Concentrations Of Pharmaceuticals And Personal Care Products Research Articles

Pharmaceuticals and other contaminants of emerging concern in Admiralty Bay as a result of untreated wastewater discharge: Status and possible environmental consequences

Considering how the impact of human activity in Antarctica is growing, the aim of this study was to conduct the first assessment of pharmaceuticals and personal care products (PPCPs), other emerging contaminants (ECs), and antibiotic resistance genes present in the western shore of the Admiralty Bay region of King George Island. In total, more than 170 substances were evaluated to assess the potential environmental risks they pose to the study area. The major evaluated source of pollutants in this study is discharged untreated wastewater. The highest PPCP concentrations in wastewater were found for naproxen (2653 ngL˗1), diclofenac (747 ngL˗1), ketoconazole (760 ngL˗1), ibuprofen (477 ngL˗1) and acetaminophen (332 ngL˗1). Moreover, the concentrations of benzotriazole (6340 ngL˗1) and caffeine (3310 ngL˗1) were also high. The Risk Quotient values indicate that azole antifungals (ketoconazole), anti-inflammatories (diclofenac, ibuprofen) and stimulants (caffeine) are the main groups responsible for the highest toxic burden. In addition, antibiotic resistance genes integrons (int 1) and sulphonamide resistance genes (sul 1–2) were detected in wastewater and seawater. These results indicate that regular monitoring of PPCPs and other ECs is of great importance in this environment. Additionally, the following mitigation strategies are suggested: (1) to create a centralised record of the medications prescribed and consumed in situ (to improve knowledge of potential contaminants without analysis); (2) to use more environmentally friendly substitutes both for pharmaceuticals and personal care products when possible (limiting consumption at the source); and (3) to apply advanced systems for wastewater treatment before discharge to the recipient (end-of-pipe technologies as a final barrier).

Fate and impact of wastewater-borne micropollutants in lettuce and the root-associated bacteria

The reuse of water for agricultural practices becomes progressively more important due to increasing demands for a transition to a circular economy. Treated wastewater can be an alternative option of blue water used for the irrigation of crops but its risks need to be evaluated. This study assesses the uptake and metabolization of pharmaceuticals and personal care products (PPCPs) derived from treated wastewater into lettuce as well as the impact on root-associated bacteria under a realistic and worst-case scenario. Lettuce was grown in a controlled greenhouse and irrigated with water or treated wastewater spiked with and without a mixture of fourteen different PPCPs at 10 μg/L or 100 μg/L. After harvesting the plants, the same soil was reused for a consecutive cultivation campaign to test for the accumulation of PPCPs. Twelve out of fourteen spiked PPCPs were detected in lettuce roots, and thirteen in leaves. In roots, highest concentrations were measured for sucralose, sulfamethoxazole and citalopram, while sucralose, acesulfame and carbamazepine were the highest in leaves. Higher PPCP concentrations were found in lettuce roots irrigated with spiked treated wastewater than in those irrigated with spiked water. The absolute bacterial abundance remained stable over both cultivation campaigns and was not affected by any of the treatments (type of irrigation water (water vs. wastewater) nor concentration of PPCPs). However, the irrigation of lettuce with treated wastewater had a significant effect on the microbial α-diversity indices at the end of the second cultivation campaign, and modified the structure and community composition of root-associated bacteria at the end of both campaigns. Five and fourteen bacterial families were shown to be responsible for the observed changes at the end of the first and second cultivation campaign, respectively. Relative abundance of Haliangium and the clade Allorhizobium-Neorhizobium-Pararhizobium-Rhizobium was significantly affected in response to PCPPs exposure. Caulobacter, Cellvibrio, Hydrogenophaga and Rhizobacter were significantly affected in microcosms irrigated with wastewater.

