Polyether Amine Research Articles

Synthesis of Polyetheramine Based Bonding Agents and Their Effect on Mechanical Properties of an AP/CL‐20/GAP Formulation

AbstractTwo types of bonding agents were synthesized based on polyetheramines (PEAs), which aim to increase the strain of AP/CL‐20/GAP formulation. The PEAs, terminated with cyano (CTPEA) and Schiff base (SBPEA) groups, were applied in the AP/CL‐20/GAP formulation, respectively. The results showed that the bonding agents TCN‐403 (CTPEA) and TBA‐403 (SBPEA), which were prepared from trifunctional PEA named as T‐403, could significantly increase the maximum elongation ratio of the formulation. The differences between the TCN‐403 and TBA‐403 were analyzed by DMA of the formulations, SEM of the coated fillers, and in‐situ tensile test, indicating that the Schiff base bonding agents can effectively inhibit the dewetting of the binder from the solid particles in the formulations.

Real‐time Raman spectroscopy measurements to monitor the effect of polypropylene crosslinking on its true mechanical behaviour

AbstractIn‐situ Raman spectroscopy analysis to mechanical tests were performed to investigate the deformation micromechanisms of an isotactic polypropylene‐grafted maleic anhydride (PP‐g‐MAH) depending on the crosslinking degree provided by functional polyether amine molecules. The switch from brittle to highly ductile mechanical behaviours was focused in terms of microstructure modifications in real time during stretching. From the Raman spectral analysis, crystallinity index and macromolecular chains orientation factors for both crystalline and amorphous phases were determined. A new orientation factor relative to the polyether segments was proposed. The results shown allow a more complete understanding of the proper micromechanisms of deformation involved in each phase and their interaction between one another. These results also highlight the impact of the crosslinking reaction on the material resilience improvement.

Synergistically optimizing interlaminar behavior of CFRP composites by simultaneously applying amino-rich graphene oxide to carbon fiber and epoxy matrix

In this study, graphene oxide (GO) with long flexible amino-rich structure, i.e., GO-COOH-T403, was prepared by grafting trifunctional polyether amine (T403) to the surface of in-situ carbonylated GO. The amino-rich GO nanosheets were employed to modify epoxy resin and fabricate multiscale carbon fiber (CF), respectively. Basing on that, carbon fiber reinforced polymer (CFRP) composites with superior interlaminar behavior were obtained via impregnating multiscale CF with the amino-rich GO modified epoxy. The interlaminar analysis indicated that simultaneously applying amino-rich graphene oxide to CF and epoxy matrix could effectively optimize the interlaminar properties of the resulting composites. Notably, the value of ILSS for multiscale CF reinforced amino-rich GO modified epoxy composites was 82.2 MPa and 32.6% higher than that single employed amino-rich GO into epoxy matrix or onto CF exhibiting a synergistic behavior. Therefore, this work was expected to provide new inspiration for developing high-performance CFRPs with excellent interlaminar properties.

Macromolecular-level polymer brush layer enabling geometric customization of lithium deposits

Dendrite formation is the major hurdle limiting the deployment of energy-dense Li-metal batteries, including the solid-state prototypes. Through grafting polyether amine (PEA) brushes onto reduced graphene oxide (RGO) sheets, here, we present precise control over the metallic deposits according to the preset two-dimensional (2D) geometry. The experiment and simulation results reveal that the lithiophilic ether groups of PEA not only induce uniform nuclei distribution but also tailor the ion migration pathway along the optimized polymer chain, enabling conformal deposits propagation via a bionic “seedling technology.” The regulated Li deposition behaviors are further demonstrated in an energy-dense battery (2.1 mAh, Li(Ni 0.85 Co 0.1 Al 0.05 )O 2 |PEA grafted RGO) and all-solid-state prototype (LiFePO 4 |PEA grafted RGO with composite electrolyte). Their encouraging cycle performance, coupled with the wide range of applicability, affords great potential to customize the geometry of Li deposits according to the preset orientations. The as-constructed all-solid-state battery exhibits superior interfacial stability The metallic nucleation and growth pattern are quantitatively controlled The diffusion pathways of Li ions are tailored by polymer brushes Uncontrolled Li dendrite growth significantly limits the cycle life of metallic batteries. In this work, Zhang et al. realize control over the metallic deposits by constructing a polymer-brush layer on a preset substrate. The all-solid-state cell incorporating the customized Li anode exhibits superior interfacial properties and cycling stability.

