Plateletcrit Values Research Articles

Hematological indices as predictors of intracerebral hematoma expansion detected on serial computed tomography

ObjectiveHematoma expansion is associated with unfavourable neurological outcomes in intracranial haemorrhage. We aimed to study association of red blood cell (RBC) indices, platelet indices, and their ratios with hematoma expansion, detected by serial computed tomography (CT). MethodsHospital-based observational study of 88 patients with intracerebral hematoma referred for serial CT head with patients grouped as having progression/ no change/ resolution of hematoma. Baseline hematological indices and ratios were analysed. Results40 patients (45.5 %) had resolution, 20 patients (22.7 %) had no change and 28 patients (31.8 %) had progression of hematoma. RBC distribution width (RDW) (p value 0.001) and Plateletcrit (p-value 0.009) showed statistically significant difference among the groups. RBC distribution width (RDW) to PC ratio (RPR)showed statistically significant increase (p < 0.001) in patients with progression.Receiver operating characteristic curve with RPR as test variable in predicting progression of hematoma showed cut-off value as 0.0615 (64.3 % sensitivity, 63.3 % specificity). Patients with RPR > 0.0615 had greater chances of hematoma progression {OR 3.1 (95 % CI 1.22 to 7.91); p = 0.0174} ConclusionRaised RPR was most significant parameter with higher RDW, lower plateletcrit values in patients with progression of intra-parenchymal hematoma. These readily available indices can aid in prompt prognostication of intracerebral haemorrhage cases.

Plateletcrit as a prognostic marker in Hodgkin lymphoma: A pilot study

Background/Aim: Hodgkin lymphoma (HL) is a lymphoproliferative malignancy associated with inflammation. Plateletcrit (PCT) is a mean platelet volume (MPV) and platelet count-derived marker that is useful for evaluating malignancies and inflammatory diseases. International Prognostic Score (IPS-7) and more recently, IPS-3, are two indices indicating the prognosis of patients; however, widespread and easy to interpret prognostic markers are still needed for HL evaluation. Very few studies evaluating the prognostic significance of platelet indices in HL have been published, so we aimed to show the relationship between PCT and other adverse prognostic factors in HL and evaluate whether PCT can be used as a prognostic marker in HL. Methods: After excluding patients with insufficient data, 75 patients diagnosed with HL and 150 healthy controls were retrospectively analyzed in this case-control study. Evaluation of relationship of PCT and adverse HL prognostic factors, such as age, gender, hemoglobin, leukocytes, lymphocytes (absolute value and percentage), albumin, Ann Arbor stage and B symptoms, IPS-3 and-7 prognostic scores and post-treatment relapse, and progression-free survival of the patients were studied. Results: Mean MPV values were significantly lower, mean platelet values were significantly higher inpatient group (all P&lt;0.001). Patients with high sedimentation had significantly higher mean PCT than those without (P=0.031) and a moderately positive correlation between PCT and sedimentation were found (r=0.33, P&lt;0.01). Mean PCT values after treatment significantly decreased compared to baseline levels (P&lt;0.001). Conclusion: PCT may be useful as a prognostic marker in HL. Further studies were needed to evaluate the relationship between PCT and other prognostic factors, such as IPS-3 and -7.

Subclinical inflammation markers in Abortus Imminens and their relation with obstetric outcomes. A case-control study

Background: In recent years, studies reveal that subclinical inflammatory markers can be used as an indicator of the inflammatory process in many diseases. Few studies have evaluated indicators of inflammation and postpartum outcomes in abortion immune patients. Objectives: The aim of the study is to investigate the relationship of subclinical inflammatory factors (Platelet crit (PCT), Neutrophil-lymphocyte ratio(NLR), Monocyte-lymphocyte ratio(MLR), Platelet-lymphocyte ratio(PLR)) obtained from complete blood count(CBC) with Abortion Immunes(AI) and obstetric results.. Material method: The study was conducted between January 2020 and January 2021. A total of 429 pregnant women, 203 of whom were pregnant with AI and 226 were healthy, were included in the study. Results: PCT, NLR, and MLR values were significantly higher and PLR values were low in the AI group (p&lt;0.05). PCT &gt; 0.22, NLR &gt; 2.29, and MLR &gt; 0.20 were significantly associated with increased risk of AI (P&lt;0.05). PLR value above 135.5 was associated with the normal group. There was a significant difference between the group whose pregnancy was terminated by abortion and the group who gave birth in terms of PCT, NLR, MLR, and PLR values. PCT, NLR, and MLR values were high in the abortion group, and PLR values were low (p&lt;0.05). Premature birth was developed in 11.3% (n=15) of AI patients. There was a significant difference between the preterm and term pregnancy in terms of PCT, NLR, MLR, and PLR levels (p&lt;0.005). PCT, NLR, and MLR values were high and PLR levels were low in pregnant women who gave birth prematurely. Conclusion: We think that close follow-up of abortion imminence patients with high levels of these inflammatory factors is appropriate.

