Physical Stability Test Research Articles

FORMULASI DAN UJI STABILITAS FISIK GEL ANTIJERAWAT EKSTRAK ETANOL DAUN SURUHAN (Peperomia pellucida L.)

Suruhan leaves (Peperomia pellucida L.) are known to be rich in secondary metabolites including alkaloids, flavonoids, saponins, tannins and triterpenoid compounds that have potential as anti-acne so that they can be applied as active ingredients in gel preparations. The purpose of this study was to determine the best base for the formulation of an anti-acne gel preparation of suruhan leaf extract that was physically stable. The research method includes the extraction of suruhan leaves by maceration using 96% ethanol. The gel formulation was designed with variations of carbopol base, HPMC, and Na CMC with a concentration of 2%. Physical stability tests include organoleptic, homogeneity, pH, dispersion, viscosity and adhesion which were carried out before and after accelerated storage using a climatic chamber. The results of this study showed that the gel preparation of the ethanol extract of suruhan leaves using carbopol and HPMC bases produced a physically stable gel based on the results of organoleptic tests, homogeneity, pH, dispersibility, adhesion and viscosity, before and after accelerated storage.

Novel Self-Nanoemulsifying Drug Delivery System of Single Bulb Garlic: Stability, Toxicity, and Antiinflammation in 3T3-L1 Cells

Single bulb garlic (SBG) has the potential as an immunomodulator; however, it has low solubility and bioavailability. A lipid-based delivery system, that is, the self-nanoemulsifying drug delivery system (SNEDDS), offers a novel opportunity in drug delivery. SBG can be a suitable candidate for SNEDDS development. This research aims to describe the physical stability, toxicity test of the SNEDDS, and SNEDDS SBG potential as antiinflammation in 3T3-L1 cells. The SNEDDS is made with various ratios of concentrations of carrier oil, surfactants, and cosurfactants, namely, 0.50: 3.45: 0.96, and added with SBG extract (SBGE) of 20 mg/mL. The results of the response test of SNEDDS SBGE formulation indicate an average and standard deviation of emulsification time of 16.38±3.01 (second), pH 7.21±0.08, and transmittance of 98.40±0.23(%). The average nanoemulsion size is 14.333±0.416 nm, polydispersion index of 0.213±0.056, and zeta potential of -14.67±0.72 mV. The results of the physical stability test indicate no segregation, deposition, cracking, or creaming in all nanoemulsion samples and SNEDDS SBG. The MTT test in a dose of 62.5, 125, 250, 500, 100, 2000, and 4000 µg/mL suggests that the highest viability of the 3T3-L1 cells is at a dose of 2000 µg/mL, which is 97.83%±1.55%. Therefore, SNEDDS SBGE can be a potential candidate for oral preparation by increasing bioavailability and reducing toxicity in the 3T3-L1 cells. An antiinflammatory test on the TNF-𝛼 and IL-1𝛽 expressions influences the 3T3-L1 cells. the SNEDDS of SBGE has the potential to reduce the expression of TNF-𝛼 and IL-1𝛽 and increase IL-10 expression in the methylglyoxal-induced 3T3-L1 cells.

Characteristic and Physical Stability of Anti-Aging Green Tea Extract (GTE) on NLC with Argan Oil as Liquid Lipid

