Abstract
Objective: To evaluate the importance of preoperative plateletcrit value predicting malignancy in patients who undergo open surgery due to small renal masses. Material and methods: Sixty-eight patients who underwent open partial or radical nephrectomy for renal masses were included in this retrospective study. In preoperative routine blood tests, renal ultrasonography and contrast-enhanced computed tomography were performed for all patients. Preoperative plateletcrit values were compared in patients with clear cell renal cell carcinoma (Group 1, 57 patients) and benign lesions (Group 2, 11 patients). The predictive ability of plateletcrit was analyzed by ROC-curves and Youden Index method was used to identify the cut-off value for plateletcrit. Results: The mean age of patients was 57.33±8.65 years in Group 1 and 59.32±10.59 years in Group 2 (p=0.546). The mean tumor size was 31.1 ± 5.84 mm in Group 1 and 28.07 ±6.25 mm in Group 2 (p=0.132). The median plateletcrit value was 1858,21 ±268,49 in Group 1 and 2258,01±524,35 in Group 2 (p:0.017). The area under a ROC-curve was 0.756 (p<0.05) . Conclusion: Preoperative plateletcrit values may predict renal masses that can not be distinguished radiologically. Our results must be confirmed by large and properly designed prospective, randomized trials.
Highlights
Renal cell carcinoma is common in western countries and constitutes 3% of all cancers [1]
Improvement in computed tomography and ultrasonography techniques have increased the diagnosis of occult renal masses [2]
We examined the diagnostic value of PCT in small renal masses
Summary
Renal cell carcinoma is common in western countries and constitutes 3% of all cancers [1]. Improvement in computed tomography and ultrasonography techniques have increased the diagnosis of occult renal masses [2]. They are usually detected incidentally on imaging studies performed for other occasions [3]. It is not possible to distinguish clinically aggressive from benign renal masses with existing clinical data. Percutaneous renal biopsy is considered a safe procedure [4], accuracy to identify malign renal masses is low [5]. In the current conditions, the number of patients going to surgery due to benign masses has been increasing [6]
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