Phytate Research Articles

Development of Advanced Processing Techniques for Pigeon Pea Dal to Enhance In vitro Protein Digestibility

Pigeon pea (Cajanus cajan) is a nutritionally significant legume, rich in protein (18–25%), carbohydrates (57.6%), and essential micronutrients such as ascorbic acid, folic acid, niacin, and pantothenic acid. However, the presence of antinutritional factors such as polyphenols, phytic acid, and enzyme inhibitors adversely impacts protein digestibility and bioavailability. This study was conducted to develop advanced, energy-efficient thermal processing methods, including hydrothermal treatment, autoclaving, and infrared heating, to enhance the in vitro protein digestibility (IVPD) and reduce the polyphenol content of pigeon pea dals. Each treatment was applied at varying intensities, followed by different drying durations, and evaluated for moisture content, IVPD, and polyphenol levels. The moisture content across treatments ranged from 8.45% to 16.78%, with the lowest levels achieved under extended drying durations (5 hours for hydrothermal and infrared heating, and 8 hours for autoclaving). IVPD significantly increased with thermal exposure, reaching 82.81% in hydrothermal (HT30+DT5), 85.72% in autoclaving (AC60+DT8), and 85.12% in infrared heating (IRH30+DT5). Polyphenol content exhibited a decreasing trend with increasing duration of thermal treatment. This reduction is attributed to thermal degradation of polyphenols during treatment. Thermal processing disrupted protein matrices and degraded polyphenols, contributing to improved digestibility.

Influence of Radical Generation and Elimination on Sebum Production of Hamster Sebaceous Gland Cells

We focused on the effects of radical induction on cell differentiation and sebum production when antioxidants and oxidants were applied to normal hamster sebaceous gland cells. We also examined the relationship between sebum production and the reactive oxygen species (ROS) scavenging rate in these cells. Eight antioxidants (fullerene, epigallocatechin gallate, α-glucosylrutin, copper (II) gluconate, tannic acid, sodium copper-chlorophyllin, phytic acid, and ascorbyl tocopheryl phosphate) and one oxidant (hydrogen peroxide, H2O2) were used. The number of differentiated cells was determined by counting the viable cells, the intracellular triglyceride (TG) level was determined by separation and quantification by HPTLC, and the superoxide anion radical scavenging rate, nitric oxide scavenging rate, and H2O2 scavenging rate were also investigated. Adding various antioxidants decreased the differentiated cell number and TG content in the hamster sebaceous gland cells. Meanwhile, adding an oxidant (H2O2) increased the differentiated cell number and cellular TG. Pretreatment with antioxidants also prevented the oxidants from increasing the differentiated cell number and TG level. A strong correlation between the intracellular TG content and the H2O2 scavenging rate was identified. These results indicate that radical generation and scavenging are involved in sebum production in hamster sebaceous gland cells, and that the scavenging rate of H2O2 may be particularly important.

Chemical Composition of <i>Rauvolfia Vomitoria</i> Leaves as a Feed Resource for Ruminant Species

Rauvolfia vomitoria is a browse plant with lactogenic properties and it is available all year round. This research sought to evaluate the proximate, minerals, vitamins composition, fibre fractions and anti-nutritional factors present in the leaves of Rauvolfia vomitoria (RV). Fresh leaves of RV were harvested and taken to the laboratory immediately for chemical analyses following standard procedures. Results obtained showed that RV contained 19.33 % crude protein, 6.64 % crude fibre, 61.69 % nitrogen free extract, 67.60 mg/100g calcium, 180.11 mg/100g magnesium, 68.31 mg/100g phosphorus, 128.16 mg/100g sodium, 47.93 mg/100g potassium, 18.82 mg/100g vitamin A, 64.74 mg/100g vitamin C, 41.62 mg/100g vitamin D, 20.85 mg/100g vitamin E and 13.26 mg/100g vitamin K. Rauvolfia vomitoria leaves also contained 62.91 % neutral detergent fibre, 39.00 % acid detergent fibre, 15.25% acid detergent lignin, 23.75 % cellulose, 23.91 % hemicellulose, 20.04 mg/100g tannins, 3,61 mg/100g saponin, 128.96 mg/100g oxalic acid, 43.18 mg/100g phytic acid and 15.78 mg/100g hydrocyanic acid. These rich chemical constituents of RV leaves will make it to support optimum reticulo-rumen fermentation, digestibility and retention of nutrients which in turn will result in maximum productivity in terms of milk and meat by ruminant animals.

