Frame synchronization is a crucial step in quantum key distribution (QKD) and a prerequisite for secure key distillation. Due to the extremely low signal-to-noise ratio (SNR) and fast phase drift in the continuous-variable QKD system, efficient frame synchronization is highly demanded. In this paper, a frame-synchronization scheme based on weak coherent states is proposed. This scheme uses a train of coherent-state pulses encoded by a Zadoff-Chu sequence to achieve frame synchronization. The synchronization performance is analyzed under different transmission distances, transmit powers, frequency offsets, and phase drifts through Monte Carlo simulation. Its performance is also compared with other synchronization sequences, confirming its noise-tolerance capability. An optical experiment is conducted to verify the feasibility of the synchronization scheme under low SNR (as low as $\ensuremath{-}20$ dB), and the applicable SNR range can be further reduced by increasing the sequence length. Due to its efficiency and noise tolerance, this scheme can provide technical support for weak-coherent-state-based QKD and future quantum network construction.
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