Objective To explore the effect of Health Failure Mode and Effect Analysis (HFMEA) on outpatient nursing safety management of Peripherally Inserted Central Catheters (PICC). Methods A total of 885 patients with PICC in the outpatient department of this hospital from January to June 2017 were selected as the observation group.In addition, a total of 800 cases of PICC patients who were placed in outpatient detention from June to December 2016 were randomly selected as the control group.Patients in the control group were given routine PICC care, while HFMEA management was implemented in the observation group on this basis.The incidence of PICC-related complications was compared between the two groups. Results The incidence of mechanical phlebitis, catheter blockage, local infection, and catheter displacement in the observation group were significantly lower than those in the control group, and the differences were statistically significant(P 0.05). Conclusions Application of HFMEA model in PICC nursing clinic can significantly reduce the risk of PICC-related complications, and the safety management effect is satisfactory. Key words: HFMEA; PICC; Nursing safety; Nursing management; Outpatient nursing service