The role of inflammation in children with specific learning disorders

Background: Specific learning disorder (SLD) is a common neurodevelopmental disorder in childhood with a delay in reading, writing, and/or mathematics. The etiology of SLD is not known exactly. Aim: In our study, we aimed to evaluate the effect of inflammation in the etiology of SLD. Materials and Methods: In our study, patients aged 7–14 years who applied to the child psychiatry outpatient clinic between November 2019 and November 2020 were retrospectively screened. The hemoglobin (Hb), red cell distribution width (RDW), platelet (PLT), plateletcrit (PCT), platelet distribution width (PDW), and white blood cell (WBC) values of the children were recorded. Neutrophil/lymphocyte ratio (NLR) and PLR values were calculated. Comparisons were carried out on different variables using SPSS version 22. Results: There was no significant difference in terms of age and gender in the SLD and control groups. When blood parameters were evaluated, there was no significant difference between the groups in terms of Hb, RDW, PCT, PDW, and WBC values. The PLT count was significantly higher in the patient group than in the control group (P = 0.049). There was no significant difference between the groups in terms of TLR and NLR values. Conclusion: The results of our study showed that Hb, RDW, PCT, PDW, WBC, NLR, and TLR values were similar in SLD and healthy control groups. This does not support the hypothesis that an increased inflammatory response may be responsible for the etiology of SLD. Considering the heterogeneity in the clinical symptoms and etiopathogenesis of SLD, more extensive studies are needed in this area.

Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia.

Alterations of plateletcrit and mean platelet volume (MPV) and pathogenesis of chronic lymphocytic leukaemia (CLL) have been linked to various inflammatory disorders. The prognostic impact of plateletcrit and MPV were evaluated. MPV and plateletcrit levels of both CLL and control group were compared and then in CLL patients, additional diseases, leukocyte count, platelet count, lactate dehydrogenase, Rai stage, progression-free and overall survival, mutations, if any, and chemotherapy, if any, were recorded. Then, the relationship between MPV and plateletcrit values and these parameters were evaluated in CLL patients. Platelet and plateletcrit values were found to be significantly lower in CLL patients than the control group (p<0.001) for both. Plateletcrit and MPV values of patients who did not receive chemotherapy were higher than those who received chemotherapy (p=0.03, p=0.02, respectively). Being over 75 years old, plateletcrit value less than 0.1565 %, platelet level below 175 x 109/L, and leukocyte count greater than 53.5 x 109/L was found to significantly reduce overall survival. Male gender, each stage increase, plateletcrit less than 0.1565 % and leukocyte count greater than 53.5 x 109/L was related to reduce treatment-free survival in CLL patients. Plateletcrit can be a viable prognostic marker for defining both treatment free and overall survival.

Could platelet indices have diagnostic properties in children with COVID-19?

Viral infections are often accompanied by reactive thrombocytosis, that is, increased activity of platelets, which is especially common in infants and children. This study aimed to test the diagnostic properties of platelet indices, plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW), in children with beta corona virus 2 (SARS-CoV-2) infection. The study included 232 patients below the age of 18 admitted to the coronavirus disease (COVID-19) isolation wards at the Institute for Child and Youth Health Care of Vojvodina. PCT, MPV and PDW values on the day of admission were recorded. In total, 245 controls were selected from those treated for SARS-CoV-2 negative respiratory infections. Descriptive and inferential statistical analyses were performed. MPV and PDW were found important as independent predictors for COVID-19 in children. Furthermore, the joint effect of MPV and PDW for predicting COVID-19 was confirmed. The parameters showed better sensitivity than specificity. Our study showed that PCT is not clinically significant, while MPV and PDW have diagnostic value in predicting COVID-19 in children. In perspective, these parameters could be implemented in the various learning algorithms in order to achieve earlier diagnosis and treatment.