P0173 The impact of dietary composition on metallothionein gene expression in the intestinal epithelium by exclusive enteral nutrition

Abstract Background The mechanism by which exclusive enteral nutrition (EEN) is effective in the treatment of Crohn’s disease remains elusive. Epidemiologic studies have shown that a substantial proportion of patients with Crohn’s disease are deficient in micronutrients such as zinc, which has been shown to play an important role in the integrity of intestinal epithelial barrier function. Zinc plays a critical role in the transcriptional regulation of metallothioneins (MT), cysteine rich binding proteins that regulate both epithelial and immune function where they are generally believed to play a beneficial role in reducing disease. Methods Transcriptomic analyses were performed by both bulk RNAseq as well as GeoMx spatial transcriptomics. Enzymatic food digests using both bile acids and pancreatic enzymes, analyzed by Proton NMR metabolomics, were used to generate cell culture media for studies in intestinal epithelial cells. Results RNAseq of rectal biopsies obtained from healthy human subjects consuming EEN (Modulen-IBD, Nestlé Health Science) vs. an omnivore diet revealed a very specific induction of genes involved in mineral transport, namely MTs such as MT1G and MT2A. Spatial transcriptomics revealed that the induction of MTs was specific to the colonic epithelium. To develop a cellular model to characterize the mechanism underlying this response, we investigated the impact of animal protein, vegetable, and EEN based foods on the transcriptome of intestinal epithelial cells in culture by both RNAseq and targeted quantitative RT-PCR. This model involved the development of a physiologically relevant modality to digest whole food to generate serum-free cell culture media that was characterized using NMR-based metabolomics. Animal protein and EEN diets induced the expression of specific MTs whereas vegetable diets reduced their expression. We also show that zinc induced MT gene expression in intestinal epithelial cells whereas phytic acid, a phytochemical with known anti-nutrient properties that chelates zinc, reduces the ability of protein-based foods and EEN to induce MT gene expression. Conclusion The consumption of EEN leads to a very specific transcriptomic signature of MT gene expression in the rectal epithelium of humans that can be reproduced in cell culture by exposure to both animal protein-based foods and EEN. By contrast, vegetable-based foods inhibit MT gene expression possibly through the chelation of zinc. These results are consistent with the notion that the exclusion of plant-based foods through the consumption of EEN may have beneficial effects in the treatment of Crohn’s disease by reducing exposure to anti-nutrient phytochemicals that reduce the absorption of beneficial micronutrients such as zinc.

Structural mechanism underlying PHO1;H1-mediated phosphate transport in Arabidopsis.

Arabidopsis PHOSPHATE 1 (AtPHO1) and its closest homologue AtPHO1;H1 are phosphate transporters that load phosphate into the xylem vessel for root-to-shoot translocation. AtPHO1 and AtPHO1;H1 are prototypical members of the unique SPX-EXS family, whose structural and molecular mechanisms remain elusive. In this study, we determined the cryogenic electron microscopy structure of AtPHO1;H1 binding with inorganic phosphate (Pi) and inositol hexakisphosphate in a closed conformation. Further molecular dynamic simulation and AlphaFold prediction support an open conformation. AtPHO1;H1 forms a domain-swapped homodimer that involves both the transmembrane ERD1/XPR1/SYG1 (EXS) domain and the cytoplasmic SYG1/Pho81/XPR1 (SPX) domain. The EXS domain presented by the SPX-EXS family represents a novel protein fold, and an independent substrate transport pathway and substrate-binding site are present in each EXS domain. Two gating residues, Trp719 and Tyr610, are identified above the substrate-binding site to control opening and closing of the pathway. The SPX domain features positively charged patches and/or residues at the dimer interface to accommodate inositol hexakisphosphate molecules, whose binding mediates dimerization and enhances AtPHO1;H1 activity. In addition, a C-terminal tail is required for AtPHO1;H1 activity. On the basis of structural and functional analysis, a working model for Pi efflux mediated by AtPHO1;H1 and its homologues was postulated, suggesting a channel-like mechanism. This study not only reveals the molecular and regulatory mechanism underlying Pi transport mediated by the unique SPX-EXS family, but also provides potential for crop engineering to enhance phosphorus-use efficiency in sustainable agriculture.

