Poor Exposure Research Articles

The relevance of the notion for all publicity is good publicity: The influencing factors in the 21st century

In the age of technology and a competitive market within the Philippines, an adverse stance or aftereffects of a situation have a significant impact on the sensibility of the audiences and are likely to prompt either positive or negative reactions from them. However, in the marketing and advertising sectors, the belief "All Publicity is Good Publicity" is well-known, which states that any form of publicity is fine as long as it cultivates presence and visibility. To be able to determine whether the notion is still highly appropriate in the 21st century and to provide a definite difference between good and bad publicity, the researchers have used a mixed-method approach and employed the use of quasi-experiment and short Focus Group Discussion (FGD) instruments for forty (40) participants under the Generation Z demographic group in Metro Manila. The researchers have also chosen six (6) business owners, advertisers, or managers within the metro for personal interviews in order to identify the perspective of both parties. Overall, the results show that the notion is no longer very relevant. According to the four influencing factors, defiance of advertising ethics does not always result in negative press, but non-compliance with corporate social responsibility (CSR), controversial advertising and situations, and corporate scandals do. It is important to highlight that every advertising or activity must be well-planned since there is a clear difference between good and poor exposure.

An embayment in the East Antarctic basement constrains the shape of the Rodinian continental margin

East Antarctic provinces lay at the heart of both Rodinian and Gondwanan supercontinents, yet poor exposure and limited geophysical data provide few constraints on the region’s tectonic evolution. The shape of the Mawson Continent, the stable nucleus of East Antarctica, is one of Antarctica’s most important, but contested features, with implications for global plate reconstructions and local tectonic models. Here we show a major marginal embayment 500–700 km wide, cuts into the East Antarctic basement in the South Pole region. This embayment, defined by new aeromagnetic and other geophysical data, truncates the Mawson Continent, which is distinct from basement provinces flanking the Weddell Sea. We favour a late Neoproterozoic rifting model for embayment formation and discuss analogies with other continental margins. The embayment and associated basement provinces help define the East Antarctic nucleus for supercontinental reconstructions, while the inherited marginal geometry likely influenced evolution of the paleo-Pacific margin of Gondwana.

Prevalence of Vitamin D Deficiency in Pregnant Ladies

Objective: To find out the prevalence of vitamin D deficiency (VDD) in pregnant ladies. Study Design: A cross-sectional study. Place and Duration of the Study: Department of Obstetrics & Gynecology, Sialkot Medical College, Sialkot Pakistan from 1st July 2021 to 30th December 2021. Methodology: We included a total of 165 pregnant women aged 18 to 40 years having singleton pregnancy with gestational age below 16 weeks. Three cc blood samples were taken during routine antenatal investigation from all pregnant ladies. The serum vitamin D was asked from the institutional laboratory. Prevalence of VDD, insufficiency and sufficiency were calculated. Results: In a total of 165 pregnant ladies, mean age was noted to be 30.2+5.5 years. There were 90 (54.5%) women who were living in rural areas. Sunlight exposure was less than 1 hour in 104 (63.0%) pregnant ladies. Ninety four (57.0%) women belonged to low socio-economic status. Evaluation of Vitamin D status revealed that 87 (52.7%) women had VDD, 52 (31.5%) vitamin D insufficiency while 26 (15.8%) had normal vitamin D levels. Sunlight exposure < 1 hour (p=0.0001) and low socio-economic status (p=0.0001) were noted to have significantly association with VDD. Conclusion: Among pregnancy ladies, prevalence of VDD was very high. Poor sunlight exposure and low socio-economic status were revealed to have significant association with VDD. Keywords: Pregnant, singleton, sunlight exposure, Vitamin D

Structural Setting of the Sixtymile Gold District, Yukon, Canada: Insights into Regional Deformation and Mineralization from Field Mapping and 3D Magnetic Inversion