Background: Green tea extract is a hydrophilic antioxidant that is difficult to penetrate. A nanostructured lipid carrier (NLC) delivers a system consisting of solid-liquid lipids that can improve penetration. Argan oil is a vegetable oil that can be used as a liquid lipid in NLC, reducing particle size and increasing penetration by hydrating the skin. Objective: To determine the formula of NLC green tea extract (NLC-GTE) with liquid lipid argan oil, which has good characteristics and is stable. Methods: Preparation of NLC-GTE used the High Shear Homogenization with solid lipids (cetyl palmitate-glyceryl stearate) - liquid lipids (argan oil) NLC-GTE1 (50:50), NLC-GTE2 (70:30), and NLC-GTE3 (90:10). Characteristic tests included organoleptic, pH, particle size (PS), and polydispersity index (PI). The physical stability test (organoleptic, pH, PS, and PI) used the thermal cycling method (3 cycles six days). Result: NLC-GTE1 – NLC-GTE2 has an odor of argan oil. NLC-GTE3 has odorless. NLC-GTE1 – NLC-GTE3 has a pH scale from 5.782-5.784; PS ranges from 359.73–432.56 nm; PI ranges from 0.175-0.257. The statistical analysis results showed no significant difference between NLC-GTE1 – NLC-GTE3 in pH and PI, there was a significant difference in PS NLC-GTE1; NLC-GTE2 against NLC-GTE3. Physical stability test NLC-GTE2 – NLC-GTE3 phase separation occurs. The statistical analysis results showed no significant difference in pH values NLC-GTE1 – NLC-GTE3 ​​before and after storage; there was a significant difference in NLC-GTE3 before and after storage. Conclusion: NLC-GTE1 was a formula with good characteristics and stability.

Physical Stability and Antioxidant Activity of Pee-Off Gel Mask Ethanol Extract of Buas-buas Leaf (Premna serratifolia L.)

This study aims to determine the physical stability and antioxidant activity of peel-off gel mask ethanol extract of buas-buas leaf (Premna serratifolia L.). The ethanol extract of buas-buas leaves was obtained by maceration using 70% ethanol solvent, then concentrated using a rotary evaporator to get a thick extract. Formulation EEDB into a peel-off gel mask with a concentration of each EEDB (FI: 1%, FII: 2%, FIII : 3%). The EEDB peel-off gel mask formula was tested for physical stability by cycling test method using a climatic chamber at a temperature of 40°C ± 2°C and 4°C ± 2°C for six cycles. The tests included organoleptic, homogeneity, viscosity, pH, spreadability, and drying time. An antioxidant test was carried out using the DPPH method. The results of the physical stability test on the three EEDB peel-off gel mask formulas (FI: 1%, FII: 2%, FIII: 3%) showed good physical stability because there was no significant difference during six storage cycles (P>0.05) with the results of the preparation have a characteristic aroma of oleum citri, brownish-green in color, have a thick, homogeneous texture, meet the requirements of pH, viscosity, spreadability, and drying time. The stability test results of the antioxidant activity of the peel-off gel mask EEDB in the three formulas showed no significant change (P>0.05). The antioxidant activity during six storage cycles with the highest average percent inhibition before and after the cycling test, namely in Formula III, was 77.20 ± 0.28%.

Formulasi Sediaan Pewarna Pipi dalam Bentuk Padat dengan Menggunakan Ekstrak Buah Buni (Antidesma bunius (L.) Spreng)

Buni fruit (Antidesma bunius (L.) Spreng) is a plant that contains anthocyanin pigments that can give a red color. The purpose of this study was to make cheek dye preparations in solid form using buni fruit extract (Antidesma bunius (L.) Spreng) as a dye. The extract was obtained by maceration using 96% ethanol containing 2% citric acid. The cheek coloring formula that was made was using buni fruit dye with a concentration of 10; 12.5; 15 and 17.5%. The tests carried out include: physical quality inspection (homogeneity, polish test, crack test), irritation test, and stability test. Formula with a concentration of 10% produces a pale cream color; preparation with a concentration of 12.5% ​​produces a cream color, a concentration of 15% produces a weak pink color and a concentration of 17.5% produces a dark pink color. The results of the physical quality examination of the preparation showed that the preparation had a homogeneous color, good polish at a concentration of 17.5% because it produced a clear pink color during polishing and did not crack when dropped from a height of 25 cm. Preparations are not irritating. From the observation of the shape, it was found that all the cheek coloring preparations made did not change shape from the initial form of printing for 90 days at room temperature storage. From the results of color observations, all preparations made remained stable during storage at room temperature for 50 days, on day 55 the color of the preparation began to fade, this was due to unstable anthocyanins. The odor of the preparation remained stable in storage for 90 days of observation at room temperature. These results indicate that buni fruit extract can be used as a colorant in cheek coloring preparations.

