Peripheral Components Research Articles

Association of Pretreatment Neutrophil-to-Eosinophil Ratio with Clinical Outcomes in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Treated with Nivolumab.

There is a need to develop biomarkers for a more efficient use of immune checkpoint inhibitors (ICIs). Recently, it has been reported that peripheral blood components, including eosinophils, may be effective ICI biomarkers. This study was designed to evaluate the prognostic value of eosinophils for measuring the effects of nivolumab on recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). The study included 47 patients with R/M HNSCC treated with nivolumab. Eosinophil-related biomarkers, such as absolute eosinophil count (AEC), relative eosinophil count (REC), and neutrophil-to-eosinophil ratio (NER), were measured from the peripheral blood of the patients before nivolumab treatment. For each biomarker, the patients were divided into a high- and a low-value group according to their cutoff values, and these groups were compared. Regarding AEC and REC, no significant improvement in the objective response rate (ORR) was observed between patients with AEC >0.9 × 103/μL and those with AEC <0.9 × 103/μL (p = 0.147) and between patients with REC >2.2% and those with REC <2.2% (p = 0.110). However, patients with NER <32 had improved ORR compared with those with NER >32 (P = 0.0361). Additionally, although patients with AEC >0.9 × 103/μL, REC >2.2%, and NER <32 had longer overall survival (OS) than those with AEC <0.9 × 103/μL, REC <2.2%, and NER >32, only patients with NER <32 showed prolonged progression-free survival (PFS) compared with those with NER >32 according to the Log rank test (p = 0.046, 0.027, and 0.035, respectively). Furthermore, the multivariate analysis revealed that baseline NER >32 (p = 0.027) was an independent prognostic factor for worse OS. A pretreatment feature of low NER (NER <32) may predict better clinical outcomes in patients with R/M HNSCC treated with nivolumab.

Remembrance of things past: The consequences of recurrent hypoglycaemia in diabetes.

People with type 1 and type 2 diabetes still frequently experience hypoglycaemia, which can be severe, leading to loss of consciousness. This review will examine the cellular consequences of recurrent hypoglycaemia. This review, based on the Dorothy Hodgkin Lecture given at the Diabetes UK 2022 annual symposium by the author, will discuss our current understanding of the mechanisms by which hypoglycaemia is detected and the consequences of recurrent exposure to hypoglycaemia. Glucose-responsive cells found in the periphery as well as multiple areas of the brain are organised in a classical sensori-motor integrative network encompassing peripheral, hindbrain and hypothalamic components. The mechanism used by glucose-responsive neurons to detect hypoglycaemia parallel those of the classical glucose sensor the pancreatic ß-cell, namely in their use of glucokinase, KATP channels and AMP-activated protein kinase. Recurrent exposure to hypoglycaemia results in a series of cellular adaptations that may be designed to increase the resilience of cells to future hypoglycaemia. This review also highlights how hypoglycaemia, as an oxidative stressor, may also exacerbate chronic hyperglycaemia-induced increases in oxidative stress and inflammation, leading to damage to vulnerable brain regions. Impaired awareness of hypoglycaemia follows the adaptation of central glucose-responsive neurons to repeated hypoglycaemia and may represent a form of memory called habituation. In diabetes, recurrent hypoglycaemia may have tissue consequences as a result of a profound disruption in the cellular response to a hypoglycaemic challenge that increases vulnerability to oxidative damage.

Duty Cycle Detection Method for High Speed Input-Output Systems

A clock coupled duty cycle detection method for high speed input-output is presented in this paper. In High speed systems duty cycle (DC) of output signal needs to be calibrated at 50% for having acceptable performance in the system. The proposed method introduces a synchronous signal in the output of system with 50% duty cycle with maximum 1 % error over process, voltage, and temperature (PVT). Proposed method also compensate input referred offset of DC detector which helps to improve overall system performance. The duty cycle detection method was implemented in 16nm technology with a power supply of 1.2V. With this type of designed architecture, the circuit can provide up to 5Gbps frequency data signal. Experimental results show that proposed architecture is reliable, and it can work operative in high frequency intervals. The presented circuit can be implemented in special serial links of several standards such as Peripheral Component Interconnect (PCI), Universal Serial Bus (USB) and Double Data Rate (DDR).