The impact of micropollutants on native algae and cyanobacteria communities in ecological filters during drinking water treatment

An attractive alternative for drinking water production is ecological filtration. Previous studies have reported high removal levels of pharmaceutical and personal care products (PPCPs) by this technology. Algae and cyanobacteria play an important role in the biological activity of ecological filters. The aim of this study was to characterize and identify the community of algae and cyanobacteria in relation to its composition, density and biovolume from 22 ecological filters that received spikings of 2 μg L−1 PPCPs. For algae and cyanobacteria species, triplicate samples were collected before and 96 h after each spiking from the interface between the top sand layer of the ecological filters and the supernatant water. Results show that Chlorophyceae and Cyanobacteria were present in high numbers of taxa and abundance. The specie Lepocinclis cf. ovum (Euglenophyceae) had the highest percentage occurrence/abundance and frequency into the filters, indicating a possible tolerance by Lepocinclis cf. ovum to the concentration of selected PPCPs. Although the concentration of PPCPs did not affect the treated water quality, they did affect the algae and cyanobacteria community. No differences were detected between filters that received a single PPCP and filters that received a mixture of the six compounds. Also, changes in the composition of algae and cyanobacteria communities were observed before and 96 h after the spikings.

Occurrence and distribution of Pharmaceuticals and Personal Care Products (PPCPs) in wastewater related riverbank groundwater

Pharmaceutical and personal care products (PPCPs) are among the most frequently reported groups of emerging contaminants in groundwater worldwide. PPCPs in rivers may infiltrate into groundwater through hydraulic exchange and potentially threaten drinking water safety and human health. In the present study, the occurrence and distribution of nine PPCPs in riverbank groundwater and adjacent rivers (distance up to 113 m) were investigated at four sites with different lithological features and permeabilities of aquifers in a city in North China. Seven of nine PPCPs were detectable in groundwater, ranging from <LOQ (limit of quantification) to 128 ng/L. N,N-diethyl-meta-toluamide (DEET), carbamazepine, and caffeine had the highest detection frequencies (>90%). The concentrations and major compounds in river water varied with the sampling location and water system distribution, resulting in distinct compositions of PPCPs in the groundwater at each site along with different lithology and hydrological conditions. The spatial distribution of PPCPs in riverbank groundwater was affected by the hydraulic connection between the groundwater and river and the lithology of aquifers. Direct hydraulic connection of a fine sand aquifer to the adjacent river caused a decrease in PPCPs with increasing distance. The results also suggested that sandy gravel aquifers had a lower capacity to attenuate PPCPs compared to that of fine sand. Significant correlations between PPCP concentrations and thirteen physicochemical factors of groundwater were discovered, including nitrate, potassium, and manganese. Overall, this study provides important evidence on the role of lithology and hydrological conditions on the composition, distribution, and influential physicochemical factors of PPCPs in riverbank groundwater.

Distribution of pharmaceutical and personal care products (PPCPs) in aquatic environment in Hanoi and Metro Manila.

Pharmaceutical and personal care products (PPCPs) recently defined as emerging pollutants that widespread in surface water all around the world. This study investigated the distribution, and ecological risk of PPCPs in urban rivers of Hanoi, Vietnam, and Metro Manila, the Philippines. Of the 56 investigated PPCPs, 48 and 33 compounds were detected in the river water in Hanoi and in Metro Manila, respectively. The individual PPCP concentrations ranged from a few ng L-1 to thousands of ng L-1. The total concentration of PPCPs detected in water samples ranged from 7.5 to 20,789ng L-1 in Hanoi and 118 to 3,394ng L-1 in Manila. The predominant antibiotics was sulfamethoxazole detected in 27/28 samples with a maximum concentration up to 2,778ng L-1 in Hanoi and presented in all samples with a maximum concentration up to 261ng L-1 in Metro Manila. In Hanoi, the level of PPCPs in urban canals of Kim Nguu and To Lich Rivers was as high as that detected in domestic wastewater. The PPCP concentrations in tributaries and mainstream were lower than those found in urban canals. In rivers of both sites, PPCPs tended to increase along the stream. The concentration ratio of the labile marker caffeine to recalcitrant marker carbamazepine indicated that untreated domestic wastewater is the significant source of PPCPs in river water in Hanoi and Metro Manila. The ecological risk estimated by the risk quotient of the obtained maximum residue of PPCPs in investigated river water predicted a high risk of PPCPs to the aquatic organism in both Hanoi and Manila.