The Sixtymile gold district, Yukon, Canada has been mined for placer gold since the late 19th century. However, increasing demand for gold has prompted exploration of new lode deposits. Previous studies in the nearby Klondike gold district have shown correlation between placer deposits and bedrock occurrences. Poor bedrock exposure and a complex deformation history, however, make it difficult to determine structural controls on gold mineralization. Through structural analysis involving mesoscopic-scale field observations of fractures, faults, foliation, and folds, and 3D geophysical inversion, the goal of this study was to determine the structural setting of the Sixtymile district to enhance discovery success. Structural measurements in the Glacier Creek, Miller Creek, Bedrock Creek, and Sixtymile River areas show the relationships among the orientations of foliation, fractures, and veins. In most localities, veins are found both parallel and at high angles to foliation, and there is generally a weaker correlation between fractures and veins compared to between foliation and veins. This correlation between foliation and veins is corroborated by inferred gold-bearing horizons from gold assay data. Outcrops of oblique reverse and strike-slip faults, possibly related to a larger-scale thrust-zone, and to the left-lateral Sixtymile-Pika Fault, respectively, were documented for the first time in this study. The results of the 3D probabilistic inversion of total magnetic intensity data for magnetic susceptibility show that magnetic susceptibility highs are preferentially associated with volcanics, but also point to possible intrusive bodies or hydrothermal alteration zones associated with mineralization. A geologic cross-section through the lithologies demonstrates highly variable deformation styles, including extensive folding, possibly indicative of a multiphase deformational history necessitating further, more detailed investigations of the area.

Mental Distress Associated with Air Quality Vulnerability During COVID-19

Yakima County, Washington is an area with prolonged exposure to poor air quality (PM 2.5) and has been one of the hardest hit counties in cases per capita of COVID-19 in the Western US. The physical health impacts of poor air quality exposure and COVID-19 have been well documented. However, the mental health impacts of these concurrent exposures are unknown. A pilot study (n=232) surveyed households using random-digit-dialing (RDD) in Yakima, County in Dec 2020-Jan 2021 to understand the spread of COVID-19 in vulnerable communities. Air quality behaviors and contexts including home filtration systems and use of community shelters during poor air quality events were measured. Mental distress was measured by the John Hopkins’s Mental Distress COVID-19 Community Response Survey. Descriptive data analysis along with Spearman’s rank correlation analysis were performed. Nearly half of the sample (45.3%) did not have access to air quality mitigation measures in their homes. The majority of the sample (54.3%) reported wanting to access clean air shelters during major air quality events such as the smoke and wildfire season of 2020. Participants who were unable to mitigate poor air quality in their households as well as those who were unable to access community clean air shelters were observed to have higher levels of mental distress (p<.05). This study adds to the body of evidence that environmental exposures play a significant role in mental health and that compounding impacts of climate change should be studied more in depth. Household interventions should be explored as COVID-19 has brought community protection measures to a halt, while climate change induced natural disasters will only increase in the future.

The association of socio-demographic and environmental factors with stunting among under-five children in Hawassa City, Sidama National Regional State, Ethiopia.

Undernutrition in children is a challenging problem in developing countries, including Ethiopia. Stunting is the most prevalent form of undernutrition. The majority of studies on childhood stunting and its associated factors focused on children, maternal and socioeconomic components. However, a few studies reported poor WaSH status and antibiotic exposure as environmental risk factors for child stunting, and the case of socio-demographic factors also lacks consistency. Concerning this, there is a lack of information in Ethiopia. Therefore, the present study assessed the association of socio-demographic, WaSH, and antibiotic exposure with stunting among under-five children. A cross-sectional study was conducted involving 340 mother-child pairs. Anthropometric data were collected using standard and calibrated height and weight scales. For factorial data, an interviewer-guided standard questionnaire was used. Logistic regression analyses were used to identify factors determining childhood stunting. In the present study, the prevalence of stunting, underweight and wasting was 14⋅7 % (95 % CI 10⋅9, 18⋅5), 4⋅4 % (95 % CI 2⋅4, 6⋅8) and 2⋅1 % (95 % CI 0⋅6, 3⋅5), respectively. Low dietary diversity, being born from a mother with an education level of secondary school, and belonging to a female-headed household were positively associated (P < 0⋅05) with stunting. The prevalence of overall undernutrition was lower (21⋅2 %) in the study area. Stunting was significantly associated with dietary diversity, maternal educational level and sex of households head. The government policy should focus on enhancing the dietary diversity of households, and encouraging women's education.