Platelet index on admission as a predictor of bacteremia in acute cholangitis: a 7-year retrospective observational study

Bacteremia frequently occurs in patients with acute cholangitis, which could increase the risk of mortality. This single-center retrospective observational study was conducted from July 2013 to July 2020 to evaluate the predictive value of platelet index for bacteremia at admission for acute cholecystitis. A total of 285 patients with acute cholangitis were divided into bacteremia group and non-bacteremia group. The incidence of bacteremia in acute cholangitis was 48.42%. The bacteremia group had more grade III patients, higher 30d mortality rate [17(12.32%) vs 8(5.44%), p = .040] and higher incidence of thrombocytopenia [76(55.07%) vs 35(23.81%), p < .001]. Platelet counts and plateletcrit were significantly lower in the bacteremia group [84.5(60, 180) vs 162(102,225) ×109/L and 0.10(0.07, 0.21)% vs 0.18(0.12, 0.25) %, both p < .001]. ROC analysis indicated a high predictive value of platelet count and plateletcrit for bacteremia in patients with acute cholangitis and the area under the ROC curve (AUC) were 0.649 and 0.655, respectively. These results support the value of platelet count and plateletcrit in early prediction of bacteremia at admission for acute cholangitis.

The effect of COVID-19 infection on hematological parameters and early pregnancy loss

Objective: Based on the fact that Coronavirus Disease 2019 (COVID-19) is associated with many hemocytometric changes, we aimed to investigate the effect of this underlying inflammatory process on the frequency of early pregnancy loss (EPL) in this clinical trial. Methods: This is a retrospective cohort study. The patients with laboratory-confirmed COVID-19 infection before the 20 weeks of gestation were determined as the study group. Healthy pregnant women in their early pregnancy were determined as the control group. Hematological parameters of all patients included in the analysis were evaluated. Results: A total of 176 pregnant women with confirmed COVID-19 infections were evaluated, of which 117 were included in the analysis. One hundred and seventeen healthy pregnant women were determined as the control group. There was no difference between the groups according to demographic characteristics. The median white blood cell (WBC) and lymphocyte levels were lower in patients with COVID-19 infection (p&lt;0.001 and p&lt;0.001, respectively). The value of platelet/lymphocyte ratio (PLR) was higher in the group with COVID-19 infection (160.95 vs. 132.42, p&lt;0.001). It was also determined that the median plateletcrit level was lower in the group with COVID-19 infection (p&lt;0.001). The rate of EPL in the COVID-19 infection group and control group was 14.2% and 9.4%, respectively (p=0.220). Conclusion: COVID-19 infection presents with low lymphocyte count and plateletcrit values in pregnant women, and an increase in PLR rates in relation to the severity of the disease is observed. Although not statistically significant, COVID-19 infection was associated with increased EPL rates in our study.

Platelet volume parameters as a tool in the evaluation of acute ischemic priapism in patients with sickle cell anemia.

This study aimed to evaluate the predictive value of platelet volume indices (PVIs), such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as prognostic parameters of detumescence in acute ischemic priapism (IP) patients with sickle cell anemia (SCA) in steady-state who received intracavernosal injections of phenylephrine with aspiration and saline irrigation. Fifty-six SCA patients with acute IP and 54 healthy male control subjects were included in the research. Priapism was diagnosed by penile Doppler ultrasound and corporal blood gas tests before intervention. Measurements of PVIs (MPV, PDW, and PCT) and TLC were ordered for all participants. Additionally, the duration of priapism was recorded. The area under the curves was calculated by receiver operating characteristic (ROC) regression analysis. The detumescence rate was 71.4% after the intervention. Compared to the control group, priapic SCA patients showed significantly higher PLT (p = 0.011), MPV (p = 0.002), PDW (p = 0.032), PCT values (p = 0.022), and TLC (p = 0.027). Higher MPV, PDW, and PCT values were observed in unsuccessful detumescence patients compared to the resolution group (p < 0.05). Statistically significant cutoff values for persistent priapism were measured by ROC as PLT: ⩾ 254x103/μL; MPV: ⩾ 13.2 fL; PDW: ⩾ 15.6 fL; PCT: ⩾ 24%; and TLC ≥ 8.5x103/L. Priapism duration of ≤ 17.9 hours was significantly related to detumescence rate (p = 0.000). Multivariable logistic regression analysis showed that priapism duration and higher MPV are prognostic parameters for detumescence in SCA. The higher MPV and duration of priapism can be used as parameters for evaluating detumescence outcomes in steady-state SCA with acute IP.

