications and prosthesis exposure. Exposure of the prosthesis several years after insertion calls for monitoring. We present the case of a patient operated on at our level for genital prolapse using the laparoscopic lateral suspension technique, with exposure of the sling three years after insertion. We describe the various lesions found and the therapeutic strategy.

Multi-scale context UNet-like network with redesigned skip connections for medical image segmentation

Background and ObjectiveMedical image segmentation has garnered significant research attention in the neural network community as a fundamental requirement for developing intelligent medical assistant systems. A series of UNet-like networks with an encoder-decoder architecture have achieved remarkable success in medical image segmentation. Among these networks, UNet2+ (UNet++) and UNet3+ (UNet+++) have introduced redesigned skip connections, dense skip connections, and full-scale skip connections, respectively, surpassing the performance of the original UNet. However, UNet2+ lacks comprehensive information obtained from the entire scale, which hampers its ability to learn organ placement and boundaries. Similarly, due to the limited number of neurons in its structure, UNet3+ fails to effectively segment small objects when trained with a small number of samples. MethodIn this study, we propose UNet_sharp (UNet#), a novel network topology named after the “#” symbol, which combines dense skip connections and full-scale skip connections. In the decoder sub-network, UNet# can effectively integrate feature maps of different scales and capture fine-grained features and coarse-grained semantics from the entire scale. This approach enhances the understanding of organ and lesion positions and enables accurate boundary segmentation. We employ deep supervision for model pruning to accelerate testing and enable mobile device deployment. Additionally, we construct two classification-guided modules to reduce false positives and improve segmentation accuracy. ResultsCompared to current UNet-like networks, our proposed method achieves the highest Intersection over Union (IoU) values ((92.67±0.96)%, (92.38±1.29)%, (95.36±1.22)%, (74.01±2.03)%) and F1 scores ((91.64±1.86)%, (95.70±2.16)%, (97.34±2.76)%, (84.77±2.65)%) on the semantic segmentation tasks of nuclei, brain tumors, liver, and lung nodules, respectively. ConclusionsThe experimental results demonstrate that the reconstructed skip connections in UNet successfully incorporate multi-scale contextual semantic information. Compared to most state-of-the-art medical image segmentation models, our proposed method more accurately locates organs and lesions and precisely segments boundaries.

Abdominal organ segmentation via deep diffeomorphic mesh deformations

Abdominal organ segmentation from CT and MRI is an essential prerequisite for surgical planning and computer-aided navigation systems. It is challenging due to the high variability in the shape, size, and position of abdominal organs. Three-dimensional numeric representations of abdominal shapes with point-wise correspondence to a template are further important for quantitative and statistical analyses thereof. Recently, template-based surface extraction methods have shown promising advances for direct mesh reconstruction from volumetric scans. However, the generalization of these deep learning-based approaches to different organs and datasets, a crucial property for deployment in clinical environments, has not yet been assessed. We close this gap and employ template-based mesh reconstruction methods for joint liver, kidney, pancreas, and spleen segmentation. Our experiments on manually annotated CT and MRI data reveal limited generalization capabilities of previous methods to organs of different geometry and weak performance on small datasets. We alleviate these issues with a novel deep diffeomorphic mesh-deformation architecture and an improved training scheme. The resulting method, UNetFlow, generalizes well to all four organs and can be easily fine-tuned on new data. Moreover, we propose a simple registration-based post-processing that aligns voxel and mesh outputs to boost segmentation accuracy.

Evaluation of organ and effective doses using anthropomorphic phantom: A comparison between experimental measurement and a commercial dose calculator

IntroductionThe aim of this study was to experimentally measure organ doses for computed tomography (CT) procedures using thermoluminescence dosimeters (TLDs) on a RANDO anthropomorphic phantom and verify the measured doses using CT-Expo software. MethodsThe phantom was irradiated using clinical CT scan protocols routinely used for specific procedures in the radiology department. Fifty TLD chips were used in this study. The scanning parameters (kVp, mA, s) used to scan the phantom were used as input parameters for CT-Expo dose estimations. ResultsThe TLD measured organ doses varied between 3.97 mGy for the esophagus and 56.22 mGy for the brain. High doses were recorded in the brain (37.80–56.22 mGy) and the eye lens (29.94–36.16 mGy). Comparing the organ dose measurements between TLD and CT-Expo, the maximum organ dose difference was obtained for the eye lens. A comparison between the two methods for the other organs were all less than 32 %. The effective doses from the TLD measurements for the head, chest, and abdominopelvic CT examinations were 2.78, 6.67, and 17 mSv, respectively and CT-Expo were 2.20, 10.30, and 16.70 mSv, respectively. ConclusionThe experimental and computational results are comparable, and the reliability of the TLD measurements and CT-Expo dose calculator has been proven. Implications for studyA reason for the difference in dose measurements between the two methods has been attributed to the dissimilarity in the organ position in the Rando anthropomorphic phantom and the standard mathematical phantom used by CT-Expo. The experimental and computational results have been found to be comparable.

The artistic nature in the 14th and 15th books of Galen’s <em>On the Usefulness of the Parts of the Body</em>

In the 14th and 15th books of the galenic work On the Usefulness of the Parts of the Body, dedicated to male and female reproductive organs and foetal development, the author presents nature (φύσις), the agent of the human body’s formation, as artistic and admirable, because it used an art (τέχνη) to make immortality possible, which consists in replacing one living being by another in an admirable way. Such an art is also related to a divine purpose, once nature’s action, possessing an intrinsic ability, is that of a demiurge. So, if, on the one hand, we have an artistic and practical nature, whose activity is proved by dissection and visible in the position and function of male and female reproductive organs, on the other, we have an abstract concept of the same nature, working to perpetuate humankind, but whose deepest and more abstract problems are not to be discovered nor solved in medical works such as On the Usefulness of the Parts of the Body. In this paper I will analyse how the concepts of φύσις and τέχνη relate to each other, by developing and deepening the role of nature as an artisan regarding the formation and function of the reproductive system and foetal development and its limits as such, pointing also the different subtleties of the concept.

New fluorescent auxin derivatives: anti-auxin activity and accumulation patterns in Arabidopsis thaliana

AbstractAuxin belongs among major phytohormones and governs multiple aspects of plant growth and development. The establishment of auxin concentration gradients, determines, among other processes, plant organ positioning and growth responses to environmental stimuli.Herein we report the synthesis of new NBD- or DNS-labelled IAA derivatives and the elucidation of their biological activity, fluorescence properties and subcellular accumulation patterns in planta. These novel compounds did not show auxin-like activity, but instead antagonized physiological auxin effects. The DNS-labelled derivatives FL5 and FL6 showed strong anti-auxin activity in roots and hypocotyls, which also occurred at the level of gene transcription as confirmed by quantitative PCR analysis. The auxin antagonism of our derivatives was further demonstrated in vitro using an SPR-based binding assay. The NBD-labelled compound FL4 with the best fluorescence properties proved to be unsuitable to study auxin accumulation patterns in planta. On the other hand, the strongest anti-auxin activity possessing compounds FL5 and FL6 could be useful to study binding mechanisms to auxin receptors and for manipulations of auxin-regulated processes.