Use of Wound Closure Strips to Maximize Ocular Exposure during Cataract Surgery in Patients with Brow Ptosis

Draping is a critical step in successful cataract surgery. Poor exposure of the globe can result in limited access during surgery, thus making the surgeon's task more challenging. Additionally, eyelash exposure from underneath the drape can raise the risk of post-operative endophthalmitis [1]. Maintaining adequate exposure while also retracting the lashes appropriately is particularly challenging in patients with brow ptosis.

The role of managerial leadership in sickness absence in health and social care: antecedent or moderator in the association between psychosocial working conditions and register-based sickness absence? A longitudinal study based on a swedish cohort

BackgroundThe prevalence of sickness absence is particularly high among employees in health and social care, where psychosocial work stressors are pertinent. Managerial leadership is known to affect sickness absence rates, but the role leadership plays in relation to sickness absence is not fully understood; that is, whether poor leadership (i) is associated with sickness absence directly, (ii) is associated with sickness absence indirectly through the establishment of poor psychosocial working conditions, or (iii) whether good leadership rather has a buffering role in the association between work stressors and sickness absence.MethodsFour biennial waves from the Swedish Longitudinal Occupational Survey of Health (SLOSH, 2010–2016, N=2333) were used. Autoregressive cross-lagged analyses within a multilevel structural equation modelling (MSEM) framework were conducted to test hypotheses i)–iii), targeting managerial leadership, register-based sickness absence and psychosocial work stressors (high psychological demands, poor decision authority and exposure to workplace violence).ResultsA direct association was found between poor leadership and sickness absence two years later, but no associations were found between leadership and the psychosocial work stressors. Finally, only in cases of poor leadership was there a statistically significant association between workplace violence and sickness absence.ConclusionsPoor managerial leadership may increase the risk of sickness absence among health and social care workers in two ways: first, directly and, second, by increasing the link between workplace violence and sickness absence.

Gestational vitamin D3 supplementation and sun exposure significantly influence cord blood vitamin D status and 3-epi-25-hydroxyvitamin D3 levels in term newborns

Background and aimsHigh prevalence of hypovitaminosis D is worldwide reported among pregnant women and newborns. We assessed cord blood 25-hydroxyvitamin D3 [25(OH)D3] and 3-epi-25-hydroxyvitamin D3 (C3-epimer) levels in relation to assumed maternal risk factors for hypovitaminosis D. MethodsWe enrolled 246 term newborns during summer. 175/246 mothers were supplemented with a daily variable dosage (200–1,000 IU) of vitamin D3 during pregnancy. Cord blood 25(OH)D3 and C3-epimer concentrations were analyzed by high performance liquid chromatography tandem mass spectrometry. ResultsMedian cord blood 25(OH)D3 levels were 23.4 ng/mL (16.9–28.8). The prevalences of vitamin D sufficiency (≥ 30.0 ng/mL), insufficiency (20.0–29.9 ng/mL), and deficiency (< 20.0 ng/mL) were 19.9%, 45.9%, and 34.2%, respectively. Non-Caucasian ethnicity, housewife life, weight excess, negligible sun exposure and absent gestational vitamin D supplementation were associated with both reduced cord blood 25(OH)D3 and C3-epimer levels. C3-epimer/25(OH)D3 ratio was 15.1% (13.6%-18.4%) and it was not related to any of the assumed risk factors for hypovitaminosis D. ConclusionsCord blood vitamin D deficiency was common, particularly in newborns from mother not receiving vitamin D supplementation and with poor sun exposure. C3-epimer levels were high in cord blood, causing possible misclassification of vitamin D status if they were not distinguished from 25(OH)D3 concentrations.

Serum Vitamin D Status its Associated Health Problem in Children with PEM

Background: Vitamin D insufficiency is an overall scourge with late gauges showing that more prominent than 50 % of the worldwide populace is in danger. Protein-energy malnutrition is probably going to be related with nutrient D admission insufficiency. The point of this review was survey serum vitamin D and its related medical issue in youngsters with protein energy ailing health Vitamin D deficiency is on the rise as a major public health problem in India. Majority of the population in India resides in areas receiving ample sunlight throughout the year; still vitamin D deficiency is a problem of growing concern 1, 2, 3. Skin complexion, poor sun exposure, vegetarian food habits and lower intake of vitamin D fortified foods could be attributing to the high prevalence of VDD in India.&#x0D; Objective: To assess serum vitamin D status its associated health problem among children with protein energy malnutrition.&#x0D; Methods: Evaluatory study cross sectional research design used to assess serum vitamin D status its associated health problem in children with Protein energy malnutrition in selected hospital of Wardha. 40 sample size taken who fulfils the inclusion and exclusion criteria. Non probability convenience sampling is used.&#x0D; Expected Results: This study is planned to assess serum vitamin D its health problem in children with Protein energy malnutrition. Hence, it expected that significant association between serum vitamin D level and its health problem (Weakness, lethargy, pain, developmental delay, fracture).