Formulation and Physical Stability Test Evaluations of Golden Sea Cucumber Extract Gel (Sticopus Hermanii) as Anti Periodontitis using Variations in Base Concentration

The prevalence of periodontitis is still quite high, which is about 74.1%. Periodontitis therapy is currently a combination of root debridement and antibiotica is still not satisfactory, especially for severe periodontitis and systemic diseases. Golden sea cucumber is a natural ingredient of marine life containing proteins and active ingredients that function as antibacterial, anti-inflammatory and antioxidant. The goal in this study was to test the formulation and physical stability of the gold sea cucumber extract gel preparation (Sticopus Hermanii) as an anti-periodontitis using variations in gel base concentrations. Gold sea cucumber extract gel with HPMC is tested formulation, stability, pH and viscosity. Stability test at weeks 0, 2, 4, 6, 8 checked for changes in consistency, color, odor stability testing using climatic chamber pH test using pH meter. Viscosity test is performed in Week 1. Measurements by using LVDV-E type Brookfiled viscometers with spindles The best stability test is obtained on formulas with HPMC 5%, the highest pH obtained on formulas with a CMC base of 3% and obtained at the measurement of the 8th week is 8. The results of the optimasi test resulted in a concentration of 5% HPMC that met organoleptic, pH, stability and viscosity tests.

Formulation and Physical Stability Test Evaluations of Golden Sea Cucumber Extract Gel (Sticopus Hermanii) as Anti Periodontitis using Variations in Base Concentration

Formulation and Physical Stability Test Evaluations of Golden Sea Cucumber Extract Gel (Sticopus Hermanii) as Anti Periodontitis using Variations in Base Concentration

FORMULASI LOTION EKSTRAK DAUN Meistera chinensis SEBAGAI TABIR SURYA Meistera chinensis LEAF EXTRACT LOTION FORMULATION AS SUNSCREEN

Excessive sunlight can have a negative impact on skin health, but the bad effects of sunlight can be overcome by using sunscreen preparations. One of the natural ingredients that can be used in the manufacture of lotion sunscreenisleaf Meistera chinensis. Meistera chinensis is a plant that belongs to the Zingiberaceae family. Previous research has stated that Zingiberaceae species such as Etlingera elatior (torch ginger) have one of the functions as antioxidants. This study aims to formulateleaves Meistera chinensis as sunscreen and determine the SPF value obtained. Leaf extract was Meistera chinensis extracted using maceration method using methanol as solvent. Physical evaluation tests, stability tests, and sunscreen activity were carried out at three concentrations, namely 1% (F1), 3% (F2) and 5% (F3) concentrations. The three formulations are pale green, green, and dark green in color, have a melon flavor and have a liquid and semi-solid texture, are homogeneous with an oil-in-water (W/A) emulsion type and meet the pH requirements of 6 and 7. The stability test results show that the three formulas do not stable because it is not homogeneous and there is a change in aroma after the cycling test. The SPF value increased along with the increase in extract concentration, namely 7.46 (extra protection), 14.12 (maximum protection), and 19.06 (ultra protection).
 Keywords: Extract, Leaf Meistera chinensis, Lotion, Sunscreen, SPF
 

Use of CMC Na as Gelling Agent in Nanoemulgel Formulation of Methanol Extract of Sappan Wood (Caesalpinia sappan L)

Sappan wood ( Caesalpinia sappan L.) contains brazilin including isoflavonoids which act as antimicrobials (against bacteria on skin) and antioxidants. Nano technology increases surface area, enhance stability, reduces skin irritation, protects from degradation, and has good drug delivery. Nano emulsion preparations can help permeability of the drug on the membrane surface. Nanoemulgel preparations can provide stability and good drug release compared to mixing drugs directly in a gel base. The purpose of this study were to determine the effect of different concentrations of CMC-Na gelling agents and which concentration of CMC-Na gelling agents that can produce the best nanoemulgel preparations. Nanoemulsion made from isopropyl myristate as oil phase, tween 80 as surfactant and polyethylenglycol as co-surfactant. Nanoemulsion formulations were tested by measurement of % transmittance by UV-Vis spectrophotometry at a wavelength 650nm. Nanoemulgel is made from nano emulsions used basis of CMC-Na at concentrations 3%, 4%, and 5%. The results showed percent transmittance was 71.86%. The results of physical quality and stability tests of the nanomulgel wood preparations showed an influence on the physical properties such as adhesion, dispersion and viscosity, the greater concentration of CMC-Na gelling agents in nanoemulgel preparations, the greater values adhesion and viscosity, while the spreadability was smaller. Concentration of CMC-Na gelling agent that produced the best of sappan wood nanoemulgel ( Caesalpinia sappan L.) was 5% that stable by freeze-thaw testing.

