Abstract
Emulgel is a semi-solid preparation, in the form of an emulsion where the viscosity is increased by the addition of the gelling agent. Emulgel can be used for formulations of active substances that are difficult to dissolve in water. Meloxicam is a first-line treatment to treat rheumatoid arthritis and osteoarthritis. The aim of the study was determine the stability of the physical properties of emulgel meloxicam with the Freeze thaw test. The research design used was quasi experimental. In this study there were 2 storage temperatures, the freeze temperature of 4-8oC and thaw temperature of 40-48oC. The treatment was carried out in 3 cycles for 6 days. Physical stability test of organoleptic (color, odor, and dosage form) showed no difference during storage. Physical stability test of homogenity also showed no difference during storage. Physical stability of the emulsion type showed that there was no phase separation in the emulsifying gel during storage. Significance of pH is 0,083 (p 0,05), viscosity is 0,083 (p0,05), and spreadabilityis 0,102 (p 0,05) can be interpreted that the physical stability of pH, viscosity and dispersion power has no significant difference. From all research data, it can be seen that the meloxicam emulgel preparation did notchanges in physical stability after passing 3 cycles.
Highlights
PENDAHULUAN Penyakit sendi telah banyak diderita oleh geriatri, diantaranya ialah Rheumatoid arthritis (RA) dan Osteoarthritis (OA)
in the form of an emulsion where the viscosity is increased by the addition of the gelling agent
Emulgel can be used for formulations of active substances
Summary
Sebanyak 1 gram sampel emulgel ditambahkan 10 ml aquades bebas CO2. Amati hasilnya dengan Elektroda pH meter yang sudah di kalibrasi dicelupkan ke dalam gelas beker. Emulgel sebanyak 50g dalam beaker glass diukur viksoitasnya menggunakan alat viskometer Brookfield DV-E. Emulgel sebanyak 0,5 g Diletakkan pada pusat antara dua lempeng gelas kaca, setelah 1 menit amati diameter sebaran sampel, lalu tambahkan beban seberat 150 gram amati setelah 1 menit. Amati sampel menunjukkan warna merata atau tidak (tidak terdapat butiran kasar). Sebanyak 1g ediaan di larutkan dengan air berlebih (± 30ml). Apabila sediaan bercampur sempurna dengan air, maka sediaan termasuk emulsi tipe M/A. Apabila sediaan tidak bercampur sempurna dengan air, maka sediaan termasuk emulsi tipe A/M
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