New Actuation Control for Hybrid Electromagnetic Valve Train

Nowadays, vehicle industries are trying to introduce actively controllable variable valve trains to achieve maximumly efficient internal combustion engines. The electromagnetic valve train (EMV) is one of the promising valve actuators. A traditional electromagnet valve needs to be continuously supplied with current and consumes more energy during valve opening and closing, and the permanent magnet-assisted valves have a demagnetization issue. Thus, this study presents a hybrid permanent magnet electromagnetic valve (PMEMV), which needs a power supply only for a short interval of time during valve opening or closing; eventually, this PMEMV consumes much less energy than conventional EMVs. This paper proposed an improved control approach for this hybrid PMEMV to achieve variable valve actuation. Magnetic stimulation was performed on the proposed valve train to analyze the direction of the magnetic circuit during the valve actuation. An improved magnetic circuit control method was introduced to achieve the release and attraction of the armature. This innovative magnetic circuit control can make the armature effectively attract at each apex, so that the PMEMV can be effectively and completely actuated. The prototype of the valve train and the experimental platform were developed to test and validate the real-time performance of the composite EM valve. Peripheral sensor components were used to measure the valve displacement. The experimental results proved that the concept of the innovative magnetic-circuit drive and control can enable the successful operation of the hybrid compound EM valve.

LUNG CANCER IS NOT ALWAYS THE ANSWER: EXPLORING THE DIFFERENTIAL DIAGNOSIS OF THORACIC MASSES

LUNG CANCER IS NOT ALWAYS THE ANSWER: EXPLORING THE DIFFERENTIAL DIAGNOSIS OF THORACIC MASSES

Development and characterization of an automated portable wound irrigation device for diabetic ulcers

&lt;p&gt;Patients with diabetes mellitus may experience peripheral neuropathy and extremity system impairment, which may lead to ulceration if the treatments are delayed. Diabetic ulcers, unfortunately, are chronic, which require proper treatments, including debridement and bacterial removal using an irrigation device. To date, commercial irrigation devices included pulsed-lavage, bulb syringe, and gravity bags. Unfortunately, the devices have limitations in terms of portability, measurability, controllability, and disposability. To tackle the limitations, this study aims to design, fabricate, and characterize an automated portable wound irrigation device (Apdice), which is controllable non-disposable, and portable. The device was designed and fabricated using a lightweight construction, a rechargeable battery, and non-disposable materials to support the portability and non-disposable means. Meanwhile, the proportional-derivative-integral controller with its peripheral components were featured to enable controllability. Furthermore, the device was also tested regarding the contamination using a particle counter, and appeared to be contamination free. In short, Apdice showed a robust technological performance. However, it is also worth the try to test the contamination test against biological agents to guarantee the biocompatibility of the device.&lt;/p&gt;

Energy-Efficient Encoding for High-Speed Serial Interfaces

Energy consumption has become a bottleneck in modern integrated circuits (ICs) with a significant part of the energy spent on data communication. High-speed, serial interfaces are widely used, offering important advantages over parallel buses. The energy demand of source synchronous, serial buses can be effectively decreased by employing encoding techniques that reduce the bit transitions of the transmitted data stream. However, these techniques are not applicable for asynchronous interfaces, such as Peripheral Component Interconnect Express (PCIe), where frequent bit transitions are required to recover the clock at the receiver to maintain link integrity. Recognizing this fundamental trait, an encoding technique named serial tuned transition encoding (STTE) is proposed that regulates the number of transitions such that the clock can be reliably recovered, while the communication energy is lowered. The proposed scheme provides at least 25% decrease in energy for a short interposer-based interconnect compared to scrambling, which is typically used in serializer/deserializer (SerDes) devices. The link integrity is experimentally evaluated using both an electrical and an optical link that interconnect two field-programmable gate array (FPGA) devices. Results demonstrate that STTE successfully preserves link integrity as no errors are induced during transmission. In addition, STTE adjusts the number of transitions, thus allowing energy reduction and link integrity to be traded off.

Tumor necrosis factor receptor regulation of peripheral node addressin biosynthetic components in tumor endothelial cells.