Effects of chain length of polyether amine on interfacial adhesion of carbon fiber/epoxy composite in the absence or presence of polydopamine bridging platform

To understand the complementary mechanisms between molecular interlocking and covalent interconnection that affects interfacial shear strength (IFSS), the adherence of polyether amine with varying chain length onto the surface of carbon fiber in the absence or presence of bio-derived adhesive polydopamine (PDA) as a bridge was subtly designed and studied. Without PDA, up to 25.6% and 34.7% increases in IFSS relative to untreated CF was achieved respectively for shorter and longer molecular chain of polyether amine. The longer chain length encourages molecular interlocking with epoxy molecules and produces a higher penetration depth into epoxy matrix, thus giving a larger increase in IFSS. In the presence of PDA, 39–42% IFSS increase by analogy to CF is observed due to the synergistic effects of hybrid interfacial interactions, the increasing rigidity of interphase and the improved wetting behavior. While, in this case, impact of chain length becomes less noticeable, which is mainly attributed to the trade-off between the enhanced chemical cross-linking points and the less molecular entanglement with resin.

Molecular simulation of polyether amines intercalation into Na-montmorillonite interlayer as clay-swelling inhibitors

Polyether amines (PEA) have been widely used in water-based drilling fluids (WBDFs) to prevent the clay swelling and maintain the wellbore stability during the drilling process due to its excellent inhibition performance and low toxicity towards the environment. Understanding the intercalation behavior of PEA within clay interlayer is of great significance to disclose the inhibition mechanism and design high-performance drilling fluid additives. In this work, molecular dynamic (MD) simulations are applied to investigate the arrangement and dynamic properties of neutral PEA (N-PEA) and protonated PEA (P-PEA) within Na-montmorillonite (MMT) interlayer in the presence of one, two and three layer water content. We found that the N-PEA molecules tend to interact with clay surface with the –NH2 groups and a stronger interaction between –NH3+ groups and clay surface is observed when 33% Na+ is replaced by P-PEA molecules. While for the scenario with 66% Na+ is substituted by P-PEA molecules, the –NH3+ groups prefer to distribute in the middle of the pore hydrating with water molecules. The N-PEA molecules are likely to form a crown-like structure wrapping Na+ inside which is detrimental for the water invasion into clay layer. Based on the analysis of Na+ distribution in MMT layer, it is observed that the introduction of P-PEA molecules replace the Na+ in the middle of the pore first and followed by the surface Na+. Both of the N-PEA and P-PEA molecules are capable of forming hydrogen bonding (H-bonding) with MMT surface reducing the propensity of MMT to attract water. Furthermore, the minimum H-bonding number between MMT and P-PEA molecules is observed when 66% Na+ is exchanged due to strong water-PEA interaction. In addition, the inhibition mechanisms of neutral PEA molecules by forming PEA-Na+ complexes to cut off the connection between Na+ and water molecules is similar for different water contents. Our study provides important insights into the structural properties of PEA molecules within MMT interlayer and clay inhibition mechanism of PEA.

Investigation into the Impact of the Composition of Ethanol Fuel Deposit Control Additives on Their Effectiveness

An increasing percentage of ethanol in fuel leads to significant changes in polarity and solubility, which makes conventional gasoline deposit control additives (DCAs) difficult to dissolve in ethanol fuels, resulting in the formation of deposits on engine elements. Critical areas of deposit formation in an engine are constituted by inlet valves, combustion chambers, and fuel injectors. As a consequence, operational parameters of the engine are disturbed to a large extent by the total effect of the deposits. To prevent the aforementioned phenomena, in the operation of engines fueled with ethanol-containing blends, it is necessary to use specifically prepared DCAs. The paper briefly presents a process of development of DCAs dedicated to high-ethanol fuels. Each of the prepared DCA formulations contained a substance having detergent-emulsifying properties (referred to in the text as DEM), a carrier oil, and a solvent. The composition and ratios of components used in the DCA, by testing their effectiveness in engine deposit formation, are verified. A motor station and a test procedure developed for this purpose were used. In search of alternative solutions to conventional polyisobutyleneamines (PIBA) and polyetheramines (PEA) surfactants, which have good solubility in hydrocarbons but not in ethanol, a substance with a benzoxazine structure and a Mannich base were synthesized. Their chemical structures were confirmed by nuclear magnetic resonance (NMR) DCAs were developed, and the effectiveness of their action was verified. Moreover, attention was paid to the dosage level of the DEM and the carrier oil in the DCA. Finally, it was confirmed in the studies carried out that DCAs used for improvement of conventional hydrocarbon engine gasolines are not efficient enough when used in E85 fuels. In the case of the latter, DCAs that have been specifically developed for such fuels should be used, because they have a different chemical structure, and are soluble in the ethanol-gasoline mixture in any ratio of both components.