Green Recovery of Toxic Prussian White Cathode From Spent All‐Climate Sodium‐Ion Batteries Using Low‐Melting Mixture Solvents (LoMMSs)

ABSTRACTA large number of spent sodium‐ion batteries (SIBs) will be produced as SIBs become more widely used. However, components of spent SIBs, such as the cathode Prussian white Na2Mn[Fe(CN)6], are toxic and hazardous, leading to water and soil pollution and posing a threat to human health. Therefore, recycling spent SIBs cathode is important and meaningful. Here, we use phytic acid‐based low‐melting mixture solvents (LoMMSs) for the efficient recovery of toxic and hazardous SIBs cathode Prussian white at mild temperatures. Results show that the highest Na leaching efficiency from Prussian white could reach 94.7% by polyethylene glycol 200:phytic acid (14:1) at 80°C for 24 h with a liquid/solid ratio of 50:1. Furthermore, the metal extracted from the leachate is found to precipitate when water is used as the anti‐solvent, with ammonium hydroxide achieving the highest precipitation efficiency of 89.3% at room temperature.

Primary Dentin Conditioning with Methylene Blue Activated Photodynamic Therapy, Phytic Acid, and Er,Cr:YSGG to Resin-Modified Glass Ionomer Cement in Comparison to Conventional Polyacrylic Acid.

Aim: Impact of surface conditioner phytic acid (IP6) Er,Cr:YSGG laser (ECYL) methylene blue photodynamic therapy (MB-PDT) on the microleakage and shear bond strength (SBS) of resin-modified glass ionomer cement (RMGIC) to primary sound dentin. Material and method: Overall, 80 extracted sound primary molars were collected followed by their submergence in self-cure acrylic resin. The dentin surface was exposed and made flat and was assigned into four groups based on the surface conditioning. Group 1: polyacrylic acid (PAA), Group 2: 1% IP6, Group 3: ECYL, and Group 4: MB-PDT. RMGIC restorative material was bonded to primary dentin. Marginal leakage assessment was performed using silver nitrate. SBS and failure mode assessment were performed using a universal testing machine and stereomicroscope. Mean and standard deviations of SBS and marginal leakage were compared using analysis of variance and multiple comparisons of Tukey's post-hoc test (p < 0.05). Results: MB-PDT treated specimens displayed the highest values of marginal leakage (37.56 ± 1.25 nm) and lowest SBS (7.93 ± 1.03 MPa). However, samples in Group 2 conditioned with IP6 presented the lowest dye penetration score (11.23 ± 1.22 nm) and highest bond strength scores (11.12 ± 0.82 MPa). Conclusions: IP6 and ECYL have proved to be better alternatives in terms of low microleakage and improved SBS scores to PAA as a primary dentin surface conditioner for bonding RMGIC restoration. Conversely, MB-PDT, when employed as a dentin surface conditioner for RMGIC restorations, exhibited suboptimal results, characterized by elevated microleakage and compromised bond strength.

Recent Advancements of Bio-Derived Flame Retardants for Polymeric Materials.

The sustainable flame retardancy of polymeric materials is a key focus for the direction of the next generation in the field of fire safety. Bio-derived flame retardants are gaining attention as environmentally friendly additives due to their low ecological impact and decreasing costs. These compounds can enhance char formation in polymeric materials by swelling upon heating, attributed to their functional groups. This review explores various biomolecules used as flame retardants, including phytic acid, chitosan, lignin, tannic acid, and bio-derived phosphorus and nitrogen compounds, emphasizing their flame-retardant properties and compatibility with different polymer matrices. The primary focus is on the structural characteristics, modifications, and flame-retardant behaviors of these bio-derived additives, particularly regarding their mechanisms of action within polymeric materials. Finally, the review explores the opportunities, current challenges, and future directions for the practical application of bio-derived flame retardants in polymer materials.

An Extensive Study of an Eco-Friendly Fireproofing Process of Lignocellulosic Miscanthus × giganteus Particles and Their Application in Flame-Retardant Panels.

Increasing the flame retardancy of lignocellulosic materials such as Miscanthus × giganteus can effectively enable their wide use. This study examines the fireproofing process of Miscanthus particles using an eco-friendly process by grafting phytic acid and urea in aqueous solution. Miscanthus particles underwent a steam explosion step before being grafted. Fireproof binderless particle panels were manufactured from miscanthus particles with or without adding olive pomace by hot-pressing. The effect of the steam explosion and/or the flame-retardant treatment on the morphology, chemical composition and thermal stability of the particles, as well as the thermal stability of the panels, was investigated. The results showed that water impregnation followed by a steam explosion at 210 °C for 8 min resulted in particles that were rich in lignin and more homogeneous in size (length and width). Fireproof particles were produced with relatively low P and N contents. The flame retardancy of the binderless particle panels was significantly improved when using miscanthus particles treated with phytic acid and urea, as shown by a reduced heat release (HRR) and an increased time-to-ignition. However, the presence of olive pomace significantly decreased the flame retardancy of the panels. Binderless particle panels prepared from grafted miscanthus particles showed the best fire properties and are considered fireproof.