PENGARUH KOMBINASI GELLING AGENT CARBOPOL 934 DAN NATRIUM CARBOXYMETHYLCELLULOSE (Na-CMC) TERHADAP STABILITAS FISIK GEL GETAH JARAK PAGAR (Jatropha curcas) SEBAGAI PENYEMBUH LUKA INSISI

Background: Jatropha sap (Jatropha curcas) is one of the herbal plants that contain tannins and saponins which are responsible for wound healing. Purpose: This study aims to determine the effect of the combination of Carbopol 934 and Na-CMC as a gelling agent on the physical stability of Jatropha curcas (Jatropha curcas) latex as a wound healing agent. Method: The method used in this study was to compare the combination of carbopol 934 and Na-CMC with different concentrations in the three formulations. The concentration used is 1%:4%, 1.5%:3,5% and 2%:3%. The three formulations will be tested for physical quality and tested for physical stability for 4 weeks. Then the formulation will be tested for primary irritation and incision wound healing test. Result: The results of the study showed that formulation I with a concentration of 1%:4% had a good physical quality test based on the results of tests carried out according to standards. Based on the results of the physical stability test, it showed stable adhesion results, while the pH, dispersibility and viscosity tests showed a change in storage for 4 weeks. Jatropha (Jatropha curcas) latex gel formulation did not cause primary irritation to rabbits. The three formulations have the ability to heal fast wounds on the 9th day.
 

FORMULATION OF TABLETS OF LONGAN (Euphoria Longana Lam) LEAVE EXTRACT WITH VARIATIONS OF POLYVYNY PIROLIDONE (PVP K-30) AS BINDER

Background: Longan leaf (Euphoria longana Lam) is one of the plants that can be used by the community as an antipyretic or fever reducer with phytochemical content of saponins, flavonoids, triterpenoids and steroids, tannins, and glycosides. The tablet preparation was chosen in the formulation because it has an accurate dosage per tablet or per unit of use. This study aims to determine the concentration of PVP K-30 can produce tablet preparations from longan leaf extract as a binder that has good physical stability.Methods: Longan leaf extract was obtained by extraction by maceration method using 96% ethanol as solvent. Tablet preparations were made with ethanol extract of longan leaves with varying concentrations of PVP K-30 2%,3%, and 4%. The granule physical stability test includes: water content test, angle of repose test, flow time test, and determination test. The results of the physical stability test of the granules all met the requirements. The tablet physical stability test was carried out on days 0, 7, 14, 21 including: organoleptic test (shape, color, smell, and taste), weight uniformity test, size uniformity test, hardness test, friability test and disintegration time test.
 
 Results: The best concentration of PVP K-30 as a binder in longan leaf extract tablets (Euphoria longana Lam) was formula I with a concentration of 2% PVP K-30 binder with a weight uniformity test value (1.611±0.056) size uniformity test ( 1.036±0.046) friability test (0.545±0.090) hardness test (5.494±0.080) disintegration time test (10:22±0.055).
 
