In recent years, an increasing number of seismically isolated high-rise buildings have been constructed in coastal and inland areas exposed to strong winds. However, the effect of wind on seismically isolated high-rise buildings has not been sufficiently investigated, especially from the perspective of wind-resistance design. Accordingly, in this study, the wind-induced effect is comprehensively investigated using a seismically base-isolated super high-rise engineering building in China as a case study. According to China’s recently released “Standard for Seismic Isolation Design of Building” (GB/T51408-2021), the integrated seismic isolation design method (ISIM) based on the theory of complex mode superposition response spectrum and complex complete quadratic combination is adopted for seismic isolation design. The ISIM and traditional seismic isolation design methods are compared from the perspectives of economy and safety. An analysis approach for evaluating the wind-induced effect on seismically isolated high-rise buildings is proposed based on current national codes. The wind-resistance stability of the seismic isolation interface is examined when the return periods of wind loads exceed the 50-year fortification value. The research results show that the ISIM improves the seismic safety of seismically isolated buildings significantly; moreover, the method is economical. The wind vibration comfort problem is observed at the top of a seismically isolated high-rise building, where it is more difficult to meet the comfort requirement under the wind load with a 1-year return period compared with those under wind loads with 5-year and 10-year return periods. The current wind-resistance design method, which is an intrinsically equivalent static calculation method, underestimates the wind-induced effect on seismically isolated high-rise buildings. The wind vibration comfort and wind-resistance stability of seismically isolated high-rise buildings require further evaluation. The possible adverse effects of wind-induced cumulative residual deformation on the seismic isolation interface must be sufficiently considered in the wind-resistance design of seismically isolated high-rise buildings in the future.
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