Flame retardancy of biopolymers enhanced by bio-based flame retardants: A review

The demand for sustainable materials has led to the development of biopolymers as alternatives to petroleum-based polymers. However, their high flammability limits their use in applications requiring stringent fire safety. Bio-based additives such as lignin and chitosan among others have charring abilities that enhance flame retardancy by forming protective barriers during combustion. Renewable additives such as phytic acid, tannic acid, casein, and hydrophobins also show potential in improving polymer dehydration, which can help create a stable char layer. Phosphorylation and the use of nitrogen-containing compounds and nanomaterials show promise in improving fire resistance. These advancements make biopolymers more suitable for high-risk fire safety applications while maintaining sustainability. While considerable progress has been made in enhancing the flame retardancy of biopolymers, challenges remain in developing highly effective, non-toxic, and fully biodegradable flame retardants that do not compromise the physical properties and processability of the biopolymers.

Phytic Acid-Induced Gradient Hydrogels for Highly Sensitive and Broad Range Pressure Sensing.

Ionic conductive hydrogels have emerged as an excellent option for constructing dielectric layers of interfacial iontronic sensors. Among these, gradient ionic hydrogels, due to the intrinsic gradient elastic modulus, can achieve a wide range of pressure responses. However, the fabrication of gradient hydrogels with optimal mechanical and sensing properties remains a challenge. In this study, it is discovered first that phytic acid (PA) interacts in remarkably distinct manners (i.e., plasticizing effects and phase separation) with different polymers (i.e., polyacrylamide and polyacrylic acid). This distinctive PA-polymer interacting mechanism is innovatively utilized to construct a modulus gradient ionic hydrogel through a simple precursor solution infiltration approach. The gradient hydrogel-based flexible pressure sensor not only achieves a high sensitivity (9.00kPa-1, <15kPa) and a broad sensing range (from ≈3.7Pa to 1.2MPa) simultaneously, but also exhibits superior low pressure sensing performance. It successfully recognizes the subtle pressure due to acoustic waves and airflow, as well as the moderate pressure due to speaking and finger pressing and the high magnitude of plantar pressure. In addition, the gradient hydrogel demonstrates remarkable antibacterial properties and biocompatibility. This functional hydrogel with excellent sensing performance and bioactivity exhibits exceptional potential for wearable sensing applications.

Nanoarchitectonics of a Skin-Like Polymeric Hydrogel with High Anti-Swelling and Self-Adhesion Performance for Underwater Communication.

Hydrogels are flexible materials characterized by a 3D network structure, which possess high water content and adjustable physicochemical properties. They have found widespread applications in tissue engineering, electronic skin, drug delivery, flexible sensors, and photothermal therapy. However, hydrogel networks often exhibit swelling behavior in aqueous environments, which can result in structural degradation and a loss of gel performance. In this study, polyacrylic acid is utilized as the primary network structure with the incorporation of the natural polymer chitosan. Furthermore, a conductive hydrogel exhibiting good mechanical strength similar to human skin and excellent anti-swelling properties is developed by integrating phytic acid into the hydrogel network. The as-prepared hydrogels exhibited maximum swelling in pure water, achieving an equilibrium swelling rate of 15%. Additionally, a dopamine-grafted polyacrylic acid binder is synthesized through a coupling reaction to enhance the adhesion of the hydrogels to various substrates. The hydrogels demonstrated strong adhesion properties with different substrates. Whether in the air or underwater, the hydrogel sensor effectively monitors human movement behaviors. Furthermore, by utilizing the sensing signals to send Morse code, the hydrogel sensor can facilitate underwater communication. This type of hydrogel sensor is anticipated to play a significant role in wearable sensing applications and underwater communication.