Removal and risk assessment of pharmaceuticals and personal care products in a decentralized greywater treatment system serving an Indian rural community

A widespread occurrence of pharmaceuticals and personal care products (PPCPs) is reported in all the environmental matrices. Thus, the present study investigated the prevalence of these emerging contaminants in the wastewater from Vichoor village, Tamil Nadu, India. Among the 14 investigated PPCPs, caffeine (CAF), triclosan (TCS), bisphenol A (BPA), and diethyl phthalate (DEP) were the most frequently detected compounds in the concentration range of 5 ng/L to 250.14 µg/L. A seasonal variation (p < 0.05) in the concentration of selected PPCPs was observed, except for BPA, DEP, and carbamazepine (CBZ), due to the difference in the consumption pattern among the households of the community. The fate of selected pollutants was investigated in each component of vertical flow constructed wetland (VFCW). The overall removal efficiencies of COD, ammonia, phosphate, and pathogens were more than 93.34 ± 1.94%, 85.25 ± 1.51, 79.81 ± 1.15%, and 99.9 ± 0.81%, respectively. Also, VFCW exhibited substantial removal of the selected pollutants in the range of 81–97.7%. Microbial degradation (74.9–93.8%) followed by sorption over the substrate materials (0.54–12.56%) seem to be the predominant mechanism for the removal of target PPCPs. The environmental risk assessment witnessed that PPCPs concentration in the treated effluent contributed lower risk to human and aquatic organisms.

Occurrence, seasonal variation, mass loading and fate of pharmaceuticals and personal care products (PPCPs) in sewage treatment plants in cities of upper Ganges bank, India

The data on the environmental concentration of pharmaceuticals and personal care products (PPCPs) is hardly investigated for major cities of the upper Ganges basin, India. In this study, fifteen PPCPs were analyzed in four sewage treatment plants (STPs) of Haridwar and Rishikesh cities located at the bank of River Ganges, India. Eleven PPCPs were detected with an average total concentration of 147.20 ng L−1 in influent, 105.06 ng L−1 in the effluent, and 87.75 ng kg−1 in sludge from STPs. The average concentration (ng L−1) of individual PPCPs was recorded highest for Caffeine (695.86) followed by, ibuprofen (387.53), acetaminophen (152.81), triclosan (98.93), tetracycline (75.39), ketoprofen (69.47), DEET (46.59), salicylic acid (45.02), erythromycin (32.98), ciprofloxacin (20.16) and metoprolol (13.61) at STPs inlets. Results suggested a spatial and seasonal variation in PPCPs loads in influent, effluent and sludge in STPs studied. The overall PPCPs removal efficiencies of STPs were recorded in the ranges of −154–63%. The total mass load of PPCPs studied ranged between 0.02 and 448.64 mg/d/1000 population. This study concluded that STPs are an active source of PPCPs in the River Ganges, which may pose a grave threat to the health of the river ecosystem and human population.

Influence of land use type and urbanization level on the distribution of pharmaceuticals and personal care products and risk assessment in Beiyun River, China

Influence of land use type and urbanization level on the distribution of pharmaceuticals and personal care products (PPCPs) from the developed regions of Beijing-Tianjin-Hebei in the northern China was evaluated. The seasonal and spatial variations of the 22 target PPCPs were analyzed in the 63 sampling sites along the whole Beiyun River Basin. Results showed that the total PPCPs concentration had a wide variation range, from 132 ng L−1 to 25474 ng L−1. Spatial interpolation analysis showed that agricultural land presented higher PPCPs contamination level than build-up land (p < 0.05) and the concentration was negatively correlated with urbanization level. Source apportionment showed the untreated sewage source contributed to 34%–53% of the PPCPs burden in the Beiyun River. Risk assessment indicated that diethyltoluamide, carbamazepine, octocrylene, gemfibrozil and triclocarban had high risks (RQ > 1), and small tributaries had the highest mixed risk (MRQ = 34). Species sensitivity distribution combined with the safety threshold method showed that PPCPs would have potential risk on aquatic organisms even at very low concentrations and triclocarban posed the highest risk in the Beiyun River.