Facile Synthesis of Carbon- and Nitrogen-Doped Iron Borate as a Highly Efficient Single-Component Heterogeneous Photo-Fenton Catalyst under Simulated Solar Irradiation.

The development of a heterogeneous catalyst for use in environmental remediation remains a challenging and attractive research endeavor. Specifically, for Fenton reactions, most research approaches have focused on the preparation of iron-containing heterostructures as photo-Fenton catalysts that utilize visible light for enhancing the degradation efficiency. Herein, the synthesis and novel application of C,N-doped iron borates are demonstrated as single-component heterogeneous photo-Fenton catalysts with high Fenton activity under visible light. Under the optimal conditions, 10 mg of the catalyst is shown to achieve effective degradation of 10 ppm methylene blue (MB) dye, Rhodamine B (RhB) dye, and tetracycline (TC) under simulated solar irradiation with a first-order rate constant of k = 0.218 min−1, 0.177 min−1, and 0.116 min−1, respectively. Using MB as a model system, the C,N-doped iron borate exhibits 10- and 26-fold increases in catalytic activity relative to that of the 50 nm hematite nanoparticles and that of the non-doped iron borate, respectively, in the presence of H2O2 under the simulated solar irradiation. Furthermore, the optimum reaction conditions used only 320 equivalents of H2O2 with respect to the concentration of dye, rather than the several thousand equivalents of H2O2 used in conventional heterogeneous Fenton catalysts. In addition, the as-prepared C,N-doped iron borate achieves 75% MB degradation after 20 min in the dark, thus enabling the continuous degradation of pollutants at night and in areas with poor light exposure. The stability and recyclability of C,N-doped iron borate for the oxidation of MB was demonstrated over three cycles with insignificant loss in photo-Fenton activity. The high Fenton activity of the C,N-doped iron borate is considered to be due to the synergistic action between the negatively-charged borate ligands and the metal center in promoting the Fenton reaction. Moreover, carbon and nitrogen doping are shown to be critical in modifying the electronic structure and increasing the conductivity of the catalyst. In view of its synthetic simplicity, high efficiency, low cost of reagents, and minimal cost of operation (driven by natural sunlight), the as-prepared heterogeneous single-component metal borate catalyst has potential application in the industrial treatment of wastewater.

Early effectiveness of robot-assisted total hip arthroplasty via direct superior approach

To evaluate the early effectiveness of the robot-assisted total hip arthroplasty (THA) via direct superior approach (DSA). Between March 2021 and April 2021, 11 patients (11 hips) were treated with a robot-assisted THA via DSA. There were 7 males and 4 females, with an average age of 55 years (range, 26-73 years). There were 5 patients of osteoarthritis secondary to hip dysplasia and 6 patients of osteonecrosis of femoral head. Preoperative hip Harris score was 55.8±6.3. The operation time, volume of blood loss, length of incision, postoperative blood transfusion and hospital stay, and the incidence of surgical complications were recorded. The visual analogue scale (VAS) score and Harris score were used to evaluate hip joint pain and function. The leg length discrepancy (LLD) was measured on the X-ray films. The inclination angle and anteversion angle of the acetabular component were also measured, and the difference between the planned and actual values were compared. One THA was performed via conventional posterolateral approach finally because of poor exposure. The rest of 10 THAs were performed with assistance of robotic arm via DSA. The average operation time was 89 minutes (range, 65-120 minutes); the average length of incision was 10.5 cm (range, 9-13 cm); and the average blood loss was 400 mL (range, 110-740 mL). One patient was given a blood transfusion for 2 unit. All incisions healed by first intention and no neurovascular injury, deep vein thrombosis, or fracture occurred. The length of hospital stay after operation was 2-6 days (mean, 4.4 days). The duration of follow-up was 1-3 months (mean, 2.1 months). The VAS score was 0 in 9 patients and 2 in 1 patient at the day of discharge. At last follow-up, the hip Harris score was 84.9±6.7, showing significant difference when compared with that before operation ( t=-8.717, P=0.000). The inclination and anteversion angles were (37.4±2.0)° and (17.1±4.5)°, respectively, and there was no significant difference when compared with the planned values [(38.2±1.6)°, (16.6±3.7)°] ( t=1.809, P=0.104; t=-1.103, P=0.299). The LLD ranged from -2 to 4 mm. No complication such as dislocation, aseptic loosening, or periprosthetic joint infection occurred. The robot-assisted THA via DSA has encouraged early effectiveness.