Loading of Ce and n co-doped TiO2 composites onto modified shell powder synergism of adsorption and photocatalysis phytic acid removal: performance and mechanism

Phytic acid was investigated as an organophosphorus pollutant. Titanium dioxide (TiO2) doped with Ce and N was prepared using the sol-gel method and loaded onto a modified shell power to produce modified shell powder/Ce-N-TiO2 (Msp/CeNT). The combined effects of adsorption and photocatalysis on phytic acid were explored. The actual phytic acid degradation rate with the composite photocatalyst was higher than the sum of the adsorption removal rate of phytic acid using the modified shell powder and the photocatalytic degradation removal rate of phytic acid using the Ce-N-TiO2 photocatalyst. Msp/CeNT synergistically affected adsorption and photocatalytic degradation. The effects of different factors, such as reaction temperature, catalyst dosage, initial pH, stirring speed, and light intensity, on the combined effect were investigated. The results showed that the synergistic effect increases with the increase of light intensity. Increasing the reaction temperature, catalyst dosage, initial pH, and stirring speed first increased and then decreased the synergistic effect of the composite photocatalysts. Phytic acid (69.54%) was degraded within 4 h when the temperature, pH, catalyst dosage, stirring speed, and light intensity were 25 °C, 5, 1 g/L, 300 rpm, and 500 W, respectively. We investigated and prepared a composite photocatalytic material, developing a new theoretical method for degrading organophosphorus dissolved in water and providing a basis for treating lake eutrophication as a practical application.

IP6K1 rewires LKB1 signaling to mediate hyperglycemic endothelial senescence.

Diabetes is a major risk factor for cardiovascular disease, but the molecular mechanisms underlying diabetic vasculopathy have been elusive. Here we report that inositol hexakisphosphate kinase 1 (IP6K1) mediates hyperglycemia-induced endothelial senescence by rewiring the liver kinase B1 (LKB1) signaling from activating the adenosine monophosphate-activated protein kinase (AMPK) pathway to the p53 pathway. We found that hyperglycemia upregulated IP6K1, which disrupts the Hsp/Hsc70 and carboxyl terminus of Hsc70-interacting protein (CHIP)-mediated LKB1 degradation, leading to increased expression levels of LKB1. High glucose also strengthens the binding of IP6K1 to AMPK, suppressing the LKB1-mediated AMPK activation. Thus, the elevated LKB1 does not lead to the activation of the AMPK pathway. Instead, it binds more to p53, resulting in p53-dependent endothelial senescence. Endothelial-specific deletion of IP6K1 alleviates, whereas endothelial-specific overexpression of IP6K1 exaggerates the hyperglycemia-induced endothelial senescence. This study reveals a regulatory mechanism of IP6K1 in switching the LKB1/AMPK pathway to LKB1/p53 pathway. IP6K1 represents a potential therapeutic target for treating hyperglycemia-induced endothelial dysfunction.

PRODUCTION AND OPTIMIZATION OF PHYTASE BY ASPERGILLUS NIGERUSING SUBMERGED FERMENTATION

Phytases are the enzymes hydrolyzing phytic acid to less phosphorylated myo-inositol derivatives, releasing inorganic phosphate. Phytase has become an important industrial enzyme and is the object of extensive research. The present article implies an extracellular phytase production by Aspergillus niger(b2) under submerged fermentation. Physical and Chemical conditions tested for optimal production of phytase using the single variable mode optimization technique. A considerable higher phytase production was obtained using phytate sodium substrate (102.46 U/ml) at pH 5, on 5th day of incubation at 300C and Agitation 200 rpm. Glucose is considered as suitable carbon source whereas pepton is for nitrogen. The phytases produced can be used further for various applications. Keywords: Aspergillus niger, Submerged fermentations, phytase optimization.

Hybrid Modification of Wheat Bran Using Microbial Processing and Ultrasound: Enhancements in Bran Composition and Bread Quality.

This study investigates the effects of microbial bioprocessing (MB), ultrasound treatment (UT), and their combined application (hybrid method, HM) on the functional and nutritional enhancement of wheat bran (WB) and its impact on bread quality. MB was performed by using Saccharomyces cerevisiae with Levilactobacillus brevis LABE 32 (MB32) and Lactiplantibacillus plantarum LABE 29 (MB29). MB32 significantly increased soluble dietary fiber (SDF) and reduced phytic acid content by up to 25.7% when compared to the control. UT further decreased phytic acid content by 52.2% and enhanced phenolic compound release, contributing to improved antioxidant activity. The hybrid method (HM) demonstrated the strongest effect, reducing phytic acid content by 95% and enhancing antioxidant properties, including a 2.4-fold increase in bound antioxidant activity (bound-AA). Bread produced from modified WB showed improvements in specific volume (SV), texture, and nutritional composition. The HM-treated WB yielded bread with the highest SV, approximately 10% greater than the control, while MB29 produced significantly harder bread than other samples (p < 0.05). The HM-treated bread had the highest crust L* value and softest texture (p < 0.05). Nutritionally, only UT and HM treatments significantly increased the total dietary fiber (TDF) content, with the most pronounced increase observed in the HM treatment. Phytic acid degradation in the WB modified with MB32 and UT was in accordance with their breads, notably lowering phytic acid content. Additionally, MB32 and HM increased total phenolic content (TPC) and antioxidant activity, enhancing the bread's overall nutritional quality. In conclusion, the hybrid application of MB and UT (HM) proved to be the most effective in improving the functional and nutritional properties of WB and the resulting bread, including increased dietary fiber content, reduced phytic acid levels, and enhanced antioxidant activity.