Removal of emerging micropollutants originating from pharmaceuticals and personal care products (PPCPs) in water and wastewater by advanced oxidation processes: A review

Because of their intrinsic potential to produce metabolic effects on the human body at smaller concentrations, pharmaceuticals and personal care products (PPCPs) are a distinct category of emerging environmental pollutants. Due to their widespread intake, limited metabolic capacity, and indecorous disposal, PPCPs pollutants are commonly found in water supplies and wastewater treatment plants. If partly oxidized PPCPs are introduced into wastewater treatment plants, they will disrupt biological wastewater treatment procedures. As a result, traditional wastewater treatment plants are inadequate for PPCPs elimination. PPCPs have been effectively eliminated using advanced oxidation methods such as electrochemical oxidation, ultrasonication, and ionizing radiation. This review summarizes recent studies on the removal of PPCPs by advanced oxidation processes, as well as knowledge useful for applying these processes in water and wastewater treatment. The degradation of different classes of PPCPs has been reviewed to analyze (i) significant factors — initial concentration of PPCPs, ultrasonication power, radiation dose, current density, temperature, pH, time, and effect of catalysts; (ii) degradation efficiency of the processes when applied in combination with other advanced oxidation methods; (iii) key factors that affect the removal of PPCPs based on their properties. In addition, suggestions for future studies on advanced oxidation methods and their limitations were discussed. Overall, this review could aid in providing an in-depth understanding of the current research trends concerning PPCPs and advanced oxidation processes. • Removal of PPCPs using conventional wastewater treatment techniques is difficult. • Ultrasonication in combination with other AOP enhanced degradation efficiency. • Ionizing radiation in tune with biological treatment methods boosted degradation. • Electrochemical oxidation is better recommended as final step in water treatment.

Pharmaceutical and Personal Care Products in Different Matrices: Occurrence, Pathways, and Treatment Processes

The procedures for analyzing pharmaceuticals and personal care products (PPCPs) are typically tedious and expensive and thus, it is necessary to synthesize all available information from previously conducted research. An extensive collection of PPCP data from the published literature was compiled to determine the occurrence, pathways, and the effectiveness of current treatment technologies for the removal of PPCPs in water and wastewater. Approximately 90% of the compiled published papers originated from Asia, Europe, and the North American regions. The incomplete removal of PPCPs in different water and wastewater treatment processes was widely reported, thus resulting in the occurrence of PPCP compounds in various environmental compartments. Caffeine, carbamazepine, diclofenac, ibuprofen, triclosan, and triclocarban were among the most commonly reported compounds detected in water and solid matrices. Trace concentrations of PPCPs were also detected on plants and animal tissues, indicating the bioaccumulative properties of some PPCP compounds. A significant lack of studies regarding the presence of PPCPs in animal and plant samples was identified in the review. Furthermore, there were still knowledge gaps on the ecotoxicity, sub-lethal effects, and effective treatment processes for PPCPs. The knowledge gaps identified in this study can be used to devise a more effective research paradigm and guidelines for PPCP management.

Rainfall Influences Occurrence of Pharmaceutical and Personal Care Products in Landfill Leachates: Evidence from Seasonal Variations and Extreme Rainfall Episodes.

Unused or expired pharmaceutical and personal care products (PPCPs) are usually discharged into municipal solid wastes, then travel to landfills, and eventually percolate into leachates. However, knowledge of their occurrence and temporal dynamics in leachates is limited, making landfill leachate an underappreciated emission source of PPCPs. Furthermore, the differences in PPCP variations in landfill leachates emphasize the necessity for identifying the influencing factors and elucidating the mechanisms for PPCP fluctuations. In this study, successive monthly monitoring of PPCPs in leachates throughout an entire year was performed to determine their seasonal variations and identify their influencing factors. Furthermore, five pairs of additional sampling campaigns were conducted before and after rainfall events during wet seasons to elucidate the influencing mechanisms. The results showed that there was a distinct seasonal variation in PPCPs in landfill leachates-elevated levels during the wet period (from April to September, with a mean concentration of 17.0 μg/L for total monitored PPCPs)-when compared to other months (mean concentration of 3.8 μg/L). Rainfall played a considerable role in mediating PPCP concentrations in leachates. The PPCP responses to five rainfall episodes further verified the influence of rainfall and demonstrated that the tendency to PPCP concentration increase was related to rainfall precipitation. Torrential rain events (i.e., 24 h cumulative precipitation of 50-99.9 mm) led to the most significant increases in PPCP concentrations in landfill leachates. In addition, the hydrophilicity of PPCPs contributed to the different fluctuations during the 1 year investigation and different responses to rainfall. To the best of our knowledge, this study provides the first direct evidence supporting the influence of rainfall on PPCPs in landfill leachates, which can help better understand the occurrence and behavior of emerging contaminants in this underappreciated emission source.