Platelet Indices in Pregnant and Non Pregnant Females: A Comparative Study at a Tertiary Care Diagnostic Laboratory

Objective: To compare the platelet indices in pregnant and non-pregnant females at a tertiary care diagnostic laboratory.&#x0D; Study Design: Comparative cross-sectional study.&#x0D; Place and Duration of Study: Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Jul to Dec 2020.&#x0D; Methodology: 166 healthy pregnant females were included in group-1, and 166 non-pregnant healthy females were recruited in group-2. 5 ml of fresh venous blood from the antecubital vein was collected under aseptic conditions in EDTA anticoagulant tubes. This sample was analyzed to determine complete blood counts (TLC, RBC, HB, and Platelet Count) and platelet parameters, namely Platelet distribution width (PDW), Mean platelet volume (MPV) and Plateletcrit (PCT), using an automated haematology analyzer Sysmex XN-3000.&#x0D; Results: A total of 332 patients with a mean age of 26.5 ± 5.12 years were included in the study. Platelet count, PCT and PDW values were higher among group-2 than the pregnant females (p=0.001). MPV was higher among the group-1 females than the group-2 females (p=0.001). The distribution of platelet parameters across the trimesters showed that platelet count and PDW among the trimesters showed a statistically significant difference (p=0.001).&#x0D; Conclusion: Pregnancy brings along many physiological changes in the female body. Various haematological and biochemical changes accompany these changes. MPV, PDW and PCT values were decreased in the pregnancy group. However, MPV was found to be increased as compared to group-2.

Evaluation of the Impact of Glycemic Control on Mean Platelet Volume and Platelet Activation in Children with Type 1 Diabetes.

The studies evaluating cases with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in the adult population reported hyperreactive platelets and increased activation of prothrombotic factors, resulting in an increased risk of thrombosis. The aim of this study was to evaluate the effects of poor glycemic control and the duration of diabetes on platelet parameters in pediatric population. The study included 366 children, out of which 144 (39.3%) were included in the T1DM group and 222 (60.6%) in the healthy control group. The platelet count, mean platelet volume (MPV), platelet distribution width and plateletcrit values were recorded. The children with T1DM were divided into three groups as per their glycated hemoglobin (HbA1c) levels, good (<7.5%), moderate (7.5-9%) and poor metabolic control (>9%). No significant difference in the MPV level between the T1DM (7.41 ± 1.49 fl) and control (7.15 ± 1.23 fl) groups was observed. However, the MPV levels were significantly higher in the poor glycemic control group than in the healthy control group (p = 0.026). Furthermore, as the duration of diabetes and HbA1c levels increased, the MPV levels also increased (p < 0.001, p = 0.441). This study suggested as the duration of diabetes and HbA1c levels increased, the MPV levels also increases. Evaluation of hematological parameters can be a cheap and useful method in the evaluation of diabetes regulation in patients with diabetes.