The effects of soybeans and its derivatives on oral diseases: a narrative review

Abstract Soybean is a widely utilized protein source that originated in China and has been associated with preventing and treating various diseases. Soy protein has been found to inhibit fat accumulation effectively, and soybeans contain isoflavones, saponins, phytic acid, and other substances with preventive and therapeutic effects on heart disease, cancer, and diabetes. Furthermore, processed soybean products, such as Avocado-Soybean unsaponifiable, Tempeh, and Bowman-Birk inhibitor, have demonstrated health benefits. These products have been shown to have antibacterial, antioxidant, and anticancer effects in oral diseases. Numerous experiments have provided evidence of the antibacterial, antioxidant, and anticancer effects of polyunsaturated fatty acids, isoflavones, and soybean polypeptides. This comprehensive review assesses the relationship and mechanism of soybeans and their derivatives on oral diseases, providing valuable insights into their prevention and treatment.

Phytic acid as a biorenewable catalyst for cellulose pyrolysis to produce levoglucosenone

Sustainable use of both carbon and phosphorus, providing levoglucosenone, a high-value platform chemical, by pyrolysis of biomass using biogenic organocatalyst, phytic acid.

Encapsulation of hydrophobically ion-paired teduglutide in nanoemulsions: Effect of anionic counterions.

This study presents a novel method for encapsulating the bioactive peptide teduglutide to enhance its oral bioavailability using O/W nanoemulsion (NE). Recombinant teduglutide (rTGT), produced in E. coli with 93% purity, was hydrophobically modified through ion-pairing with phytic acid (PA) and sodium dodecyl sulfate (SDS). This approach increased encapsulation efficiency from 48.5% to 87.5% and 88.3%, respectively. rTGT/SDS was incorporated within the core of lipid particles, whereas rTGT/PA was likely oriented on the surface. rTGT/SDS_NE exhibited smaller particle size, greater stability, and low cytotoxicity across all tested concentrations in HT-29 cells. Additionally, rTGT/SDS_NE achieved the highest upregulation of genes associated with intestinal function (VIL1, SGLT1, and GLUT2), although the differences were not statistically significant. These findings highlight the potential of the hydrophobic ion-pairing of rTGT with SDS and its encapsulation in nanoemulsion for efficient delivery of rTGT, suggesting promise for advancing oral peptide therapeutics.

Synergistic color-changing and conductive photonic cellulose nanocrystal patches for sweat sensing with biodegradability and biocompatibility.

Given the ongoing requirements for versatility, sustainability, and biocompatibility in wearable applications, cellulose nanocrystal (CNC) photonic materials emerge as excellent candidates for multi-responsive wearable devices due to their tunable structural color, strong electron-donating capacity, and renewable nature. Nonetheless, most CNC-derived materials struggle to incorporate color-changing and electrical sensing into one system since the self-assembly of CNCs is incompatible with conventional conductive mediums. Here we report the design of a conductive photonic patch through constructing a CNC/polyvinyl alcohol hydrogel modulated by phytic acid (PA). The introduction of PA significantly enhances the hydrogen bonding interaction, resulting in the composite film with impressive flexibility (1.4 MJ m-3) and progressive color changes from blue, green, yellow, to ultimately red upon sweat wetting. Interestingly, this system simultaneously demonstrates selective and sensitive electrical sensing functions, as well as satisfactory biocompatibility, biodegradability, and breathability. Importantly, a proof-of-concept demonstration of a skin-adhesive patch is presented, where the optical and electrical dual-signal sweat sensing allows for intuitive visual and multimode electric localization of sweat accumulation during physical exercises. This innovative interactive strategy for monitoring human metabolites could offer a fresh perspective into the design of wearable health-sensing devices, while greatly expanding the applications of CNC-based photonic materials in medicine-related fields.