Tumor-associated tertiary lymphoid structures are ectopic lymphoid aggregates that have considerable morphological, cellular, and molecular similarity to secondary lymphoid organs, particularly lymph nodes. Tumor vessels expressing peripheral node addressin (PNAd) are hallmark features of these structures. Previous work from our laboratory demonstrated that PNAd is displayed on intratumoral vasculature of murine tumors, and its expression is controlled by the engagement of lymphotoxin-α3, secreted by effector CD8 T cells, with tumor necrosis factor receptors (TNFR) on tumor endothelial cells (TEC). The goals of the present work were: 1) to identify differences in expression of genes encoding the scaffolding proteins and glycosyl transferases associated with PNAd biosynthesis in TEC and lymph node blood endothelial cells (LN BEC); and 2) to determine which of these PNAd associated components are regulated by TNFR signaling. We found that the same genes encoding scaffolding proteins and glycosyl transferases were upregulated in PNAd+ LN BEC and PNAd+ TEC relative to their PNAdneg counterparts. The lower level of PNAd expression on TEC vs LN BEC was associated with relatively lower expression of these genes, particularly the carbohydrate sulfotransferase Chst4. Loss of PNAd on TEC in the absence of TNFR signaling was associated with lack of upregulation of these same genes. A small subset of PNAd+ TEC remaining in the absence of TNFR signaling showed normal upregulation of a subset of these genes, but reduced upregulation of genes encoding the scaffolding proteins podocalyxin and nepmucin, and carbohydrate sulfotransferase Chst2. Lastly, we found that checkpoint immunotherapy augmented both the fraction of TEC expressing PNAd and their surface level of this ligand. This work points to strong similarities in the regulation of PNAd expression on TEC by TNFR signaling and on LN BEC by lymphotoxin-β receptor signaling, and provides a platform for the development of novel strategies that manipulate PNAd expression on tumor vasculature as an element of cancer immunotherapy.

CONTINUUM OF PARAPHRASING – SYNTAX SYNONYMY IN THE DICHOTOMY LANGUAGE IS SPEECH (on the material of modern French artistic prose)

This paper is dedicated to the studies of syntactical synonymy as one of kinds of periphrasing in the dichotomy language/ discourse and theory of mental kinetism. It is establishedthat in the process of transformation in language are formed the one basic (with one terminal chain) and two basic (with two or more terminal chains)synonymic periphrases of pivotal (primary) syntagm or proposition, that are actualized in discourse in the form of co(n)textually preferential options. On the bases of syntactical and semantic valence of elements of synonymic constructionsare defined the key lexemes of each option which form with peripheral lexical components certain models of synonymic derivational trees (nominal, verbal, adjectival etc.). As the result of studies the virtual terminal chains of discourse innovations-synonymic structures are reconstructed and the hierarchical and horizontal semantic and syntactical relations between them are established in the functional-semantic field of syntactical synonymy.

TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy

Chronic pain and pruritus are highly disabling pathologies that still lack appropriate therapeutic intervention. At cellular level the transduction and transmission of pain and pruritogenic signals are closely intertwined, negatively modulating each other. The molecular and cellular pathways involved are multifactorial and complex, including peripheral and central components. Peripherally, pain and itch are produced by subpopulations of specialized nociceptors that recognize and transduce algesic and pruritogenic signals. Although still under intense investigation, cumulative evidence is pointing to the thermosensory channel TRPV1 as a hub for a large number of pro-algesic and itchy agents. TRPV1 appears metabolically coupled to most neural receptors that recognize algesic and pruritic molecules. Thus, targeting TRPV1 function appears as a valuable and reasonable therapeutic strategy. In support of this tenet, capsaicin, a desensitizing TRPV1 agonist, has been shown to exhibit clinically relevant analgesic, anti-inflammatory, and anti-pruritic activities. However, potent TRPV1 antagonists have been questioned due to an hyperthermic secondary effect that prevented their clinical development. Thus, softer strategies directed to modulate peripheral TRPV1 function appear warranted to alleviate chronic pain and itch. In this regard, soft, deactivatable TRPV1 antagonists for topical or local application appear as an innovative approach for improving the distressing painful and itchy symptoms of patients suffering chronic pain or pruritus. Here, we review the data on these compounds and propose that this strategy could be used to target other peripheral therapeutic targets.