COMPREHENSIVE ASSESSMENT OF VITAMIN D STATUS IN PRESCHOOL CHILDREN SUFFERING FROM RECURRENT RESPIRATORY INFECTIONS

Relevance. Vitamin D has a wide range of biological effects. The immunomodulatory properties of this vitamin and the higher incidence rate of respiratory infections against the background of its lack are of particular interest.&#x0D; Objective to determine the relationship between 25-hydroxycalciferol serum concentration, the main parameters of clinical blood test, the particular features of undifferentiated connective tissue dysplasia and the burden indicators of acute respiratory infections among preschool children.&#x0D; Materials and methods. Seventy-four children (34 boys and 40 girls) aged one to six years old, undergoing inpatient treatment on acute respiratory infection, were involved in the clinical study. Two markers of acute respiratory infections recurrence (infectious index, resistance index) and dolichostenomelia integral indicator were calculated in the patients. The main erythrocyte and platelet parameters of clinical blood test and 25-hydroxycalciferol serum concentration were quantified as well.&#x0D; Results. The inverse interdependence was revealed between the resistance index and the variation coefficient of erythrocytes in terms of their volume (ρ =-0,312; p=0,011). The regression dependence of infectious index on the dolichostenomelia integral indicator was found. The results obtained gave preconditions for further research on the problem of recurrent respiratory infections in pediatric practice.&#x0D; Conclusions. The examined children, who had lower categorical levels of 25-hydroxycalciferol concentration, also had higher maximum body temperature against the background of acute inflammatory process in respiratory system (H=10,079; p=0,018). The highly close relationship was established between the distribution categories of the patients according to the concentration of 25-hydroxycalciferol and the value of dolichostenomelia integral indicator (φс=0,624; p=0,004). The inverse moderate correlation was found between the concentration of 25-hydroxycalciferol and the resistance index (ρ=-0,347; p=0,043). Partial correlation analysis showed the interdependence of 25-hydroxycalciferol concentration with platelets number (ρ(xy-z)=0,336; p=0,048) and platelet Crit value (ρ(xy-z)=0,342; p=0,043) without taking into account the patients’ age.

Characteristics of platelet-associated parameters and their predictive values in Chinese patients with affective disorders

ObjectivePlatelets are increasingly considered to play an important role in inflammation and are being regarded as a putative bridge linking mental diseases and inflammatory response. Platelet-associated haematological parameters including mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), systemic immune-inflammation index (SII), platelet to lymphocyte ratio (PLR), platelet to albumin ratio (PAR) and red blood cell distribution width (RDW) to platelet ratio (RPR), have been recently investigated as simple, easily available, and inexpensive inflammatory markers. In this study, we aimed is to use large-scale clinical data to study platelet parameters in patients with affective disorders, to further investigate the predictive power of platelet parameters for major depressive disorder (MDD) and bipolar disorder (BD).MethodsThe retrospective, naturalistic, cross-sectional study analysed the data of 14,007 Chinese affective disorder patients, including 4,801 patients with first-episode MDD, 4,098 patients with recurrent MDD, 3,444 patients with BD manic episodes and 1,664 patients with BD depressive episodes. Meanwhile, 6,847 healthy subjects were served as the control group. The differences in the MPV, PDW, PCT, SII, PLR, PAR, RPR and albumin among different groups were compared, and the contributing factors for the occurrence of MDD or BD were analysed.ResultsThere were significant differences in MPV, PDW, PCT, SII, PLR, RPR and albumin values among the study groups. In the subjects, patients experiencing BD manic episodes had the highest mean values of MPV and SII, patients experiencing BD depressive episodes had the lowest mean values of platelet counts and PAR, and patients with MDD had the highest mean values of PLR and RDW. The levels of MPV, PDW and albumin were independently correlated with MDD and BD, and they are important predictors for differentiating patients with MDD or BD from healthy controls.ConclusionsOur study demonstrated that different affective disorders have unique platelet parameter variation patterns, highlighting the role of platelet parameters and systemic inflammation in the pathophysiology of MDD and BD.

Evaluation of the association between platelet tests and thyroid-stimulating hormone levels in patients with vitiligo.

Vitiligo is a common dermatological disease of unknown cause and progressing with depigmentation and affects approximately 1% of the world population. In the study, we aimed to compare plateletcrit (PCT), mean platelet volume (MPV), platelet (PLT), and thyroid-stimulating hormone (TSH) values in vitiligo patients. We retrospectively evaluated the medical data of 100 patients who were admitted to the dermatology outpatient clinic between January 2020 and December 2021 with a diagnosis of vitiligo. The control group was retrospectively constituted from medical records of 90 healthy individuals. PCT, MPV, PLT, and TSH levels of both groups were compared statistically. A total of 190 participants (100 vitiligo patients and 90healthy volunteers) were included in the study. The mean age of the patient group was 38.62±1.62, while the mean age of the control group was 41.52±1.54. There were no differences between the two groups in terms of age and gender. It was found that the mean MPV value in the patient group was lower than the control group (p=0.00). PLT and PCT values were significantly higher in the patient group than the control group (p=0.00, p=0.01, respectively). There was no statistically significant difference between the two groups in terms of TSH (p>0.05). A negative correlation between MPV and PLT values in the patient group (r=-0.218, p=0.029), and a negative correlation between MPV and TSH (r=-0.218, p=0.029), (-0.230, p=0.021). In the study, a comparison of the PCT, MPV, and PLT levels showed a difference between both groups, but no differences in TSH levels. To clarify these results, comprehensive studies with more samples are needed.