Occurrence and ecological risk assessment of PPCPs in typical inflow rivers of Taihu lake, China

The occurrence and ecological risks of ten typical pharmaceutical and personal care products (PPCPs) at 12 typical inflow rivers of Taihu lake was investigated in this study. Seven out of the ten typical PPCPs targeted were detected in all the water samples and sediment samples tested. The PPCPs concentration detected were 0–94.91 ng/L for water samples and 0–18.27 ng/g for sediment samples. Sulfamethoxazole (SMZ) and erythromycin (ERY) has relatively higher concentration than other PPCPs in surface water samples, ciprofloxacin (CIP) and ofloxacin (OFX) has relatively higher concentration in the sediment samples. Inflow river-Caoqiao river has a relatively highest contamination of TN and TP, the PPCPs concentration in the river channel, estuary, lake-body also shows high value. This occurs in both the surface water and sediment sample, implied a relatively high pollution input from Caoqiao river. SMZ holds high long-term ecological risks in both surface water and sediment of almost all the tested inflow rivers of Taihu lake. Only ERY has medium short-term risks in surface water, other analyzed PPCPs hold low or insignificant short-terms risks for both surface water and sediments. This study fills the gap of PPCPs ecological risk of surface water and sediment of 12 typical inflow rivers of Taihu Lake, and revealed the importance of control sulfanilamide of the economic belt around Taihu Lake. The results of the present study are useful in providing information for PPCPs control and sustainable water management in freshwater lakes.

Seasonal Removal Efficiency and Degradation Products of Two Typical PPCPs in Subsurface Flow Constructed Wetlands

The pollution of surface waters by pharmaceuticals and personal care products (PPCPs) has aroused widespread concern. Constructed wetlands (CWs) have outstanding advantages in the removal of PPCPs; however, few studies have focused on the interaction of different types of PPCPs in CWs. In this study, two typical PPCPs[broad-spectrum antimicrobial agents triclosan (TCS) and non-steroidal anti-inflammatory drug diclofenac (DCF)] were selected as target pollutants and their removal behavior in subsurface flow CWs was analyzed. The effects of different seasons and influent conditions (i.e., single and combined addition of TCS and DCF) on removal efficiency was also examined. The main parameters of the CW system were as follows:the up-flow subsurface CW had a hydraulic load of 0.20 m·d-1 and a hydraulic residence time of 3 d with a continuous flow inlet. The initial influent concentration of PPCPs was 80 g·L-1 for TCS and 25 g·L-1 for DCF. The results showed that the average removal efficiencies for TCS and DCF in summer (91.72% and 85.86%, respectively) were significantly higher than in winter (52.88% and 32.47%, respectively). Independent sample t-tests confirmed that there was no significant difference in the removal efficiency of TCS and DCF under the different influent conditions (single and combined addition). The degradation products of TCS and DCF were also no different between the influent systems, and the representative degradation products of TCS were not detected in all systems. The main degradation products of DCF in the different systems were 3,5-dichlorobenzoic acid and m-dichlorobenzene. The two studied PPCPs showed no significant antagonism and competition effects at trace levels.