Loss of key endosymbiont genes may facilitate early host control of the chromatophore in Paulinella

SummaryThe primary plastid endosymbiosis (∼124 Mya) that occurred in the heterotrophic amoeba lineage, Paulinella, is at an earlier stage of evolution than in Archaeplastida, and provides an excellent model for studying organelle integration. Using genomic data from photosynthetic Paulinella, we identified a plausible mechanism for the evolution of host control of endosymbiont (termed the chromatophore) biosynthetic pathways and functions. Specifically, random gene loss from the chromatophore and compensation by nuclear-encoded gene copies enables host control of key pathways through a minimal number of evolutionary innovations. These gene losses impact critical enzymatic steps in nucleotide biosynthesis and the more peripheral components of multi-protein DNA replication complexes. Gene retention in the chromatophore likely reflects the need to maintain a specific stoichiometric balance of the encoded products (e.g., involved in DNA replication) rather than redox state, as in the highly reduced plastid genomes of algae and plants.

Cold Water Immersion Improves the Recovery of Both Central and Peripheral Fatigue Following Simulated Soccer Match-Play.

The present study aimed to investigate the effect of cold water immersion (CWI) on the recovery of neuromuscular fatigue following simulated soccer match-play. In a randomized design, twelve soccer players completed a 90-min simulated soccer match followed by either CWI or thermoneutral water immersion (TWI, sham condition). Before and after match (immediately after CWI/TWI through 72 h recovery), neuromuscular and performance assessments were performed. Maximal voluntary contraction (MVC) and twitch responses, delivered through electrical femoral nerve stimulation, were used to assess peripheral fatigue (quadriceps resting twitch force, Qtw,pot) and central fatigue (voluntary activation, VA). Performance was assessed via squat jump (SJ), countermovement jump (CMJ), and 20 m sprint tests. Biomarkers of muscle damages (creatine kinase, CK; Lactate dehydrogenase, LDH) were also collected. Smaller reductions in CWI than TWI were found in MVC (-9.9 ± 3%vs-23.7 ± 14.7%), VA (-3.7 ± 4.9%vs-15.4 ± 5.6%) and Qtw,pot (-15.7 ± 5.9% vs. -24.8 ± 9.5%) following post-match intervention (p < 0.05). On the other hand, smaller reductions in CWI than TWI were found only in Qtw,pot (-0.2 ± 7.7% vs. -8.8 ± 9.6%) at 72 h post-match. Afterwards, these parameters remained lower compared to baseline up to 48–72 h in TWI while they all recovered within 24 h in CWI. The 20 m sprint performance was less impaired in CWI than TWI (+11.1 ± 3.2% vs. +18 ± 3.6%, p < 0.05) while SJ and CMJ were not affected by the recovery strategy. Plasma LDH, yet no CK, were less increased during recovery in CWI compared to TWI. This study showed that CWI reduced both central and peripheral components of fatigue, which in turn led to earlier full recovery of the neuromuscular function and performance indices. Therefore, CWI might be an interesting recovery strategy for soccer players.

Is Chinese Thyroid Imaging Reporting and Data Systems superior to American College of Radiology or American Thyroid Association guidelines for consistency and efficacy in the diagnosis of thyroid cancer?

Is Chinese Thyroid Imaging Reporting and Data Systems superior to American College of Radiology or American Thyroid Association guidelines for consistency and efficacy in the diagnosis of thyroid cancer?

The effects of certain TRP channels and voltage-gated KCNQ/Kv7 channel opener retigabine on calcitonin gene-related peptide release in the trigeminovascular system.

Calcitonin gene-related peptide release in trigeminovascular system is a pivotal component of neurogenic inflammation underlying migraine pathophysiology. Transient receptor potential channels and voltage-gated KCNQ/Kv7 potassium channels expressed throughout trigeminovascular system are important targets for modulation of calcitonin gene-related peptide release. We investigated the effects of certain transient receptor potential (TRP) channels the vanilloid 1 and 4 (TRPV1 and TRPV4), the ankyrin 1 (TRPA1), and metastatin type 8 (TRPM8), and voltage-gated potassium channel (Kv7) opener retigabine on calcitonin gene-related peptide release from peripheral (dura mater and trigeminal ganglion) and central (trigeminal nucleus caudalis) trigeminal components of rats. The experiments were carried out using well-established in-vitro preparations (hemiskull, trigeminal ganglion and trigeminal nucleus caudalis) from male Wistar rats. Agonists and antagonists of TRPV1, TRPV4, TRPA1 and TRPM8 channels, and also retigabine were tested on the in-vitro release of calcitonin gene-related peptide. Calcitonin gene-related peptide concentrations were measured using enzyme-linked immunosorbent assay. Agonists of these transient receptor potential channels induced calcitonin gene-related peptide release from hemiskull, trigeminal ganglion and trigeminal nucleus caudalis, respectively. The transient receptor potential channels-induced calcitonin gene-related peptide releases were blocked by their specific antagonists and reduced by retigabine. Retigabine also decreased basal calcitonin gene-related peptide releases in all preparations. Our findings suggest that favorable antagonists of these transient receptor potential channels, or Kv7 channel opener retigabine may be effective in migraine therapy by inhibiting neurogenic inflammation that requires calcitonin gene-related peptide release.