Remarkably improved interfacial adhesion of pitch-based carbon fiber composites by constructing a synergistic hybrid network at interphase

Ultralow interfacial adhesion of pitch-based carbon fiber composites has always a disturbing problem in reality since the fiber surface is of high graphite degree. Herein, a novel strategy for remarkably increasing the interfacial shear strength (IFSS) of composites via incorporating silane coupling agent (APTES)-polydopamine (PDA) -polyether amine (PEA) ternary organic materials on fiber surface is reported. Due to the solid connection of pitch-based carbon fiber with APTES-PDA-PEA through previous carboxylation and hydroxylation, as well as the increased surface energy and improved wettability, a synergistic hybrid network is formed at the interphase, where various interfacial interactions, including covalent bonding, hydrogen bonding, π-π conjugated bonding and intermolecular entanglement, cooperate with each other. The IFSS of modified fiber composites exhibits an amazing 427.7% increase, much higher than publicly reported pitch-based carbon fiber composites (20.3%~235.1%). The findings in this article offer a unique insight on the design of synergistic hybrid bridging transition strategy addressing the weak interphase in pitch-based carbon fiber composites.

An Efficiently Reworkable Thermosetting Adhesive Based on Photoreversible [4+4] Cycloaddition Reaction of Epoxy‐Based Prepolymer with Four Anthracene End Groups

AbstractThe solid–liquid phase transition is always the key to the design and preparation of reworkable adhesives. However, an efficient photoinduced reworkable thermosetting adhesive at room temperature remains a challenge. Here, a photoinduced reworkable thermosetting adhesive of epoxy‐based prepolymer with four anthracene end groups are prepared. The highly active light‐induced [4+4] cycloaddition and depolymerization, as well as a large number anthracene groups endow this adhesive with high optical activity. Soft segments of polyether amines are used to adjust glass transition temperature of these cross‐linked networks which is significant for highly efficient solid–liquid phase transition of photoinduced reworkable adhesive at room temperature. As a reworkable adhesive, the obtained AER/D2000 exhibits desirable viscosity, lap shear strength up to 2.4 MPa for quartz glass substrate in the cross‐linked state, and ideal reworkable efficiency as high as 91.7%. Therefore, this research provides a strategy for a photoinduced reworkable adhesive, and as an alternative for heat‐induced reworkable adhesives.

Novel Bionanocompounds: Outer Membrane Protein A and Lacasse Co-Immobilized on Magnetite Nanoparticles for Produced Water Treatment.

The oil and gas industry generates large amounts of oil-derived effluents such as Heavy Crude Oil (HCO) in water (W) emulsions, which pose a significant remediation and recovery challenge due to their high stability and the presence of environmentally concerning compounds. Nanomaterials emerge as a suitable alternative for the recovery of such effluents, as they can separate them under mild conditions. Additionally, different biomolecules with bioremediation and interfacial capabilities have been explored to functionalize such nanomaterials to improve their performance even further. Here, we put forward the notion of combining these technologies for the simultaneous separation and treatment of O/W effluent emulsions by a novel co-immobilization approach where both OmpA (a biosurfactant) and Laccase (a remediation enzyme) were effectively immobilized on polyether amine (PEA)-modified magnetite nanoparticles (MNPs). The obtained bionanocompounds (i.e., MNP-PEA-OmpA, MNP-PEA-Laccase, and MNP-PEA-OmpA-Laccase) were successfully characterized via DLS, XRD, TEM, TGA, and FTIR. The demulsification of O/W emulsions was achieved by MNP-PEA-OmpA and MNP-PEA-OmpA-Laccase at 5000 ppm. This effect was further improved by applying an external magnetic field to approach HCO removal efficiencies of 81% and 88%, respectively. The degradation efficiencies with these two bionanocompounds reached levels of between 5% and 50% for the present compounds. Taken together, our results indicate that the developed nanoplatform holds significant promise for the efficient treatment of emulsified effluents from the oil and gas industry.