 Conclusion: Higher levels of PVP K-30 increase hardness, reduce friability and increase tablet disintegration time

The Quality of Cream Formulated From Gambier Leaf Extract

Gambier (Uncaria gambier (Hunter) Roxb) is one of the natural ingredients which have quite a lot of empirical use. Many pharmacological compounds have found Gambier extract, one of which is as an antioxidant. The most dominant compound content is phenolic compounds. The present work was to evaluate the characteristics of the cream formulated from Gambier extract and its antioxidant properties. The research method was carried out in several stages, including extraction of Gambier leaf, formulation, and analysis of the characteristic of the product. The experimental design was completely randomized with 2 replications. The physical stability test was carried out by observing the cream stored at three different temperatures, namely 4 ± 2°C, 27 ± 2°C, 40 ± 2°C. The stability parameters observed were visual, pH, and viscosity. Determination of antioxidant activity was carried out using the DPPH (1,1-Diphenyl-2-picrylhydrazyl) suppression method based on the DPPH inhibition value (IC50). The result showed that the cream has a homogeneous with a greenish yellow color to green, pH ranging from 7.62 to 7.80, and viscosity in the range of 1500 to 5000 cP at a speed of 2 rpm. After storage 6 weeks, the viscosity tends to increase, particularly in speed at 2 rpm. Meanwhile, stability testing of 3 level temperature storage, there was no changing its homogeneity, odor, and texture. The concentration of extract Gambier leaf in the formula affected the % inhibition of product. The addition of Gambier leaf extract with different concentrations to the cream is thought to affect the physical stability of cream. The inhibition of product was ranging from 44.2 to 72.9 ppm

Formulasi dan Evaluasi Kestabilan Fisik Krim Ekstrak Biji Lada Hitam (Piper nigrum L.) Menggunakan Variasi Emulgator

Black papper seed extract has known for its antivitiligo potential. The addition of black papper seed extract was predicted can influence the physical stability of the cream. Therefore, this research was aimed to test the physical stability of cream contained black papper seed extract in varity of emulgator there is tween® 60-span® 60, tween® 80-span® 80, novemer®, dan viscolam®. Physical stability test using the cycling test method by storing the preparation at 4 ° ± 2 ° C for 24 hours and then storing it at 40°±2°C) for 24 hours. The storage time at these two different temperatures is considered as one cycle and carried out for 12 days. The stability parameters were organoleptic observations, homogeneity, dispersion, pH, viscosity and cycling test results. The results showed that there were differences in organoleptic values, pH, viscosity, homogeneity and dispersibility. The most stable cream was obtained, namely the cream formula using emulgator Tween® 60-span® 60, had a good organoleptic value, cream type m/a, pH 5.10, viscosity 46,800 cPs, spreadability 4.2 cm2, homogeneous cream . The results of this study indicate that black pepper seed extract cream can be formulated into a stable cream preparation.

Development of Nanoparticles Pegagan Leaves Ethanolic Extract (centella asiatica (L.) Urban) using Variation Concentration of Poly-Lactic-CO-Glycolic Acid (PLGA) Polymer

Pegagan is a plant that plays an important role in health because of its secondary metabolite. However, many secondary metabolites tend to be unstable when exposed to UV light and oxygen such as flavonoid and terpenoid. The purpose of this study was to formulate the ethanolic extract of pegagan leaves into nanoparticle preparations to increase the stability of the extract. Nanoparticle preparations were made using the emulsion solvent evaporation method using Poly-Lactic-Co-Glycolic Acid (PLGA) and polyvinyl alcohol (PVA). PLGA acts as a polymer that will coat the extract and PVA as a stabilizer. Variations in the concentration of PLGA used were 50 mg, 75 mg, and 100 mg, while the concentration of PVA used was 40 mg and the extract concentration was 158 mg. Determination of the best formula is done by looking at the results of the percent encapsulation efficiency obtained from the three formulas, namely 93.68%, 85.35%, and 88.76%, respectively. Based on these results, formula 1 was determined as the best formula. The particle size obtained in the best formula was 288.1667±3.4195 nm, the polydispersity index (PDI) was 0.371±0.0045 and the zeta potential value was -10.6333±0.1154. A physical stability test (cycling test method) of the best formula found a decrease in pH of 0.54 and no organoleptic changes or precipitate formed.