Optimal peripheral nerve stimulation intensity for paired associative stimulation with high-frequency peripheral component in healthy subjects

Paired associative stimulation (PAS) with high-frequency peripheral nerve stimulation (PNS), called “high-PAS”, induces motor-evoked potential (MEP) potentiation in healthy subjects and improves muscle activity and independence in incomplete spinal cord injury patients. Data on optimal PNS intensity in PAS are scarce. In a high-PAS protocol, PNS intensity is defined as “minimal intensity required to produce F-responses”. We sought to further refine this definition and to investigate how PNS intensity affects PAS outcome. Two experiments were performed on 10 healthy subjects where MEP amplitude change was measured 0, 30, and 60 min after PAS. In the first experiment, the intensity required to achieve 7/10 persistence of F-responses was used to define PNS intensity level. In the second experiment, we used the intensity required to achieve 1/10 persistence (“baseline”). In addition, we applied this intensity at + 25%, − 25%, and − 50% levels. In the first experiment, PAS did not produce significant MEP potentiation. In the second experiment, PAS produced statistically significant MEP potentiation, with PNS intensity of “baseline” and “baseline − 25%” levels but not at + 25% or − 50% levels. In conclusion, for PAS utilizing high-frequency PNS, the intensity required to achieve 1/10 F-response persistence or the intensity 25% lower produces significant MEP potentiation in healthy subjects.

An Approach for Automated Disassembly of Lithium-Ion Battery Packs and High-Quality Recycling Using Computer Vision, Labeling, and Material Characterization

A large number of battery pack returns from electric vehicles (EV) is expected for the next years, which requires economically efficient disassembly capacities. This cannot be met through purely manual processing and, therefore, needs to be automated. The variance of different battery pack designs in terms of (non-) solvable fitting technology and superstructures complicate this. In order to realize an automated disassembly, a computer vision pipeline is proposed. The approach of instance segmentation and point cloud registration is applied and validated within a demonstrator grasping busbars from the battery pack. To improve the sorting of the battery pack components to achieve high-quality recycling after the disassembly, a labeling system containing the relevant data (e.g., cathode chemistry) about the battery pack is proposed. In addition, the use of sensor-based sorting technologies for peripheral components of the battery pack is evaluated. For this purpose, components such as battery pack and module housings of multiple manufacturers were investigated for their variation in material composition. At the current stage, these components are usually produced as composites, so that, for a high-quality recycling, a pre-treatment may be necessary.

Two-dimensional polarization doping of GaN heterojunction and its potential for realizing lateral p–n junction devices

In the gallium nitride (GaN) commercial applications such as high-power illumination and portable charging station, bipolar devices are highly demanded because of their superior power transfer capability. Also, in other scenarios of the monolithic integration where high electron mobility transistors (HEMTs) or superlattice-based devices are presented, the peripheral components are preferred to be lateral. However, to realize such a lateral bipolar junction in GaN, high-concentration p-type dopant doping is still challenging and hardly compatible with the HEMT integration. In this work, we proposed a novel strategy to form lateral bipolar GaN p–n junctions, enabled by the two-dimensional polarization doping. The theory and the simulation reveal this strategy features inspiring forwarding, blocking, and switching performance. Given the recent success of the GaN selective area regrowth techniques, the proposed lateral bipolar junction is highly promising in monolithic heterojunction integration in the future.