Application of polyether amine intercalated graphene oxide as filler for enhancing hydrophobicity, thermal stability, mechanical and anti-corrosion properties of waterborne polyurethane

Waterborne polyurethane (WPU) composites containing polyether amine functionalized graphene oxide (PAFG) were successfully fabricated via the in situ polymerization. The hydrophobicity, thermal stability, mechanical and anti-corrosion properties of WPU and WPU composites were investigated. As a result, the properties of WPU composites, such as hydrophobicity, thermal stability, mechanical and anti-corrosion properties were all enhanced when an appropriate concentration of nanoparticles were grafted. The content of PAFG was 0.05 wt%, the water contact angle and water absorption content were up to 98.5° and 3.01 wt% of WPU composite compared to that of pure WPU (70.5° and 8.31 wt%), respectively. In addition, the thermal and mechanical properties of WPU composite were also apparently enhanced. When the content of PAFG was 0.05 wt%, the decomposition temperature of 10 wt% weight loss of WPU composite could reach 322 °С, an increase of 29.3 °С compared to that of pure WPU. The tensile strength of WPU with the content of 0.05 wt% PAFG prominently improved by 130.92% relative to pure WPU. For electrochemical results, the |Z|0.01Hz of WPU was decreased dramatically from 2.95 × 107 to 1.37 × 106 Ω·cm2 after 31 days immersion. In contrast, the |Z|0.01Hz of WPU/PAFG0.05 was decreased to 3.98 × 107 from 5.00 × 107 Ω·cm2, implying that 0.05 wt% PAFG significantly enhanced barrier property of WPU coating.

Interconnected Ni(OH)2 and polyether amine on carbon fiber surface for simultaneously improving interfacial adhesion of epoxy composites and electrochemical properties

Interconnected Ni(OH)2 nanoflakes and polyether amine (PEA) were deposited on carbon fiber tows via a facial and effective process of chemical bath deposition and dip coating. Based on this, a win–win benefit of simultaneously improvements in interfacial shear strength (IFSS) of carbon fiber/epoxy composites and the electrochemical activity has been achieved. Compared with CF and CF-Ni(OH)2 composites, the IFSS of CF-Ni(OH)2-PEA/epoxy composite respectively increased 7.9% and 45.4%, which was put down to the covalent bonding of Ni(OH)2-PEA coating with fiber and epoxy matrix, as well as the effective stress transfer by the uniform honeycomb structure of Ni(OH)2. In aqueous KOH electrolyte, the CF-Ni(OH)2-PEA electrode presented the maximum specific capacitance of 689.98F·g−1 at 5 mV·s−1, 572.28F·g−1 at a current density of 0.5 A·g−1 due to the strong adhesion of carbon fiber with Ni(OH)2 by PEA, the reservation of the three-dimensional hollow honeycomb structure of Ni(OH)2 for easy ion-transport and –NH2 functional groups from PEA for providing more active sites. The excellent performance of CF-Ni(OH)2-PEA reinforcement demonstrates its promising potential for application in high performance composites with integrated structure and function, which shows great advantages in various fields of aerospace, energy, electronics, automobile, civil engineering, sports, etc.

Enhancements of foamability, electromagnetic interference shielding and mechanical property of epoxy microcellular composite foam with well-dispersed f-MWCNTs

In this work, the well-dispersed functionalized MWCNTs (f-MWCNTs), which was fabricated by simply decorating the polyether amine (M2070) and organosilanes (KH560) chains, has been applied as filler in preparation of the epoxy/f-MWCNTs microcellular foam through batch foaming process with supercritical carbon dioxide (scCO2). Compared with acidified MWCNT (acid-MWCNTs) without decorating the organic groups, the f-MWCNTs achieved more uniform dispersion in epoxy matrix, acted as plasticizing agent to reduce the glass transition temperature (Tg) of epoxy/f-MWCNTs composites, as well as increasing the composite CO2 adsorption ability, hence greatly enhanced the foamability of epoxy/f-MWCNTs composite. By adding 20 wt% f-MWCNTs, the average cell size reduced from 46.32 μm to 0.21 μm and cell density increased from 2.70 × 107 cell/cm3 to 2.74 × 1013 cell/cm3, respectively. In addition, the epoxy/f-MWCNTs microcellular foams presented enhanced electrical conductivity to 5.2 × 10−4 S/m, electromagnetic interference shielding effectiveness (EMI SE) to 22.73 dB and compressive strength to 26.46 MPa.

Comparison Study on the Adsorption Behavior of Chemically Functionalized Graphene Oxide and Graphene Oxide on Cement.