Atypical keratitis caused by Leifsonia aquatica with “cracked windshield” appearance and disabling ocular pain

Microbial keratitis is a potentially sight-threatening complication of contact lens (CL) wear. Microbiological investigations, close follow-up, and culture-guided treatment are mandatory to achieve a favorable outcome. Poor CL hygiene and exposure to contaminated water, associated with severe ocular pain, are hallmarks of Acanthamoeba keratitis (AK). However, AK is characterized by an insidious onset. We report a case of an acute onset CL-related keratitis associated with L. aquatica, a Gram-positive bacterium. A history of river water exposure and disabling ocular pain, which resembled AK but with unusual slit-lamp findings, made the diagnosis challenging.

Neuro-Ophthalmic Complications of Vestibular Schwannoma Resection: Current Perspectives.

Vestibular schwannomas (VSs), also called acoustic neuromas, are benign intracranial neoplasms of the vestibulocochlear (VIII) cranial nerve. Management options include “wait-and-scan,” stereotactic radiosurgery and surgical resection. Due to the proximity of the VIII nerve to the facial (VII) nerve in the cerebello-pontine angle, the VII nerve is particularly vulnerable to the effects of surgical resection. This can result in poor eye closure, lagophthalmos and resultant corneal exposure post VS resection. Additionally, compression from the tumor or resection can cause trigeminal (V) nerve damage and a desensate cornea. The combination of an exposed and desensate cornea puts the eye at risk of serious ocular complications including persistent epithelial defects, corneal ulceration, corneal vascularization, corneal melting and potential perforation. The abducens (VI) nerve can be affected by a large intracranial VS causing raised intracranial pressure (a false localizing sign) or as a result of damage to the VI nerve at the time of resection. Other types of neurogenic strabismus are rare and typically transient. Contralaterally beating nystagmus as a consequence of vestibular dysfunction is common post-operatively. This generally settles to pre-operative levels as central compensation occurs. Ipsilaterally beating nystagmus post-operatively should prompt investigation for post-operative cerebrovascular complications. Papilledema (and subsequent optic atrophy) can occur as a result of a large VS causing raised intracranial pressure. Where papilledema follows surgical resection of a VS, it can indicate that cerebral venous sinus thrombosis has occurred. Poor visual function following VS resection can result as a combination of all these potential complications and is more likely with larger tumors.

Cambrian and earliest Ordovician fauna and geology of the Sông Đà and adjacent terranes in Việt Nam (Vietnam)

AbstractLater Cambrian and earliest Ordovician trilobites and brachiopods spanning eight horizons from five localities within the Sông Mã, Hàm Rồng and Đông Sơn formations of the Thanh Hóa province of Việt Nam, constrain the age and faunal affinities of rocks within the Sông Đà terrane, one of several suture/fault-bounded units situated between South China to the north and Indochina to the south. ‘Ghost-like’ preservation in dolomite coupled with tectonic deformation leaves many of the fossils poorly preserved, and poor exposure precludes collecting within continuously exposed stratigraphic successions. Cambrian carbonate facies pass conformably into Lower Ordovician carbonate-rich strata that also include minor siliciclastic facies, and the recovered fauna spans several uppermost Cambrian and Lower Ordovician biozones. The fauna is of equatorial Gondwanan affinity, and comparable to that from South China, North China, Sibumasu and Australia. A new species of Miaolingian ‘ptychopariid’ trilobite,Kaotaia xuanensis, is described. Detrital zircon samples from Cambrian–Ordovician rocks of the North Việt Nam and Sông Đà terranes, and from Palaeozoic samples from the Trường Sơn sector of Indochina immediately to the south, contain a predominance of ages spanning the Neoproterozoic period and have a typical equatorial Gondwanan signature. We associate the Cambrian and Tremadocian of the Sông Đà terrane with areas immediately to the north of it, including the North Việt Nam terrane and the southern parts of Yunnan and Guangxi provinces of China.