Modeling the fate and human health impacts of pharmaceuticals and personal care products in reclaimed wastewater irrigation for agriculture

Wastewater reclamation and reuse for agriculture have attracted a great deal of interest, due to water stress caused by rapid increase in human population and agricultural water demand as well as climate change. However, the application of treated wastewater for irrigation can lead to the accumulation of pharmaceuticals and personal care products (PPCPs) in the agricultural crops, grazing animals, and consequently to human dietary exposure. In this study, a model was developed to simulate the fate of five PPCPs; triclosan (TCS), carbamazepine (CBZ), naproxen (NPX), gemfibrozil (GFB), and fluoxetine (FXT) during wastewater reuse for agriculture, and potential human dietary exposure and health risk. In a reclaimed wastewater-irrigated grazing farm growing alfalfa, it took 100-535 days for PPCPs to achieve the steady-state concentrations of 1.43 × 10-6, 4.73 × 10-5, 1.17 × 10-6, 1.53 × 10-5, and 7.38 × 10-6 mg/kg for TCS, CBZ, NPX, GFB, and FXT in soils, respectively. The accumulated concentration of PPCPs in the plant (alfalfa) and grazing animals (beef) ranged 2.86 × 10-7- 4.02 × 10-3 and 4.39 × 10-15- 6.27 × 10-7 mg/kg, respectively. Human dietary exposure to these compounds through beef consumption was calculated to be 1.67 × 10-18- 1.74 × 10-10 mg/kg bodyweight/d, much lower than the acceptable daily intake (ADI). Similar results were obtained for a 'typical' reclaimed wastewater irrigated farm based on the typical setup using our model. Screening analysis showed that PPCPs with relatively high LogD value and lower ratios of degradation rate (in soils) to plant uptake have a greater potential to be transferred to humans and cause potential health risks. We established a modeling method for evaluating the fate and human health effects of PPCPs in reclaimed wastewater reuse for the agricultural system and developed an index for screening PPCPs with high potential to accumulate in agricultural products. The model and findings are valuable for managing water reuse for irrigation and mitigating the harmful effects of PPCPs.

Removal of Pharmaceutical Micropollutants with Integrated Biochar and Marine Microalgae.

Using microalgae to remove pharmaceuticals and personal care products (PPCPs) micropollutants (MPs) have attracted considerable interest. However, high concentrations of persistent PPCPs can reduce the performance of microalgae in remediating PPCPs. Three persistent PPCPs, namely, carbamazepine (CBZ), sulfamethazine (SMT) and tramadol (TRA), were treated with a combination of Chaetoceros muelleri and biochar in a photobioreactor during this study. Two reactors were run. The first reactor comprised Chaetoceros muelleri, as the control, and the second reactor comprised Chaetoceros muelleri and biochar. The second reactor showed a better performance in removing PPCPs. Through the response surface methodology, 68.9% (0.330 mg L−1) of CBZ, 64.8% (0.311 mg L−1) of SMT and 69.3% (0.332 mg L−1) of TRA were removed at the initial concentrations of MPs (0.48 mg L−1) and contact time of 8.1 days. An artificial neural network was used in optimising elimination efficiency for each MP. The rational mean squared errors and high R2 values showed that the removal of PPCPs was optimised. Moreover, the effects of PPCPs concentration (0–100 mg L−1) on Chaetoceros muelleri were studied. Low PPCP concentrations (<40 mg L−1) increased the amounts of chlorophyll and proteins in the microalgae. However, cell viability, chlorophyll and protein contents dramatically decreased with increasing PPCPs concentrations (>40 mg L−1).

Pharmaceuticals and personal care products in a Mediterranean coastal wetland: Impact of anthropogenic and spatial factors and environmental risk assessment.

The present study focused on the occurrence, distribution and risk assessment of 32 pharmaceuticals and personal care products (PPCPs) in water and sediment, as well as the surrounding soil of the irrigation channels and lake of a Mediterranean coastal wetland, the Albufera Natural Park (Valencia, Spain). Moreover, the influent and effluent of ten wastewater treatment plants (WWTPs) that treat wastewater from Valencia and the surrounding areas were also studied. BPA, caffeine, diclofenac, ethyl paraben, methyl paraben, metformin, tramadol and salicylic acid were the predominant PPCPs detected in the channels and the lake, and are in good agreement with those detected in the effluent. Furthermore, 22 PPCPs were detected in >47% of the sediment samples. Of them, BPA, ethyl paraben, furosemide, ibuprofen and salicylic acid were at higher concentrations. In contrast, only seven PPCPs were detected in >44% of the soil samples. Spatial variation showed that the concentration of many PPCPs was higher in the northern area of the park, whereas the ibuprofen concentrations were higher in the south. Differences were also observed according to the type of water used for irrigation and the land uses of the area. A risk assessment based on the hazardous quotient (HQ) indicated that caffeine is a compound of concern, and tramadol at the highest concentration showed a moderate risk for the organisms assessed. Considering the mixture of the PPCPs found at each sampling point, the green algae are at risk, particularly in those points located near the city of Valencia (the most important nearby human settlement). These results indicate the need for further studies.

