Phase change materials (PCMs) exploit their cyclic phase change (solidification and melting) to enable latent heat storage. While incorporating them in thermally activated building systems can potentially enhance energy savings and thermal comfort, they can introduce significant challenges to the building energy management system. This work first reports the result of small-scale side-by-side experiments on two thermally active cuboids with and without BioPCMs at different supply water and PCM melting temperatures, as well as irradiance levels. Next, a dynamic model is developed in TRNSYS v18.05 for a typical design of an office space under hot desert climate conditions. The model is then integrated into a multi-objective optimization routine using NSGA-II algorithms to identify the optimal characteristic cooling curves, melting temperatures, and PCM thicknesses that simultaneously minimize energy consumption and maximize the percentage of comfortable hours. The experimental observations of the PCM-integrated cuboid highlighted energy savings between 80.45 and 84.56 %, compared to the reference cuboid, at nearly the same levels of indoor temperatures. The PCM panels reduced the cooling capacity of the radiant floor but also dampened air temperature variations by up to 83.17 %. Besides, higher solar irradiance levels, encountered in desert areas, were found to enhance the cooling capacity by up to 46.8 %. The Pareto solutions highlighted the possibility of achieving acceptable unmet hours of 3.16 % using PCMs and without the need for an assisting air system, compared to 14.1 % without PCMs. Besides, at the same unmet hours of the reference system, the PCMs reduced the total energy consumption and the peak cooling power by 9.75 and 41.2 %, which translates into substantial operation and capital investments, respectively. Moreover, the study demonstrated by example the importance of calibrating the commonly used cooling curves of thermally active buildings when planning for PCM integration.