Retrospective Study of the Epidemiological Profile of Facial Trauma Related to Violence.

Facial trauma is now considered an epidemic due to its high incidence. This type of injury represents an impact on the social, psychological and professional life of the victim. It may be associated with poor protection and exposure of this region of the body, as well as with the attempt to disfigure the face of victims of aggression, to affect their identity and self-image. This study aims to carry out an epidemiological survey on the profile of facial trauma related to violence at the First Aid Hospital of Porto Alegre from November 2015 to July 2016. In this retrospective descriptive cross-sectional study, data such as age and sex of the patient, type of trauma, anatomical region, etiology, and reasons for the aggression of patients' records were analyzed using the Chi-Square test in Paws Statistics 18 software, evaluating P < 0.05. During the period evaluated, 1224 cases were recorded. The most prevalent sex was male. The age group with the most injuries varied from 21 to 40. The most affected type of lesion was soft tissue injury. Scalp regions (parietal, occipital, temporal) and multiple regions were the most affected in males, differing from females, where the frontal and nasal regions were the most predominant. Violence is a major risk factor for facial trauma in adult patients and it is from epidemiological studies like this that we have the possibility to know the magnitude and severity of the results of violence, allowing the definition of public policies for coping.

DMD – ANIMAL MODELS: EP.81 Enhanced exon skipping and Dystrophin production in a mouse model of Duchenne muscular dystrophy with EEV-PMO treatment

Antisense oligonucleotide-induced (ASOs) exon skipping is a promising treatment strategy for Duchenne muscular dystrophy (DMD), an X-linked recessive and fatal neuromuscular disease. DMD is caused by mutations in the dystrophin gene and affects approximately 1 in 3,500-5,000 male births. By modulating the splicing of dystrophin pre-mRNA, ASOs can restore the mRNA reading frame and generate a truncated, functional dystrophin protein. This exon skipping approach can address ∼80% of the mutations that cause DMD. However, the poor exposure and endosomal escape in target tissue after systemic administration of ASOs remains the biggest hurdle for the treatment of patients with DMD and results in insufficient dystrophin protein restoration, especially in non-skeletal muscle tissues such as the heart. We have developed a novel ASO delivery system by conjugation of Entrada's proprietary Endosomal Escape Vehicle (EEVTM) to a phosphorodiamidate morpholino oligomer (PMO), an effective ASO for DMD treatment. The EEV is composed of a cyclic cell-penetrating peptide coupled with a nuclear localization sequence, which is rationally designed to facilitate intracellular delivery, endosomal escape and finally localization in the nucleus. The EEV-PMO significantly enhances the systematic delivery of PMOs and results in robust exon skipping and restoration of dystrophin protein in the mdx mouse model skeletal as well as cardiac muscle. A single dose (20 mg/kg) by intravenous administration of EEV-PMO led to >50% exon skipping and >15% correction of dystrophin protein in the heart seven days post injection, and dystrophin protein levels were sustained for up to four weeks. Repeat dosing (10 mg/kg, 4 QW) resulted in >30% of wild-type dystrophin protein in the heart and normalized serum creatine kinase level seven days post last injection. These results have confirmed the significant therapeutic potential of the EEV-PMO delivery system for DMD. Furthermore, these results demonstrate that EEVs can serve as a general and highly efficient delivery platform that possesses great potential for the delivery of other therapeutic ASOs beyond DMD.

Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes

The epidermal growth factor receptor inhibitor BIBX1382 has failed in drug development because of poor oral exposure and low bioavailability associated with its extensive metabolism by aldehyde oxidase (AOX) in humans. In this study, we investigated the metabolic profiles and pharmacokinetics of BIBX1382 in chimeric NOG-TKm30 mice with humanized liver (humanized liver mice). After intravenous and oral BIBX1382 administration, increased plasma clearance and decreased oral exposure together with high production of the predominant oxidative metabolite (M1, BIBU1476) and secondary oxidized metabolite (M2) were observed in humanized liver mice. Extensive oxidation rates of BIBX1382 were observed in hepatocytes from humanized liver mice and were suppressed by the typical human AOX1 inhibitors raloxifene and hydralazine. Liver cytosolic fractions from humans, humanized liver mice, cynomolgus monkeys, minipigs, and guinea pigs, but not fractions from dogs, rabbits, rats, and mice, displayed high BIBX1382 clearance and resulted in oxidative metabolite production. These results indicate that humanized liver mice have human-type AOX activity based on the transplanted human liver AOX1 function. Humanized liver mice can be considered an important animal model for understanding the metabolism and pharmacokinetics of AOX drug substrates.