Occurrence, seasonal variations, and ecological risk of pharmaceuticals and personal care products in River Ganges at two holy cities of India

Occurrence of 15 different pharmaceuticals and personal care products (PPCPs) (ibuprofen, diclofenac, ketoprofen, acetaminophen, ciprofloxacin, erythromycin, amoxicillin, ofloxacin, tetracycline, metoprolol, triclosan, salicylic acid, N, N diethyl-meta-toluamide, caffeine and β-Estradiol) belongs to eight different classes in an urban stretch of River Ganges were detected for three seasons in two holy cities Rishikesh and Haridwar (India). The overall concentration of PPCPs in the River Ganges ranged between Below Detectable Limit (BDL) to 1104.84 ng/L, with higher concentrations at anthropogenically influenced lower reaches of the River Ganges at Haridwar. Acetaminophen, triclosan, N, N diethyl-meta-toluamide (DEET), tetracycline, and caffeine showed the highest detection frequency (>90–100%) in the river. PPCPs concentration, especially for NSAIDs (Ibuprofen, ketoprofen and acetaminophen), antibiotics (ciprofloxacin, tetracycline and ofloxacin) and metabolite (salicylic acid) was found to be higher in winter compared to summer in the Ganges, possibly due to the lower biodegradation efficiency related to lesser temperatures and inadequate sunlight. While metoprolol (beta-blockers), triclosan (antibacterial), DEET (insect repellent) and caffeine (human indicator) showed a higher load in summer, possibly due to their intense uses during this period. Results of risk quiescent (RQ) revealed higher ecological risk for algae while the moderate risk for river fish biota.

Pharmaceuticals and personal care products and their sublethal and lethal effects in aquatic organisms

Pharmaceuticals and personal care products (PPCPs) include over-the-counter and prescription drugs, veterinary drugs, fragrances, and cosmetics. PPCPs have been detected in aquatic environments at low concentrations and are emerging as contaminants of concern. PPCPs are primarily released into aquatic environments via untreated sewage, wastewater treatment plants, landfill leachate and can affect aquatic life through persistence, bioaccumulation, and toxicity. However, there are limited reviews of lethal and sublethal effects of PPCP exposures on aquatic organisms. To understand PPCP toxicity on aquatic organisms, a literature review was conducted that identified aquatic organisms known to be affected by PPCPs; concentrations of PPCPs reported as producing sublethal and lethal effects in aquatic organisms; and research gaps on PPCP aquatic toxicity. Twelve PPCPs were selected from three seminal studies for review, including bisphenol A, carbamazepine, erythromycin, fluoxetine, linear alkylbenzene sulfonate, metoprolol, naproxen, nonylphenol, ofloxacin, sertraline, sulfamethoxazole, and triclosan. Many aquatic species were affected by PPCPs at sublethal and lethal exposures, including sublethal effects at environmentally relevant concentrations. Because lethal effects were seldom observed at environmentally relevant concentrations, many studies considered PPCPs non-toxic. Few studies have compared effects of PPCPs on the same organisms for identical exposure parameters (time and concentration), resulting in wide variation in reported toxicity levels with limited consensus in the academic literature. Consensus in lethal concentrations was reported for Daphnia magna with 48 h exposure for bisphenol A and triclosan and Vibrio fischeri with 15 min exposure to carbamazepine. Environmentally relevant sublethal concentrations were higher than water quality guidelines developed for Canada and predicted no-effect concentrations derived globally. Species sensitivity distributions for some PPCPs show that aquatic species are affected lethally at environmentally relevant concentrations. More studies on indirect and long-term ecological effects along with testing chronic toxicity of PPCPs at environmentally relevant concentrations are recommended. These will help guide future research to determine extent and magnitude of PPCP concentrations in aquatic environments and help inform management decisions to reduce sources of PPCPs into the environment. Future management requires effective monitoring strategies regarding use, disposal, occurrence, and impacts at different life cycle stages of PPCPs in the environment.