High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia.

This study aimed to evaluate the predictive value of platelet volume indices (PVI), such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as prognostic indicators of testicular viability in torsion patients with steady-state sickle cell anemia (SCA) who underwent surgical exploration. Forty-eight patients with SCA with testicular torsion and 46 male control subjects were enrolled in the study. All patients underwent scrotal color Doppler ultrasonography before surgery, and PVI (MPV, PDW, and PCT) values were measured in all participants. Symptom duration and testicular volume were also recorded. The testicular salvage rate in patients with SCA was 73% after surgery. Analyses showed that MPV, PDW, and PCT values were significantly higher in torsed SCA as compared with controls (p<0.05). Orchiectomy in patients with SCA showed significantly higher MPV, PDW, and PCT values than the orchiopexy group (p<0.05). The MPV values of orchiectomy patients showed a higher significant cut-off of ≥11.5 fL, which is higher than in torsed patients without SCA, as an indicator of testis survival. PDW also demonstrated a higher significant cut-off of ≥12.7 fL for detorsion outcomes in patients with SCA. Symptom duration of less than 7 hours was also significantly correlated with orchiopexy (p≤0.001). Univariate analysis showed that higher MPV, increased PDW, and symptom duration were indicative of the outcome of testicular detorsion in SCA. Multivariable analysis showed that increased PDW and symptom duration are prognostic parameters for testicular viability in SCA. Increased PDW and symptom duration can be used as parameters for predicting testicular detorsion outcomes in patients with steady-state SCA.

Platelet Indexes for Predicting Disease Severity and Prognosis in Elderly Patients with Coronavirus Disease-19.

This study aimed to investigate the usefulness of platelet indices in predicting prognosis in coronavirus disease-19 (COVID-19). Patients aged ≥ 65 years who presented to the emergency department with a positive polymerase chain reaction test were retrospectively analyzed. Significant differences were found in the mean values of platelet (PLT) and plateletcrit (PCT) parameters in those with severe disease, those who died, and those who required intensive care unit (ICU) admission. Mean PLT and PCT values were higher in patients with severe COVID-19 (p-values < 0.001, for both), those requiring ICU admission (p = 0.016; p = 0.006; respectively), and those who died (p = 0.015; p = 0.005, respectively). PLT and PCT were found to be statistically significant in predicting death [PLT (area under the curve (AUC): 0.598; p = 0.0145) and PCT (AUC: 0.617; p = 0.0034)], severity [PLT (AUC: 0.653; p = 0.0002) and PCT (AUC: 0.654; p = 0.0002)], and ICU admission [PLT (AUC: 0.598; p = 0.0235) and PCT (AUC: 0.605; p = 0.0148)]. PLT and PCT values were significantly higher in patients with high disease severity, those requiring ICU admission, and those who died. Furthermore, they were statistically significant in predicting disease severity, ICU admission, and death.

Study on Platelet Indices in Benign Paroxysmal Positional Vertigo

Objectives: Benign paroxysmal positional vertigo (BPPV) is one of the most common causes of dizziness. Even though the etiology of BPPV has been widely studied, the exact mechanism remains still unclear. One of the possible factors explaining the pathophysiology of BPPV is ischemia of vestibule. In the present study, we have focused on the platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit (PCT) to assess a risk of vestibule ischemia causing BPPV.Methods: From January 2021 to March 2021, a retrospective review was performed on 39 patients diagnosed with BPPV through vestibular nystagmography. For each platelet indices, a comparative analysis was conducted between the patient group and control group.Results: There were no significant differences when the platelet, MPV, PDW, and PCT values were compared between the study and control group. Rather, the control group showed higher PDW value than the study group.Conclusions: Ischemia of vestibule is one of the well-known causes of BPPV, but the current study showed that BPPV cannot be explained by the vestibule ischemia itself. Further studies are needed to identify the potential of ischemia regarding BPPV by approaching with other methods with a large study group.