Life cycle assessment (LCA) of a battery home storage system based on primary data

While the market for battery home storage systems (HSS) is growing rapidly, there are still few well-modelled life cycle assessment (LCA) studies available for quantifying their potential environmental benefits and impacts. Existing studies mainly rely on data for electric vehicles and often lack a thorough modelling approach, especially regarding the peripheral components. This paper presents a full cradle to grave LCA of a Lithium iron phosphate (LFP) battery HSS based on primary data obtained by part-to-part dismantling of an existing commercial system with a focus on the impact of the peripheral components. Additionally, alternative battery chemistries (Sodium ion battery (SIB) and two lithium nickel manganese cobalt oxides, (NMC811,and NMC622) are investigated under the consideration of the same periphery. This approach allows a comprehensive comparison between present and emerging cell chemistries that can be potentially considered for an HSS.The total greenhouse gas emissions of the HSS are 84 g CO2eq/KWh of electricity delivered over its lifetime in a residential PV application, or 31 g CO2eq/KWh over lifetime when excluding the use-phase impact. The peripheral components contribute between 37% and 85% to the total gross manufacturing impacts of the HSS, depending on the considered cell chemistry and the impact category. Especially the inverter plays an important role, and its impacts are significantly higher than those obtained when using the standard ecoinvent dataset, indicating that the contribution of power electronics might often be underestimated when using this dataset. In terms of cell chemistries, the considered SIB turns out to be not yet competitive with LIB chemistries due to its lower energy density and lifetime, but might become so when reaching similar lifetimes.

Understanding fatigue in primary biliary cholangitis: From pathophysiology to treatment perspectives.

Fatigue is considered one of the most frequent and debilitating symptoms in primary biliary cholangitis (PBC), affecting over 50% of PBC patients. One in five patients with PBC suffer from severe fatigue, which significantly impairs quality of life. Fatigue is made up of a central and a peripheral component, whose pathophysiology is still greatly unresolved. Central fatigue is characterised by a lack of self-motivation and can manifest both in physical and mental activities (lack of intention). Peripheral fatigue includes neuromuscular dysfunction and muscle weakness (lack of ability). Peripheral fatigue could be explained by an excessive deviation from aerobic to anaerobic metabolism leading to excessive lactic acid accumulation and therefore accelerated decline in muscle function and prolonged recovery time. As opposed to itching, and with the exception of end-stage liver disease, fatigue is not related to disease progression. The objective of this review is to outline current understanding regarding the pathophysiology of fatigue, the role of comorbidities and contributing factors, the main tools for fatigue assessment, the failed therapeutic options, and future treatment perspectives for this disabling symptom. Since fatigue is an extremely common and debilitating symptom and there is still no licensed therapy for fatigue in PBC patients, further research is warranted to understand its causative mechanisms and to find an effective treatment.

T-Lymphocyte Interactions with the Neurovascular Unit: Implications in Intracerebral Hemorrhage.

In the pathophysiology of hemorrhagic stroke, the perturbation of the neurovascular unit (NVU), a functional group of the microvascular and brain intrinsic cellular components, is implicated in the progression of secondary injury and partially informs the ultimate patient outcome. Given the broad NVU functions in maintaining healthy brain homeostasis through its maintenance of nutrients and energy substrates, partitioning central and peripheral immune components, and expulsion of protein and metabolic waste, intracerebral hemorrhage (ICH)-induced dysregulation of the NVU directly contributes to numerous destructive processes in the post-stroke sequelae. In ICH, the damaged NVU precipitates the emergence and evolution of perihematomal edema as well as the breakdown of the blood–brain barrier structural coherence and function, which are critical facets during secondary ICH injury. As a gateway to the central nervous system, the NVU is among the first components to interact with the peripheral immune cells mobilized toward the injured brain. The release of signaling molecules and direct cellular contact between NVU cells and infiltrating leukocytes is a factor in the dysregulation of NVU functions and further adds to the acute neuroinflammatory environment of the ICH brain. Thus, the interactions between the NVU and immune cells, and their reverberating consequences, are an area of increasing research interest for understanding the complex pathophysiology of post-stroke injury. This review focuses on the interactions of T-lymphocytes, a major cell of the adaptive immunity with expansive effector function, with the NVU in the context of ICH. In cataloging the relevant clinical and experimental studies highlighting the synergistic actions of T-lymphocytes and the NVU in ICH injury, this review aimed to feature emergent knowledge of T cells in the hemorrhagic brain and their diverse involvement with the neurovascular unit in this disease.