Chemical functionalization of graphene oxide (GO) is one kind of advanced strategy to eliminate the negative effects on the flowability of cement with GO. The adsorption behavior of admixture on cement plays a vital role in the flowability of cement-based materials. Herein, the comparison study on the adsorption behavior (including adsorption amount, adsorption kinetics, adsorption isotherms and adsorption layer thickness) of three kinds of chemically functionalized graphene oxides (CFGOs) with different polyether amine branched-chain lengths and GO on cement is reported. The results of CFGOs and GO adsorption data on cement particles were all best fitted with the pseudo-second-order kinetic model, and also conformed to the Freundlich isothermal model, indicating that the adsorption of CFGOs and GO on cement both were multilayer type and took place in a heterogeneous manner. The adsorption of CFGOs and GO on cement was not just physical adsorption, but also engaged chemical adsorption. In contrast to GO, the adsorption behavior of CFGOs on cement represented a lesser adsorption amount, weaker adsorption capacity and thinner adsorption layer thickness. Moreover, the longer the branched-chain length of CFGOs, the greater the decreasing degrees of adsorption amount, adsorption capacity and adsorption layer thickness. Due to the consumption of the carboxyl group (-COOH) by chemical functionalization, the anchoring effect of CFGOs was weaker than GO, and the steric hindrance effect generated from branched-chains which weakened the van der Waals forces among CFGOs layers. Moreover, the steric hindrance effect strengthened with the increasing branched-chain length, thus preventing the cement particles from aggregation, which resulted in satisfactory flowability of CFGOs with incorporation of cement rather than GO.

Magnetite Nanoparticles Functionalized with RNases against Intracellular Infection of Pseudomonas aeruginosa.

Current treatments against bacterial infections have severe limitations, mainly due to the emergence of resistance to conventional antibiotics. In the specific case of Pseudomonas aeruginosa strains, they have shown a number of resistance mechanisms to counter most antibiotics. Human secretory RNases from the RNase A superfamily are proteins involved in a wide variety of biological functions, including antimicrobial activity. The objective of this work was to explore the intracellular antimicrobial action of an RNase 3/1 hybrid protein that combines RNase 1 high catalytic and RNase 3 bactericidal activities. To achieve this, we immobilized the RNase 3/1 hybrid on Polyetheramine (PEA)-modified magnetite nanoparticles (MNPs). The obtained nanobioconjugates were tested in macrophage-derived THP-1 cells infected with Pseudomonas aeruginosa PAO1. The obtained results show high antimicrobial activity of the functionalized hybrid protein (MNP-RNase 3/1) against the intracellular growth of P. aeruginosa of the functionalized hybrid protein. Moreover, the immobilization of RNase 3/1 enhances its antimicrobial and cell-penetrating activities without generating any significant cell damage. Considering the observed antibacterial activity, the immobilization of the RNase A superfamily and derived proteins represents an innovative approach for the development of new strategies using nanoparticles to deliver antimicrobials that counteract P. aeruginosa intracellular infection.

PH-Responsive, Cell-Penetrating, Core/Shell Magnetite/Silver Nanoparticles for the Delivery of Plasmids: Preparation, Characterization, and Preliminary In Vitro Evaluation.

Over the past decade, gene therapies have attracted much attention for the development of treatments for various conditions, including cancer, neurodegenerative diseases, protein deficiencies, and autoimmune disorders. Despite the benefits of this approach, several challenges are yet to be solved to reach clinical implementation. Some of these challenges include low transfection rates, limited stability under physiological conditions, and low specificity towards the target cells. An avenue to overcome such issues is to deliver the therapies with the aid of potent cell-penetrating vectors. Non-viral vectors, such as nanostructured materials, have been successfully tested in drug and gene delivery. Here, we propose the development and in vitro evaluation of a nanostructured cell-penetrating vehicle based on core/shell, magnetite/silver nanoparticles. A subsequent conjugation of a pH-responsive polymer was used to assure that the vehicle can carry and release circular DNA. Additionally, the translocating peptide Buforin II was conjugated with the aid of a polyether amine polymer to facilitate translocation and endosome escape. The obtained nanobioconjugates (magnetite/silver-pDMAEMA-PEA-BUFII) were characterized by UV-Vis spectrophotometry, dynamic light scattering (DLS), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope equipped with energy dispersive spectroscopy (SEM+EDS), and transmission electron microscopy (TEM). They were also encapsulated in lecithin liposomes to form magnetoliposomes. The cell viability of Vero cells in the presence of the nanobioconjugates was above 95% and declined to 80% for the magnetoliposomes. The hemolytic tendency of nanobioconjugates and magnetoliposomes was below 10%, while the platelet aggregation approached that of the negative control (i.e., 35%). Cytoplasm coverage values of about 50% for both Vero and neuroblastoma cells confirmed significant cell penetration. Pearson’s correlation coefficients for both cell lines allowed us to estimate 20–40% colocalization of the nanobioconjugates with lysotracker green, which implied high levels of endosomal escape. The developed vehicles were also capable of loading around 16% of the added DNA and releasing such cargo with 8% efficiency. The developed nanoplatform holds a significant promise to enable highly efficient gene therapies as it overcomes some of the major issues associated with their eventual translation to the pre-clinical and clinical scale.