Formulation of fig leaf extract (ficus carica L) as an anti-bacterial gel for acne using HPMC base

Acne is a skin disease caused by inflammation, accompanied by blockage of the sebaceous ducts of the skin. One of the causes of acne is Propionibacterium acnes. The purpose of this study is to find out whether the anti-acne gel preparation of fig leaf (Ficus Carica L) can inhibit the growth of P. acnes bacteria and has good physical stability of the preparation.This experimental research started by the preparation of fig leaf extract with 96% ethanol dipping method, and converts it into a gel of 3 formulations with a gelling agent percentage of 2% and a HPMC concentration of 3 n 4%. The evaluation includes stability test and effectiveness test. The well diffusion method is used to inhibit the bacteria of p.acnes, and the stability test is carried out by the accelerated storage method. 10 cycles are 1 cycle, and the time span is 12 hours. The tests performed include sensory tests, uniformity, viscosity, pH, dispersion, viscosity, and syneresis. Data analysis uses a one-way analysis of variance test, followed by post-hock test.The results of this study shows that the physical stability test of Formulation I meets all test requirements except the pH test, and Formulation II and Formulation III meet all test requirements except the viscosity test, spreadability and pH test. In antibacterial test, the antibacterial rate of formula 1 was the highest with 5.3 mm. And the analysis of variance shows that all the formulas are significantly different (p <0.05) Keywords : Formula, gel, acne, tin leaf extract(ficus carica L), Propionibacterium acnes.

Pengembangan Plastik Pengemas Obat yang Informatif dan Beradsorben

The problem of labeling on plastic medicine packaging which is less informative and its function in maintaining drug quality is very crucial. The purpose of this research and development is to produce informative and absorbent drug packaging plastics. The method used is the ADDIE research and development model. The development stage is carried out by testing physical stability and chemical stability testing. The implementation phase was carried out by asking for responses from 10 pharmacists and 15 ordinary people. Based on the results of the physical stability test, the drug stored in the plastic packaging of the drug that was developed was more physically stable. Based on the results of chemical stability tests, the absorbance of drugs stored in drug packaging plastics developed is more stable than ordinary drug packaging plastics, which is indicated by a smaller slope value. Based on the questionnaires distributed to pharmacists, they strongly agree with the adequacy of the information and agree with the readability, attractiveness of appearance, and usefulness of the adsorbent in the plastic drug packaging developed. Based on the questionnaires distributed to the general public, they strongly agree with the adequacy of the information and agree with the readability, attractiveness of appearance, and the usefulness of the adsorbent in the plastic drug packaging developed.

STABILITAS FISIK EMULGEL MELOKSIKAM MENGGUNAKAN METODE FREEZE THAW

Emulgel is a semi-solid preparation, in the form of an emulsion where the viscosity is increased by the addition of the gelling agent. Emulgel can be used for formulations of active substances that are difficult to dissolve in water. Meloxicam is a first-line treatment to treat rheumatoid arthritis and osteoarthritis. The aim of the study was determine the stability of the physical properties of emulgel meloxicam with the Freeze thaw test. The research design used was quasi experimental. In this study there were 2 storage temperatures, the freeze temperature of 4-8oC and thaw temperature of 40-48oC. The treatment was carried out in 3 cycles for 6 days. Physical stability test of organoleptic (color, odor, and dosage form) showed no difference during storage. Physical stability test of homogenity also showed no difference during storage. Physical stability of the emulsion type showed that there was no phase separation in the emulsifying gel during storage. Significance of pH is 0,083 (p 0,05), viscosity is 0,083 (p0,05), and spreadabilityis 0,102 (p 0,05) can be interpreted that the physical stability of pH, viscosity and dispersion power has no significant difference. From all research data, it can be seen that the meloxicam emulgel preparation did notchanges in physical stability after passing 3 cycles.

Lotion deodorant formulation of ethanolic extract of red betel leaf (Piper crocatum Ruiz & Pav) with stearic acid as base

