As scientists and other professionals from a variety of disciplines, we are concerned about the production and release into the environment of an increasing number of poly- and perfluoroalkyl substances (PFASs) for the following reasons: PFASs are man-made and found everywhere. PFASs are highly persistent, as they contain perfluorinated chains that only degrade very slowly, if at all, under environmental conditions. It is documented that some polyfluorinated chemicals break down to form perfluorinated ones (D’Eon and Mabury 2007). PFASs are found in the indoor and outdoor environments, wildlife, and human tissue and bodily fluids all over the globe. They are emitted via industrial processes and military and firefighting operations (Darwin 2011; Fire Fighting Foam Coalition 2014), and they migrate out of consumer products into air (Shoeib et al. 2011), household dust (Bjorklund et al. 2009), food (Begley et al. 2008; Tittlemier et al. 2007; Trier et al. 2011), soil (Sepulvado et al. 2011; Strynar et al. 2012), ground and surface water, and make their way into drinking water (Eschauzier et al. 2012; Rahman et al. 2014). In animal studies, some long-chain PFASs have been found to cause liver toxicity, disruption of lipid metabolism and the immune and endocrine systems, adverse neurobehavioral effects, neonatal toxicity and death, and tumors in multiple organ systems (Lau et al. 2007; Post et al. 2012). In the growing body of epidemiological evidence, some of these effects are supported by significant or suggestive associations between specific long-chain PFASs and adverse outcomes, including associations with testicular and kidney cancers (Barry et al. 2013; Benbrahim-Tallaa et al. 2014), liver malfunction (Gallo et al. 2012), hypothyroidism (Lopez-Espinosa et al. 2012), high cholesterol (Fitz-Simon et al. 2013; Nelson et al. 2009), ulcerative colitis (Steenland et al. 2013), lower birth weight and size (Fei et al. 2007), obesity (Halldorsson et al. 2012), decreased immune response to vaccines (Grandjean et al. 2012), and reduced hormone levels and delayed puberty (Lopez-Espinosa et al. 2011). Due to their high persistence, global distribution, bioaccumulation potential, and toxicity, some PFASs have been listed under the Stockholm Convention (United Nations Environment Programme 2009) as persistent organic pollutants (POPs). As documented in the Helsingor Statement (Scheringer et al. 2014), Although some of the long-chain PFASs are being regulated or phased out, the most common replacements are short-chain PFASs with similar structures, or compounds with fluorinated segments joined by ether linkages. While some shorter-chain fluorinated alternatives seem to be less bioaccumulative, they are still as environmentally persistent as long-chain substances or have persistent degradation products. Thus, a switch to short-chain and other fluorinated alternatives may not reduce the amounts of PFASs in the environment. In addition, because some of the shorter-chain PFASs are less effective, larger quantities may be needed to provide the same performance. While many fluorinated alternatives are being marketed, little information is publicly available on their chemical structures, properties, uses, and toxicological profiles. Increasing use of fluorinated alternatives will lead to increasing levels of stable perfluorinated degradation products in the environment, and possibly also in biota and humans. This would increase the risks of adverse effects on human health and the environment. Initial efforts to estimate overall emissions of PFASs into the environment have been limited due to uncertainties related to product formulations, quantities of production, production locations, efficiency of emission controls, and long-term trends in production history (Wang et al. 2014). The technical capacity to destroy PFASs is currently insufficient in many parts of the world. Global action through the Montreal Protocol (United Nations Environment Programme 2012) successfully reduced the use of the highly persistent ozone-depleting chlorofluorocarbons (CFCs), thus allowing for the recovery of the ozone layer. However, many of the organofluorine replacements for CFCs are still of concern due to their high global warming potential. It is essential to learn from such past efforts and take measures at the international level to reduce the use of PFASs in products and prevent their replacement with fluorinated alternatives in order to avoid long-term harm to human health and the environment. For these reasons, we call on the international community to cooperate in limiting the production and use of PFASs and in developing safer nonfluorinated alternatives. We therefore urge scientists, governments, chemical and product manufacturers, purchasing organizations, retailers, and consumers to take the following actions:
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Jan 25, 2024
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