Abstract The coal mining has brought a series of ecological problems and environmental problems in permafrost regions. Taking Muli coal-mining area as an example, this article attempts to analyse the environmental harms caused by coal mining and its protection measures in permafrost regions of Qinghai–Tibet Plateau. This article analyses the influence of open mining on the surrounding permafrost around the open pit by using the numerical simulation. The results show that (1) based on the interrelation between coal mining and permafrost environment, these main environmental harm include the permafrost change and the natural environment change in cold regions; (2) once the surface temperature rises due to open mining, the permafrost will disappear with the increase of exploitation life. If considering the solar radiation, the climate conditions and the geological condition around the pit edge, the maximum thaw depth will be more than 2 m; (3) the protection measures are proposed to avoid the disadvantage impact on the permafrost environment caused by coal mining. It will provide a scientific basis for the resource development and environment protection in cold regions.