Abstract Background: Red betel leaf (P. crocatum Ruiz & Pav) possesses antibacterial properties, so the prospect is to be developed as a deodorant in lotion dosage forms. Objective: This study was conducted with the intention to prepare, evaluate, and investigate the stability of deodorant lotion preparations from the ethanolic extract of red betel leaf (P. crocatum Ruiz & Pav) based on stearic acid. Methods: The maceration method used 70% ethanol as solvent to obtain red betel leaf extract. Furthermore, the concentrated extract was formulated as a deodorant lotion formula into three formulas, FI, FII, and FIII, with varying concentrations of stearic acid 2, 4, and 6%, respectively. All the deodorant lotion formulas were evaluated, their characteristics and stability of organoleptic, pH, homogeneity, viscosity, spreadability, adhesion, and irritation properties. The physical stability test was done by cycling test. The storage stability test was evaluated for 28 days. Results: Evaluation of physical properties for 28 days showed that deodorant lotion was homogeneous and pH in the range of 5.5-6.4; viscosity, spreadability, and adhesion tests gave good results and stability. In the irritation test, all formulas showed no irritation. Statistical test paired T-test on stability testing during storage and cycling test showed that the best and most stable formula was F3 with 6% stearic acid concentration. Conclusion: Ethanolic extract of red betel leaf (P. crocatum Ruiz & Pav) can be formulated into a deodorant lotion preparation that is stable and good during storage. Keywords: deodorant lotion, Piper crocatum Ruiz & Pav, stearic acid

PENGARUH METODE MASERASI DAN SOKLETASI TERHADAP STABILITAS FISIK SEDIAAN HAIR TONIC EKSTRAK ETANOL DAUN LIDAH MERTUA (Sansevieria trifasciata P.)

Hair loss is a disorder in which the amount of hair decreases or falls out more than usual without visible thinning. Hair care requires a variety of cosmetic products such as hair conditioner, cream bath and hair tonic. Hair tonic has several advantages in optimizing efforts to prevent hair loss compared to other hair treatments. Sansevieria leaves (Sansevieria trifasciata) is a plant known as an ornamental plant. Almost all parts of the sansevieria leaves can be used, but not many know that the sansevieria leaves can be used as a hair tonic to treat hair loss. The purpose of this study was to determine the effect of maceration and soxhletation methods on the physical stability of hair tonic preparations of sansevieria leaves extract with varying concentrations of 1%, 3% and 6%. Evaluation of the preparation includes organoleptic, pH, specific gravity and viscosity tests. Physical stability tests were carried out at low temperatures (4oC) and high temperatures (40oC). The test results showed (p-value <0.05) there was no effect between maceration and soxhletation methods on the physical stability of the hair tonic preparation of sansevieria leaves extract.
 Keywords: Hair Tonic, Sansevieria Leaves, Maceration, Soxhletation, Physical Stability.

FORMULATION AND PHYSICAL STABILITY TEST OF NANOEMULGEL CONTAINING Petrosia Sp. ETHANOLIC EXTRACT

Petrosia sp. is one of the sponges from the demospongia class that has biological activity as anti-inflammatory, antimalarial, cytotoxic agent, and can be used in nanoemulgel formulation. Nanoemulsion system is thermodynamically stable and produces globule size that can increase the permeability and diffusibility of Petrosia sp. The presence of gelling agent in the nanoemulgel gives the viscosity and spreadability of Petrosia sp nanoemulsion optimally to increase the effectiveness of the active substances on the skin. This study aims to determine the formulation, characterization, and physical stability of nanoemulgel ethanol extract of sponge Petrosia sp. with carbopol 940 as the gel base. Nanoemulsion characterization included transmittance value, particle size, polydispersity index, and type of emulsion formed. The physical stability test of nanoemulgel included centrifugation and freeze thaw tests with organoleptic, pH, viscosity, and dispersibility evaluation. Nanoemulsion of Petrosia sp ethanolic extract with a composition of 1% VCO, 7% Tween-80, and 2% PEG-400 produced an oil-in-water (O/W) nanoemulsion, transmittance value of 94.84%, droplet size of 23.9 nm and particle size distribution of 0.176. The optimum formula for nanoemulgel is F1 with a nanoemulsion concentration of 75 mL and 25 g of gel base produced a clear and transparent nanoemulgel, semi-solid, soft texture, distinctive aroma, pH value of 5, viscosity of 28,000, dispersibility of 5.7 cm and the shape/color did not change after freeze thaw stability test. Based on the data above, it can be concluded that the F1 nanoemulgel formula with carbopol 940 as the base gel produced an optimal nanoemulgel.