Anthropogenic disturbances on distribution and sources of pharmaceuticals and personal care products throughout the Jinsha River Basin, China

Pharmaceuticals and personal care products (PPCPs) are recognized as a group of emerging contaminants closely related to anthropogenic activities, which capture increasing attention worldwide. To evaluate the anthropogenic disturbances on PPCP distribution and sources, this study investigated the distribution and sources of 50 PPCPs along the 2300 km long Jinsha River and revealed different anthropogenic disturbances on PPCPs. Results showed that 40 out of the 50 PPCPs were ubiquitously detected among these river water samples, with the concentrations varied from less than 1 ng/L to more than 500 ng/L. Although most PPCPs concentrations were much lower in the Jinsha River than in highly developed rivers, the prevalence of PPCPs suggested the widespread use and improper disposal of PPCPs in the Jinsha River. The risk assessment also revealed that some PPCPs posed risks to aquatic organisms in the Jinsha River. Anthropogenic activities including human habitation and dam construction had different influence on PPCPs. PPCP distribution varied significantly across the “Hu Huanyong line”, indicating human habitation significantly influenced PPCP distribution. Dam construction was insignificant in altering PPCP distribution throughout the Jinsha River. Moreover, the land use index indicated degradation level of multiple lands related to anthropogenic activities and represented the major sources of PPCPs in the Jinsha River. Most PPCPs were correlated with anthropogenic lands, for example, antibiotics, analgesics, and endocrine disrupting chemicals mainly originated from artificial surfaces, whereas other PPCPs mainly originated from cultivated lands. Together, this study indicates the disturbances of multiple anthropogenic activities on PPCP distribution and sources along the Jinsha River, which contributes to PPCP management in rural areas.

Sediment contamination and toxic effects on Violet Goby fish (Gobioides broussonnetii - Gobiidae) from a marine protected area in South Atlantic

The Estuarine-Lagoon Complex of Iguape-Cananéia (ELCIC), a Marine Protected Area (MPA) in Brazil, was the focus of this study that aimed to relate external levels of exposure to contaminants to toxic effects on Gobioides broussonnetii fish. Different anthropogenic contaminants such as metals, polycyclic aromatic hydrocarbons (PAHs) and pharmaceuticals and personal care products (PPCPs) were analyzed in the sediments; and biochemical, histopathological and genotoxicity biomarkers evaluated in fish; in two different seasons at three sites of the estuarine region. Higher contamination of the sediments was observed near the main urban center (Iguape city - IG). Metal concentrations were considered low to moderate, while PAHs concentrations were considered low. The concentrations of PPCPs increased due to the anthropogenic presence and were higher near IG and the Cananéia Island (CI). Contributions from historical mining, agriculture, nautical activities, oil, sewage and waste disposal, biomass and fossil fuels combustion were identified. Higher concentrations of metals and PPCPs were observed during the cold-dry season, suggesting influences of the lower hydrodynamics during the season of lower precipitation. Higher PAHs concentrations occurred in the hot-rainy season, indicating influences of greater human presence in summer. In fish, biological responses followed the same spatial and seasonal pattern. More pronounced changes in antioxidant, biotransformation, histopathological and genotoxic biomarkers were observed in IG and CI. The multivariate analysis and the integrated biomarkers response index (IBR) also evidenced worse environmental conditions in these sites. This result can indicate a negative influence of anthropogenic activities on the contamination of sediments and on the biological responses of fish. This study presented the first ecotoxicological data for the species and suggested that these chronic exposures can cause adverse effects on this fish population. The data contribute to the understanding of local environmental quality and can be applied in the future to the environmental and social management of marine protected areas.