Re‐Os Isotopic Age of Molybdenite of the Jingren Deposit and its Mineralogical Significance of Magnetite, Pyrite and Chalcopyrite

AbstractThe Jingren deposit is part of the Qimantage metallogenic belt within the eastern Kunlun orogenic belt, the largest metallogenic belt in Qinghai Province, northwestern China. Exploration data show that the metal resources of the Jingren deposit are greater than 93000 t in a mining area of 76.15 km2, which indicates significant exploration potential in the near future. Three W–E‐trending faults, F1‐3, dominate the extension of the mineralization zone, which consists of chalcopyrite, pyrite, magnetite, galena, sphalerite, and molybdenite as well as bismuth‐bearing minerals. The deposit contains a large amount of late Triassic intrusive rocks, however, previous research did not reach a consensus on the timing or the origin of the mineralization owing to a lack of geochronological data and poor exposure conditions. In the present study, Re‐Os isotopic dating from six molybdenite samples collected from a borehole of the granodiorite in the Jingren deposit using negative thermal ionization mass spectrometry (NTIMS) showed 187Re and 187Os concentrations of 0.26–4.40 ppm and 1.03–16.46 ppb, respectively, with an initial 187Os/188Os value of 0.06 ± 0.19. This proves that the Jingren deposit has a metallogenic age of (225 ± 4) Ma and is the product of united mineralization of the Qimantage metallogenic belt and that the Jingren deposit might actually be an Indosinian metallogeny. In addition, the Re content of these samples, at 0.42 ppm to 7.00 ppm shows that the mineralization was derived mainly from a crustal source. Furthermore, electron probe microanalysis (EPMA) conducted on chalcopyrite obtained from 22 metallic mineral samples revealed (Fe + Cu)/S ratios of 1.801–1.947 with an average of 1.852, which is lower than the ideal value (1.875). Besides, the main ore body formed in a relatively higher temperature environment than the surrounding rocks in the Jingren deposit. These data indicate that the Jingren deposit formed in a metallogenic environment at lower temperature. Moreover, according to the TiO2‐Al2O3‐(MgO + MnO) and TiO2‐Al2O3‐MgO genetic classification diagram for magnetite, the Jingren deposit most likely belongs to the skarn family. In addition, the Co‐Ni‐As genetic classification diagram of the pyrite indicates sedimentary and skarn genetic characteristics.

Implications of vitamin D Deficiency on Egyptian Adults’ Health

Aim: Highlighting some health consequences of hypovitaminosis D on adult Egyptian population.Methods: Fifty-five apparently healthy volunteers aged from 20 to 40 years were involved in the study and by history and physical examination 40 of them had mild clinical manifestation of negligible medical importance that affect the quality of their life without interfering with their daily activity. All volunteers were subjected to vitamin D and calcium dietary intake history, sun exposure assessment, body mass index (BMI), serum vitamin D and calcium profile, bone mineral density measured by Dual-energy X-ray absorptiometry (DXA), psychometric evaluation by the Beck Depression Inventory (BDI) score and physical activity evaluation by the International Physical Activity Questionnaire (IPAQ). Results: About 73% of our subjects had hypovitaminosis D (61.8% insufficient and 10.9% deficient). The prevalence was more in the female gender (OR 4.5; p≤ 0.05), older subjects (31-40) age group (OR 4.4; p≤ 0.05), with poor sun exposure (OR 7.8; p≤ 0.05), and low vitamin D and calcium dietary intake (OR 4.6; p≤0.05). Vitamin D deficient group showed the higher prevalence of obesity (45.5%). Osteopenia was detected in seven subjects (14.3%) who had low vitamin D levels. The vitamin D status had a negative correlation (r=-0.653; p=