Layer-by-layer assembled nacre-like polyether amine/GO hierarchical structure on carbon fiber surface toward composites with excellent interfacial strength and toughness

Inspired by nacre's sophisticated “brick-and-mortar” structure, multilayered polyether amine (PEA)/graphene oxide (GO) hybrid building blocks were incorporated onto the surface of carbon fiber via Layer-by-Layer (LbL) assembly to strengthen and toughen the interphase of composites. Impressive improvements of 67.7% and 129.0% in interfacial strength and toughness over those of untreated fiber composites are achieved for composites with 9 layers of PEA/GO on fiber surface. The synergistic effects stemming from covalent bonds, hydrogen bonds and π-π interaction, as well as crack deflection caused by homogeneous GO layers, improved surface energy and wettability are major reasons for the increase in interfacial adhesion. The major toughening mechanisms are attributed to interfacial micro-cracks, viscoplastic energy dissipation of PEA and GO slippage. This work provides a promising route of bio-inspired structural composites with excellent strength and toughness.

Extractive Desulfurization and Denitrogenation from Fuel Oil by a Polyether-Amine-Based Solvent

Polyether amine (PEA)-based solvent, which can be synthesized by PEA and formic acid (FA), is a green, low-cost and efficient extractant for desulfurization and denitrogenation. Under the condition...

A loose polyamide nanofiltration membrane prepared by polyether amine interfacial polymerization for dye desalination

It is crucial for fractionating dye/salt mixture in dyeing wastewater treatment. Herein, a polyamide nanofiltration (NF) membrane (PEA-TMC) for high efficient dye desalination was prepared through polyether amine (PEA) and trimesoyl chloride interfacial polymerization. Due to the large molecular size and hydrophilicity of PEA, the resulting NF membrane possessed a relatively loose membrane structure and good hydrophilicity, which improved membrane water flux and dye desalination performance. The influences of PEA concentration and reaction time on the NF performance were systematically investigated. Under the optimal conditions, the membrane exhibited a high water flux of 66.4 L m-2h−1 at low operating pressure (0.4 MPa), and showed a high methyl blue rejection (95.4%) and low NaCl rejection (16.4%) when nanofiltrated methyl blue/ NaCl mixture solution. Moreover, PEA-TMC membrane exhibited good stability in continuous operation and antifouling performance. These results disclosed the promising applications of PEA-TMC membrane in dye/salt separation process.

Preparation and inhibition mechanism of bis-quaternary ammonium salt as shale inhibitor used in shale hydrocarbon production

Countries around the world have shown great enthusiasm for shale gas and shale oil. Their production accounts for an increasing proportion in the output of unconventional oil and gas resources in the past several years. The clay minerals with large content in shale will be hydrated and swelled when encountering the external working fluid, thus causing water-sensitivity damage, which is the main problem that the efficient development of shale hydrocarbon resources reservoirs faces. Polyether amine is a kind of newly developed clay stabilizer in recent years, which exhibiting good shale inhibition performance. However, it was found in experiments that changing the pH value of polyether amine solution can strengthen or weaken its shale inhibition property. In response to this finding, the bis-quaternary ammonium salt was prepared with polyether amine as raw material. Its anti-swelling rate on sodium bentonite was 95.2%, which was 24.8%, 7.7%, 12.5% and 17.8% higher than that of the commonly used clay stabilizers such as tetramethyl ammonium chloride, poly epichlorohydrin-dimethylamine, poly dimethyl diallyl ammonium chloride, and polyether amine respectively. And bis-quaternary ammonium salt can effectively inhibit the hydration, swelling and dispersion of shale samples in water. The inhibition mechanism was studied systematically from the aspects of adsorption characteristics of bis-quaternary ammonium salt on clay surface, effect of bis-quaternary ammonium salt on clay hydration, and effect of bis-quaternary ammonium salt on clay swelling. This study provides an excellent shale inhibitor to reduce the permeability damage for efficient and sustainable development of shale gas and shale oil.