Platelet Parameters in First-Episode Patients with Schizophrenia and Bipolar Disorder.

Measurement of platelet parameters, especially mean platelet volume (MPV), in mental disorders has been gaining importance. MPV is an indicator of platelet activity, and increased MPV is considered a risk factor for cardiovascular disease. Cardiovascular diseases and associated mortality are more common in patients with schizophrenia (SZ) and bipolar disorder (BD) than in the general population. We aimed to evaluate platelet parameters, including MPV, platelet count (PLT), platelet distribution volume (PDW), and plateletcrit (PCT) level, in first-episode patients with SZ and BD before disease progression and the effect of antipsychotic drugs caused changes in their lives. In this retrospective cohort study, we compared the platelet parameters in 72 patients with SZ at the time of their first psychotic episode and 63 patients with BD at the time of their first manic episode with 64 healthy controls. SZ group had significantly lower MPV and PCT values than the control group (P = .003 and P = .03, respectively). BD group had significantly lower MPV and PCT values than the control group (P = .001 and P = .02, respectively). This is the first study to compare the platelet parameters between first-episode patients with SZ and BD and healthy controls. Although a few studies have reported an increase or decrease in platelet parameters in SZ and BD, our results are valuable in terms of evaluating platelet parameters in first-episode patients who have not started drugs.

Effect of perinatal factors on platelet indices in late preterm and term newborns

Abstract&#x0D; Aim: This study aimed to compare platelet indices between late preterm and term newborns, and to analyze their relationship with perinatal conditions. &#x0D; Materials and Methods: Ninety-eight late preterm and 102 term newborns admitted to the neonatal intensive care unit 2018 and 2020 were retrospectively evaluated. Platelet indices including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) were measured in blood samples taken on the first day of life.&#x0D; Results: There was no significant difference in the PLT, MPV, PCT, and PDW values between late preterm and term newborns. In late preterm newborns, multivariable analysis showed that maternal hypertension was significantly related to lower PLT (p=0.001). In term newborns, multivariable analysis showed that being small for gestational age (SGA), male sex and maternal hypertension were significantly related to lower PLT (p

Evaluation of diagnostic performance of haematological parameters in Behçet's disease.

Behçet's Disease (BD) is a polygenic and chronic autoinflammatory multisystemic vasculitis disease characterised by mucocutaneous, musculoskeletal, neurological, gastrointestinal and ophthalmologic lesions. There has been no specific test or serum marker to measure and determine the diagnosis and severity of BD. The study aimed to investigate the diagnostic performance of haematological parameters as MLR (monocyte to lymphocyte ratio), NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), MPV (mean platelet volume), MPVPR (mean platelet volume to platelet ratio), LMR (lymphocyte to monocyte ratio), LPM (lymphocyte and platelet multiplication), WLP (lymphocyte and leukocyte multiplication), RDW (red blood cell distribution width) and PCT (plateletcrit) in BD and compare these with disease activity and clinical findings. A total of 266 participants (49 healthy control and 217 BD patients) were recruited from the rheumatology department in a single-centre as a case-control study. The laboratory data were obtained from the electronic registration database. BD Activity scores (BDCAF/Behcet's Disease Current Activity Form) were calculated. Laboratory findings of BD patients and healthy controls were compared and evaluated. RDW, Platelet, PCT, NLR and PLR values were significantly higher in patient group than in the healthy controls. However, haemoglobin, MPVPR and LMR were significantly lower in the patient group which compared with the healthy controls. LPM in BD with genital ulcers, WLP in BD with genital ulcers and arthritis, MPR in BD with uveitis, RDW in BD with thrombosis and neuro-Behçet's disease (NBD), PLR in NBD were observed to be higher. However, LMR in NBD and MPV in BD with thrombosis were lower than those without. There was a positive correlation between BDCAF score and RDW, and NLR. Haemoglobin, RDW, Platelet, PCT, NLR, LMR, PLR and MPVPR were statistically significant predictors for BD. RDW, PCT and NLR are the most valuable predictors for BD.