This chapter considers applications of MNFs and photonic devices that can be fabricated from or using MNFs as sensors that detect changes in the ambient medium by monitoring changes in the transmission power of light propagation through MNFs. The changes in the medium may be caused by variation in temperature, radiation, concentration of chemical or biological species, microparticles, etc. As has been described in Chapter 2, an electromagnetic field mode supported by an MNF has an evanescent part, which is distributed outside the MNF. The evanescent part may include a significant part of the propagating mode and, therefore, can be very sensitive to changes which take place at or near the surface of the MNF. Fig. 6.1 illustrates the principle of optical MNF sensor performance. An MNF either directly performs sensing (Figs. 6.1(a) — (f)) or serves as a waveguide, which connects a photonic sensor to the source and the detector of light (Figs. 6.1(c) and (g) — (k)). Fig. 6.1(a) depicts the simplest uncoated MNF sensor, whose thickness is usually less than the radiation wavelength. For this sensor it is assumed that a significant fraction of the fundamental mode of radiation propagates in the ambient medium. Transmission power of this sensor changes with its optical properties, which depend on the properties of the ambient medium. The sensor illustrated in Fig. 6.1(b) is an MNF, which is coated with chemical or biological reagents. The reagents are supposed to be sensitive to selective chemical or biological species. Fig. 6.1(c) illustrates a generic photonic sensor having MNF input and output. Figs. 6.1(d) — (j) depict the straight MNF sensor[1-8], the MNF loop sensor[9-12], the MNF coil sensor[12-18], the MNF/microsphere sensor[19-30], the MNF/microdisk sensor[31-34], the MNF/microcylinder sensor[4], and the MNF/microcapillary sensor[35-39], respectively. Fig. 6.1(k) illustrates the possible assembly of several MNF-based sensors. The performance of sensors shown in Fig. 6.1 can either be dependent or independent of the interaction of the ambient medium with the evanescent field. The sensors of the first group are devices whose transmission characteristics vary due to changes in optical and/or geometrical properties of the MNF itself and/or of the mode propagating along the MNF. Changes of this kind can be caused by incident radiation, variation of temperature, mechanical vibration, etc. For example, an MNF loop resonator illustrated in Fig. 6.1(e) has been demonstrated as a fast temperature sensor and infrared radiation sensor[9]. The simplest sensor of the second group is a single MNF shown in Fig. 6.1(b), which can detect changes caused by proximity of chemical/biological species and microparticles at the MNF surface. This sensor was demonstrated for silica MNFs[1-7] and polymer MNFs[8].